The microbiota in adaptive immune homeostasis and disease
Abstract
In the mucosa, the immune system's T cells and B cells have position-specific phenotypes and functions that are influenced by the microbiota. These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. Imbalances in the gut microbiota, known as dysbiosis, can trigger several immune disorders through the activity of T cells that are both near to and distant from the site of their induction. Elucidation of the mechanisms that distinguish between homeostatic and pathogenic microbiota-host interactions could identify therapeutic targets for preventing or modulating inflammatory diseases and for boosting the efficacy of cancer immunotherapy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Th17 cells play an important role in tissue homeostasis, especially in the intestinal mucosa.
“Th17 cells have been found to play an important role in tissue homeostasis, especially in the intestinal mucosa.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [46]
Selective binding of bacterial components and metabolites, such as flagellin and lipopolysaccharide, to pattern-recognition receptors and/or direct adhesion of bacteria to the gut epithelium triggers an antigen-specific response that stimulates the adaptive immune system.
“At the molecular level, the selective binding of bacterial components and metabolites (e.g., flagellin and LPS) to pattern-recognition receptors and/or the direct adhesion of bacteria themselves to the gut epithelium triggers an antigen-specific response that stimulates the adaptive immune system [89].”
Cites
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works
Self-citationSmith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works
Self-citationMetabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works
Self-citationSokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Commensal <i>Bifidobacterium</i> promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888 · see citing works
Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works
Self-citationAnticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Vétizou, M., Pitt, J. M., Daillère, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M. P., Duong, C. P. M., et al. (2015) · Science · doi:10.1126/science.aad1329 · Cited by 3,488 · see citing works
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220 · see citing works
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works
Self-citationRegulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708 · see citing works
Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368 · see citing works
Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233 · see citing works
The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide
Viaud, S., Saccheri, F., Mignot, G., Yamazaki, T., Daillère, R., Hannani, D., Enot, D. P., Pfirschke, C., Engblom, C., Pittet, M. J., et al. (2013) · Science · doi:10.1126/science.1240537 · Cited by 2,050 · see citing works
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Scher, J. U., Sczesnak, A., Longman, R. S., Segata, N., Ubeda, C., Bielski, C., Rostron, T., Cerundolo, V., Pamer, E. G., Abramson, S. B., et al. (2013) · eLife · doi:10.7554/elife.01202 · Cited by 2,047 · see citing works
Self-citationDietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works
Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880 · see citing works
Early infancy microbial and metabolic alterations affect risk of childhood asthma
Arrieta, M., Stiemsma, L. T., Dimitriu, P. A., Thorson, L., Russell, S., Yurist‐Doutsch, S., Kuzeljevic, B., Gold, M. J., Britton, H. M., Lefebvre, D. L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab2271 · Cited by 1,783 · see citing works
Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770 · see citing works
Self-citationMicrobial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661 · see citing works
Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586 · see citing works
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells
Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577 · see citing works
Self-citationMicrobiota regulates immune defense against respiratory tract influenza A virus infection
Ichinohe, T., Pang, I. K., Kumamoto, Y., Peaper, D. R., Ho, J. H., Murray, T. S., & Iwasaki, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019378108 · Cited by 1,502 · see citing works
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
Kleinewietfeld, M., Manzel, A., Titze, J., Kvakan, H., Yosef, N., Linker, R. A., Muller, D. N., & Hafler, D. A. (2013) · Nature · doi:10.1038/nature11868 · Cited by 1,394 · see citing works
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323 · see citing works
Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286 · see citing works
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251 · see citing works
Fate mapping of IL-17-producing T cells in inflammatory responses
Hirota, K., Duarte, J. H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D. J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., et al. (2011) · Nature Immunology · doi:10.1038/ni.1993 · Cited by 1,176 · see citing works
Compartmentalized Control of Skin Immunity by Resident Commensals
Naik, S., Bouladoux, N., Wilhelm, C., Molloy, M. J., Salcedo, R., Kastenmuller, W., Deming, C., Quinones, M., Koo, L., Conlan, S., et al. (2012) · Science · doi:10.1126/science.1225152 · Cited by 1,092 · see citing works
ATP drives lamina propria TH17 cell differentiation
Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., et al. (2008) · Nature · doi:10.1038/nature07240 · Cited by 1,089 · see citing works
McGeachy, M. J., Chen, Y., Tato, C. M., Laurence, A., Joyce-Shaikh, B., Blumenschein, W. M., McClanahan, T. K., O'Shea, J. J., & Cua, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1698 · Cited by 1,074 · see citing works
Normalizing the environment recapitulates adult human immune traits in laboratory mice
Beura, L. K., Hamilton, S. E., Bi, K., Schenkel, J. M., Odumade, O. A., Casey, K. A., Thompson, E. A., Fraser, K. A., Rosato, P. C., Filali-Mouhim, A., et al. (2016) · Nature · doi:10.1038/nature17655 · Cited by 1,072 · see citing works
El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G.-X., Dittel, B. N., & Rostami, A. (2011) · Nature Immunology · doi:10.1038/ni.2031 · Cited by 1,071 · see citing works
Th17 cell induction by adhesion of microbes to intestinal epithelial cells
