Interaction between the gut microbiome and mucosal immune system

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

Diversity of the Human Intestinal Microbial Flora

Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works

A metagenome-wide association study of gut microbiota in type 2 diabetes

Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

Toll-like receptors: critical proteins linking innate and acquired immunity

Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777 · see citing works

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works

Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605 · see citing works

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works

Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides

Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091 · see citing works

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works

Human nutrition, the gut microbiome and the immune system

Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588 · see citing works

Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus

Arbuckle, M. R., McClain, M. T., Rubertone, M. V., Scofield, R. H., Dennis, G. J., James, J. A., & Harley, J. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021933 · Cited by 2,581 · see citing works

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554 · see citing works

A microbial symbiosis factor prevents intestinal inflammatory disease

Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340 · see citing works

Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?

Nasir, O. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000350152 · Cited by 2,331 · see citing works

Inducible Foxp3 ⁺ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233 · see citing works

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

Scher, J. U., Sczesnak, A., Longman, R. S., Segata, N., Ubeda, C., Bielski, C., Rostron, T., Cerundolo, V., Pamer, E. G., Abramson, S. B., et al. (2013) · eLife · doi:10.7554/elife.01202 · Cited by 2,047 · see citing works

Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis

Rantapää‐Dahlqvist, S., Jong, B. A. W. D., Berglin, E. H., Hallmans, G., Wadell, G., Stenlund, H. C., Sundin, U., & VENROOIJ, W. J. V. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11223 · Cited by 1,946 · see citing works

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

Zhang, X., Zhang, D., Jia, H., Feng, Q., Wang, D., Liang, D., Wu, X., Li, J., Tang, L., Li, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3914 · Cited by 1,690 · see citing works

The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota

Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604 · see citing works

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577 · see citing works

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Lamas, B., Richard, M. L., Leducq, V., Pham, H.-P., Michel, M.-L., Da Costa, G., Bridonneau, C., Jegou, S., Hoffmann, T. W., Natividad, J. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4102 · Cited by 1,482 · see citing works

Gut Dysbiosis Is Linked to Hypertension

Yang, T., Santisteban, M. M., Rodriguez, V., Li, E., Ahmari, N., Carvajal, J. M., Zadeh, M., Gong, M., Qi, Y., Zubcevic, J., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05315 · Cited by 1,478 · see citing works

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,464 · see citing works

Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Cash, H. L., Whitham, C. V., Behrendt, C. L., & Hooper, L. V. (2006) · Science · doi:10.1126/science.1127119 · Cited by 1,432 · see citing works

The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412 · see citing works

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345 · see citing works

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323 · see citing works

Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus

AbuMaziad, A. S., Torrealba, J. R., Seikaly, M. G., Hassler, J. R., & Hendricks, A. R. (2017) · Case Reports in Nephrology and Dialysis · doi:10.1159/000475493 · Cited by 1,299 · see citing works

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286 · see citing works

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285 · see citing works

Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?

Lee, Y. K., & Mazmanian, S. K. (2010) · Science · doi:10.1126/science.1195568 · Cited by 1,115 · see citing works

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,076 · see citing works

Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

Ayabe, T., Satchell, D. P., Wilson, C. L., Parks, W. C., Selsted, M. E., & Ouellette, A. J. (2000) · Nature Immunology · doi:10.1038/77783 · Cited by 1,060 · see citing works

Angiogenins: a new class of microbicidal proteins involved in innate immunity

Hooper, L. V., Stappenbeck, T. S., Hong, C. V., & Gordon, J. I. (2003) · Nature Immunology · doi:10.1038/ni888 · Cited by 929 · see citing works

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

Zenewicz, L. A., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Stevens, S. G., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.003 · Cited by 797 · see citing works

Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon

Seksik, P., Rigottier‐Gois, L., Gramet, G., BRIEND‐SUTREN, M., Pochart, P., Marteau, P. R., Jian, R., & Dore, J. M. (2003) · Gut · doi:10.1136/gut.52.2.237 · Cited by 746 · see citing works

The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses

Scott, M. G., Davidson, D. J., Gold, M. R., Bowdish, D. M. E., & Hancock, R. E. W. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3883 · Cited by 713 · see citing works

