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PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
Open accessAbstract
Neutrophils trap and kill bacteria by forming highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs). We previously reported that histone hypercitrullination catalyzed by peptidylarginine deiminase 4 (PAD4) correlates with chromatin decondensation during NET formation. However, the role of PAD4 in NET-mediated bacterial trapping and killing has not been tested. Here, we use PAD4 knockout mice to show that PAD4 is essential for NET-mediated antibacterial function. Unlike PAD4+/+ neutrophils, PAD4−/− neutrophils cannot form NETs after stimulation with chemokines or incubation with bacteria, and are deficient in bacterial killing by NETs. In a mouse infectious disease model of necrotizing fasciitis, PAD4−/− mice are more susceptible to bacterial infection than PAD4+/+ mice due to a lack of NET formation. Moreover, we found that citrullination decreased the bacterial killing activity of histones and nucleosomes, which suggests that PAD4 mainly plays a role in chromatin decondensation to form NETs instead of increasing histone-mediated bacterial killing. Our results define a role for histone hypercitrullination in innate immunity during bacterial infection.
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“Next, we determined the importance of peptidylarginine deiminase type 4 (PAD4), the enzyme responsible for histone modifications required for decondensing neutrophil DNA before expulsion (25).”
From Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps (2016) · cites this paper as [25]
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Cites
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Novel cell death program leads to neutrophil extracellular traps
Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197
Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
Segal, A. W. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115653 · Cited by 1,783
Wang, Y., Li, M., Stadler, S. C., Correll, S., Li, P., Wang, D., Hayama, R., Leonelli, L., Han, H., Grigoryev, S. A., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200806072 · Cited by 1,579
Self-citationSimplified mammalian DNA isolation procedure
Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. J. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,497
The structure of DNA in the nucleosome core
Richmond, T. J., & Davey, C. A. (2003) · Nature · doi:10.1038/nature01595 · Cited by 1,287
Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination
Wang, Y., Wysocka, J., Sayegh, J., Lee, Y., Perlin, J. R., Leonelli, L., Sonbuchner, L. S., McDonald, C. H., Cook, R. G., Dou, Y., et al. (2004) · Science · doi:10.1126/science.1101400 · Cited by 1,013
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Flagged first, then by citations
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Items 901–1,000 of 1,001
Cell death classification: A new insight based on molecular mechanisms
Dehghan, S., Kheshtchin, N., Hassannezhad, S., & Soleimani, M. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113860 · Cited by 21
Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma
Zhu, W., Fan, C., Dong, S., Li, X., Chen, H., & Zhou, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1253964 · Cited by 18
Martinod, K., Denorme, F., Meyers, S., Crescente, M., Bruggen, S. V., Stroobants, M., Siegel, P. M., Grandhi, R., Glatz, K., & Witsch, T. (2024) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2024.02.010 · Cited by 18
Wu, Y., & Shen, J. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.10.003 · Cited by 18
Lin, C., Chien, S.-Y., Chen, C., Hsieh, C.-Y., Tseng, P., & Wang, Y. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2015.0011 · Cited by 18
