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PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
Open accessAbstract
Neutrophils trap and kill bacteria by forming highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs). We previously reported that histone hypercitrullination catalyzed by peptidylarginine deiminase 4 (PAD4) correlates with chromatin decondensation during NET formation. However, the role of PAD4 in NET-mediated bacterial trapping and killing has not been tested. Here, we use PAD4 knockout mice to show that PAD4 is essential for NET-mediated antibacterial function. Unlike PAD4+/+ neutrophils, PAD4−/− neutrophils cannot form NETs after stimulation with chemokines or incubation with bacteria, and are deficient in bacterial killing by NETs. In a mouse infectious disease model of necrotizing fasciitis, PAD4−/− mice are more susceptible to bacterial infection than PAD4+/+ mice due to a lack of NET formation. Moreover, we found that citrullination decreased the bacterial killing activity of histones and nucleosomes, which suggests that PAD4 mainly plays a role in chromatin decondensation to form NETs instead of increasing histone-mediated bacterial killing. Our results define a role for histone hypercitrullination in innate immunity during bacterial infection.
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“Next, we determined the importance of peptidylarginine deiminase type 4 (PAD4), the enzyme responsible for histone modifications required for decondensing neutrophil DNA before expulsion (25).”
From Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps (2016) · cites this paper as [25]
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Cites
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Novel cell death program leads to neutrophil extracellular traps
Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197
Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
Segal, A. W. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115653 · Cited by 1,783
Wang, Y., Li, M., Stadler, S. C., Correll, S., Li, P., Wang, D., Hayama, R., Leonelli, L., Han, H., Grigoryev, S. A., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200806072 · Cited by 1,579
Self-citationSimplified mammalian DNA isolation procedure
Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. J. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,497
The structure of DNA in the nucleosome core
Richmond, T. J., & Davey, C. A. (2003) · Nature · doi:10.1038/nature01595 · Cited by 1,287
Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination
Wang, Y., Wysocka, J., Sayegh, J., Lee, Y., Perlin, J. R., Leonelli, L., Sonbuchner, L. S., McDonald, C. H., Cook, R. G., Dou, Y., et al. (2004) · Science · doi:10.1126/science.1101400 · Cited by 1,013
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Items 401–500 of 1,001
Dwivedi, N., Neeli, I., Schall, N., Wan, H., Desiderio, D. M., Csernok, E., Thompson, P. R., Dali, H., Briand, J., Muller, S., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-247254 · Cited by 79
Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance
Revelo, X. S., Ghazarian, M., Chng, M. H. Y., Luck, H., Kim, J. H., Zeng, K., Shi, S. Y., Tsai, S. J., Lei, H., Kenkel, J. A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.024 · Cited by 83
Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity
Tu, H., Ren, H., Jiang, J., Shao, C., Shi, Y., & Li, P. (2023) · Advanced Science · doi:10.1002/advs.202306457 · Cited by 80
Self-citationNeutrophils come of age in chronic inflammation
Caielli, S., Banchereau, J., & Pascual, V. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.09.008 · Cited by 79
Neutrophil Extracellular Traps: A Potential Therapeutic Target in MPO-ANCA Associated Vasculitis?
