Cited by 1,846Gut microbiota and healthT-cell and B-cell ImmunologyInflammatory Bowel Disease

The microbiota in adaptive immune homeostasis and disease

Honda, Kenya, Littman, Dan R.·2016·Nature

Abstract

In the mucosa, the immune system's T cells and B cells have position-specific phenotypes and functions that are influenced by the microbiota. These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. Imbalances in the gut microbiota, known as dysbiosis, can trigger several immune disorders through the activity of T cells that are both near to and distant from the site of their induction. Elucidation of the mechanisms that distinguish between homeostatic and pathogenic microbiota-host interactions could identify therapeutic targets for preventing or modulating inflammatory diseases and for boosting the efficacy of cancer immunotherapy.

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Crossref · 10.1038/nature18848

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135 of 135 references verified0 citation errors · 0 not checkable

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  • Th17 cells play an important role in tissue homeostasis, especially in the intestinal mucosa.

    “Th17 cells have been found to play an important role in tissue homeostasis, especially in the intestinal mucosa.”

    From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [46]

  • Selective binding of bacterial components and metabolites, such as flagellin and lipopolysaccharide, to pattern-recognition receptors and/or direct adhesion of bacteria to the gut epithelium triggers an antigen-specific response that stimulates the adaptive immune system.

    “At the molecular level, the selective binding of bacterial components and metabolites (e.g., flagellin and LPS) to pattern-recognition receptors and/or the direct adhesion of bacteria themselves to the gut epithelium triggers an antigen-specific response that stimulates the adaptive immune system [89].”

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Authors
Honda, K., & Littman, D. R.
Affiliations
  • Keio University (JP)
  • Howard Hughes Medical Institute (US)
Corresponding author
  • Honda, Kenya
  • Littman, Dan R.
Venue
Nature
Published
2016-07-06
Volume
535
Issue
7610
Pages
75-84
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2463836225
Cited by
1,846
References
135
Citations by year
2026: 141 · 2025: 168 · 2024: 203 · 2023: 183 · 2022: 232 · 2021: 258 · 2020: 210 · 2019: 163 · 2018: 125 · 2017: 142 · 2016: 20
FWCI
13.57
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords
gut microbiota, mucosal immunity, T cells, B cells, dysbiosis, immune tolerance, intestinal barrier integrity, inflammatory diseases, cancer immunotherapy, microbiota-host interactions
MeSH terms
Gastrointestinal Microbiome, Animals, B-Lymphocytes, Disease, Homeostasis, Humans, Inflammation, Intestinal Mucosa, Neoplasms, Skin, T-Lymphocytes, Autoimmunity, Dysbiosis

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