The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
Open accessAbstract
The ribonucleic acid (RNA) helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation–associated gene 5 (MDA5) recognize distinct viral and synthetic RNAs, leading to the production of interferons. Although 5′-triphosphate single-stranded RNA is a RIG-I ligand, the role of RIG-I and MDA5 in double-stranded (ds) RNA recognition remains to be characterized. In this study, we show that the length of dsRNA is important for differential recognition by RIG-I and MDA5. The MDA5 ligand, polyinosinic-polycytidylic acid, was converted to a RIG-I ligand after shortening of the dsRNA length. In addition, viral dsRNAs differentially activated RIG-I and MDA5, depending on their length. Vesicular stomatitis virus infection generated dsRNA, which is responsible for RIG-I–mediated recognition. Collectively, RIG-I detects dsRNAs without a 5′-triphosphate end, and RIG-I and MDA5 selectively recognize short and long dsRNAs, respectively.
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A Toll-like receptor recognizes bacterial DNA
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Self-citationRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
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Recognition of microorganisms and activation of the immune response
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
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Self-citationCardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
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Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
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Pattern Recognition Receptors and Inflammation
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Coffman, R. L., Sher, A., & Seder, R. A. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.002 · Cited by 1,924
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Roulois, D., Loo Yau, H., Singhania, R., Wang, Y., Danesh, A., Shen, S. Y., Han, H., Liang, G., Jones, P. A., Pugh, T. J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.056 · Cited by 1,527
Innate Immune Pattern Recognition: A Cell Biological Perspective
Brubaker, S. W., Bonham, K. S., Zanoni, I., & Kagan, J. C. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112240 · Cited by 1,475
Metadata
- Authors
- Kato, H., Takeuchi, O., Mikamo-Satoh, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A., Dermody, T. S., Fujita, T., & Akira, S.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-06-30
- Volume
- 205
- Issue
- 7
- Pages
- 1601-1610
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2125566625
- Cited by
- 1,599
- References
- 10
- FWCI
- 38.52
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5. https://app.cochat.ai/papers/10.1084/jem.20080091
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- Kato, H., Takeuchi, O., Mikamo-Satoh, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A., Dermody, T. S., Fujita, T., & Akira, S. (2008). Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20080091
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