Cited by 628T-cell and B-cell ImmunologyCell Adhesion Molecules ResearchImmunotherapy and Immune Responses

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Dynamic T cell migration program provides resident memory within intestinal epithelium

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Masopust, David, Choo, Daniel, Vezys, Vaiva, Wherry, E. John, Duraiswamy, Jaikumar, Akondy, Rama, Wang, Jun, Casey, Kerry A., Barber, Daniel L., Kawamura, Kim S., Fraser, Kathryn A., Webby, Richard J., Brinkmann, Volker, Butcher, Eugene C., Newell, Kenneth A., Ahmed, Rafi·2010·Journal of Experimental Medicine

DOI 10.1084/jem.20090858PMC PMC2839151

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Abstract

Migration to intestinal mucosa putatively depends on local activation because gastrointestinal lymphoid tissue induces expression of intestinal homing molecules, whereas skin-draining lymph nodes do not. This paradigm is difficult to reconcile with reports of intestinal T cell responses after alternative routes of immunization. We reconcile this discrepancy by demonstrating that activation within spleen results in intermediate induction of homing potential to the intestinal mucosa. We further demonstrate that memory T cells within small intestine epithelium do not routinely recirculate with memory T cells in other tissues, and we provide evidence that homing is similarly dynamic in humans after subcutaneous live yellow fever vaccine immunization. These data explain why systemic immunization routes induce local cell-mediated immunity within the intestine and indicate that this tissue must be seeded with memory T cell precursors shortly after activation.

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Authors: Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., Fraser, K. A., Webby, R. J., Brinkmann, V., Butcher, E. C., Newell, K. A., & Ahmed, R.
Affiliations: University of Minnesota (US)
Emory University (US)
St. Jude Children's Research Hospital (US)
Novartis (Switzerland) (CH)
Stanford Medicine (US)
Corresponding author: Masopust, David
Ahmed, Rafi
ORCID: Masopust, David
Vezys, Vaiva
Wherry, E. John
Duraiswamy, Jaikumar
Akondy, Rama
Wang, Jun
Casey, Kerry A.
Barber, Daniel L.
Fraser, Kathryn A.
Webby, Richard J.
Brinkmann, Volker
Butcher, Eugene C.
Newell, Kenneth A.
Ahmed, Rafi
Venue: Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 2010-02-15
Volume: 207
Issue: 3
Pages: 553-564
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.20090858
PMC: PMC2839151
OpenAlex: W2161689282
Cited by: 628
References: 48
Citations by year: 2026: 22 · 2025: 35 · 2024: 33 · 2023: 28 · 2022: 45 · 2021: 49 · 2020: 58 · 2019: 59 · 2018: 50 · 2017: 38 · 2016: 38 · 2015: 35 · 2014: 36 · 2013: 45 · 2012: 29
FWCI: 14.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI072618, R37AI084913)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: T cell migration, memory T cells, intestinal epithelium, intestinal mucosa, subcutaneous immunization, yellow fever vaccine, skin-draining lymph nodes, T cell recirculation
MeSH terms: Animals, Cell Movement, Humans, Immunization, Immunologic Memory, Intestinal Mucosa, Lymphocyte Activation, Mice, Inbred C57BL, Spleen, T-Lymphocytes, Receptors, Lymphocyte Homing, CD8-Positive T-Lymphocytes, Antigens, CD34, Yellow Fever Vaccine, Mice

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Dynamic T cell migration program provides resident memory within intestinal epithelium

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