The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice
Open accessAbstract
Granulocyte colony-stimulating factor (G-CSF), the prototypical mobilizing cytokine, induces hematopoietic stem and progenitor cell (HSPC) mobilization from the bone marrow in a cell-nonautonomous fashion. This process is mediated, in part, through suppression of osteoblasts and disruption of CXCR4/CXCL12 signaling. The cellular targets of G-CSF that initiate the mobilization cascade have not been identified. We use mixed G-CSF receptor (G-CSFR)–deficient bone marrow chimeras to show that G-CSF–induced mobilization of HSPCs correlates poorly with the number of wild-type neutrophils. We generated transgenic mice in which expression of the G-CSFR is restricted to cells of the monocytic lineage. G-CSF–induced HSPC mobilization, osteoblast suppression, and inhibition of CXCL12 expression in the bone marrow of these transgenic mice are intact, demonstrating that G-CSFR signals in monocytic cells are sufficient to induce HSPC mobilization. Moreover, G-CSF treatment of wild-type mice is associated with marked loss of monocytic cells in the bone marrow. Finally, we show that bone marrow macrophages produce factors that support the growth and/or survival of osteoblasts in vitro. Together, these data suggest a model in which G-CSFR signals in bone marrow monocytic cells inhibit the production of trophic factors required for osteoblast lineage cell maintenance, ultimately leading to HSPC mobilization.
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Adult haematopoietic stem cell niches
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Metadata
- Authors
- Christopher, M. J., Rao, M., Liu, F., Woloszynek, J. R., & Link, D. C.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2011-01-31
- Volume
- 208
- Issue
- 2
- Pages
- 251-260
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2119526236
- Cited by
- 331
- References
- 40
- FWCI
- 20.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Christopher, M. J., Rao, M., Liu, F., Woloszynek, J. R., & Link, D. C. (2011). Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20101700
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