PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

Chromatin modifications and their function

Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883

Neutrophil Extracellular Traps Kill Bacteria

Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756

Novel cell death program leads to neutrophil extracellular traps

Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197

Neutrophils and immunity: challenges and opportunities

Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971

HOW NEUTROPHILS KILL MICROBES

Segal, A. W. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115653 · Cited by 1,783

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

Wang, Y., Li, M., Stadler, S. C., Correll, S., Li, P., Wang, D., Hayama, R., Leonelli, L., Han, H., Grigoryev, S. A., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200806072 · Cited by 1,579

Simplified mammalian DNA isolation procedure

Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. J. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,497

The structure of DNA in the nucleosome core

Richmond, T. J., & Davey, C. A. (2003) · Nature · doi:10.1038/nature01595 · Cited by 1,287

Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination

Wang, Y., Wysocka, J., Sayegh, J., Lee, Y., Perlin, J. R., Leonelli, L., Sonbuchner, L. S., McDonald, C. H., Cook, R. G., Dou, Y., et al. (2004) · Science · doi:10.1126/science.1101400 · Cited by 1,013

Synthesis of Human Neutrophil Extracellular Traps Contributes to Angiopoietin-Mediated In Vitro Proinflammatory and Proangiogenic Activities

Lavoie, S. B., Dumas, E., Vulesevic, B., Neagoe, P., White, M., & Sirois, M. G. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701203 · Cited by 47

Early intravenous administration of tranexamic acid ameliorates intestinal barrier injury induced by neutrophil extracellular traps in a rat model of trauma/hemorrhagic shock

Chu, C., Yang, C., Wang, X., Xie, T., Sun, S., Liu, B., Wang, K., Duan, Z., Ding, W., & Li, J. (2019) · Surgery · doi:10.1016/j.surg.2019.10.009 · Cited by 45

Lysophosphatidylserine induces eosinophil extracellular trap formation and degranulation: Implications in severe asthma

Kim, H. J., Sim, M. S., Lee, D. H., KIM, C. S., Choi, Y., Park, H., & Chung, I. Y. (2020) · Allergy · doi:10.1111/all.14450 · Cited by 45

Structural and functional diversity of neutrophil glycosylation in innate immunity and related disorders

Ugonotti, J., Chatterjee, S., & Thaysen‐Andersen, M. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100882 · Cited by 47

Pyroptosis Mediates Neutrophil Extracellular Trap Formation during Bacterial Infection in Zebrafish

Chen, W., Zhao, J., Mu, D., Wang, Z., Liu, Q., Zhang, Y., & Yang, D. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001335 · Cited by 48

NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns

Surolia, R., Li, F. J., Wang, Z., Kashyap, M. P., Srivastava, R. K., Traylor, A., Singh, P., Dsouza, K. G., Kim, H., Pittet, J., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.147564 · Cited by 48

Protein‐arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination

Funayama, R., Taniguchi, H., Mizuma, M., Fujishima, F., Kobayashi, M., Ohnuma, S., Unno, M., & Nakayama, K. (2017) · Cancer Science · doi:10.1111/cas.13179 · Cited by 45

A quantitative and site-specific atlas of the citrullinome reveals widespread existence of citrullination and insights into PADI4 substrates

Rebak, A. S., Hendriks, I. A., Elsborg, J. D., Buch-Larsen, S. C., Nielsen, C. H., Terslev, L., Kirsch, R., Damgaard, D., Doncheva, N. T., Lennartsson, C., et al. (2024) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01214-9 · Cited by 45

Neutrophil elastase promotes neointimal hyperplasia by targeting toll‐like receptor 4 (TLR4)–NF‐κB signalling

Yang, M., Chen, Q., Li, M., Wen, G., An, W., Zhou, X., Niu, K., Liu, C., Ren, M., Sun, K., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15583 · Cited by 44