Atarashi, K., Tanoue, T., Ando, M., Kamada, N., Nagano, Y., Narushima, S., Suda, W., Imaoka, A., Setoyama, H., Nagamori, T., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.058 · Cited by 1,071 · see citing works
Self-citationChronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
Puel, A., Cypowyj, S., Bustamante, J., Wright, J. F., Liu, L., Lim, H. K., Migaud, M., Israel, L., Chrabieh, M., Audry, M., et al. (2011) · Science · doi:10.1126/science.1200439 · Cited by 1,056 · see citing works
Peripheral education of the immune system by colonic commensal microbiota
Lathrop, S. K., Bloom, S. M., Rao, S. M., Nutsch, K., Lio, C.-W., Santacruz, N., Peterson, D. A., Stappenbeck, T. S., & Hsieh, C.-S. (2011) · Nature · doi:10.1038/nature10434 · Cited by 1,034 · see citing works
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
Wu, C., Yosef, N., Thalhamer, T., Zhu, C., Xiao, S., Kishi, Y., Regev, A., & Kuchroo, V. K. (2013) · Nature · doi:10.1038/nature11984 · Cited by 1,022 · see citing works
The alarmin IL-33 promotes regulatory T-cell function in the intestine
Schiering, C., Krausgruber, T., Chomka, A., Fröhlich, A., Adelmann, K., Wohlfert, E. A., Pott, J., Griseri, T., Bollrath, J., Hegazy, A. N., et al. (2014) · Nature · doi:10.1038/nature13577 · Cited by 1,007 · see citing works
Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.009 · Cited by 1,004 · see citing works
Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine
Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.-H., May, C., Wilck, N., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.007 · Cited by 927 · see citing works
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
Berod, L., Friedrich, C., Nandan, A., Freitag, J., Hagemann, S., Harmrolfs, K., Sandouk, A., Hesse, C., Castro, C. N., Bähre, H., et al. (2014) · Nature Medicine · doi:10.1038/nm.3704 · Cited by 927 · see citing works
Cadwell, K., Patel, K., Maloney, N. S., Liu, T., Ng, A., Storer, C. E., Head, R. D., Xavier, R. J., Stappenbeck, T. S., & Virgin, H. W. (2010) · Cell · doi:10.1016/j.cell.2010.05.009 · Cited by 897 · see citing works
Early life antibiotic‐driven changes in microbiota enhance susceptibility to allergic asthma
Russell, S. L., Gold, M. J., Hartmann, M., Willing, B. P., Thorson, L., Wlodarska, M., Gill, N., Blanchet, M., Mohn, W. W., McNagny, K. M., et al. (2012) · The EMBO Reports · doi:10.1038/embor.2012.32 · Cited by 883 · see citing works
Sakaguchi, N., Takahashi, T., Hata, H., Nomura, T., Tagami, T., Yamazaki, S., Sakihama, T., Matsutani, T., Negishi, I., Nakatsuru, S., et al. (2003) · Nature · doi:10.1038/nature02119 · Cited by 881 · see citing works
Individual intestinal symbionts induce a distinct population of RORγ <sup>+</sup> regulatory T cells
Sefik, E., Geva-Zatorsky, N., Oh, S., Konnikova, L., Zemmour, D., McGuire, A. M., Burzyn, D., Ortiz-Lopez, A., Lobera, M., Yang, J., et al. (2015) · Science · doi:10.1126/science.aaa9420 · Cited by 879 · see citing works
The microbiota regulates type 2 immunity through RORγt <sup>+</sup> T cells
Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., et al. (2015) · Science · doi:10.1126/science.aac4263 · Cited by 863 · see citing works
Self-citationIntestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses
Geuking, M. B., Cahenzli, J., Lawson, M. A. E., Ng, D. C. K., Slack, E., Hapfelmeier, S., McCoy, K. D., & Macpherson, A. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.021 · Cited by 840 · see citing works
Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses
Hapfelmeier, S., Lawson, M. A. E., Slack, E., Kirundi, J. K., Stoel, M., Heikenwalder, M., Cahenzli, J., Velykoredko, Y., Balmer, M. L., Endt, K., et al. (2010) · Science · doi:10.1126/science.1188454 · Cited by 835 · see citing works
Schlitzer, A., McGovern, N. N., Teo, P., Zelante, T., Atarashi, K., Low, D., Ho, A. W. S., See, P., Shin, A., Wasan, P. S., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.011 · Cited by 834 · see citing works
Self-citationIgA Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis
Peterson, D. A., McNulty, N. P., Guruge, J. L., & Gordon, J. I. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.09.013 · Cited by 828 · see citing works
Commensal–dendritic-cell interaction specifies a unique protective skin immune signature
Naik, S., Bouladoux, N., Linehan, J. L., Han, S.-J., Harrison, O. J., Wilhelm, C., Conlan, S., Himmelfarb, S., Byrd, A. L., Deming, C., et al. (2015) · Nature · doi:10.1038/nature14052 · Cited by 820 · see citing works
Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis
Mortha, A., Chudnovskiy, A., Hashimoto, D., Bogunovic, M., Spencer, S. P., Belkaid, Y., & Merad, M. (2014) · Science · doi:10.1126/science.1249288 · Cited by 820 · see citing works
Bacterial flagellin is a dominant antigen in Crohn disease
Lodes, M. J., Cong, Y., Elson, C. O., Mohamath, R., Landers, C. J., Targan, S. R., Fort, M., & Hershberg, R. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420295 · Cited by 802 · see citing works
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
Gagliani, N., Vesely, M. C. A., Iseppon, A., Brockmann, L., Xu, H. Y., Palm, N. W., de Zoete, M. R., Licona-Limón, P., Paiva, R., Ching, T. H., et al. (2015) · Nature · doi:10.1038/nature14452 · Cited by 797 · see citing works
Commensal bacteria protect against food allergen sensitization
Stefka, A. T., Feehley, T., Tripathi, P., Qiu, J., McCoy, K. D., Mazmanian, S. K., Tjota, M. Y., Seo, G., Cao, S. Z., Theriault, B. R., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412008111 · Cited by 795 · see citing works
Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism
Vujkovic-Cvijin, I., Dunham, R. M., Iwai, S., Maher, M. C., Albright, R. G., Broadhurst, M. J., Hernandez, R. D., Lederman, M. M., Huang, Y., Somsouk, M., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006438 · Cited by 734 · see citing works
Mathewson, N. D., Jenq, R., Mathew, A. V., Koenigsknecht, M., Hanash, A., Toubai, T., Oravecz-Wilson, K., Wu, S.-R., Sun, Y., Rossi, C., et al. (2016) · Nature Immunology · doi:10.1038/ni.3400 · Cited by 725 · see citing works
Self-citationOuter Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection
Shen, Y., Torchia, M. L. G., Lawson, G. W., Karp, C. L., Ashwell, J. D., & Mazmanian, S. K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.08.004 · Cited by 714 · see citing works
New concepts in the generation and functions of IgA
Pabst, O. (2012) · Nature reviews. Immunology · doi:10.1038/nri3322 · Cited by 656 · see citing works
