The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
Open accessAbstract
IL-9 fate reporter mice established type 2 innate lymphoid cells (ILC2s) as major producers of this cytokine in vivo. Here we focus on the role of IL-9 and ILC2s during the lung stage of infection with Nippostrongylus brasiliensis, which results in substantial tissue damage. IL-9 receptor (IL-9R)–deficient mice displayed reduced numbers of ILC2s in the lung after infection, resulting in impaired IL-5, IL-13, and amphiregulin levels, despite undiminished numbers of Th2 cells. As a consequence, the restoration of tissue integrity and lung function was strongly impaired in the absence of IL-9 signaling. ILC2s, in contrast to Th2 cells, expressed high levels of the IL-9R, and IL-9 signaling was crucial for the survival of activated ILC2s in vitro. Furthermore, ILC2s in the lungs of infected mice required the IL-9R to up-regulate the antiapoptotic protein BCL-3 in vivo. This highlights a unique role for IL-9 as an autocrine amplifier of ILC2 function, promoting tissue repair in the recovery phase after helminth-induced lung inflammation.
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Cites
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
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Diversity and dialogue in immunity to helminths
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Cited by
Lambrecht, B. N., & Hammad, H. (2015) · Nature Immunology · doi:10.1038/ni.3049 · Cited by 1,673
Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine
Vizoso, F., Eiro, N., Cid, S., Schneider, J., & Perez-Fernandez, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091852 · Cited by 1,363
Interleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
Sonnenberg, G. F., & Artis, D. (2015) · Nature Medicine · doi:10.1038/nm.3892 · Cited by 503
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Metadata
- Authors
- Turner, J.-E., Morrison, P. J., Wilhelm, C., Wilson, M., Ahlfors, H., Renauld, J.-C., Panzer, U., Helmby, H., & Stockinger, B.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2013-11-18
- Volume
- 210
- Issue
- 13
- Pages
- 2951-2965
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2096545973
- Cited by
- 397
- References
- 10
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Turner, J.-E., Morrison, P. J., Wilhelm, C., Wilson, M., Ahlfors, H., Renauld, J.-C., Panzer, U., Helmby, H., & Stockinger, B. (2013). IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20130071
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