The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
Open accessAbstract
Compelling evidence suggests that the epithelial cell–derived cytokine thymic stromal lymphopoietin (TSLP) may initiate asthma or atopic dermatitis through a dendritic cell–mediated T helper (Th)2 response. Here, we describe how TSLP might initiate and aggravate allergic inflammation in the absence of T lymphocytes and immunoglobulin E antibodies via the innate immune system. We show that TSLP, synergistically with interleukin 1 and tumor necrosis factor, stimulates the production of high levels of Th2 cytokines by human mast cells (MCs). We next report that TSLP is released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines. Direct epithelial cell–mediated, TSLP-dependent activation of MCs may play a central role in “intrinsic” forms of atopic diseases and explain the aggravating role of infection and scratching in these diseases.
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Cites
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Soumelis, V., Reche, P. A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M., Ho, S., Antonenko, S., Lauerma, A., et al. (2002) · Nature Immunology · doi:10.1038/ni805 · Cited by 2,183
New insights into atopic dermatitis
Leung, D. Y. M., Boguniewicz, M., Howell, M. D., Nomura, I., & Hamid, Q. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21060 · Cited by 1,435
Ito, T., Wang, Y.-H., Duramad, O., Hori, T., Delespesse, G. J., Watanabe, N., Qin, F. X.-F., Yao, Z., Cao, W., & Liu, Y.-J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051135 · Cited by 1,129
Self-citationMAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. M., & Tsai, M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141025 · Cited by 1,017
Ying, S., O’Connor, B., Ratoff, J., Meng, Q., Mallett, K., Cousins, D., Robinson, D., Zhang, G., Zhao, J., Lee, T. H., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.8183 · Cited by 873
Evidence of a Role of Tumor Necrosis Factor α in Refractory Asthma
Berry, M. A., Hargadon, B., Shelley, M., Parker, D., Shaw, D. E., Green, R. H., Bradding, P., Brightling, C. E., Wardlaw, A. J., & Pavord, I. D. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa050580 · Cited by 826
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
Fortini, M. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm910 · Cited by 824
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
Zhou, B., Comeau, M. R., Smedt, T. D., Liggitt, H. D., Dahl, M. E., Lewis, D. B., Gyarmati, D., Aye, T., Campbell, D. J., & Ziegler, S. F. (2005) · Nature Immunology · doi:10.1038/ni1247 · Cited by 819
Self-citationRimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G. M., Nespoli, A., Viale, G., Allavena, P., & Rescigno, M. (2005) · Nature Immunology · doi:10.1038/ni1192 · Cited by 816
Interleukin‐13 in asthma pathogenesis
Wills‐Karp, M. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00215.x · Cited by 683
Cited by
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
Moussion, C., Ortega, N., & Girard, J.-P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003331 · Cited by 1,179
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
Artis, D. (2008) · Nature reviews. Immunology · doi:10.1038/nri2316 · Cited by 1,136
Nakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., Kotol, P. F., Bouslimani, A., Melnik, A. V., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah4680 · Cited by 1,095
The cytokine network in asthma and chronic obstructive pulmonary disease
Barnes, P. J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36130 · Cited by 982
Metadata
- Authors
- Allakhverdi, Z., Comeau, M. R., Jessup, H. K., Yoon, B.-R. P., Brewer, A., Chartier, S., Paquette, N., Ziegler, S. F., Sarfati, M., & Delespesse, G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2007-01-22
- Volume
- 204
- Issue
- 2
- Pages
- 253-258
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2162803006
- Cited by
- 786
- References
- 28
- FWCI
- 19.09
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. https://app.cochat.ai/papers/10.1084/jem.20062211
- The paper
- Allakhverdi, Z., Comeau, M. R., Jessup, H. K., Yoon, B.-R. P., Brewer, A., Chartier, S., Paquette, N., Ziegler, S. F., Sarfati, M., & Delespesse, G. (2007). Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20062211
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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