Weiss, J. M., Bilate, A. M., Gobert, M., Ding, Y., Curotto de Lafaille, M. A., Parkhurst, C. N., Xiong, H., Dolpady, J., Frey, A. B., Ruocco, M. G., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120914 · Cited by 621 · see citing works
Self-citationIntestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels
Cahenzli, J., Köller, Y., Wyss, M., Geuking, M. B., & McCoy, K. D. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.10.004 · Cited by 611 · see citing works
Charbonneau, M. R., O’Donnell, D., Blanton, L. V., Totten, S. M., Davis, J. C. C., Barratt, M. J., Cheng, J., Guruge, J., Talcott, M., Bain, J. R., et al. (2016) · Cell · doi:10.1016/j.cell.2016.01.024 · Cited by 606 · see citing works
Frank, D. N., Robertson, C. E., Hamm, C. M., Kpadeh, Z. Z., Zhang, T., Chen, H., Zhu, W., Sartor, R. B., Boedeker, E. C., Harpaz, N., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21339 · Cited by 594 · see citing works
Persson, E. K., Uronen‐Hansson, H., Semmrich, M., Rivollier, A., Hägerbrand, K., Marsal, J., Guðjónsson, S., Håkansson, U., Reizis, B., Kotarsky, K., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.009 · Cited by 591 · see citing works
Coccia, M., Harrison, O. J., Schiering, C., Asquith, M. J., Becher, B., Powrie, F. M., & Maloy, K. J. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111453 · Cited by 588 · see citing works
A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes
Scharschmidt, T. C., Vasquez, K. S., Truong, H.-A., Gearty, S. V., Pauli, M. L., Nosbaum, A., Gratz, I. K., Otto, M., Moon, J. J., Liese, J., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.016 · Cited by 586 · see citing works
Huber, S., Gagliani, N., Esplugues, E., O'Connor, W., Huber, F. J., Chaudhry, A., Kamanaka, M., Kobayashi, Y., Booth, C. J., Rudensky, A. Y., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.01.020 · Cited by 581 · see citing works
CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut
Sonnenberg, G. F., Monticelli, L. A., Elloso, M. M., Fouser, L. A., & Artis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.12.009 · Cited by 573 · see citing works
Induced CD4<sup>+</sup>Foxp3<sup>+</sup>Regulatory T Cells in Immune Tolerance
Bilate, A. M., & Lafaille, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075043 · Cited by 569 · see citing works
Innate lymphoid cells regulate intestinal epithelial cell glycosylation
Goto, Y., Obata, T., Kunisawa, J., Sato, S., Ivanov, I. I., Lamichhane, A., Takeyama, N., Kamioka, M., Sakamoto, M., Matsuki, T., et al. (2014) · Science · doi:10.1126/science.1254009 · Cited by 568 · see citing works
Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A
Bunker, J. J., Flynn, T. M., Koval, J., Shaw, D. G., Meisel, M., McDonald, B. D., Ishizuka, I. E., Dent, A. L., Wilson, P. C., Jabrì, B., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.007 · Cited by 557 · see citing works
GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
Wohlfert, E. A., Grainger, J. R., Bouladoux, N., Konkel, J. E., Oldenhove, G., Ribeiro, C. H., Hall, J. A., Yagi, R., Naik, S., Bhairavabhotla, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57456 · Cited by 556 · see citing works
Sano, T., Huang, W., Hall, J. A., Yang, Y., Chen, A., Gavzy, S. J., Lee, J.-Y., Ziel, J. W., Miraldi, E. R., Domingos, A. I., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.061 · Cited by 547 · see citing works
Self-citationDietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine
Kim, K. S., Hong, S., Han, D., Yi, J., Jung, J., Yang, B., Lee, J. Y., Lee, M., & Surh, C. D. (2016) · Science · doi:10.1126/science.aac5560 · Cited by 541 · see citing works
Lewis, K. L. T., Caton, M. L., Bogunovic, M., Greter, M., Grajkowska, L. T., Ng, D., Klinakis, A., Charo, I. F., Jung, S., Gommerman, J. L., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.013 · Cited by 538 · see citing works
Kawamoto, S., Maruya, M., Kato, L. M., Suda, W., Atarashi, K., Doi, Y., Tsutsui, Y., Qin, H., Honda, K., Okada, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.016 · Cited by 531 · see citing works
Self-citationInterleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
Ahern, P. P., Schiering, C., Buonocore, S., McGeachy, M. J., Cua, D. J., Maloy, K. J., & Powrie, F. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.010 · Cited by 528 · see citing works
Giacinto, C. D., Marinaro, M., Sanchez, M., Strober, W., & Boirivant, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3237 · Cited by 522 · see citing works
Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
Yang, Y., Torchinsky, M. B., Gobert, M., Xiong, H., Xu, M., Linehan, J. L., Alonzo, F., Ng, C., Chen, A., Lin, X., et al. (2014) · Nature · doi:10.1038/nature13279 · Cited by 520 · see citing works
Self-citationHepworth, M. R., Fung, T. C., Masur, S. H., Kelsen, J. R., McConnell, F. M., Dubrot, J., Withers, D. R., Hugues, S., Farrar, M. A., Reith, W., et al. (2015) · Science · doi:10.1126/science.aaa4812 · Cited by 515 · see citing works
An enteric virus can replace the beneficial function of commensal bacteria
Kernbauer, E., Ding, Y., & Cadwell, K. (2014) · Nature · doi:10.1038/nature13960 · Cited by 513 · see citing works
Hirota, K., Turner, J.-E., Villa, M., Duarte, J. H., Demengeot, J., Steinmetz, O. M., & Stockinger, B. (2013) · Nature Immunology · doi:10.1038/ni.2552 · Cited by 509 · see citing works
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation
Hill, D. A., Siracusa, M. C., Abt, M. C., Kim, B. S., Kobuley, D., Kubo, M., Kambayashi, T., LaRosa, D. F., Renner, E. D., Orange, J. S., et al. (2012) · Nature Medicine · doi:10.1038/nm.2657 · Cited by 468 · see citing works
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
Weaver, C. T., Elson, C. O., Fouser, L. A., & Kolls, J. K. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130318 · Cited by 462 · see citing works
Yang, B.-H., Hagemann, S., Mamareli, P., Lauer, U., Hoffmann, U., Beckstette, M., Föhse, L., Prinz, I., Pezoldt, J., Suerbaum, S., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.74 · Cited by 435 · see citing works
A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota
Cong, Y., Feng, T., Fujihashi, K., Schoeb, T. R., & Elson, C. O. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812681106 · Cited by 430 · see citing works
Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis
Harbour, S. N., Maynard, C. L., Zindl, C. L., Schoeb, T. R., & Weaver, C. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415675112 · Cited by 427 · see citing works
Kriegel, M. A., Sefik, E., Hill, J. A., Wu, H.-J. J., Benoist, C. O., & Mathis, D. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108924108 · Cited by 423 · see citing works