Low-Density Granulocytes in Immune-Mediated Inflammatory Diseases

Ning, X. B., Wang, W., & Jin, H. (2022) · Journal of Immunology Research · doi:10.1155/2022/1622160 · Cited by 45

Polyglycerol‐Amine Covered Nanosheets Target Cell‐Free DNA to Attenuate Acute Kidney Injury

Wu, K., Lu, X., Li, Y., Wang, Y., Liu, M., Li, H., Li, H., Liu, Q., Shao, D., Chen, W., et al. (2023) · Advanced Science · doi:10.1002/advs.202300604 · Cited by 44

Targeting peptidylarginine deiminase reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis

Madhi, R., Rahman, M., Taha, D., Mörgelin, M., & Thorlacius, H. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27874 · Cited by 44

Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent

Kesäniemi, J., Jernfors, T., Lavrinienko, A., Kivisaari, K., Kiljunen, M., Mappes, T., & Watts, P. C. (2019) · Molecular Ecology · doi:10.1111/mec.15241 · Cited by 44

Pathological consequences of anti-citrullinated protein antibodies in tear fluid and therapeutic potential of pooled human immune globulin-eye drops in dry eye disease

Kwon, J., Surenkhuu, B., Raju, I., Atassi, N. Y., Mun, J., Chen, Y., Sarwar, M. A., Rosenblatt, M. I., Pradeep, A., An, S., et al. (2019) · The Ocular Surface · doi:10.1016/j.jtos.2019.10.004 · Cited by 44

Microbes and the fate of neutrophils

Kobayashi, S. D., DeLeo, F. R., & Quinn, M. T. (2022) · Immunological Reviews · doi:10.1111/imr.13163 · Cited by 45

GSK484, an inhibitor of peptidyl arginine deiminase 4, increases the radiosensitivity of colorectal cancer and inhibits neutrophil extracellular traps

Wang, B., Su, X., Zhang, B., & Pan, S. (2023) · The Journal of Gene Medicine · doi:10.1002/jgm.3530 · Cited by 43

Neutrophil biology in injuries and diseases of the central and peripheral nervous systems

Balog, B. M., Sonti, A., & Zigmond, R. E. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102488 · Cited by 46

Neutrophil biology

Kobayashi, Y. (2015) · EXCLI journal · doi:10.17179/excli2015-102 · Cited by 44

Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase

Damgaard, D., Bjørn, M. E., Jensen, P. Ø., & Nielsen, C. H. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2017.1368505 · Cited by 43

Histone Deacetylase Inhibitors Dose-Dependently Switch Neutrophil Death from NETosis to Apoptosis

Hamam, H. J., & Palaniyar, N. (2019) · Biomolecules · doi:10.3390/biom9050184 · Cited by 43

The role of neutrophil extracellular traps and TLR signaling in skeletal muscle ischemia reperfusion injury

Edwards, N., Hwang, C. D., Marini, S., Pagani, C. A., Spreadborough, P. J., Rowe, C. J., Yu, P., Mei, A., Visser, N. D., Li, S., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000994rr · Cited by 43

Inhibition of Peptidyl Arginine Deiminase-4 Prevents Renal Ischemia-Reperfusion-Induced Remote Lung Injury

Du, M., Yang, L., Gu, J., Wu, J., Ma, Y., & Wang, T. (2020) · Mediators of Inflammation · doi:10.1155/2020/1724206 · Cited by 43

Ferroptosis, novel therapeutics in asthma

Lv, X., Dong, M., Tang, W., Qin, J., Wang, W., Li, M., Teng, F., Yi, L., Dong, J., & Wei, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113516 · Cited by 43

The role of NETosis in heart failure

Sawa Kostin, D., Krizanic, F., Kelesidis, T., & Pagonas, N. (2024) · Heart Failure Reviews · doi:10.1007/s10741-024-10421-x · Cited by 43

Environmental Factors Contribute to β Cell Endoplasmic Reticulum Stress and Neo-Antigen Formation in Type 1 Diabetes