Modulation of Epithelial Cell Growth by Intraepithelial γδ T Cells

Boismenu, R., & Havran, W. L. (1994) · Science · doi:10.1126/science.7973709 · Cited by 652 · see citing works

Wnt signalling induces maturation of Paneth cells in intestinal crypts

van Es, J. H., Jay, P., Gregorieff, A., van Gijn, M. E., Jonkheer, S. M., Hatzis, P., Thiele, A., van den Born, M., Begthel, H., Brabletz, T., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1240 · Cited by 651 · see citing works

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

Chu, H., Khosravi, A., Kusumawardhani, I. P., Kwon, A. H. K., Vasconcelos, A. C., Cunha, L. D., Mayer, A. E., Shen, Y., Wu, W.-L., Kambal, A., et al. (2016) · Science · doi:10.1126/science.aad9948 · Cited by 647 · see citing works

Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus

Hevia, A., Milani, C., López, P., Cuervo, A., Arboleya, S., Duranti, S., Turroni, F., González, S., Suárez, A., Gueimonde, M., et al. (2014) · mBio · doi:10.1128/mbio.01548-14 · Cited by 620 · see citing works

CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut

Sonnenberg, G. F., Monticelli, L. A., Elloso, M. M., Fouser, L. A., & Artis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.12.009 · Cited by 573 · see citing works

Differences between Tissue-Associated Intestinal Microfloras of Patients with Crohn's Disease and Ulcerative Colitis

Gophna, U., Sommerfeld, K., Gophna, S., Doolittle, W., & van Zanten, S. V. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.01004-06 · Cited by 541 · see citing works

Fecal Microbiota in Premature Infants Prior to Necrotizing Enterocolitis

Mai, V., Young, C., Ukhanova, M., Wang, X., Sun, Y., Casella, G., Theriaque, D. W., Li, N., Sharma, R. R., Hudak, M. L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020647 · Cited by 503 · see citing works

Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis

Costello, M., Ciccia, F., Willner, D. L., Warrington, N. M., Robinson, P. C., Gardiner, B., Marshall, M. S., Kenna, T., Triolo, G., & Brown, M. A. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38967 · Cited by 436 · see citing works

CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22

Longman, R., Diehl, G. E., Victorio, D., Huh, J. R., Galan, C., Miraldi, E. R., Swaminath, A., Bonneau, R., Scherl, E., & Littman, D. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20140678 · Cited by 376 · see citing works

Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells

Sierro, F., Dubois, B., Coste, A., Kaiserlian, D., Kraehenbuhl, J.-P., & Sirard, J.-C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241308598 · Cited by 368 · see citing works

The Impact of the Level of the Intestinal Short Chain Fatty Acids in Inflammatory Bowel Disease Patients Versus Healthy Subjects

Faujan, N. H., Abdulamir, A. S., Fatimah, A. B., Anas, O. M., Shuhaimi, M., Yazid, A. M., & Loong, Y. Y. (2010) · The Open Biochemistry Journal · doi:10.2174/1874091x01004010053 · Cited by 361 · see citing works

The microbiome and regulation of mucosal immunity

McDermott, A. J., & Huffnagle, G. B. (2013) · Immunology · doi:10.1111/imm.12231 · Cited by 335 · see citing works

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo, J., Grabe, M., Jiang, Q., et al. (2013) · Nature · doi:10.1038/nature12729 · Cited by 326 · see citing works

Peyer's patches: organizing B‐cell responses at the intestinal frontier

Reboldi, A., & Cyster, J. G. (2016) · Immunological Reviews · doi:10.1111/imr.12400 · Cited by 309 · see citing works

Augmentation of Innate Host Defense by Expression of a Cathelicidin Antimicrobial Peptide

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NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells.

Awane, M., Andres, P. G., Li, D. J., & Reinecker, H. (1999) · PubMed · Cited by 288 · see citing works

The Normal Microbial Flora as a Major Stimulus for Proliferation of Plasma Cells Synthesizing IgA in the Gut

Crabbé, P. A., Bazin, H., Eyssen, H., & Heremans, J. F. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000230130 · Cited by 281 · see citing works

Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization.