Okada, S., Markle, J. G., Deenick, E. K., Mele, F., Averbuch, D., Lagos, M., Alzahrani, M., Al-Muhsen, S., Halwani, R., Ma, C. S., et al. (2015) · Science · doi:10.1126/science.aaa4282 · Cited by 413 · see citing works
Horai, R., Zárate-Bladés, C. R., Dillenburg-Pilla, P., Chen, J., Kielczewski, J. L., Silver, P. B., Jittayasothorn, Y., Chan, C.-C., Yamane, H., Honda, K., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.014 · Cited by 402 · see citing works
Self-citationAcute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses
Hand, T. W., dos Santos, L. M., Bouladoux, N. J., Molloy, M. J., Pagán, A. J., Pepper, M., Maynard, C. L., Elson, C. O., & Belkaid, Y. (2012) · Science · doi:10.1126/science.1220961 · Cited by 393 · see citing works
CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity
Wang, C., Yosef, N., Gaublomme, J. T., Wu, C., Lee, Y., Clish, C. B., Kaminski, J., Xiao, S., zu Hörste, G. M., Pawlak, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.068 · Cited by 387 · see citing works
Innate and Adaptive Immunity Interact to Quench Microbiome Flagellar Motility in the Gut
Cullender, T. C., Chassaing, B., Janzon, A., Kumar, K., Muller, C. E., Werner, J. J., Angenent, L. T., Bell, M. E., Hay, A. G., Peterson, D. A., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.10.009 · Cited by 383 · see citing works
Stary, G., Olive, A., Radovic-Moreno, A. F., Gondek, D., Alvarez, D., Basto, P. A., Perro, M., Vrbanac, V. D., Tager, A. M., Shi, J., et al. (2015) · Science · doi:10.1126/science.aaa8205 · Cited by 379 · see citing works
Mucida, D., Husain, M. M., Muroi, S., van Wijk, F., Shinnakasu, R., Naoe, Y., Reis, B. S., Huang, Y., Lambolez, F., Docherty, M., et al. (2013) · Nature Immunology · doi:10.1038/ni.2523 · Cited by 376 · see citing works
Self-citationCX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22
Longman, R., Diehl, G. E., Victorio, D., Huh, J. R., Galan, C., Miraldi, E. R., Swaminath, A., Bonneau, R., Scherl, E., & Littman, D. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20140678 · Cited by 376 · see citing works
Self-citationKau, A. L., Planer, J. D., Liu, J., Rao, S. M., Yatsunenko, T., Trehan, I., MANARY, M. J., Liu, T., Stappenbeck, T. S., Maleta, K. M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa4877 · Cited by 373 · see citing works
Faith, J. J., Ahern, P. P., Ridaura, V. K., Cheng, J., & Gordon, J. I. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008051 · Cited by 373 · see citing works
Lécuyer, E., Rakotobé, S., Garnier‐Lengliné, H., Lebreton, C., Picard, M., Juste, C., Fritzen, R., Eberl, G., McCoy, K. D., Macpherson, A. J., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.009 · Cited by 364 · see citing works
Karimi, K., Inman, M. D., Bienenstock, J., & Forsythe, P. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200806-951oc · Cited by 361 · see citing works
MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health
Kubinak, J. L., Petersen, C., Stephens, W. Z., Soto, R., Bake, E., O’Connell, R. M., & Round, J. L. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2014.12.009 · Cited by 328 · see citing works
Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis
Kullberg, M. C., Jankovic, D. L., Gorelick, P. L., Caspar, P., Letterio, J. J., Cheever, A. W., & Sher, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020556 · Cited by 322 · see citing works
Roers, A., Siewe, L., Strittmatter, E., Deckert, M., Schlüter, D., Stenzel, W., Gruber, A. D., Krieg, T. M., Rajewsky, K., & Müller, W. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041789 · Cited by 309 · see citing works
GPR15-Mediated Homing Controls Immune Homeostasis in the Large Intestine Mucosa
Kim, S. V., Xiang, W., Kwak, C., Yang, Y., Lin, X., Ota, M., Sarpel, U., Rifkin, D. B., Xu, R., & Littman, D. R. (2013) · Science · doi:10.1126/science.1237013 · Cited by 292 · see citing works
Self-citationTang, C., Kamiya, T., Liu, Y., Kadoki, M., Kakuta, S., Oshima, K., Hattori, M., Takeshita, K., Kanai, T., Saijo, S., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.07.003 · Cited by 285 · see citing works
Fransen, F., Zagato, E., Mazzini, E., Fosso, B., Manzari, C., Aidy, S. E., Chiavelli, A., D’Erchia, A. M., Sethi, M. K., Pabst, O., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.011 · Cited by 284 · see citing works
Reis, B. S., Rogoz, A., Costa‐Pinto, F. A., Taniuchi, I., & Mucida, D. (2013) · Nature Immunology · doi:10.1038/ni.2518 · Cited by 275 · see citing works
Umesaki, Y., Setoyama, H., Matsumoto, S., Imaoka, A., & Itoh, K. (1999) · Infection and Immunity · doi:10.1128/iai.67.7.3504-3511.1999 · Cited by 271 · see citing works
Ramanan, D., Tang, M. S., Bowcutt, R., Loke, P., & Cadwell, K. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.015 · Cited by 269 · see citing works
Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation
Moon, C., Baldridge, M. T., Wallace, M. A., Burnham, C.-A. D., Virgin, H. W., & Stappenbeck, T. S. (2015) · Nature · doi:10.1038/nature14139 · Cited by 268 · see citing works
Nonredundant Function of Soluble LTα 3 Produced by Innate Lymphoid Cells in Intestinal Homeostasis
Kruglov, A., Grivennikov, S. I., Kuprash, D. V., Winsauer, C., Prepens, S., Seleznik, G. M., Eberl, G., Littman, D. R., Heikenwälder, M. F., Tumanov, A. V., et al. (2013) · Science · doi:10.1126/science.1243364 · Cited by 262 · see citing works
Self-citationWei, M., Shinkura, R., Doi, Y., Maruya, M., Fagarasan, S., & Honjo, T. (2011) · Nature Immunology · doi:10.1038/ni.1991 · Cited by 262 · see citing works
Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells
Santori, F. R., Huang, P., van de Pavert, S. A., Douglass, E. F., Leaver, D. J., Haubrich, B. A., Keber, R., Lorbek, G., Konijn, T., Rosales, B. N., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.004 · Cited by 239 · see citing works
Self-citationLindner, C., Thomsen, I., Wahl, B., Ugur, M., Sethi, M. K., Friedrichsen, M., Smoczek, A., Ott, S. J., Baumann, U., Suerbaum, S., et al. (2015) · Nature Immunology · doi:10.1038/ni.3213 · Cited by 228 · see citing works
Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia
Narushima, S., Sugiura, Y., Oshima, K., Atarashi, K., Hattori, M., Suematsu, M., & Honda, K. (2014) · Gut Microbes · doi:10.4161/gmic.28572 · Cited by 210 · see citing works
Self-citationEndoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut
Morton, A. M., Sefik, E., Upadhyay, R., Weissleder, R., Benoist, C. O., & Mathis, D. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405634111 · Cited by 200 · see citing works