Self-citationAnti-high Mobility Group Box 1 Antibody Ameliorates Albuminuria in MRL/lpr Lupus-Prone Mice
Watanabe, H., Sunahori-Watanabe, K., Liu, K., Hiramatsu, S., Zeggar, S., Katsuyama, E., Tatebe, N. T., Akahoshi, A., Takenaka, F., Hanada, T., et al. (2017) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2017.05.006 · Cited by 18
Zhou, Y., Mittereder, N., & Sims, G. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00034 · Cited by 18
Tanner, L., Bhongir, R. K. V., Karlsson, C. A. Q., Le, S., Ljungberg, J. K., Andersson, P., Andersson, C. K., Malmström, J. A., Egesten, A., & Single, A. (2020) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2020.07.010 · Cited by 18
Reithofer, M., Karacs, J., Strobl, J., Kitzmüller, C., Polak, D., Seif, K., Kamalov, M., Becker, C. F. W., Greiner, G., Schmetterer, K. G., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202001413r · Cited by 18
Liu, X., Fu, Y., Wang, J., Wu, D., Li, S., Wang, C., Yang, Z., & Zhou, E. (2020) · Food & Function · doi:10.1039/d0fo02337j · Cited by 18
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models
Bruggeman, Y., Sodré, F. M. C., Buitinga, M., Mathieu, C., Overbergh, L., & Kracht, M. J. L. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1918104 · Cited by 18
Okeke, E. B., Louttit, C., Snyder, C. M., & Moon, J. J. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01243-1 · Cited by 19
Current Challenges and Limitations in Antibody-Based Detection of Citrullinated Histones
Neeli, I., & Radic, M. Z. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00528 · Cited by 20
Xiong, Y., Liu, S., Liu, Y., Zhao, J., Sun, J., Li, Y., Pan, B., & Wang, W. (2024) · JCI Insight · doi:10.1172/jci.insight.183237 · Cited by 18
The role of neutrophils in ANCA-associated vasculitis
Prendecki, M. F., Gurung, A., Pisacano, N., & Pusey, C. D. (2024) · Immunology Letters · doi:10.1016/j.imlet.2024.106933 · Cited by 17
Neutrophil NET Formation with Microbial Stimuli Requires Late Stage NADPH Oxidase Activity
Parker, H. A., Jones, H. L., Kaldor, C. D., Hampton, M. B., & Winterbourn, C. C. (2021) · Antioxidants · doi:10.3390/antiox10111791 · Cited by 18
Yang, S., Xiao, Y., Du, Y., Chen, J., Ni, Q., Guo, X., Xue, G., & Xie, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.683445 · Cited by 17
Extracellular trap can be trained as a memory response
Yu, G., Zhang, J., Liu, Z., Ma, K., Lin, X., Zhang, J., Chen, W., & Yang, Y. (2022) · Virulence · doi:10.1080/21505594.2022.2046950 · Cited by 17
Roles, detection, and visualization of neutrophil extracellular traps in acute pancreatitis
Li, H., Zhao, L., Wang, Y., Zhang, M.-C., & Qiao, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.974821 · Cited by 18
Self-citationNappi, F., Bellomo, F., & Singh, S. S. A. (2023) · Biomedicines · doi:10.3390/biomedicines11010113 · Cited by 17
Monreal, M. T. M., Hansen, B. E., Iversen, P. F., Enevold, C., Ødum, N., Sellebjerg, F. T., Højrup, P., von Essen, M. R., & Nielsen, C. H. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103092 · Cited by 17
Neutrophil Virucidal Activity Against SARS-CoV-2 Is Mediated by Neutrophil Extracellular Traps
Almeida, C. J. L. D. R., Veras, F. P., Paiva, I. M., Schneider, A. H., Silva, J. C., Gomes, G. F., Costa, V. F., Silva, B. M. S., Caetité, D. B., Silva, C. M. S., et al. (2023) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiad526 · Cited by 17
Sae‐khow, K., Charoensappakit, A., Udompornpitak, K., Saisorn, W., Issara-Amphorn, J., Palaga, T., & Leelahavanichkul, A. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02342-x · Cited by 17
Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection
Wang, N., Yang, X., Sun, J., Sun, Z., Ma, Q., Wang, Z., Chen, Z., Wang, Z., Hu, F., Wang, H., et al. (2019) · Cell Death Discovery · doi:10.1038/s41420-019-0193-3 · Cited by 18
