The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells
Open accessAbstract
We analyzed interleukin (IL) 12 and IL-23 production by monocyte-derived dendritic cells (mono-DCs). Mycobacterium tuberculosis H37Rv and zymosan preferentially induced IL-23. IL-23 but not IL-12 was efficiently induced by the combination of nucleotide-binding oligodimerization domain and Toll-like receptor (TLR) 2 ligands, which mimics activation by M. tuberculosis, or by the human dectin-1 ligand β-glucan alone or in combination with TLR2 ligands, mimicking induction by zymosan. TLR2 ligands inhibited IL-12 and increased IL-23 production. DC priming with interferon (IFN) γ strongly increased IL-12 production, but was not required for IL-23 production and inhibited IL-23 production induced by β-glucan. The pattern of IL-12 and IL-23 induction was reflected in accumulation of the IL-12p35 and IL-23p19 transcripts, respectively, but not IL-12/23p40. Although IL-23, transforming growth factor β, and IL-6 contained in the supernatants of activated mono-DCs played a role in the induction of IL-17 by human CD4+ T cells, IL-1β, in combination with one or more of those factors, was required for IL-17 production, and its production determined the differential ability of the stimuli used to elicit mono-DCs to produce soluble factors directing IL-17 production. Thus, the differential ability of pathogens to induce antigen-presenting cells to produce cytokines regulates the immune response to infection.
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Cites
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
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Self-citationAcosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
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Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
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IL-23 promotes tumour incidence and growth
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Self-citationRequirement of Interleukin‐17A for Systemic Anti– Candida albicans Host Defense in Mice
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Geijtenbeek, T. B. H., & Gringhuis, S. I. (2009) · Nature Reviews Immunology · doi:10.1038/nri2569 · Cited by 1,379
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Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,162
Interleukin-22: Immunobiology and Pathology
Dudakov, J. A., Hanash, A. M., & van den Brink, M. R. M. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112123 · Cited by 905
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Metadata
- Authors
- Gerosa, F., Baldani-Guerra, B., Lyakh, L. A., Batoni, G., Esin, S., Winkler-Pickett, R. T., Consolaro, M. R., De Marchi, M., Giachino, D., Robbiano, A., Astegiano, M., Sambataro, A., Kastelein, R. A., Carra, G., & Trinchieri, G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-05-19
- Volume
- 205
- Issue
- 6
- Pages
- 1447-1461
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2098365610
- Cited by
- 280
- References
- 12
- FWCI
- 13.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gerosa, F., Baldani-Guerra, B., Lyakh, L. A., Batoni, G., Esin, S., Winkler-Pickett, R. T., Consolaro, M. R., De Marchi, M., Giachino, D., Robbiano, A., Astegiano, M., Sambataro, A., Kastelein, R. A., Carra, G., & Trinchieri, G. (2008). Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20071450
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