T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides
Harkiolaki, M., Holmes, S. L., Svendsen, P., Gregersen, J. W., Jensen, L. T., McMahon, R. M., Friese, M. A., van Boxel, G., Etzensperger, R., Tzartos, J. S., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.009 · Cited by 190 · see citing works
Small, C.-L. N., Reid‐Yu, S. A., McPhee, J. B., & Coombes, B. K. (2013) · Nature Communications · doi:10.1038/ncomms2957 · Cited by 187 · see citing works
Sczesnak, A., Segata, N., Qin, X., Gevers, D., Petrosino, J. F., Huttenhower, C., Littman, D. R., & Ivanov, I. I. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.08.005 · Cited by 186 · see citing works
Self-citationGrowth and host interaction of mouse segmented filamentous bacteria in vitro
Schnupf, P., Gaboriau‐Routhiau, V., Gros, M., Friedman, R. C., Moya‐Nilges, M., Nigro, G., Cerf–Bensussan, N., & Sansonetti, P. J. (2015) · Nature · doi:10.1038/nature14027 · Cited by 175 · see citing works
Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells
Jain, R., Chen, Y., Kanno, Y., Joyce-Shaikh, B., Vahedi, G., Hirahara, K., Blumenschein, W. M., Sukumar, S., Haines, C. J., Sadekova, S., et al. (2016) · Immunity · doi:10.1016/j.immuni.2015.11.009 · Cited by 167 · see citing works
T Regulatory Cells Maintain Intestinal Homeostasis by Suppressing γδ T Cells
Park, S., Mathur, R., Long, M., Hosh, N., Hao, L., Hayden, M. S., & Ghosh, S. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.014 · Cited by 166 · see citing works
Intestinal monocyte-derived macrophages control commensal-specific Th17 responses
Panea, C., Farkas, A. M., Goto, Y., Abdollahi-Roodsaz, S., Lee, C., Koscsó, B., Gowda, K., Hohl, T. M., Bogunovic, M., & Ivanov, I. I. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.040 · Cited by 152 · see citing works
Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
Derebe, M. G., Zlatkov, C. M., Gattu, S., Ruhn, K. A., Vaishnava, S., Diehl, G. E., MacMillan, J. B., Williams, N. S., & Hooper, L. V. (2014) · eLife · doi:10.7554/elife.03206 · Cited by 147 · see citing works
Sarrabayrouse, G., Bossard, C., Chauvin, J.-M., Jarry, A., Meurette, G., Quévrain, E., Bridonneau, C., Preisser, L., Asehnoune, K., Labarrière, N., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001833 · Cited by 139 · see citing works
Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation
Loschko, J., Schreiber, H. A., Rieke, G. J., Esterházy, D., Meredith, M. M., Pedicord, V. A., Yao, K.-H., Caballero, S., Pamer, E. G., Mucida, D., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160062 · Cited by 139 · see citing works
Prakash, T., Oshima, K., Morita, H., Fukuda, S., Imaoka, A., Kumar, N., Sharma, V. K., Kim, S.-W., Takahashi, M., Saitou, N., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.08.007 · Cited by 135 · see citing works
Krause, P., Morris, V., Greenbaum, J., Park, Y., Bjoerheden, U., Mikulski, Z., Muffley, T., Shui, J., Kim, G., Cheroutre, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8055 · Cited by 123 · see citing works
Interleukin (IL)-21 promotes intestinal IgA response to microbiota
Cao, A., Yao, S., Gong, B., Nurieva, R., Elson, C. O., & Cong, Y. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.134 · Cited by 120 · see citing works
Antibody blocks acquisition of bacterial colonization through agglutination
Roche, A. M., Richard, A. L., Rahkola, J., Janoff, E. N., & Weiser, J. N. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.55 · Cited by 110 · see citing works
Gut Microbiota Regulates K/BxN Autoimmune Arthritis through Follicular Helper T but Not Th17 Cells
Block, K. E., Zheng, Z., Dent, A. L., Kee, B. L., & Huang, H. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501904 · Cited by 99 · see citing works
Itoh, K., & MITSUOKA, T. (1985) · Laboratory Animals · doi:10.1258/002367785780942589 · Cited by 55 · see citing works
Friman, V., Nowrouzian, F. L., Adlerberth, I., et al. (2002) · Microbial Pathogenesis · doi:10.1006/mpat.2001.0477 · Cited by 32 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679 · see citing works
Interactions between the microbiota, immune and nervous systems in health and disease
Fung, T. C., Olson, C. A., & Hsiao, E. Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4476 · Cited by 1,900 · see citing works
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529 · see citing works
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
Gopalakrishnan, V., Helmink, B. A., Spencer, C. N., Reuben, A., & Wargo, J. A. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.015 · Cited by 1,392 · see citing works
The microbiome and human cancer
Sepich-Poore, G. D., Zitvogel, L., Straussman, R., Hasty, J., Wargo, J. A., & Knight, R. (2021) · Science · doi:10.1126/science.abc4552 · Cited by 1,332 · see citing works
Salt-responsive gut commensal modulates TH17 axis and disease
Wilck, N., Matus, M. G., Kearney, S. M., Olesen, S. W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., et al. (2017) · Nature · doi:10.1038/nature24628 · Cited by 1,310 · see citing works
Strains, functions and dynamics in the expanded Human Microbiome Project
Lloyd-Price, J., Mahurkar, A., Rahnavard, G., Crabtree, J., Orvis, J., Hall, A. B., Brady, A., Creasy, H. H., McCracken, C., Giglio, M. G., et al. (2017) · Nature · doi:10.1038/nature23889 · Cited by 1,267 · see citing works
The microbiome, cancer, and cancer therapy
Helmink, B. A., Khan, M. A. W., Hermann, A., Gopalakrishnan, V., & Wargo, J. A. (2019) · Nature Medicine · doi:10.1038/s41591-019-0377-7 · Cited by 1,200 · see citing works
Wang, X., Sun, G., Feng, T., Zhang, J., Huang, X., Wang, T., Xie, Z., Chu, X., Yang, J., Wang, H., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0216-x · Cited by 1,144 · see citing works
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804 · see citing works
Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner
Thion, M. S., Low, D., Silvin, A., Chen, J., Grisel, P., Schulte-Schrepping, J., Blecher, R., Ulas, T., Squarzoni, P., Hoeffel, G., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.042 · Cited by 779 · see citing works
Mechanisms and consequences of intestinal dysbiosis
Weiss, G. A., & Hennet, T. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2509-x · Cited by 775 · see citing works
Impact of Omega-3 Fatty Acids on the Gut Microbiota
Costantini, L., Molinari, R., Farinon, B., & Merendino, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122645 · Cited by 741 · see citing works
