The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells
Open accessAbstract
CD4 T cell responses are crucial to prevent and control viral infection; however, virus-specific CD4 T cell activity is considered to be rapidly lost during many persistent viral infections. This is largely caused by the fact that during viral persistence CD4 T cells do not produce the classical Th1 cytokines associated with control of acute viral infections. Considering that CD4 T cell help is critical for both CD8 T cell and B cell functions, it is unclear how CD4 T cells can lose responsiveness but continue to sustain long-term control of persistent viral replication. We now demonstrate that CD4 T cell function is not extinguished as a result of viral persistence. Instead, viral persistence and prolonged T cell receptor stimulation progressively redirects CD4 T cell development away from the Th1 response induced during an acute infection toward T follicular helper cells. Importantly, this sustained CD4 T cell functionality is critical to maintain immunity and ultimately aid in the control of persistent viral infection.
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Citations
Cites
Restoring function in exhausted CD8 T cells during chronic viral infection
Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2006) · Nature · doi:10.1038/nature04444 · Cited by 3,986
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
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Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
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Bcl6 mediates the development of T follicular helper cells
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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
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The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment
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Cited by
Molecular and cellular insights into T cell exhaustion
Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652
T follicular helper cell differentiation, function, and roles in disease
Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847
Vinuesa, C. G., Linterman, M. A., Yu, D., & MacLennan, I. C. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055605 · Cited by 1,141
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,014
Expanding roles for CD4+ T cells in immunity to viruses
Swain, S. L., McKinstry, K. K., & Strutt, T. M. (2012) · Nature Reviews Immunology · doi:10.1038/nri3152 · Cited by 956
Metadata
- Authors
- Fahey, L. M., Wilson, E. B., Elsaesser, H., Fistonich, C. D., McGavern, D. B., & Brooks, D. G.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2011-05-02
- Volume
- 208
- Issue
- 5
- Pages
- 987-999
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2147038308
- Cited by
- 320
- References
- 50
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fahey, L. M., Wilson, E. B., Elsaesser, H., Fistonich, C. D., McGavern, D. B., & Brooks, D. G. (2011). Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20101773
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