O’Sullivan, K. M., & Holdsworth, S. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.635188 · Cited by 77
Fisher, J., Mohanty, T., Karlsson, C. A. Q., Khademi, S. M. H., Malmström, E., Frigyesi, A., Nordenfelt, P., Malmström, J. A., & Linder, A. (2021) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2021.100113 · Cited by 76
Neutrophils’ Extracellular Trap Mechanisms: From Physiology to Pathology
Schoen, J., Euler, M., Schauer, C., Schett, G. A., i, M. H., Knopf, J., & Yaykaşlı, K. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112855 · Cited by 81
PAD4 and Its Inhibitors in Cancer Progression and Prognosis
Zhu, D., Lu, Y., Wang, Y., & Wang, Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112414 · Cited by 83
Self-citationNeutrophil Extracellular Traps in Cerebral Ischemia/Reperfusion Injury: Friend and Foe
Luo, H., Guo, H., Zhou, Y., Fang, R., Zhang, W., & Mei, Z. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230308090351 · Cited by 78
Lee, W., Ko, S. Y., Akasaka, H., Weigert, M., Lengyel, E. R., & Naora, H. (2025) · Cancer Cell · doi:10.1016/j.ccell.2024.12.004 · Cited by 81
Rao, A. N. (2015) · World Journal of Cardiology · doi:10.4330/wjc.v7.i12.829 · Cited by 80
Nucleases from Prevotella intermedia can degrade neutrophil extracellular traps
Doke, M., Fukamachi, H., Morisaki, H., Arimoto, T., Kataoka, H., & Kuwata, H. (2016) · Molecular Oral Microbiology · doi:10.1111/omi.12171 · Cited by 76
Silva, J. C., Rodrigues, N. C., Thompson‐Souza, G. A., Muniz, V. S., Neves, J. S., & Figueiredo, R. T. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.4a0119-009rr · Cited by 79
Neutrophil extracellular traps in bacterial infections and evasion strategies
Baz, A. A., Hao, H., Lan, S., Li, Z., Liu, S., Chen, S., & Chu, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1357967 · Cited by 79
Sendtner, N., Seitz, R., Brandl, N., Müller, M., & Gülow, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010240 · Cited by 81
Virus-Induced NETs – Critical Component of Host Defense or Pathogenic Mediator?
Jenne, C. N., & Kubes, P. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004546 · Cited by 76
de Buhr, N., & von Köckritz‐Blickwede, M. (2019) · Methods in molecular biology · doi:10.1007/978-1-0716-0154-9_25 · Cited by 75
Role of Extracellular Trap Release During Bacterial and Viral Infection
Schultz, B. M., Acevedo, O. A., Kalergis, A. M., & Bueno, S. M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.798853 · Cited by 77
Methods for the Detection of Peptidylarginine Deiminase (PAD) Activity and Protein Citrullination
Hensen, S. M. M., & Pruijn, G. J. M. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r113.033746 · Cited by 74
Bacterial Siderophores Hijack Neutrophil Functions
Saha, P., Yeoh, B. S., Olvera, R. A., Xiao, X., Singh, V., Awasthi, D., Subramanian, B. C., Chen, Q., Dikshit, M., Wang, Y., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700261 · Cited by 76
Self-citationWang, S., Chen, X. A., Hu, J., Jiang, J.-K., Li, Y., Chan-Salis, K. Y., Gu, Y., Chen, G., Thomas, C. J., Pugh, B. F., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-1093-t · Cited by 75
Self-citationOdqvist, L., Jevnikar, Z., Riise, R. E., Öberg, L., Rhedin, M., Leonard, D., Yrlid, L., Jackson, S. G., Mattsson, J., Nanda, S. K., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215434 · Cited by 75
Chemokine isoforms and processing in inflammation and immunity
Proost, P., Struyf, S., Damme, J. V., Fiten, P., Ugarte-Berzal, E., & Opdenakker, G. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.06.009 · Cited by 73
PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium
Saha, P., Yeoh, B. S., Xiao, X., Golonka, R. M., Singh, V., Wang, Y., & Vijay–Kumar, M. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0139-3 · Cited by 75
Self-citationHoste, E., Maueröder, C., Hove, L. V., Catrysse, L., Vikkula, H., Sze, M., Maes, B., Karjosukarso, D. W., Martens, L., Gonçalves, A. C., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.104 · Cited by 75
The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis
Wan, J., Ren, Y., Yang, X., Li, X., Xia, L., & Lü, N. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.565758 · Cited by 74