Marré, M. L., & Piganelli, J. D. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00262 · Cited by 47

Neutrophil Extracellular Traps May Contribute to the Pathogenesis in Adult-onset Still Disease

Ahn, M., Han, J. H., Chwae, Y.-J., Jung, J., Suh, C., Kwon, J. E., & Kim, H. (2019) · The Journal of Rheumatology · doi:10.3899/jrheum.181058 · Cited by 42

Extracellular vesicles from cod (Gadus morhua L.) mucus contain innate immune factors and deiminated protein cargo

Magnadóttir, B., Kraev, I., Guðmundsdóttir, S., Dodds, A. W., & Lange, S. (2019) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2019.103397 · Cited by 42

Trypanosoma brucei brucei Induces Polymorphonuclear Neutrophil Activation and Neutrophil Extracellular Traps Release

Grob, D., Conejeros, I., Velásquez, Z. D., Preußer, C., Gärtner, U., Alarcón, P., Burgos, R. A., Hermosilla, C. R., & Taubert, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.559561 · Cited by 43

Quantification of Citrullinated Histone H3 Bound DNA for Detection of Neutrophil Extracellular Traps

Li, M., Lin, C., Leso, A., & Nefedova, Y. (2020) · Cancers · doi:10.3390/cancers12113424 · Cited by 43

The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis

Czerwińśka, J., & Owczarczyk-Saczonek, A. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031840 · Cited by 42

Macrophage extracellular traps require peptidylarginine deiminase 2 and 4 and are a source of citrullinated antigens bound by rheumatoid arthritis autoantibodies

Bashar, S. J., Holmes, C. L., & Shelef, M. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1167362 · Cited by 41

NETosis in tumour microenvironment of liver: From primary to metastatic hepatic carcinoma

Yang, Y. C., Yu, S., Lv, C., & Tian, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102297 · Cited by 42

Citrullination: A Target for Disease Intervention in Multiple Sclerosis and other Inflammatory Diseases?

Chirivi, R. G. S. (2013) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000146 · Cited by 41

Eosinophils in fungal diseases: An overview

Figueiredo, R. T., & Neves, J. S. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr1117-473r · Cited by 43

Circulating H3Cit is elevated in a human model of endotoxemia and can be detected bound to microvesicles

Göranson, S. P., Thålin, C., Lundström, A., Hållström, L., Lasselin, J., Wallén, H., Soop, A., & Mobarrez, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-31013-4 · Cited by 41

1,25-Dihydroxyvitamin D3 induces formation of neutrophil extracellular trap-like structures and modulates the transcription of genes whose products are neutrophil extracellular trap-associated proteins: A pilot study

Agraz‐Cibrián, J. M., Giraldo, D. M., & Inchima, S. U. (2018) · Steroids · doi:10.1016/j.steroids.2018.11.001 · Cited by 41

Baricitinib for the treatment of rheumatoid arthritis and systemic lupus erythematosus: a 2019 update

Kubo, S., Nakayamada, S., & Tanaka, Y. (2019) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2019.1608821 · Cited by 42

The Emerging Role of Neutrophils in the Pathogenesis of Thrombosis in COVID-19

Iliadi, V., Konstantinidou, I., Aftzoglou, K., Iliadis, S., Konstantinidis, T. G., & Tsigalou, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105368 · Cited by 41

Interorgan communication networks in the kidney–lung axis

Komaru, Y., Bai, Y. Z., Kreisel, D., & Herrlich, A. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00760-7 · Cited by 42

Platelet factor 4 limits neutrophil extracellular trap– and cell-free DNA–induced thrombogenicity and endothelial injury

Ngo, A. T. P., Skidmore, A. E., Oberg, J., Yarovoi, I., Sarkar, A., Levine, N., Bochenek, V., Zhao, G., Rauova, L., Kowalska, M. A., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.171054 · Cited by 40