Mauracher, L., Buchtele, N., Schoergenhofer, C., Weiser, C., Herkner, H., Merrelaar, A. E., Spiel, A. O., Hell, L., Ay, C., Pabinger, I., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101568 · Cited by 17
Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate
Nolan, E., & Malanchi, I. (2020) · Nature · doi:10.1038/d41586-020-01672-3 · Cited by 18
Peptidyl Arginine Deiminase Type 4 Gene Promoter Hypo-Methylation in Rheumatoid Arthritis
Kolarz, B., Cieśla, M., Dryglewska, M., & Majdan, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072049 · Cited by 17
Shimonaga, K., Matsushige, T., Takahashi, H., Hashimoto, Y., Yoshiyama, M., Ono, C., & Sakamoto, S. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2021.105816 · Cited by 17
Díaz-Godínez, C., Jorge-Rosas, J. F., Néquiz, M., Martínez‐Calvillo, S., Laclette, J. P., Rosales, C., & Carrero, J. C. (2021) · Antioxidants · doi:10.3390/antiox10060974 · Cited by 17
PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis
Sun, B., Tomita, B., Salinger, A. J., Tilvawala, R. R., Li, L., Hakami, H., Liu, T., Tsoyi, K., Rosas, I. O., Reinhardt, D. P., et al. (2021) · Matrix Biology · doi:10.1016/j.matbio.2021.07.001 · Cited by 17
Ohyama, A., Osada, A., Kawaguchi, H., Kurata, I., Nishiyama, T., Iwai, T., Ishigami, A., Kondo, Y., Tsuboi, H., Sumida, T., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147633 · Cited by 17
NETosis - Dr. Jekyll and Mr. Hyde in inflammation
Lauková, L., & Konečná, B. (2017) · Journal of Applied Biomedicine · doi:10.1016/j.jab.2017.10.002 · Cited by 17
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Saffarzadeh, M. (2019) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201020666190111164145 · Cited by 18
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Alhamar, G., Vinci, C., Franzese, V., Tramontana, F., Goux, N. L., Ludvigsson, J., Nissim, A., & Strollo, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1537405 · Cited by 16
Chen, J., Tong, Y. A., Zhu, Q., Gao, L.-Q., & Sun, Y. (2022) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2022.105467 · Cited by 16
Śmiałek, J., Bzowska, M., Hinz, A., Mężyk-Kopeć, R., Sołtys, K., & Mak, P. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s362066 · Cited by 18
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La, C. C., Takeuchi, L. E., Abbina, S., Vappala, S., Abbasi, U., & Kizhakkedathu, J. N. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00654 · Cited by 16
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Osaka, M., Deushi, M., Aoyama, J., Funakoshi, T., Ishigami, A., & Yoshida, M. (2021) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.04.002 · Cited by 17
Sul, C., Lewis, C., Dee, N. M., Burns, N., Oshima, K., Schmidt, E. P., Vohwinkel, C. U., & Nozik‐Grayck, E. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00217.2022 · Cited by 16
Li, L., Jiao, Q., Yang, Q., Lu, H., Zhou, X., Zhang, Q., Zhang, F., Li, H., Tian, Z., & Zeng, Z. (2025) · Immunity · doi:10.1016/j.immuni.2025.02.002 · Cited by 16
Mondal, N. S., Islam, A., Gautam, M. K., Mondal, S., Ahmed, M., Jamir, S. I., Khongwir, L. D., & Mahajon, B. (2025) · Current Diabetes Reviews · doi:10.2174/0115733998368222250509185511 · Cited by 15
Liu, D., Mai, D., Jahn, A. N., Murray, T. A., Aitchison, J. D., Gern, B. H., Urdahl, K. B., Aderem, A. A., Diercks, A. H., & Gold, E. S. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013267 · Cited by 15
NETosis in ischemic stroke: Mechanisms, implications, and therapeutic prospects
Krishnamoorthy, N., Kalyan, M., Vichitra, C., Paneyala, S., Rashan, L. J., Azeeze, M. S. T. A., Sakharkar, M. K., Chang, S. L., Monaghan, T. M., Mahalakshmi, A. M., et al. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.108999 · Cited by 15
DNA demethylation increases NETosis
Yasuda, H., Takishita, Y., Morita, A., Tsutsumi, T., Tsuchiya, M., & Sato, E. F. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108465 · Cited by 15