Dai, W., Tian, R., Yu, L., Bian, S., Chen, Y., Yin, B., Luan, Y., Chen, S., Fan, Z., Yan, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44576-2 · Cited by 72
Yoshida, M., Sasaki, M., Sugisaki, K., Yamaguchi, Y., & Yamada, M. (2013) · Clinical Kidney Journal · doi:10.1093/ckj/sft048 · Cited by 72
Nakken, B., Papp, G., Bosnes, V., Zeher, M., Nagy, G., & Szodoray, P. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.05.010 · Cited by 72
Role of Neutrophil Extracellular Traps Following Injury
Liu, F.-C., Chuang, Y.-H., Tsai, Y., & Yu, H.-P. (2014) · Shock · doi:10.1097/shk.0000000000000146 · Cited by 75
Neutrophil extracellular traps and pulmonary fibrosis: an update
Yan, S., Li, M., Liu, B., Ma, Z., & Yang, Q. (2023) · Journal of Inflammation · doi:10.1186/s12950-023-00329-y · Cited by 71
Self-citationClark, H., Abbondante, S., Minns, M., Greenberg, E. N., Sun, Y., & Pearlman, E. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01182 · Cited by 73
Shi, L. S., Yao, H., Liu, Z., Xu, M. Q., Tsung, A., & Wang, Y. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0018 · Cited by 73
Self-citationGomez‐Lopez, N., Romero, R. J., Xu, Y., Miller, D., Unkel, R., Shaman, M., Jacques, S. M., Panaitescu, B., Garcia‐Flores, V., & Hassan, S. S. (2016) · Reproductive Sciences · doi:10.1177/1933719116678690 · Cited by 71
Roles of mitochondria in neutrophils
Cao, Z., Zhao, M. L., Sun, H., Hu, L., Chen, Y., & Fan, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.934444 · Cited by 74
Expanding roles of neutrophils in aging hosts
Tseng, C. W., & Liu, G. Y. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.03.009 · Cited by 73
The other myeloperoxidase: Emerging functions
Vanhamme, L., Boudjeltia, K. Z., Antwerpen, P. V., & Delporte, C. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.03.037 · Cited by 70
Annexin A1 and Autoimmunity: From Basic Science to Clinical Applications
Bruschi, M., Petretto, A., Vaglio, A., Santucci, L., Candiano, G., & Ghiggeri, G. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051348 · Cited by 69
Neutrophil Extracellular Traps in Autoimmunity and Allergy: Immune Complexes at Work
Granger, V., Peyneau, M., Chollet‐Martin, S., & de Chaisemartin, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02824 · Cited by 75
Neutrophil inhibition improves acute inflammation in a murine model of viral myocarditis
Carai, P., González, L. F., Bruggen, S. V., Spalart, V., Giorgio, D. D., Geuens, N., Martinod, K., Jones, E. A. V., & Heymans, S. R. B. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac052 · Cited by 69
Neutrophil extracellular traps in sheep mastitis
Pisanu, S., Cubeddu, T., Pagnozzi, D., Rocca, S., Cacciotto, C., Alberti, A., Marogna, G., Uzzau, S., & Addis, M. F. (2015) · Veterinary Research · doi:10.1186/s13567-015-0196-x · Cited by 71
Pondering neutrophil extracellular traps with healthy skepticism
Nauseef, W. M., & Kubes, P. (2016) · Cellular Microbiology · doi:10.1111/cmi.12652 · Cited by 73
Holmes, C. L., Shim, D., Kernien, J. F., Johnson, C. J., Nett, J. E., & Shelef, M. A. (2019) · Journal of Immunology Research · doi:10.1155/2019/2160192 · Cited by 70
Hu, S., Liu, X., Gao, Y., Zhou, R., Wei, M., Dong, J., Yan, H., & Zhao, Y. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800871 · Cited by 71
Schroder, A. L., Chami, B., Liu, Y., Doyle, C. M., Kazzi, M. E., Ahlenstiel, G., Ahmad, G., Pathma‐Nathan, N., Collins, G. P., Toh, J. W. T., et al. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab239 · Cited by 72
Liu, K., Zhang, Y., Du, G., Chen, X., Xiao, L., Jiang, L., Jing, N., Xu, P., Zhao, C., Liu, Y., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci183544 · Cited by 69
Autodeimination of Protein Arginine Deiminase 4 Alters Protein–Protein Interactions but Not Activity
Slack, J. L., Jones, L. E., Bhatia, M., & Thompson, P. R. (2011) · Biochemistry · doi:10.1021/bi200309e · Cited by 68
Yamamoto, T., Kida, Y., Sakamoto, Y., & Kuwano, K. (2016) · Cellular Microbiology · doi:10.1111/cmi.12666 · Cited by 70
