The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22
Open accessAbstract
Interleukin (IL)-22–producing group 3 innate lymphoid cells (ILC3) promote mucosal healing and maintain barrier integrity, but how microbial signals are integrated to regulate mucosal protection offered by these cells remains unclear. Here, we show that in vivo depletion of CX3CR1+ mononuclear phagocytes (MNPs) resulted in more severe colitis and death after infection with Citrobacter rodentium. This phenotype was rescued by exogenous IL-22, which was endogenously produced by ILC3 in close spatial proximity to CX3CR1+ MNPs that were dependent on MyD88 signaling. CX3CR1+ MNPs from both mouse and human tissue produced more IL-23 and IL-1β than conventional CD103+ dendritic cells (cDCs) and were more efficient than cDCs in supporting IL-22 production in ILC3 in vitro and in vivo. Further, colonic ILC3 from patients with mild to moderate ulcerative colitis or Crohn’s disease had increased IL-22 production. IBD-associated SNP gene set analysis revealed enrichment for genes selectively expressed in human intestinal MNPs. The product of one of these, TL1A, potently enhanced IL-23– and IL-1β-induced production of IL-22 and GM-CSF by ILC3. Collectively, these results reveal a critical role for CX3CR1+ mononuclear phagocytes in integrating microbial signals to regulate colonic ILC3 function in IBD.
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Cites
Macrophage biology in development, homeostasis and disease
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“In addition to supporting ILC3, MNPs may also directly promote epithelial barrier repair (Wynn et al., 2013).”
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Batf3 Deficiency Reveals a Critical Role for CD8α + Dendritic Cells in Cytotoxic T Cell Immunity
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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
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Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
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Cited by
The microbiota in adaptive immune homeostasis and disease
Honda, K., & Littman, D. R. (2016) · Nature · doi:10.1038/nature18848 · Cited by 1,846
Self-citationInterleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity
Mantovani, A., Dinarello, C. A., Molgora, M., & Garlanda, C. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.012 · Cited by 1,046
Interaction between the gut microbiome and mucosal immune system
Shi, N., Li, N., Duan, X., & Niu, H. (2017) · Military Medical Research · doi:10.1186/s40779-017-0122-9 · Cited by 940
The host shapes the gut microbiota via fecal microRNA
Liu, S., da Cunha, A. P., Rezende, R. M., Cialic, R., Wei, Z., Bry, L., Comstock, L. E., Gandhi, R., & Weiner, H. L. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2015.12.005 · Cited by 808
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Metadata
- Authors
- Longman, R. S., Diehl, G. E., Victorio, D. A., Huh, J. R., Galan, C., Miraldi, E. R., Swaminath, A., Bonneau, R., Scherl, E. J., & Littman, D. R.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2014-07-14
- Volume
- 211
- Issue
- 8
- Pages
- 1571-1583
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2104397453
- Cited by
- 383
- References
- 9
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- green
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