Calcium‐dependent antimicrobials: Nature‐inspired materials and designs

Wang, Z., Zeng, Y., Ahmed, Z., Qin, H., Bhatti, I. A., & Cao, H. (2024) · Exploration · doi:10.1002/exp.20230099 · Cited by 41

Citrullination modulation stabilizes HIF-1α to promote tumour progression

Chen, R., Lin, Z., Shen, S., Zhu, C., Yan, K., Suo, C., Liu, R., Wei, H., Gao, L., Fan, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51882-w · Cited by 40

Rab27a Is Essential for the Formation of Neutrophil Extracellular Traps (NETs) in Neutrophil-Like Differentiated HL60 Cells

Kawakami, T., He, J., Morita, H., Kunio, Y., Kaji, H., Tanaka, C., Suemori, S., Tohyama, K., & Tohyama, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084704 · Cited by 42

Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation

Bawadekar, M., Gendron‐Fitzpatrick, A., Rebernick, R. J., Shim, D., WARNER, T. F. C. S., Nicholas, A. P., Lundblad, L. K. A., Thompson, P. R., & Shelef, M. A. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1068-0 · Cited by 40

Extracellular vesicles, deiminated protein cargo and microRNAs are novel serum biomarkers for environmental rearing temperature in Atlantic cod (Gadus morhua L.)

Magnadóttir, B., Onganer, P. U., Kraev, I., Dodds, A. W., Guðmundsdóttir, S., & Lange, S. (2019) · Aquaculture Reports · doi:10.1016/j.aqrep.2019.100245 · Cited by 40

Insights of rheumatoid arthritis biomarkers

Kolarz, B., Podgórska, D., & Podgórski, R. (2020) · Biomarkers · doi:10.1080/1354750x.2020.1794043 · Cited by 40

The Role of the Microbiome in Driving RA-Related Autoimmunity

Rooney, C. M., Mankia, K. S., & Emery, P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.538130 · Cited by 41

Neutrophil Extracellular Traps in the Autoimmunity Context

Bruschi, M., Moroni, G. L., Sinico, R. A., Franceschini, F., Fredi, M., Vaglio, A., Cavagna, L., Petretto, A., Pratesi, F., Migliorini, P., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.614829 · Cited by 42

The virtues and vices of protein citrullination

Christophorou, M. A. (2022) · Royal Society Open Science · doi:10.1098/rsos.220125 · Cited by 41

Detection and Quantification of Citrullinated Chemokines

Moelants, E. A. V., Damme, J. V., & Proost, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028976 · Cited by 40

Neutrophils and NETs in Pathophysiology and Treatment of Inflammatory Bowel Disease

Ortega-Zapero, M., Gómez-Bris, R., Pascual-Laguna, I., Saéz, Á., & González, J. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157098 · Cited by 41

Neutrophils in animal models of autoimmune disease

Németh, T., Mócsai, A., & Lowell, C. A. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.04.001 · Cited by 39

High‐Titer Rheumatoid Arthritis Antibodies Preferentially Bind Fibrinogen Citrullinated by Peptidylarginine Deiminase 4

Blachère, N. E., Parveen, S., Frank, M. O., Dill, B. D., Molina, H., & Orange, D. E. (2016) · Arthritis & Rheumatology · doi:10.1002/art.40035 · Cited by 39

2-Chlorofatty acids: lipid mediators of neutrophil extracellular trap formation

Palladino, E. N. D., Katunga, L. A., Kolar, G. R., & Ford, D. A. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m084731 · Cited by 39

Multi-facets of neutrophil extracellular trap in infectious diseases: Moving beyond immunity

Tabrizi, Z. A., Khosrojerdi, A., Aslani, S., Hemmatzadeh, M., Babaie, F., Bairami, A., Shomali, N., Hosseinzadeh, R., Safari, R., & Mohammadi, H. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105066 · Cited by 40

Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury

Bachmaier, K., Stuart, A., Singh, A., Mukhopadhyay, A., Chakraborty, S., Hong, Z., Wang, L., Tsukasaki, Y., Maienschein‐Cline, M., Ganesh, B. B., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c09762 · Cited by 39