Bandeira, A., Mota‐Santos, T. A., Itohara, S., Degermann, S., Heusser, C., Tonegawa, S., & Coutinho, A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.1.239 · Cited by 280 · see citing works

Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

Muñoz, M., Heimesaat, M. M., Danker, K., Struck, D., Lohmann, U., Plickert, R., Bereswill, S., Fischer, A., Dunay, I. R., Wolk, K., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090900 · Cited by 277 · see citing works

NF-κB-Inducing Kinase Is a Common Mediator of IL-17-, TNF-α-, and IL-1β-Induced Chemokine Promoter Activation in Intestinal Epithelial Cells

Awane, M., Andres, P. G., Li, D. J., & Reinecker, H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5337 · Cited by 272 · see citing works

Are the Two Human Papillomavirus Vaccines Really Similar? A Systematic Review of Available Evidence: Efficacy of the Two Vaccines against HPV

Mario, S. D., Basevi, V., Lopalco, P. L., Balduzzi, S., D’Amico, R., & Magrini, N. (2015) · Journal of Immunology Research · doi:10.1155/2015/435141 · Cited by 257 · see citing works

Impaired regulatory T cell function in germ‐free mice

Östman, S., Rask, C., Wold, A. E., Hultkrantz, S., & Telemo, E. (2006) · European Journal of Immunology · doi:10.1002/eji.200535244 · Cited by 257 · see citing works

Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

Richards, J. L., Yap, Y. A., McLeod, K. H., Mackay, C. R., & Mariño, E. (2016) · Clinical &amp; Translational Immunology · doi:10.1038/cti.2016.29 · Cited by 250 · see citing works

Analysis of Fecal Lactobacillus Community Structure in Patients with Early Rheumatoid Arthritis

Liu, X., Zou, Q., Zeng, B., Fang, Y., & Wei, H. (2013) · Current Microbiology · doi:10.1007/s00284-013-0338-1 · Cited by 249 · see citing works

Porphyromonas gingivalis and disease‐related autoantibodies in individuals at increased risk of rheumatoid arthritis

Mikuls, T. R., Thiele, G. M., Deane, K. D., Payne, J. B., O’Dell, J. R., Yu, F. H. Z., Sayles, H. R., Weisman, M. H., Gregersen, P. K., Buckner, J. H., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34595 · Cited by 230 · see citing works

Recent Advances in Characterizing the Gastrointestinal Microbiome in Crohnʼs Disease

Wright, E. K., Kamm, M. A., Teo, S. M., Inouye, M., Wagner, J., & Kirkwood, C. D. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000382 · Cited by 207 · see citing works

Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells

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Epidemiology of inflammatory bowel disease in a German twin cohort: Results of a nationwide study

Spehlmann, M. E., Begun, A. Z., Burghardt, J., Lepage, P., Raedler, A., & Schreiber, S. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20380 · Cited by 189 · see citing works

Microbiota and Mucosal Immunity in Amphibians

Colombo, B. M., Scalvenzi, T., Benlamara, S., & Pollet, N. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00111 · Cited by 169 · see citing works

Impact of Kefir Derived<i>Lactobacillus kefiri</i>on the Mucosal Immune Response and Gut Microbiota

Carasi, P., Racedo, S. M., Jacquot, C., Romanin, D. E., Serradell, M. A., & Urdaci, M. C. (2015) · Journal of Immunology Research · doi:10.1155/2015/361604 · Cited by 145 · see citing works

Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease

Wang, Z.-K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14805 · Cited by 132 · see citing works

T Cell-Independent IgA Class Switch Recombination Is Restricted to the GALT and Occurs Prior to Manifest Germinal Center Formation

Bergqvist, P. J., Stensson, A., Lycke, N. Y., & Bemark, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901895 · Cited by 131 · see citing works

The Human Gut Microbiota

Harmsen, H. J. M., & de Goffau, M. C. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-31248-4_7 · Cited by 128 · see citing works

The role of Paneth cells and their antimicrobial peptides in innate host defense

Ayabe, T., Ashida, T., Kohgo, Y., & Kono, T. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.06.007 · Cited by 124 · see citing works

Salmonella-Induced Mucosal Lectin RegIIIβ Kills Competing Gut Microbiota

Stelter, C., Käppeli, R., König, C., Krah, A., Hardt, W., Stecher, B., & Bumann, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020749 · Cited by 123 · see citing works

Expression of pro‐inflammatory cytokines by TCRαβ+ T and TCRγδ+ T cells in an experimental model of colitis

