The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Dicer-dependent microRNA pathway safeguards regulatory T cell function
Open accessAbstract
Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell–mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indistinguishable from that in T reg cell–deficient mice. In disease-free mice lacking Dicer in all T cells or harboring both Dicer-deficient and -sufficient T reg cells, Dicer-deficient T reg cells were suppressive, albeit to a lesser degree, whereas their homeostatic potential was diminished as compared with their Dicer-sufficient counterparts. However, in diseased mice, Dicer-deficient T reg cells completely lost suppressor capacity. Thus, miRNA preserve the T reg cell functional program under inflammatory conditions.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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Self-citationA function for interleukin 2 in Foxp3-expressing regulatory T cells
Fontenot, J. D., Rasmussen, J. P., Gavin, M. A., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1263 · Cited by 1,819
Self-citationRegulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586
Self-citationFoxp3 occupancy and regulation of key target genes during T-cell stimulation
Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724
Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells
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Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
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Cited by
Regulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866
Self-citationPhysiological and pathological roles for microRNAs in the immune system
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature Reviews Immunology · doi:10.1038/nri2708 · Cited by 1,378
MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development
O'Connell, R. M., Kahn, D., Gibson, W. S. J., Round, J. L., Scholz, R. L., Chaudhuri, A. A., Kahn, M. E., Rao, D. S., & Baltimore, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.009 · Cited by 889
Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses
Lu, L.-F., Boldin, M. P., Chaudhry, A., Lin, L.-L., Taganov, K. D., Hanada, T., Yoshimura, A., Baltimore, D., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.08.012 · Cited by 849
Self-citationmicroRNA Regulation of Inflammatory Responses
O'Connell, R. M., Rao, D. S., & Baltimore, D. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075013 · Cited by 843
Metadata
- Authors
- Liston, A., Lu, L.-F., O'Carroll, D., Tarakhovsky, A., & Rudensky, A. Y.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-08-25
- Volume
- 205
- Issue
- 9
- Pages
- 1993-2004
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2128856901
- Cited by
- 378
- References
- 7
- FWCI
- 13.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liston, A., Lu, L.-F., O'Carroll, D., Tarakhovsky, A., & Rudensky, A. Y. (2008). Dicer-dependent microRNA pathway safeguards regulatory T cell function. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20081062
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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