Neutrophil extracellular trap inhibition improves survival in neonatal mouse infectious peritonitis

Denorme, F., Rustad, J. L., Portier, I., Crandell, J. L., de Araujo, C. V., Cody, M. J., Campbell, R. A., & Yost, C. C. (2022) · Pediatric Research · doi:10.1038/s41390-022-02219-0 · Cited by 40

Traps and hyper inflammation – new ways that neutrophils promote or hinder survival

Gunzer, M. (2013) · British Journal of Haematology · doi:10.1111/bjh.12608 · Cited by 41

The Formation of NETs and Their Mechanism of Promoting Tumor Metastasis

Li, J., Chen, J., Sun, J., & Li, K. (2023) · Journal of Oncology · doi:10.1155/2023/7022337 · Cited by 39

Neutrophil autophagy induced by monosodium urate crystals facilitates neutrophil extracellular traps formation and inflammation remission in gouty arthritis

Huang, S., Wang, Y., Lin, S., Guan, W., Liang, H., & Shen, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1071630 · Cited by 38

Eosinophil extracellular traps in asthma: implications for pathogenesis and therapy

Shen, K., Zhang, M., Zhao, R., Li, Y., Li, C., Hou, X., Sun, B., Liu, B., Xiang, M., & Lin, J. (2023) · Respiratory Research · doi:10.1186/s12931-023-02504-4 · Cited by 38

Anti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases

van der Linden, M., Kumari, S., Montizaan, D., van Dalen, S. C. M., Kip, A., Foster, M. R., Reinieren-Beeren, I., Neubert, E., Erpenbeck, L., Waaijenberg, K., et al. (2023) · mAbs · doi:10.1080/19420862.2023.2281763 · Cited by 38

Infections as a cause of autoimmune rheumatic diseases

Sakkas, L. I., & Bogdanos, D. P. (2016) · Autoimmunity Highlights · doi:10.1007/s13317-016-0086-x · Cited by 38

The Immune Response in Periodontal Tissues

Nędzi-Góra, M., Kowalski, J., & Górska, R. (2017) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-017-0472-8 · Cited by 38

The emerging role of neutrophil extracellular traps in autoimmune and autoinflammatory diseases

Zeng, L., Xiang, W., Xiao, W., Wu, Y., & Sun, L. (2025) · MedComm · doi:10.1002/mco2.70101 · Cited by 37

Neutrophil extracellular trap formation upon exposure of hydrophobic materials to human whole blood causes thrombogenic reactions

Sperling, C., Fischer, M., Maitz, M. F., & Werner, C. (2017) · Biomaterials Science · doi:10.1039/c7bm00458c · Cited by 37

Post-translational protein deimination in cod (Gadus morhua L.) ontogeny novel roles in tissue remodelling and mucosal immune defences?

Magnadóttir, B., Hayes, P. M., Hristova, M., Bragason, B. Þ., Nicholas, A. P., Dodds, A. W., Guðmundsdóttir, S., & Lange, S. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.06.006 · Cited by 37

Polypharmacological Profiles Underlying the Antitumor Property of Salvia miltiorrhiza Root (Danshen) Interfering with NOX‐Dependent Neutrophil Extracellular Traps

Li, T., Xu, M., Dai, X., Ni, T., Li, D., Jin, F., Wang, H., Tao, L., Pan, B., Woodgett, J. R., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4908328 · Cited by 40

Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation

Agarwal, S., Loder, S. J., Cholok, D. J., Li, J., Bian, G., Yalavarthi, S., Li, S., Carson, W. F., Hwang, C. D., Marini, S., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02148 · Cited by 39

Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-α therapy effectiveness

Ruiz‐Limón, P., Ladehesa-Pineda, L., Castro, C., Abalos-Aguilera, M. D. C., López‐Medina, C., López-Pedrera, C., Barbarroja, N., Espejo-Peralbo, D., González-Reyes, J. A., Villalba, J. M., et al. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00634-1 · Cited by 37