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The Gut Microbiota in Inflammatory Bowel Disease

Macfarlane, G. T., Blackett, K. L., Nakayama, T., Steed, H., & Macfarlane, S. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168146 · Cited by 108 · see citing works

Induction of gut IgA production through T cell‐dependent and T cell‐independent pathways

Bemark, M., Boysen, P., & Lycke, N. Y. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06378.x · Cited by 107 · see citing works

Interleukin-10 and Interleukin-10–Receptor Defects in Inflammatory Bowel Disease

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Rheumatoid arthritis is linked to Proteus—the evidence

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Impact of Drug Therapy and Surgery on Quality of Life in Crohnʼs Disease

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Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System

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The dietary supplement Rhodiola crenulata extract alleviates dextran sulfate sodium-induced colitis in mice through anti-inflammation, mediating gut barrier integrity and reshaping the gut microbiome

Wang, Y. N., Tao, H., Huang, H., Xiao, Y., Wu, X., Li, M., Shen, J., Xiao, Z., Zhao, Y., Du, F., et al. (2021) · Food & Function · doi:10.1039/d0fo03061a · Cited by 95 · see citing works

Omega-3 Polyunsaturated Fatty Acids and the Intestinal Epithelium—A Review

Durkin, L., Childs, C. E., & Calder, P. C. (2021) · Foods · doi:10.3390/foods10010199 · Cited by 94 · see citing works

Possible role of gut microbes and host's immune response in gut-lung homeostasis

Rastogi, S., Mohanty, S., Sharma, S., & Tripathi, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954339 · Cited by 94 · see citing works

The emerging role of the small intestinal microbiota in human health and disease

Ruigrok, R. A. A. A., Weersma, R. K., & Vila, A. V. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2201155 · Cited by 96 · see citing works

Diet as a Modulator of Intestinal Microbiota in Rheumatoid Arthritis

Dourado, E., Ferro, M., Guerreiro, C. S., & Fonseca, J. E. (2020) · Nutrients · doi:10.3390/nu12113504 · Cited by 94 · see citing works

Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis

Yang, Y., Wang, Y., Zhao, L., Wang, F., Li, M., Wang, Q., Luo, H., Zhao, Q., Zeng, J., Zhao, Y., et al. (2023) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2023.03.003 · Cited by 93 · see citing works

Neuro-immune regulation of mucosal physiology

Chesné, J., Cardoso, V., & Veiga‐Fernandes, H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0063-y · Cited by 92 · see citing works

New Players in Immunity to Tuberculosis: The Host Microbiome, Lung Epithelium, and Innate Immune Cells

Gupta, N., Kumar, R. K., & Agrawal, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00709 · Cited by 89 · see citing works

Dietary Macleaya cordata extract supplementation improves the growth performance and gut health of broiler chickens with necrotic enteritis

Song, B., He, J., Pan, X., Kong, L., Xiao, C., Keerqin, C., & Song, Z. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00916-2 · Cited by 89 · see citing works

Modulation of microbial communities and mucosal gene expression in chicken intestines after galactooligosaccharides delivery In Ovo

Sławińska, A., Dunisławska, A., Płowiec, A., Radomska, M., Lachmanska, J., Siwek, M. Z., Tavaniello, S., & Maiorano, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212318 · Cited by 88 · see citing works

Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

Zhang, K.-K., Chen, L., Yang, J.-Z., Liu, J., Li, J.-H., Liu, Y., Li, X., Chen, L., Hsu, C., Zeng, J., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.09.010 · Cited by 88 · see citing works

The Role of Gut Microbiota in Some Liver Diseases: From an Immunological Perspective

Wang, L., Cao, Z.-M., Zhang, L., Li, J.-M., & Lv, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.923599 · Cited by 87 · see citing works

Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice

Xiang, X., Zheng, H., Wang, R., Chen, H., Xiao, J., Zheng, B., Liu, S., & Ding, Y. (2021) · Marine Drugs · doi:10.3390/md19080456 · Cited by 84 · see citing works

Gut-disc axis: A cause of intervertebral disc degeneration and low back pain?

