The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Dynamic T cell migration program provides resident memory within intestinal epithelium
Open accessAbstract
Migration to intestinal mucosa putatively depends on local activation because gastrointestinal lymphoid tissue induces expression of intestinal homing molecules, whereas skin-draining lymph nodes do not. This paradigm is difficult to reconcile with reports of intestinal T cell responses after alternative routes of immunization. We reconcile this discrepancy by demonstrating that activation within spleen results in intermediate induction of homing potential to the intestinal mucosa. We further demonstrate that memory T cells within small intestine epithelium do not routinely recirculate with memory T cells in other tissues, and we provide evidence that homing is similarly dynamic in humans after subcutaneous live yellow fever vaccine immunization. These data explain why systemic immunization routes induce local cell-mediated immunity within the intestine and indicate that this tissue must be seeded with memory T cell precursors shortly after activation.
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“Further research revealed that the presence of CD103+CD8+ TILs is a positive prognostic marker in several cancers [269-272].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [269]
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Molecular determinants of brain-resident CD8 + T cell formation and functionPreprint
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Optimal transport fate mapping resolves T cell differentiation dynamics across tissuesPreprint
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Metadata
- Authors
- Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., Fraser, K. A., Webby, R. J., Brinkmann, V., Butcher, E. C., Newell, K. A., & Ahmed, R.
- Affiliations
- University of Minnesota (US)
- Emory University (US)
- St. Jude Children's Research Hospital (US)
- Novartis (Switzerland) (CH)
- Stanford Medicine (US)
- Corresponding author
- Masopust, David
- Ahmed, Rafi
- ORCID
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2010-02-15
- Volume
- 207
- Issue
- 3
- Pages
- 553-564
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2839151
- OpenAlex
- W2161689282
- Cited by
- 628
- References
- 48
- Citations by year
- 2026: 22 · 2025: 35 · 2024: 33 · 2023: 28 · 2022: 45 · 2021: 49 · 2020: 58 · 2019: 59 · 2018: 50 · 2017: 38 · 2016: 38 · 2015: 35 · 2014: 36 · 2013: 45 · 2012: 29
- FWCI
- 14.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI072618, R37AI084913)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- T cell migration, memory T cells, intestinal epithelium, intestinal mucosa, subcutaneous immunization, yellow fever vaccine, skin-draining lymph nodes, T cell recirculation
- MeSH terms
- Animals, Cell Movement, Humans, Immunization, Immunologic Memory, Intestinal Mucosa, Lymphocyte Activation, Mice, Inbred C57BL, Spleen, T-Lymphocytes, Receptors, Lymphocyte Homing, CD8-Positive T-Lymphocytes, Antigens, CD34, Yellow Fever Vaccine, Mice
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