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A role for human skin–resident T cells in wound healing
Open accessAbstract
Epidermal T cells have been shown to play unique roles in tissue homeostasis and repair in mice through local secretion of distinct growth factors in the skin. Human epidermis contains both αβ+ and γδ+ T cells whose functional capabilities are not understood. We demonstrate that human epidermal T cells are able to produce insulin-like growth factor 1 (IGF-1) upon activation and promote wound healing in a skin organ culture model. Moreover, an analysis of the functional capabilities of T cells isolated from acute versus chronic wounds revealed a striking difference. Both αβ+ and Vδ1+ T cells isolated from acute wounds actively produced IGF-1, demonstrating that they are activated during tissue damage to participate in wound repair. In contrast, IGF-1 production could not be detected in T cells isolated from chronic wounds. In fact, skin T cells isolated from chronic wounds were refractory to further stimulation, suggesting an unresponsive state. Collectively, these results define a novel role for human epidermis–resident T cells in wound healing and provide new insight into our understanding of chronic wound persistence.
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“S. epidermidis association promoted the expression of genes associated specifically with angiogenesis, including angiogenin (Ang) and Hgf (47, 48), as well as genes that more broadly promote tissue repair, like Ceacam1, Grn, Hmox1, Igf1, and Pdgfa (49–53) (Fig. 3R).”
From MAIT cells are imprinted by the microbiota in early life and promote tissue repair (2019) · cites this paper as [49]
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“skin-resident T cells, which are proficient in IL-17A production, are dysfunctional in nonhealing wounds76;”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [76]
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Metadata
- Authors
- Toulon, A., Breton, L., Taylor, K. R., Tenenhaus, M., Bhavsar, D., Lanigan, C., Rudolph, R., Jameson, J., & Havran, W. L.
- Affiliations
- Scripps Research Institute (US)
- L'Oréal (France) (FR)
- University of California San Diego (US)
- Corresponding author
- Havran, Wendy L.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2009-03-23
- Volume
- 206
- Issue
- 4
- Pages
- 743-750
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2715110
- OpenAlex
- W199441549
- Cited by
- 339
- References
- 22
- Citations by year
- 2026: 7 · 2025: 22 · 2024: 21 · 2023: 25 · 2022: 23 · 2021: 25 · 2020: 37 · 2019: 23 · 2018: 21 · 2017: 20 · 2016: 13 · 2015: 20 · 2014: 18 · 2013: 21 · 2012: 12
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- The FASEB Journal (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- The Journal of Immunology
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM80301, R01GM080301)
- National Institute of Allergy and Infectious Diseases (AI 36964, T32AI007244, R01AI036964)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- skin wound healing, chronic wounds, γδ T cells, alpha beta T cells, insulin-like growth factor I, T cell cytokine secretion, acute wounds, T cell activation, skin repair
- MeSH terms
- Chronic Disease, Epidermis, Flow Cytometry, Humans, Insulin-Like Growth Factor I, Lymphocyte Activation, Male, Organ Culture Techniques, Skin, Skin Physiological Phenomena, T-Lymphocytes, Wound Healing, Foreskin
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