Rebernick, R. J., Fahmy, L. M., Glover, C., Bawadekar, M., Shim, D., Holmes, C. L., Rademacher, N., Potluri, H. K., Bartels, C. M., & Shelef, M. A. (2018) · Biological Procedures Online · doi:10.1186/s12575-018-0072-y · Cited by 68
Winslow, S., Odqvist, L., Diver, S. E., Riise, R. E., Abdillahi, S. M., Wingren, C., Lindmark, H., Wellner, A., Lundin, S., Yrlid, L., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.03312-2020 · Cited by 67
Recent progress in the mechanistic understanding of NET formation in neutrophils
Liu, M., Lyu, X., & Werth, V. P. (2021) · FEBS Journal · doi:10.1111/febs.16036 · Cited by 69
Huang, S. U.-S., & O’Sullivan, K. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073793 · Cited by 72
Veras, F. P., Gomes, G. F., Silva, B. M. S., Caetité, D. B., Almeida, C. J. L. R., Silva, C. M. S., Schneider, A. H., Córneo, E. D. S., Bonilha, C. S., Batah, S. S., et al. (2023) · Respiratory Research · doi:10.1186/s12931-023-02336-2 · Cited by 71
Chowdhury, C. S., Kinsella, R. L., McNehlan, M. E., Naik, S. K., Lane, D. S., Talukdar, P., Smirnov, A., Dubey, N., Rankin, A. N., McKee, S. R., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.11.008 · Cited by 72
Lu, T., Kobayashi, S. D., Quinn, M. T., & DeLeo, F. R. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00365 · Cited by 71
Fighting against the dark side of neutrophil extracellular traps in disease
Saffarzadeh, M., & Preissner, K. T. (2012) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32835a0025 · Cited by 70
Neutrophils’ Contribution to Periodontitis and Periodontitis-Associated Cardiovascular Diseases
Bassani, B., Cucchiara, M., Butera, A., Kayali, O., Chiesa, A., Palano, M. T., Olmeo, F., Gallazzi, M., Dellavia, C. P. B., Mortara, L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015370 · Cited by 71
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages
Trzebanski, S., Kim, J., Larossi, N., Raanan, A., Kancheva, D., Bastos, J., Haddad, M., Solomon, A., Sivan, E., Aizik, D., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.04.019 · Cited by 71
Neutrophils and NETs in kidney disease
Nakazawa, D., Masuda, S., Nishibata, Y., Watanabe‐Kusunoki, K., Tomaru, U., & Ishizu, A. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-00944-3 · Cited by 69
Gao, F., Peng, H., Gou, R., Zhou, Y., Ren, S., & Li, F. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00670-3 · Cited by 68
The cell biology of inflammation: From common traits to remarkable immunological adaptations
Weavers, H., & Martin, P. B. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202004003 · Cited by 68
Heuer, A., Stiel, C., Elrod, J., Königs, I., Vincent, D., Schlegel, P., Trochimiuk, M., Appl, B., Reinshagen, K., Raluy, L. P., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.614347 · Cited by 66
Chen, Y., Li, X., Lin, X., Liang, H., Liu, X., Zhang, X., Zhang, Q., Zhou, F., Chen, Y., Lei, L., et al. (2022) · Thrombosis Journal · doi:10.1186/s12959-022-00384-0 · Cited by 68
NETosis: an emerging therapeutic target in renal diseases
Juha, M., Molnár, A., Jakus, Z., & Ledó, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1253667 · Cited by 67
Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps
He, D., Wu, Q., Tian, P., Liu, Y., Jia, Z., Li, Z., Wang, Y., Jin, Y., Luo, W., Li, L., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.06.007 · Cited by 69
Self-citationPAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression
Nakashima, K., Arai, S., Suzuki, A., Nariai, Y., Urano, T., Nakayama, M., Ohara, O., Yamamura, K., Yamamoto, K., & Miyazaki, T. (2013) · Nature Communications · doi:10.1038/ncomms2862 · Cited by 65
Neutrophil-Extracellular Traps, Cell-Free DNA, and Immunothrombosis in Companion Animals: A Review
Goggs, R. A. N., Jeffery, U., LeVine, D. N., & Li, R. H. L. (2019) · Veterinary Pathology · doi:10.1177/0300985819861721 · Cited by 68
NETosis as a Pathogenic Factor for Heart Failure
Ling, S., & Xu, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6687096 · Cited by 64
Neutrophil extracellular traps and organ dysfunction in sepsis
Kumar, S., Payal, N., Srivastava, V. K., Kaushik, S., Saxena, J., & Jyoti, A. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.09.012 · Cited by 66
Neutrophil extracellular traps and cancer-associated thrombosis
