Cited by 628T-cell and B-cell ImmunologyCell Adhesion Molecules ResearchImmunotherapy and Immune Responses

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Dynamic T cell migration program provides resident memory within intestinal epithelium

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Masopust, David, Choo, Daniel, Vezys, Vaiva, Wherry, E. John, Duraiswamy, Jaikumar, Akondy, Rama, Wang, Jun, Casey, Kerry A., Barber, Daniel L., Kawamura, Kim S., Fraser, Kathryn A., Webby, Richard J., Brinkmann, Volker, Butcher, Eugene C., Newell, Kenneth A., Ahmed, Rafi·2010·Journal of Experimental Medicine

DOI 10.1084/jem.20090858PMC PMC2839151

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Abstract

Migration to intestinal mucosa putatively depends on local activation because gastrointestinal lymphoid tissue induces expression of intestinal homing molecules, whereas skin-draining lymph nodes do not. This paradigm is difficult to reconcile with reports of intestinal T cell responses after alternative routes of immunization. We reconcile this discrepancy by demonstrating that activation within spleen results in intermediate induction of homing potential to the intestinal mucosa. We further demonstrate that memory T cells within small intestine epithelium do not routinely recirculate with memory T cells in other tissues, and we provide evidence that homing is similarly dynamic in humans after subcutaneous live yellow fever vaccine immunization. These data explain why systemic immunization routes induce local cell-mediated immunity within the intestine and indicate that this tissue must be seeded with memory T cell precursors shortly after activation.

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Lymphocyte Homing and Homeostasis
Butcher, E. C., & Picker, L. J. (1996) · Science · doi:10.1126/science.272.5258.60 · Cited by 2,846
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Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
Mora, J. R., Bono, M. R., Manjunath, N., Weninger, W., Cavanagh, L. L., Rosemblatt, M. S., & von Andrian, U. H. (2003) · Nature · doi:10.1038/nature01726 · Cited by 1,068
Visualizing the generation of memory CD4 T cells in the whole body
Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., & Jenkins, M. K. (2001) · Nature · doi:10.1038/35065111 · Cited by 1,026
The Vast Majority of CLA+ T Cells Are Resident in Normal Skin
Clark, R. A., Chong, B., Mirchandani, N., Brinster, N. K., Yamanaka, K.-I., Dowgiert, R. K., & Kupper, T. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4431 · Cited by 796
Naive and memory T cells show distinct pathways of lymphocyte recirculation.
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Im, S. J., Hashimoto, M., Gerner, M. Y., Lee, J., Kissick, H. T., Burger, M. C., Shan, Q., Hale, J. S., Lee, J., Nasti, T. H., et al. (2016) · Nature · doi:10.1038/nature19330 · Cited by 2,070
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Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628
The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
Mackay, L. K., Rahimpour, A., Ma, J. Z., Collins, N., Stock, A. T., Hafon, M.-L., Vega-Ramos, J., Lauzurica, P., Mueller, S. N., Stefanovic, T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2744 · Cited by 1,331
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Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
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Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006
Human memory T cells: generation, compartmentalization and homeostasis
Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897
Mechanisms regulating skin immunity and inflammation
Pasparakis, M., Haase, I., & Nestle, F. O. (2014) · Nature reviews. Immunology · doi:10.1038/nri3646 · Cited by 946
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity
Jiang, X., Clark, R. A., Liu, L., Wagers, A. J., Fuhlbrigge, R. C., & Kupper, T. S. (2012) · Nature · doi:10.1038/nature10851 · Cited by 883
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets
Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J. J. C., Bickham, K. L., Lerner, H., Goldstein, M., Sykes, M., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.09.020 · Cited by 848
Memory T Cell Subsets, Migration Patterns, and Tissue Residence
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Pan, Y., Tian, T., Park, C. O., Lofftus, S. Y., Mei, S., Liu, X., Luo, C., O’Malley, J. T., Gehad, A. E., Teague, J. E., et al. (2017) · Nature · doi:10.1038/nature21379 · Cited by 730
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Milner, J. J., Toma, C., Yu, B., Zhang, K., Omilusik, K., Phan, A. T., Wang, D., Getzler, A. J., Nguyen, T., Crotty, S., et al. (2017) · Nature · doi:10.1038/nature24993 · Cited by 677
Location, location, location: Tissue resident memory T cells in mice and humans
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A vaccine strategy that protects against genital herpes by establishing local memory T cells
Shin, H., & Iwasaki, A. (2012) · Nature · doi:10.1038/nature11522 · Cited by 665
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Self-citation
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Self-citation
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
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Self-citation
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Self-citation
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Self-citation
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Pizzolla, A., Nguyen, T. H. O., Smith, J. M., Brööks, A. G., Kedzierska, K., Heath, W. R., Reading, P. C., & Wakim, L. M. (2017) · Science Immunology · doi:10.1126/sciimmunol.aam6970 · Cited by 283
Generation of effector CD8 + T cells and their conversion to memory T cells
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Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection
Sheikh‐Mohamed, S., Isho, B., Chao, G. Y. C., Zuo, M., Cohen, C., Lustig, Y., Nahass, G. R., Salomon, R. E. A., Blacker, G., Fazel‐Zarandi, M., et al. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00511-0 · Cited by 276
Proinflammatory microenvironments within the intestine regulate differentiation of tissue-resident CD8 T cells responding to infection
Bergsbaken, T., & Bevan, M. (2015) · Nature Immunology · doi:10.1038/ni.3108 · Cited by 269
The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance
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Ariotti, S., Beltman, J. B., Chodaczek, G., Hoekstra, M. E., van Beek, A. E., Gomez, R., Ritsma, L., van Rheenen, J., Marée, A. F. M., Żal, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208927109 · Cited by 274
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Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity
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Regional and mucosal memory T cells
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Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier
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Self-citation
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McKinnon, L. R., & Kaul, R. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e3283504941 · Cited by 245
Quantifying T lymphocyte turnover
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Takamura, S., Yagi, H., Hakata, Y., Motozono, C., McMaster, S. R., Masumoto, T., Fujisawa, M., Chikaishi, T., Komeda, J., Itoh, J., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160938 · Cited by 243
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Sandoval, F., Terme, M., Nizard, M., Badoual, C., Bureau, M., Freyburger, L., Clémеnt, O., Marcheteau, E., Gey, A., Fraisse, G., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004888 · Cited by 252
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Self-citation
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Self-citation
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Mohammed, J., Beura, L. K., Bobr, A., Astry, B., Chicoine, B., Kashem, S. W., Welty, N. E., Igyártó, B. Z., Wijeyesinghe, S., Thompson, E. A., et al. (2016) · Nature Immunology · doi:10.1038/ni.3396 · Cited by 231
Self-citation
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Schenkel, J. M., Fraser, K. A., & Masopust, D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400003 · Cited by 216
Self-citation
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A guide to adaptive immune memory
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Long-lasting stem cell–like memory CD8 + T cells with a naïve-like profile upon yellow fever vaccination
Fuertes Marraco, S. A., Soneson, C., Cagnon, L., Gannon, P. O., Allard, M., Maillard, S. A., Montandon, N., Rufer, N., Waldvogel, S., Delorenzi, M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3700 · Cited by 206
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Schreurs, R., Baumdick, M. E., Sagebiel, A. F., Kaufmann, M., Mokrý, M., Klarenbeek, P. L., Schaltenberg, N., Steinert, F. L., van Rijn, J. M., Drewniak, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.010 · Cited by 206
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
Arsenio, J., Kakaradov, B., Metz, P. J., Kim, S. H., Yeo, G. W.-M., & Chang, J. T. (2014) · Nature Immunology · doi:10.1038/ni.2842 · Cited by 201
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Shin, H., & Iwasaki, A. (2013) · Immunological Reviews · doi:10.1111/imr.12087 · Cited by 215
Tissue‐resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance
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Mucosal Resident Memory CD4 T Cells in Protection and Immunopathology
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Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids
McNamara, H. A., Cai, Y., Wagle, M. V., Sontani, Y., Roots, C. M., Miosge, L. A., O’Connor, J. H., Sutton, H. J., Ganusov, V. V., Heath, W. R., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aaj1996 · Cited by 181
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Mikhak, Z., Strassner, J. P., & Luster, A. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130091 · Cited by 195
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E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands
Hofmann, M., & Pircher, H. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1107200108 · Cited by 173
Identification and characterization of HIV-specific resident memory CD8 + T cells in human lymphoid tissue
Buggert, M., Nguyen, S., de Oca, G. S. M., Bengsch, B., Darko, S. W., Ransier, A., Roberts, E. R., Alcazar, D. D., Brody, I. B., Vella, L. A., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar4526 · Cited by 165
Self-citation
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Walsh, D., da Silva, H. B., Beura, L. K., Peng, C., Hamilton, S. E., Masopust, D., & Jameson, S. C. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900052 · Cited by 174
Self-citation
Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma
McMaster, S. R., Wein, A. N., Dunbar, P. R., Hayward, S. L., Cartwright, E. K., Denning, T. L., & Kohlmeier, J. E. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0003-x · Cited by 160

