The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
A neuroprotective role for microglia in prion diseases
Open accessAbstract
Microglial activation is a hallmark of most neurodegenerative disorders, and is particularly conspicuous in prion diseases. However, the role of microglia, which function as both primary immune effector cells and professional phagocytes in the central nervous system, remains contentious in the context of neurodegeneration. Here, we evaluated the effect of microglial depletion/deficiency on prion pathogenesis. We found that ganciclovir-mediated microglial ablation on tga20/CD11b-thymidine kinase of Herpes simplex virus (HSVTK) cerebellar organotypic cultured slices markedly aggravated prion-induced neurotoxicity. A similar deterioration of disease was recapitulated in in vivo microglial depletion in prion-infected tga20/CD11b-HSVTK mice. Additionally, deficiency of microglia in interleukin 34 knockout (IL34−/−) mice again resulted in significantly augmented proteinase K–resistant prion protein deposition and accelerated prion disease progression. These results provide unambiguous evidence for a general protective role of microglia in prion pathogenesis.
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“Work on prion-infected organotypic brain-slice cultures support the prion clearing and neuroprotective functions of microglia [50].”
From Loss of Homeostatic Microglia Signature in Prion Diseases (2022) · cites this paper as [50]
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“In contrast, reducing microglia numbers by knocking out interleukin 34 (IL-34), an essential signaling molecule, led to augmented PrPSc deposition and shortened survival in a prion mouse model [50,51]”
From Loss of Homeostatic Microglia Signature in Prion Diseases (2022) · cites this paper as [50]
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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
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“In the brain, microglia interact with neurons and exert a wide variety of physiological functions (Chen et al., 2010; Paolicelli et al., 2011; Rogers et al., 2011; Derecki et al., 2012; Schafer et al., 2012; Parkhurst et al., 2013; Zhan et al., 2014).”
BackgroundATP mediates rapid microglial response to local brain injury in vivo
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Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
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A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
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Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
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Unaltered prion disease in mice lacking developmental endothelial locus-1
Zhu, C., Li, Z., Li, B., Pfammatter, M., Hornemann, S., & Aguzzi, A. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.01.003 · Cited by 4
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Metadata
- Authors
- Zhu, C., Herrmann, U. S., Falsig, J., Abakumova, I., Nuvolone, M., Schwarz, P., Frauenknecht, K., Rushing, E. J., & Aguzzi, A.
- Affiliations
- University Hospital Zurich (CH)
- Corresponding author
- Zhu, Caihong
- Aguzzi, Adriano
- ORCID
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2016-05-16
- Volume
- 213
- Issue
- 6
- Pages
- 1047-1059
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC4886355
- OpenAlex
- W2406691442
- Cited by
- 134
- References
- 44
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 9 · 2023: 7 · 2022: 17 · 2021: 11 · 2020: 12 · 2019: 17 · 2018: 17 · 2017: 25 · 2016: 5
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- European Research Council (250356)
- Swiss National Foundation
- Novartis Research Foundation
- Stavros Niarchos Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- microglia, prion disease, neuroprotection, microglial depletion, ganciclovir, IL-34, prion protein deposition, neurodegeneration
- MeSH terms
- Animals, Interleukins, Prions, Prion Diseases, Microglia, Mice, Knockout, Mice
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