TLR4 regulates ROS and autophagy to control neutrophil extracellular traps formation against Streptococcus pneumoniae in acute otitis media

Dong, Y., Jin, C., Ding, Z., Zhu, Y., He, Q., Zhang, X., Ai, R., Yin, Y., & He, Y. (2020) · Pediatric Research · doi:10.1038/s41390-020-0964-9 · Cited by 37

Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer

Rosell, A., Aguilera, K., Hisada, Y., Schmedes, C. M., Mackman, N., Wallén, H., Lundström, S., & Thålin, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-84476-3 · Cited by 37

Role of NETosis in Central Nervous System Injury

Chen, Y., Zhang, H., Hu, X., Cai, W., Ni, W., & Zhou, K. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3235524 · Cited by 39

Genetic basis of defects in immune tolerance underlying the development of autoimmunity

Hocking, A. M., & Buckner, J. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.972121 · Cited by 38

Neutrophil extracellular traps in dermatology: Caught in the NET

Hoffmann, J. H. O., & Enk, A. (2016) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2016.07.001 · Cited by 37

Neutrophil Extracellular Traps: Inflammation and Biomaterial Preconditioning for Tissue Engineering

Fetz, A. E., & Bowlin, G. L. (2022) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2021.0013 · Cited by 36

Mechanisms of neutrophil extracellular trap in chronic inflammation of endothelium in atherosclerosis

Yang, X., Ma, Y., Chen, X., Zhu, J., Xue, W., & Ning, K. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121867 · Cited by 36

Myeloid-related protein-14 regulates deep vein thrombosis

Wang, Y., Gao, H., Kessinger, C. W., Schmaier, A. H., Jaffer, F. A., & Simon, D. I. (2017) · JCI Insight · doi:10.1172/jci.insight.91356 · Cited by 40

Missing in action—The meaning of cell death in tissue damage and inflammation

Munoz, L. E., Leppkes, M., Fuchs, T. A., Hoffmann, M. H., & i, M. H. (2017) · Immunological Reviews · doi:10.1111/imr.12569 · Cited by 36

Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin

Locke, M., Francis, R. J., Tsaousi, E., & Longstaff, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-68584-0 · Cited by 36

Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice

Watanabe, S., Iwata, Y., Fukushima, H., Saito, K., Tanaka, Y., Hasegawa, Y., Akiyama, M., & Sugiura, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-76864-y · Cited by 38

NETs Are Double-Edged Swords with the Potential to Aggravate or Resolve Periodontal Inflammation

Vitkov, L., Minnich, B., Knopf, J., Schauer, C., Hannig, M., & i, M. H. (2020) · Cells · doi:10.3390/cells9122614 · Cited by 37

The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis

Blanch‐Ruiz, M. A., Ortega‐Luna, R., Martínez-Cuesta, M. Á., & Álvarez, Á. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084170 · Cited by 41

Intact Toll-like receptor 9 signaling in neutrophils modulates normal thrombogenesis in mice

El-Sayed, O. M., Dewyer, N. A., Luke, C. E., Elfline, M. A., Laser, A., Hogaboam, C. M., Kunkel, S. L., & Henke, P. K. (2015) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2015.08.070 · Cited by 36

Neutrophil extracellular traps in neuropathy with anti-neutrophil cytoplasmic autoantibody-associated microscopic polyangiitis

Takeuchi, H., Kawasaki, T., Shigematsu, K., Kawamura, K., & Oka, N. (2017) · Clinical Rheumatology · doi:10.1007/s10067-017-3546-4 · Cited by 36

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Mamtimin, M., Pinarci, A., Han, C., Braun, A., Anders, H., Gudermann, T. W., & Mammadova‐Bach, E. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.869706 · Cited by 35

DNase based therapeutic approaches for the treatment of NETosis related inflammatory diseases

