The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy
Open accessAbstract
By triggering immunogenic cell death, some anticancer compounds, including anthracyclines and oxaliplatin, elicit tumor-specific, interferon-γ–producing CD8+ αβ T lymphocytes (Tc1 CTLs) that are pivotal for an optimal therapeutic outcome. Here, we demonstrate that chemotherapy induces a rapid and prominent invasion of interleukin (IL)-17–producing γδ (Vγ4+ and Vγ6+) T lymphocytes (γδ T17 cells) that precedes the accumulation of Tc1 CTLs within the tumor bed. In T cell receptor δ−/− or Vγ4/6−/− mice, the therapeutic efficacy of chemotherapy was compromised, no IL-17 was produced by tumor-infiltrating T cells, and Tc1 CTLs failed to invade the tumor after treatment. Although γδ T17 cells could produce both IL-17A and IL-22, the absence of a functional IL-17A–IL-17R pathway significantly reduced tumor-specific T cell responses elicited by tumor cell death, and the efficacy of chemotherapy in four independent transplantable tumor models. Adoptive transfer of γδ T cells restored the efficacy of chemotherapy in IL-17A−/− hosts. The anticancer effect of infused γδ T cells was lost when they lacked either IL-1R1 or IL-17A. Conventional helper CD4+ αβ T cells failed to produce IL-17 after chemotherapy. We conclude that γδ T17 cells play a decisive role in chemotherapy-induced anticancer immune responses.
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Calreticulin exposure dictates the immunogenicity of cancer cell death
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Self-citationCaspase-dependent immunogenicity of doxorubicin-induced tumor cell death
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Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303
Self-citationImmunogenic cell death in cancer and infectious disease
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Self-citationImmunological effects of conventional chemotherapy and targeted anticancer agents
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Macrophages and Therapeutic Resistance in Cancer
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Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
Michaud, M., Martins, I., Sukkurwala, A. Q., Adjemian, S., Ma, Y., Pellegatti, P., Shen, S., Kepp, O., Scoazec, M., Mignot, G., et al. (2011) · Science · doi:10.1126/science.1208347 · Cited by 1,377
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Metadata
- Authors
- Ma, Y., Aymeric, L., Locher, C., Mattarollo, S. R., Delahaye, N. F., Pereira, P., Boucontet, L., Apetoh, L., Ghiringhelli, F., Casares, N., Lasarte, J. J., Matsuzaki, G., Ikuta, K., Ryffel, B., Benlagha, K., Tesnière, A., Ibrahim, N., Déchanet-Merville, J., Chaput, N., Smyth, M. J., Kroemer, G., & Zitvogel, L.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2011-03-07
- Volume
- 208
- Issue
- 3
- Pages
- 491-503
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2995442355
- Cited by
- 337
- References
- 12
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ma, Y., Aymeric, L., Locher, C., Mattarollo, S. R., Delahaye, N. F., Pereira, P., Boucontet, L., Apetoh, L., Ghiringhelli, F., Casares, N., Lasarte, J. J., Matsuzaki, G., Ikuta, K., Ryffel, B., Benlagha, K., Tesnière, A., Ibrahim, N., Déchanet-Merville, J., Chaput, N., . . . Zitvogel, L. (2011). Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20100269
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