Authors: Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., Fraser, K. A., Webby, R. J., Brinkmann, V., Butcher, E. C., Newell, K. A., & Ahmed, R.
Affiliations: University of Minnesota (US)
Emory University (US)
St. Jude Children's Research Hospital (US)
Novartis (Switzerland) (CH)
Stanford Medicine (US)
Corresponding author: Masopust, David
Ahmed, Rafi
ORCID: Masopust, David
Vezys, Vaiva
Wherry, E. John
Duraiswamy, Jaikumar
Akondy, Rama
Wang, Jun
Casey, Kerry A.
Barber, Daniel L.
Fraser, Kathryn A.
Webby, Richard J.
Brinkmann, Volker
Butcher, Eugene C.
Newell, Kenneth A.
Ahmed, Rafi
Venue: Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 2010-02-15
Volume: 207
Issue: 3
Pages: 553-564
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.20090858
PMC: PMC2839151
OpenAlex: W2161689282
Cited by: 628
References: 48
Citations by year: 2026: 22 · 2025: 35 · 2024: 33 · 2023: 28 · 2022: 45 · 2021: 49 · 2020: 58 · 2019: 59 · 2018: 50 · 2017: 38 · 2016: 38 · 2015: 35 · 2014: 36 · 2013: 45 · 2012: 29
FWCI: 14.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI072618, R37AI084913)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: T cell migration, memory T cells, intestinal epithelium, intestinal mucosa, subcutaneous immunization, yellow fever vaccine, skin-draining lymph nodes, T cell recirculation
MeSH terms: Animals, Cell Movement, Humans, Immunization, Immunologic Memory, Intestinal Mucosa, Lymphocyte Activation, Mice, Inbred C57BL, Spleen, T-Lymphocytes, Receptors, Lymphocyte Homing, CD8-Positive T-Lymphocytes, Antigens, CD34, Yellow Fever Vaccine, Mice

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Dynamic T cell migration program provides resident memory within intestinal epithelium

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