Bachem, A., Makhlouf, C., Binger, K. J., de Souza, D. P., Tull, D., Hochheiser, K., Whitney, P. G., Fernandez-Ruiz, D., Dähling, S., Kastenmüller, W., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.002 · Cited by 702 · see citing works
The multiple pathways to autoimmunity
Theofilopoulos, A. N., Kono, D. H., & Baccala, R. (2017) · Nature Immunology · doi:10.1038/ni.3731 · Cited by 590 · see citing works
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · see citing works
Anticancer effects of the microbiome and its products
Zitvogel, L., Daillère, R., Roberti, M. P., Routy, B., & Kroemer, G. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.44 · Cited by 538 · see citing works
Gut microbiome, liver immunology, and liver diseases
Wang, R., Tang, R., Li, B., Ma, X., Schnabl, B., & Tilg, H. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00592-6 · Cited by 466 · see citing works
Gut microbiota: A player in aging and a target for anti-aging intervention
Vaiserman, A. M., Koliada, A. K., & Marotta, F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.001 · Cited by 465 · see citing works
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans
Bacher, P., Hohnstein, T., Beerbaum, E., Röcker, M., Blango, M. G., Kaufmann, S., Röhmel, J., Eschenhagen, P., Grehn, C., Seidel, K., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.041 · Cited by 473 · see citing works
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair
Linehan, J. L., Harrison, O. J., Han, S.-J., Byrd, A. L., Vujkovic-Cvijin, I., Villarino, A. V., Sen, S. K., Shaik, J., Smelkinson, M., Tamoutounour, S., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.033 · Cited by 456 · see citing works
“Far from being ignored by the immune system as originally perceived, microbes at all barrier surfaces are tonically educating tissues for antimicrobial functions and are actively recognized by both the innate and the adaptive immune systems (Belkaid and Hand, 2014; Honda and Littman, 2016; Pamer, 2016).”
BackgroundInfluentialMoeser, A. J., Pohl, C. S., & Rajput, M. (2017) · Animal nutrition · doi:10.1016/j.aninu.2017.06.003 · Cited by 452 · see citing works
Is autoimmunity the Achilles' heel of cancer immunotherapy?
June, C. H., Warshauer, J. T., & Bluestone, J. A. (2017) · Nature Medicine · doi:10.1038/nm.4321 · Cited by 445 · see citing works
Tan, T. G., Sefik, E., Geva-Zatorsky, N., Kua, L., Naskar, D., Teng, F., Pasman, L., Ortiz-Lopez, A., Jupp, R., Wu, H.-J. J., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617460113 · Cited by 427 · see citing works
The progress of gut microbiome research related to brain disorders
Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works
Modulating the microbiome to improve therapeutic response in cancer
McQuade, J. L., Daniel, C. R., Helmink, B. A., & Wargo, J. A. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30952-5 · Cited by 376 · see citing works
Kawano, Y., Edwards, M., Huang, Y., Bilate, A. M., Araujo, L. P., Tanoue, T., Atarashi, K., Ladinsky, M. S., Reiner, S. L., Wang, H. H., et al. (2022) · Cell · doi:10.1016/j.cell.2022.08.005 · Cited by 349 · see citing works
Self-citationGut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases
Belizário, J. E., Faintuch, J., & Garay-Malpartida, M. (2018) · Mediators of Inflammation · doi:10.1155/2018/2037838 · Cited by 341 · see citing works
Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair
Tang, T. W. H., Chen, H.-C., Chen, C.-Y., Yen, C. Y. T., Lin, C.-J., Prajnamitra, R. P., Chen, L.-L., Ruan, S.-C., Lin, J.-H., Lin, P.-J., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.035235 · Cited by 348 · see citing works
Scott, N. A., Andrusaite, A., Andersen, P., Lawson, M., Alcon-Giner, C., Leclaire, C., Caim, S., Le Gall, G., Shaw, T., Connolly, J. P. R., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao4755 · Cited by 336 · see citing works
Overacre-Delgoffe, A. E., Bumgarner, H. J., Cillo, A. R., Burr, A. H. P., Tometich, J. T., Bhattacharjee, A., Bruno, T. C., Vignali, D. A. A., & Hand, T. W. (2021) · Immunity · doi:10.1016/j.immuni.2021.11.003 · Cited by 318 · see citing works
Local immune response to food antigens drives meal-induced abdominal pain
Aguilera-Lizarraga, J., Florens, M. V., Viola, M. F., Jain, P., Decraecker, L., Appeltans, I., Cuende-Estevez, M., Fabre, N., Van Beek, K., Perna, E., et al. (2021) · Nature · doi:10.1038/s41586-020-03118-2 · Cited by 311 · see citing works
The Relationship Between the Human Genome and Microbiome Comes into View
Goodrich, J. K., Davenport, E. R., Clark, A. G., & Ley, R. E. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155532 · Cited by 311 · see citing works
Host Genetics and Gut Microbiome: Challenges and Perspectives
Kurilshikov, A., Wijmenga, C., Fu, J., & Zhernakova, A. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.06.003 · Cited by 309 · see citing works
TH17 cell heterogeneity and its role in tissue inflammation
Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology · doi:10.1038/s41590-022-01387-9 · Cited by 286 · see citing works
Self-citationThe gut microbiome in Alzheimer’s disease: what we know and what remains to be explored
Chandra, S., Sisodia, S. S., & Vassar, R. J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00595-7 · Cited by 278 · see citing works
Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease
Mangalam, A., Shahi, S. K., Luckey, D., Karau, M., Marietta, E., Luo, N., Choung, R. S., Ju, J., Sompallae, R., Gibson-Corley, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.031 · Cited by 266 · see citing works
Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., et al. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2018.12.005 · Cited by 260 · see citing works
Interleukin-17 in chronic inflammatory neurological diseases
Milovanovic, J., Arsenijevic, A., Stojanovic, B., Kanjevac, T., Arsenijevic, D., Radosavljevic, G., Milovanovic, M., & Arsenijevic, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00947 · Cited by 250 · see citing works
Yissachar, N., Zhou, Y., Ung, L., Lai, N. Y., Mohan, J. F., Ehrlicher, A., Weitz, D. A., Kasper, D. L., Chiu, I. M., Mathis, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.009 · Cited by 242 · see citing works
“We know, just for the immune system, that the host/microbiome duet engages a bewildering array of cell-types: myeloid cells like macrophages and dendritic cells, innate lymphoid cells (ILC), T regulatory and effector cells (Treg, Teff), and B lymphocytes (Thaiss et al., 2016; Honda and Littman, 2016).”