Rosell, A., Martinod, K., Mackman, N., & Thålin, C. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2021.12.018 · Cited by 69
Immunothrombosis: Molecular Aspects and New Therapeutic Perspectives
Marcos‐Jubilar, M., Lecumberri, R., & Páramo, J. A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041399 · Cited by 66
Park, W., Gray, J. M., Holewinski, R. J., Andrésson, Þ., So, J. Y., Carmona‐Rivera, C., Hollander, M. C., Yang, H. H., Lee, M. P., Kaplan, M. J., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00524-z · Cited by 65
Increased Polyamines Alter Chromatin and Stabilize Autoantigens in Autoimmune Diseases
Brooks, W. H. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00091 · Cited by 66
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Nishi, H., & Mayadas, T. N. (2018) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000577 · Cited by 64
Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock
Wu, Z., Deng, Q., Pan, B., Alam, H. B., Tian, Y., Bhatti, U. F., Liu, B., Mondal, S., Thompson, P. R., & Li, Y. (2020) · Inflammation · doi:10.1007/s10753-020-01221-0 · Cited by 63
On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little
Santocki, M., & Kołaczkowska, E. (2020) · Cells · doi:10.3390/cells9092079 · Cited by 63
Zhai, M., Gong, S., Luan, P., Shi, Y., Kou, W., Zeng, Y., Shi, J., Yu, G., Hou, J., Yu, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35330-1 · Cited by 63
Wang, S., Song, Y., Wang, Z., Chang, X., Wu, H., Yan, Z., Wu, J., He, Z., Kang, L., Hu, W., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01158-6 · Cited by 64
NETopathies? Unraveling the Dark Side of Old Diseases through Neutrophils
Mitsios, A., Αραμπατζιόγλου, Α., Arelaki, S., Mitroulis, I., & Ritis, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00678 · Cited by 68
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Zhou, X., Jin, J., Lv, T., & Song, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031464 · Cited by 62
Neutrophil extracellular traps in cancer
Ma, Y., Wei, J., He, W., & Ren, J. (2024) · MedComm · doi:10.1002/mco2.647 · Cited by 67
Wang, C., Lin, T., Hu, L., Xu, C.-J., Hu, F., Wan, L., Yang, X., Wu, X., Zhang, X., Li, Y., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104499 · Cited by 62
The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities
Assohou-Luty, C., Raijmakers, R., Benckhuijsen, W. E., Stammen‐Vogelzangs, J., de Ru, A., van Veelen, P. A., Franken, K. L. M. C., Drijfhout, J. W., & Pruijn, G. J. M. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.02.019 · Cited by 61
A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22
Chang, H., Liu, G., Dwivedi, N., Sun, B., Okamoto, Y., Kinslow, J. D., Deane, K. D., Demoruelle, M. K., Norris, J. M., Thompson, P. R., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.90045 · Cited by 61
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O’Brien, X. M., Girard, B., & Reichner, J. S. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000303 · Cited by 61
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Metadata
- Authors
- Li, P., Li, M., Lindberg, M. R., Kennett, M. J., Xiong, N., & Wang, Y.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Wang, Yanming
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2010-08-23
- Volume
- 207
- Issue
- 9
- Pages
- 1853-1862
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2931169
- OpenAlex
- W2135849676
- Cited by
- 1,495
- References
- 31
- Citations by year
- 2026: 104 · 2025: 121 · 2024: 122 · 2023: 121 · 2022: 134 · 2021: 123 · 2020: 125 · 2019: 118 · 2018: 94 · 2017: 92 · 2016: 81 · 2015: 68 · 2014: 60 · 2013: 61 · 2012: 51
- FWCI
- 17.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA136856)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- PAD4, neutrophil extracellular traps, neutrophils, chromatin decondensation, bacterial killing, necrotizing fasciitis, nucleosome
- MeSH terms
- Protein-Arginine Deiminase Type 4, Animals, Cell Differentiation, Dysentery, Bacillary, Extracellular Space, Histones, Hydrolases, Immunity, Innate, Neutrophils, Shigella flexneri, Mice, Knockout, Mice
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