A variety of death modes of neutrophils and their role in the etiology of autoimmune diseases
Li, Y., Wu, Y., Huang, J., Cao, X., An, Q., Peng, Y., Zhao, Y., & Luo, Y. (2023) · Immunological Reviews · doi:10.1111/imr.13284 · Cited by 16
The role of NETosis in the pathogenesis of immunoinflammatory rheumatic diseases
Nasonov, E. L., Avdeeva, A. S., Reshetnyak, T. M., Aleksankin, A. P., & Rubtsov, Y. P. (2023) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2023-513-530 · Cited by 15
The Role of Neutrophils in Multiple Sclerosis and Ischemic Stroke
Nowaczewska-Kuchta, A., Ksiazek-Winiarek, D. J., Szpakowski, P., & Glabinski, A. R. (2024) · Brain Sciences · doi:10.3390/brainsci14050423 · Cited by 16
Li, F., Zhao, P., Zhao, L., Bai, L., Su, Q., Feng, Y., Ma, W., Zhu, J., Yang, J., & Zhang, S. (2024) · Inflammation · doi:10.1007/s10753-024-02220-1 · Cited by 15
Moelants, E. A. V., Mortier, A., Damme, J. V., Proost, P., & Loos, T. (2012) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2012.06.002 · Cited by 15
Hollingsworth, T., Radic, M. Z., Beranová-Giorgianni, Š., Giorgianni, F., Wang, Y., & Iannaccone, A. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24118 · Cited by 15
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Cai, X., Panicker, S. R., Biswas, I., Giri, H., & Rezaie, A. R. (2021) · Thrombosis and Haemostasis · doi:10.1055/s-0041-1726093 · Cited by 15
Cutaneous ischemia‐reperfusion injury is exacerbated by IL‐36 receptor antagonist deficiency
Tanaka, Y., Iwata, Y., Saito, K., Fukushima, H., Watanabe, S., Hasegawa, Y., Akiyama, M., & Sugiura, K. (2021) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.17767 · Cited by 16
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Vitkov, L., Knopf, J., Krunić, J., Schauer, C., Schoen, J., Minnich, B., Hannig, M., & i, M. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.872695 · Cited by 16
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Thompson‐Souza, G. A., Vasconcelos, C. R. I., & Neves, J. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121191 · Cited by 15
PADs and NETs in digestive system: From physiology to pathology
Song, Y., Wang, Z., Kang, L., He, Z., Zhao, S., Fang, X., Li, Z., Wang, S., & Bai, Y. Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1077041 · Cited by 15
Lee, C., Lin, C., Liu, Y.-L., Liu, G., Liu, J., & Hung, H. (2017) · Scientific Reports · doi:10.1038/srep42662 · Cited by 15
Jang, B., Ishigami, A., Kim, Y., & Choi, E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112258 · Cited by 15
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Umeda, N., Matsumoto, I., & Sumida, T. (2017) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.40.391 · Cited by 15
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Morrell, C. N., Hilt, Z. T., Pariser, D. N., & Maurya, P. (2019) · Circulation Research · doi:10.1161/circresaha.119.315601 · Cited by 15
Ma, Y., Zhang, J., Qi, Y., Lu, Y., Dong, Y., & Hu, D. (2025) · Biomolecules · doi:10.3390/biom15091263 · Cited by 15
Cell-free DNA in sepsis: from molecular insights to clinical management
Li, L., Huang, H., He, Y., Pang, J., Xiao, S.-C., Xia, Z., & Zheng, Y. (2025) · Military Medical Research · doi:10.1186/s40779-025-00668-2 · Cited by 16
Zhu, Y., Xu, J., Chai, Y., Li, P., Liu, L., Zhang, S., Zhang, J., & Chen, X. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00739-5 · Cited by 14
Self-citationBrambilla, M., Zanichelli, A., Cancila, V., Colombo, M. P., Chiodoni, C., & Sangaletti, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08218-3 · Cited by 18
Ho, J. W., Quan, C., Gauger, M. A., Alam, H. B., & Li, Y. (2023) · Shock · doi:10.1097/shk.0000000000002052 · Cited by 15