BackgroundMartínez-López, M., Iborra, S., Conde-Garrosa, R., Mastrangelo, A., Danne, C., Mann, E. R., Reid, D. M., Gaboriau-Routhiau, V., Chaparro, M., Lorenzo, M. P., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.020 · Cited by 228 · see citing works
Yang, C., Mogno, I., Contijoch, E. J., Borgerding, J. N., Aggarwala, V., Li, Z., Siu, S., Grasset, E. K., Helmus, D. S., Dubinsky, M. C., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.01.016 · Cited by 221 · see citing works
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
The role of the gut microbiota in multiple sclerosis
Correale, J., Hohlfeld, R., & Baranzini, S. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00697-8 · Cited by 207 · see citing works
Gong, S., Yan, Z., Liu, Z., Niu, M., Fang, H., Li, N., Huang, C., Li, L., Chen, G., Luo, H., et al. (2019) · Hepatology · doi:10.1002/hep.30361 · Cited by 188 · see citing works
Limeta, A., Ji, B., Levin, M., Gatto, F., & Nielsen, J. (2020) · JCI Insight · doi:10.1172/jci.insight.140940 · Cited by 185 · see citing works
Cutaneous barrier dysfunction in allergic diseases
Leung, D. Y. M., Berdyshev, E., & Goleva, E. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.02.021 · Cited by 190 · see citing works
Gut microbiome modulates efficacy of immune checkpoint inhibitors
Yi, M., Yu, S., Qin, S., Liu, Q., Xu, H., Zhao, W., Chu, Q., & Wu, K. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0592-6 · Cited by 179 · see citing works
An organoid-based organ-repurposing approach to treat short bowel syndrome
Sugimoto, S., Kobayashi, E., Fujii, M., Ohta, Y., Arai, K., Matano, M., Ishikawa, K., Miyamoto, K., Toshimitsu, K., Takahashi, S., et al. (2021) · Nature · doi:10.1038/s41586-021-03247-2 · Cited by 175 · see citing works
Xu, X., Lv, J., Guo, F., Li, J., Jia, Y., Jiang, D., Wang, N., Zhang, C., Kong, L., Liu, Y., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00814 · Cited by 173 · see citing works
Grajeda-Iglesias, C., Durand, S., Daillère, R., Iribarren, K., Lemaitre, F., Derosa, L., Aprahamian, F., Bossut, N., Nirmalathasan, N., Madeo, F., et al. (2021) · Aging · doi:10.18632/aging.202739 · Cited by 161 · see citing works
Microbiota-modulated CART <sup>+</sup> enteric neurons autonomously regulate blood glucose
Muller, P. A., Matheis, F., Schneeberger, M., Kerner, Z., Jové, V., & Mucida, D. (2020) · Science · doi:10.1126/science.abd6176 · Cited by 154 · see citing works
Sodium in the microenvironment regulates immune responses and tissue homeostasis
Müller, D. N., Wilck, N., Haase, S., Kleinewietfeld, M., & Linker, R. A. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0113-4 · Cited by 149 · see citing works
Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury
Zhou, X., & Liao, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.779620 · Cited by 153 · see citing works
Increased gut permeability in cancer cachexia: mechanisms and clinical relevance
Bindels, L. B., Neyrinck, A. M., Loumaye, A., Catry, E., Walgrave, H., Cherbuy, C., Leclercq, S., Van Hul, M., Plovier, H., Pachikian, B., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24804 · Cited by 147 · see citing works
Murray, E., Sharma, R., Smith, K. B., Mar, K. D., Barve, R., Lukasik, M., Pirwani, A. F., Malette-Guyon, E., Lamba, S., Thomas, B. J., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.016 · Cited by 150 · see citing works
Carcinogenesis and therapeutics: the microbiota perspective
Tsilimigras, M. C. B., Fodor, A., & Jobin, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.8 · Cited by 144 · see citing works
Inflammasomes and Cancer: The Dynamic Role of the Inflammasome in Tumor Development
Kantono, M., & Guo, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01132 · Cited by 133 · see citing works
The gut microbiome in psoriasis and psoriatic arthritis
Myers, B., Brownstone, N., Reddy, V., Chan, S., Thibodeaux, Q., Truong, A., Bhutani, T., Chang, H.-W., & Liao, W. (2019) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2020.101494 · Cited by 127 · see citing works
Immunology of the ageing kidney
Sato, Y., & Yanagita, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0185-9 · Cited by 126 · see citing works
Huber-Ruano, I., Calvo, E., Mayneris-Perxachs, J., Rodríguez-Peña, M.-M., Ceperuelo-Mallafré, V., Cedó, L., Núñez-Roa, C., Miro-Blanch, J., Arnoriaga-Rodríguez, M., Balvay, A., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01306-y · Cited by 122 · see citing works
Gut microbiota-mediated immunomodulation in tumor
Liu, X., Chen, Y., Zhang, S., & Dong, L. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01983-x · Cited by 112 · see citing works
Pröbstel, A.-K., & Baranzini, S. E. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0587-y · Cited by 110 · see citing works
Ishaque, S. M., Khosruzzaman, S. M., Ahmed, D. S., & Sah, M. P. (2018) · BMC Gastroenterology · doi:10.1186/s12876-018-0788-9 · Cited by 109 · see citing works
The Commensal Microbe V eillonella as a Marker for Response to an FGF19 Analog in NASH
Loomba, R., Ling, L., Dinh, D. M., DePaoli, A. M., Lieu, H. D., Harrison, S. A., & Sanyal, A. J. (2021) · Hepatology · doi:10.1002/hep.31523 · Cited by 88 · see citing works
Bacterially produced metabolites protect C. elegans neurons from degeneration
Urrutia, A., García-Angulo, V. A., Fuentes, A., Caneo, M., Legüe, M., Urquiza, S., Delgado, S. E., Ugalde, J., Burdisso, P., & Calixto, A. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000638 · Cited by 71 · see citing works
Lam, Y., Maguire, S., Palacios, T., & Caterson, I. (2017) · Nutrients · doi:10.3390/nu9060602 · Cited by 86 · see citing works
“, flagellin and LPS) to pattern-recognition receptors and/or the direct adhesion of bacteria themselves to the gut epithelium triggers an antigen-specific response that stimulates the adaptive immune system [89].”