Yadav, R., Momin, A., & Godugu, C. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110846 · Cited by 38

Enterococcus faecalis suppresses Staphylococcus aureus -induced NETosis and promotes bacterial survival in polymicrobial infections

Kao, P. H. N., Ch’ng, J.-H., Chong, K. K. L., Stocks, C. J., Wong, S. L., & Kline, K. A. (2023) · FEMS Microbes · doi:10.1093/femsmc/xtad019 · Cited by 38

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Xu, C., Zhang, L., Xu, S., Wang, Z., Han, Q., Lv, Y., Wang, X., Zhang, X., Zhang, Q., Zhang, Y., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01146-w · Cited by 35

Neutrophils in glioma microenvironment: from immune function to immunotherapy

Sun, C., Wang, S., Ma, Z., Zhou, J., Ding, Z., Yuan, G., & Pan, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1393173 · Cited by 36

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Torres, A., Michea, M. A., Végvári, Á., Arce, M., Pérez, V., Alcota, M., Morales, A., Vernal, R., Budini, M., Zubarev, R. A., et al. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00306-y · Cited by 38

In vitro study: HIF-1α-dependent glycolysis enhances NETosis in hypoxic conditions

Ye, Y., Wang, Y., Xu, Q., Liu, J., Yang, Z., Wuren, T., & Ge, R.-L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1583587 · Cited by 35

Different procedures of diphenyleneiodonium chloride addition affect neutrophil extracellular trap formation

Ostafin, M., Pruchniak, M. P., Ciepiela, O., Reznick, A. Z., & Demkow, U. A. (2016) · Analytical Biochemistry · doi:10.1016/j.ab.2016.05.003 · Cited by 35

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Nemmara, V. V., Subramanian, V., Muth, A., Mondal, S., Salinger, A. J., Maurais, A. J., Tilvawala, R. R., Weerapana, E., & Thompson, P. R. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.7b00957 · Cited by 35

Systemic levels of anti-PAD4 autoantibodies correlate with airway obstruction in cystic fibrosis

Yadav, R., Yoo, D., Kahlenberg, J. M., Bridges, S. L., Oni, O., Huang, H., Stecenko, A. A., & Rada, B. (2019) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2018.12.010 · Cited by 35

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Criscitiello, M. F., Kraev, I., & Lange, S. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.06.012 · Cited by 35

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Barroso, M. V., Gropillo, I., Detoni, M. A. A., Thompson‐Souza, G. A., Muniz, V. S., Vasconcelos, C. R. I., Figueiredo, R. T., Melo, R. C. N., & Neves, J. S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.633696 · Cited by 36

Privileged heterocycles for DNA-encoded library design and hit-to-lead optimization

Wen, X., Wu, X., Jin, R., & Lu, X. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.115079 · Cited by 36

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Dreyton, C. J., Anderson, E. D., Subramanian, V., Boger, D. L., & Thompson, P. R. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.12.064 · Cited by 35

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Hägglöf, T., Sedimbi, S. K., Yates, J. L., Parsa, R., Hauff-Salas, B., Harris, R. A., Leadbetter, E. A., & Karlsson, M. C. I. (2016) · Nature Immunology · doi:10.1038/ni.3583 · Cited by 35

PAD4 is essential for NET-mediated antibacterial function

Zhenguo, Y. (2012) · Shengming de Huaxue

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Leshner, M., Wang, S., Lewis, C., Zheng, H., Chen, X. A., Santy, L. C., & Wang, Y. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00307 · Cited by 499

Activation of PAD4 in NET formation

Rohrbach, A. S., Slade, D. J., Thompson, P. R., & Mowen, K. A. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00360 · Cited by 419

Histone citrullination mediates neutrophil extracellular trap formation

Hai, Z. (2009)

PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium

Saha, P., Yeoh, B. S., Xiao, X., Golonka, R. M., Singh, V., Wang, Y., & Vijay–Kumar, M. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0139-3 · Cited by 75