Cao, X., Li, Y., Luo, Y., Chu, T., Yang, H., Ji, W., Liu, Y., Zhao, Y., & i, M. H. (2023) · Journal of Inflammation · doi:10.1186/s12950-023-00334-1 · Cited by 14
Goldspink, A., Schmitz, J., Babyak, O., Brauns, N., Milleck, J., Breloh, A. M., Fleig, S. V., Jobin, K., Schwarz, L., Haller, H. G., et al. (2023) · Kidney International · doi:10.1016/j.kint.2023.03.034 · Cited by 15
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Geary, B., Sun, B., Tilvawala, R. R., Barasa, L., Tsoyi, K., Rosas, I. O., Thompson, P. R., & Ho, I. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1290585 · Cited by 14
Willems, R. A. L., Biesmans, C., Campello, E., Simioni, P., de Laat, B., de Vos‐Geelen, J., Roest, M., & Cate, H. T. (2023) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0043-1777304 · Cited by 14
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Liu, Y., Qu, Y., Liu, C., Zhang, D., Xu, B., Wan, Y., & Jiang, P. (2024) · Phytotherapy Research · doi:10.1002/ptr.8311 · Cited by 14
Yasuda, H., Takishita, Y., Mortia, A., Tsutsumi, T., Nakagawa, N., & Sato, E. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168757 · Cited by 14
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Zhang, Y., Zhao, Y., Liu, Y., Zhang, M., & Zhang, J. (2024) · Cancer · doi:10.1002/cncr.35559 · Cited by 15
Barbu, E. A., Dominical, V. M., Mendelsohn, L. G., & Thein, S. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01335 · Cited by 14
Ai, P., Pan, H., Chen, K., Zheng, J., Gao, Z., & Jin, G. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.05.091 · Cited by 14
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Kudo, T., Nakazawa, D., Watanabe‐Kusunoki, K., Kanda, M., Shiratori‐Aso, S., Abe, N., Nishio, S., Koga, J., Iwasaki, S., Tsuji, T., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42314 · Cited by 14
Bonilla, M. C., Quiros, O. N., Wendt, M., Hennig‐Pauka, I., Mörgelin, M., von Köckritz‐Blickwede, M., & de Buhr, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168953 · Cited by 14
Macedo, I. S., Lima, M. V. A., Souza, J. S., Rochael, N. C., Caldas, P. N., Barbosa, H. S., Lara, F. A., Saraiva, E. M., & Mariante, R. M. (2020) · Microorganisms · doi:10.3390/microorganisms8111628 · Cited by 14
Huang, S. U.-S., & O’Sullivan, K. M. (2022) · doi:10.20944/preprints202203.0021.v1 · Cited by 65
Mortazavi‐Jahromi, S. S., & Aslani, M. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109040 · Cited by 13
Linnemann, C., Nussler, A. K., Histing, T., & Ehnert, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416208 · Cited by 13
Ni, C., Gao, S., Li, X. J., Zheng, Y., Jiang, H., Liu, P., Lv, Q., Huang, W., Li, Q., Ren, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1094331 · Cited by 13
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Metadata
- Authors
- Li, P., Li, M., Lindberg, M. R., Kennett, M. J., Xiong, N., & Wang, Y.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Wang, Yanming
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2010-08-23
- Volume
- 207
- Issue
- 9
- Pages
- 1853-1862
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2931169
- OpenAlex
- W2135849676
- Cited by
- 1,495
- References
- 31
- Citations by year
- 2026: 104 · 2025: 121 · 2024: 122 · 2023: 121 · 2022: 134 · 2021: 123 · 2020: 125 · 2019: 118 · 2018: 94 · 2017: 92 · 2016: 81 · 2015: 68 · 2014: 60 · 2013: 61 · 2012: 51
- FWCI
- 17.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA136856)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- PAD4, neutrophil extracellular traps, neutrophils, chromatin decondensation, bacterial killing, necrotizing fasciitis, nucleosome
- MeSH terms
- Protein-Arginine Deiminase Type 4, Animals, Cell Differentiation, Dysentery, Bacillary, Extracellular Space, Histones, Hydrolases, Immunity, Innate, Neutrophils, Shigella flexneri, Mice, Knockout, Mice
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