Li, W., Lai, K., Chopra, N., Zheng, Z., Das, A., & Diwan, A. D. (2022) · European Spine Journal · doi:10.1007/s00586-022-07152-8 · Cited by 84 · see citing works

The Impact of Food Additives on the Abundance and Composition of Gut Microbiota

Zhou, X., Qiao, K., Wu, H., & Zhang, Y. (2023) · Molecules · doi:10.3390/molecules28020631 · Cited by 84 · see citing works

Activated Drp1-mediated mitochondrial ROS influence the gut microbiome and intestinal barrier after hemorrhagic shock

Duan, C., Kuang, L., Xiang, X., Zhang, J., Zhu, Y., Wu, Y., Yan, Q., Liu, L., & Li, T. (2020) · Aging · doi:10.18632/aging.102690 · Cited by 82 · see citing works

Immune regulation of the gut-brain axis and lung-brain axis involved in ischemic stroke

Xie, X., Wang, L., Dong, S., Ge, S., & Zhu, T. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.380869 · Cited by 85 · see citing works

Probiotic Enhancement of Antioxidant Capacity and Alterations of Gut Microbiota Composition in 6-Hydroxydopamin-Induced Parkinson’s Disease Rats

Tsao, S.-P., Nurrahma, B. A., Kumar, R., Wu, C.-H., Yeh, T.-H., Chiu, C.-C., Lee, Y.-P., Liao, Y.-C., Huang, C.-H., Yeh, Y.-T., et al. (2021) · Antioxidants · doi:10.3390/antiox10111823 · Cited by 79 · see citing works

Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis

Cannarella, L. A. T., Mari, N. L., de Alcantara, C. C., Iryioda, T. M. V., Costa, N. T., Oliveira, S. R., Lozovoy, M. A. B., Reiche, E. M. V., Dichi, I., & Simão, A. N. C. (2021) · Nutrition · doi:10.1016/j.nut.2021.111282 · Cited by 79 · see citing works

The Core Human Microbiome: Does It Exist and How Can We Find It? A Critical Review of the Concept

Sharon, I., Quijada, N. M., Pasolli, E., Fabbrini, M., Vitali, F., Agamennone, V., Dötsch, A., Selberherr, E., Grau, J. H., Meixner, M., et al. (2022) · Nutrients · doi:10.3390/nu14142872 · Cited by 79 · see citing works

Mold, Mycotoxins and a Dysregulated Immune System: A Combination of Concern?

Kraft, S., Buchenauer, L., & Polte, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212269 · Cited by 82 · see citing works

FETR-ALS Study Protocol: A Randomized Clinical Trial of Fecal Microbiota Transplantation in Amyotrophic Lateral Sclerosis

Mandrioli, J., Amedei, A., Cammarota, G., Niccolai, E., Zucchi, E., D’Amico, R., Ricci, F., Quaranta, G., Spanu, T., & Masucci, L. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01021 · Cited by 78 · see citing works

Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies

Lu, Q., Liang, Y., Tian, S., Jin, J., Zhao, Y., & Fan, H. (2023) · Toxics · doi:10.3390/toxics11121011 · Cited by 76 · see citing works

Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine

Kumar, M., Garand, M., & Khodor, S. A. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-02174-1 · Cited by 76 · see citing works

Vaccine Strategies to Elicit Mucosal Immunity

Song, Y., Mehl, F., & Zeichner, S. L. (2024) · Vaccines · doi:10.3390/vaccines12020191 · Cited by 80 · see citing works

Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

Ferenc, K., Sokal-Dembowska, A., Helma, K., Motyka, E., Jarmakiewicz-Czaja, S., & Filip, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021228 · Cited by 74 · see citing works

The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal Mucosa

Hirano, T., & Nakase, H. (2021) · Immuno · doi:10.3390/immuno1040041 · Cited by 6 · see citing works

Gut microbiota as a key regulator of intestinal mucosal immunity

Wang, J., He, M., Yang, M., & Ai, X. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122612 · Cited by 96 · see citing works

Microbiota–immune system interaction: an uneasy alliance

Salzman, N. H. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.09.018 · Cited by 96 · see citing works

The Role of Microbiota on the Gut Immunology

Min, Y. W., & Rhee, P. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.009 · Cited by 111 · see citing works

Commensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor

Tian, K., Jing, D., Lan, J., Lv, M., & Wang, T. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1316 · Cited by 34 · see citing works