BackgroundResolution of inflammation in inflammatory bowel disease
Rogler, G. (2017) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(17)30031-6 · Cited by 79 · see citing works
Detka, J., & Głombik, K. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00274-8 · Cited by 79 · see citing works
Host-microbiota interactions and adaptive immunity
McCoy, K. D., Ronchi, F., & Geuking, M. B. (2017) · Immunological Reviews · doi:10.1111/imr.12575 · Cited by 77 · see citing works
Immunoglobulin A and liver diseases
Inamine, T., & Schnabl, B. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-017-1400-8 · Cited by 76 · see citing works
Role of the endocannabinoid system in the regulation of intestinal homeostasis
Cuddihey, H., MacNaughton, W. K., & Sharkey, K. A. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.05.015 · Cited by 79 · see citing works
Microbial Immuno-Communication in Neurodegenerative Diseases
Main, B. S., & Minter, M. R. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00151 · Cited by 68 · see citing works
Probiotic species in the modulation of the anticancer immune response
Marinelli, L., Tenore, G. C., & Novellino, E. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.007 · Cited by 64 · see citing works
Short-term dietary changes can result in mucosal and systemic immune depression
Siracusa, F., Schaltenberg, N., Kumar, Y., Lesker, T. R., Steglich, B., Liwinski, T., Cortesi, F., Frommann, L., Diercks, B.-P., Bönisch, F., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01587-x · Cited by 64 · see citing works
McQuade, J. L., Ologun, G. O., Arora, R., & Wargo, J. A. (2020) · Current Oncology Reports · doi:10.1007/s11912-020-00913-y · Cited by 63 · see citing works
The battle for iron in enteric infections
Sousa Gerós, A., Simmons, A., Drakesmith, H., Aulicino, A., & Frost, J. N. (2020) · Immunology · doi:10.1111/imm.13236 · Cited by 58 · see citing works
Gut microbiota and probiotics: Novel immune system modulators in myasthenia gravis?
Rinaldi, E., Consonni, A., Guidesi, E., Elli, M., Mantegazza, R., & Baggi, F. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13567 · Cited by 57 · see citing works
Dong, S., Harrington, B. K., Hu, E. Y., Greene, J. T., Lehman, A. M., Tran, M., Wasmuth, R. L., Long, M., Muthusamy, N., Brown, J. R., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99386 · Cited by 52 · see citing works
Li, Y., Ye, Z., Zhu, J., Fang, S., Meng, L., & Zhou, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.844335 · Cited by 45 · see citing works
Zhang, Q., Zhao, W., Hou, Y., Song, X., Yu, H., Tan, J., Zhou, Y., & Zhang, H. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14132 · Cited by 40 · see citing works
Contribution of Aging, Obesity, and Microbiota on Tumor Immunotherapy Efficacy and Toxicity
Baiden-Amissah, R. E. M., & Tuyaerts, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143586 · Cited by 30 · see citing works
Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH
Woestemeier, A., Scognamiglio, P., Zhao, Y., Wagner, J., Muscate, F., Casar, C., Siracusa, F., Cortesi, F., Agalioti, T., Müller, S., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.153831 · Cited by 28 · see citing works
Pathogenesis, Animal Models, and Drug Discovery of Alzheimer’s Disease
Xia, Z.-D., Ma, R.-X., Wen, J.-F., Zhai, Y.-F., Wang, Y.-Q., Wang, F.-Y., Liu, D., Zhao, X.-L., Sun, B., Jia, P., et al. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-230326 · Cited by 19 · see citing works
Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside
Zhan, Y., Liu, Q., Zhang, B., Huang, X., & Lu, Q. (2022) · Frontiers of Medicine · doi:10.1007/s11684-022-0957-7 · Cited by 3 · see citing works
Erasmo, N. (2024) · International Journal of Clinical Microbiology and Biochemical Technology · doi:10.29328/journal.ijcmbt.1001029 · Cited by 1 · see citing works
- Authors
- Honda, K., & Littman, D. R.
- Affiliations
- Keio University (JP)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Honda, Kenya
- Littman, Dan R.
- Venue
- Nature
- Published
- 2016-07-06
- Volume
- 535
- Issue
- 7610
- Pages
- 75-84
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2463836225
- Cited by
- 1,846
- References
- 135
- Citations by year
- 2026: 141 · 2025: 168 · 2024: 203 · 2023: 183 · 2022: 232 · 2021: 258 · 2020: 210 · 2019: 163 · 2018: 125 · 2017: 142 · 2016: 20
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- gut microbiota, mucosal immunity, T cells, B cells, dysbiosis, immune tolerance, intestinal barrier integrity, inflammatory diseases, cancer immunotherapy, microbiota-host interactions
- MeSH terms
- Gastrointestinal Microbiome, Animals, B-Lymphocytes, Disease, Homeostasis, Humans, Inflammation, Intestinal Mucosa, Neoplasms, Skin, T-Lymphocytes, Autoimmunity, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review