Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors
Open accessAbstract
Cognitive impairment occurs in 40-90% of patients with systemic lupus erythematosus (SLE), which is characterized by autoantibodies to nuclear antigens, especially DNA. We discovered that a subset of anti-DNA antibodies, termed DNRAbs, cross reacts with the N-methyl-d-aspartate receptor (NMDAR) and enhances NMDAR signaling. In patients, DNRAb presence associates with spatial memory impairment. In a mouse model, DNRAb-mediated brain pathology proceeds through an acute phase of excitotoxic neuron loss, followed by persistent alteration in neuronal integrity and spatial memory impairment. The latter pathology becomes evident only after DNRAbs are no longer detectable in the brain. Here we investigate the mechanism of long-term neuronal dysfunction mediated by transient exposure to antibody. We show that activated microglia and C1q are critical mediators of neuronal damage. We further show that centrally acting inhibitors of angiotensin-converting enzyme (ACE) can prevent microglial activation and preserve neuronal function and cognitive performance. Thus, ACE inhibition represents a strong candidate for clinical trials aimed at mitigating cognitive dysfunction.
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Mechanistic dissections of the CNS manifestations of lupus have demonstrated a role for type I interferon signaling and autoantibodies in promoting inappropriate complement- and microglia-mediated engulfment of synapses.
“Strikingly, mechanistic dissections of the CNS manifestations of the autoimmune disorder, lupus, have demonstrated a role for type I interferon signaling and autoantibodies in promoting inappropriate complement- and microglia-mediated engulfment of synapses (5, 106).”
From The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease (2019) · cites this paper as [106]
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2 retracted
Bialas, A. R., & Stevens, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3560 · Cited by 519 · see citing works
RetractedMicroglia-dependent synapse loss in type I interferon-mediated lupus
Bialas, A. R., Presumey, J., Das, A., van der Poel, C. E., Lapchak, P. H., Mesin, L., Victora, G., Tsokos, G. C., Mawrin, C., Herbst, R., et al. (2017) · Nature · doi:10.1038/nature22821 · Cited by 197 · see citing works
RetractedMicroglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · cited 2× · see citing works
“Recent studies have shown microglia-mediated synaptic loss in the hippocampus in a mouse model of Alzheimer’s disease (AD) in which amyloid is injected into the brain; dendritic loss can be blocked by the administration of anti-C1q antibody (Hong et al., 2016).”
BackgroundMethodThe Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490 · see citing works
Elmore, M. R. P., Najafi, A. R., Koike, M. A., Dagher, N. N., Spangenberg, E. E., Rice, R. A., Kitazawa, M., Matusow, B., Nguyen, H., West, B. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.040 · Cited by 1,968 · see citing works
Microglia emerge as central players in brain disease
Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767 · see citing works
The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease
Stephan, A. H., Barres, B. A., & Stevens, B. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113810 · Cited by 1,113 · see citing works
The Role of Microglia in the Healthy Brain: Figure 1.
Tremblay, M.-È., Stevens, B., Sierra, A., Wake, H., Bessis, A., & Nimmerjahn, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4158-11.2011 · Cited by 992 · see citing works
Maroso, M., Balosso, S., Ravizza, T., Liu, J., Aronica, E., Iyer, A. M., Rossetti, C., Molteni, M., Casalgrandi, M., Manfredi, A. A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2127 · Cited by 921 · see citing works
DeGiorgio, L. A., Konstantinov, K. N., Lee, S. C., Hardin, J., Volpe, B. T., & Diamond, B. (2001) · Nature Medicine · doi:10.1038/nm1101-1189 · Cited by 798 · see citing works
Novel role of PKR in inflammasome activation and HMGB1 release
Lü, B., Nakamura, T., Inouye, K., Li, J., Tang, Y., Lundbäck, P., Valdés‐Ferrer, S. I., Olofsson, P. S., Kalb, T. H., Roth, J., et al. (2012) · Nature · doi:10.1038/nature11290 · Cited by 772 · see citing works
HMGB1: Endogenous Danger Signaling
Klune, J. R., Dhupar, R., Cardinal, J., Billiar, T. R., & Tsung, A. (2008) · Molecular Medicine · doi:10.2119/2008-00034.klune · Cited by 762 · see citing works
Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels
Karataş, H., Erdener, Ş. E., Özdemir, Y., Lüle, S., Eren‐Koçak, E., Şen, Z. D., & Dalkara, T. (2013) · Science · doi:10.1126/science.1231897 · Cited by 516 · see citing works
Human lupus autoantibodies against NMDA receptors mediate cognitive impairment
Kowal, C., DeGiorgio, L. A., Lee, J. Y., Edgar, M. A., Huerta, P. T., Volpe, B. T., & Diamond, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608397104 · Cited by 415 · see citing works
Kowal, C., DeGiorgio, L. A., Nakaoka, T., Hetherington, H. P., Huerta, P. T., Diamond, B., & Volpe, B. T. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.011 · Cited by 403 · see citing works
Molecular biology of the renin-angiotensin system.
Griendling, K. K., Murphy, T. J., & Alexander, R. W. (1993) · Circulation · doi:10.1161/01.cir.87.6.1816 · Cited by 401 · see citing works
Enhanced synaptic connectivity and epilepsy in C1q knockout mice
Chu, Y., Jin, X., Parada, I., Pesic, A., Stevens, B., Barres, B., & Prince, D. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913449107 · Cited by 364 · see citing works
JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation
Lü, B., Antoine, D. J., Kwan, K., Lundbäck, P., Wähämaa, H., Schierbeck, H., Robinson, M., van Zoelen, M. A. D., Yang, H., Li, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316925111 · Cited by 364 · see citing works
Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain
Fonseca, M. I., Chu, S.-H., Hernandez, M. X., Fang, M. J., Modarresi, L., Selvan, P., MacGregor, G. R., & Tenner, A. J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0814-9 · Cited by 337 · see citing works
Crews, F. T., Qin, L., Sheedy, D. L., Vetreno, R. P., & Zou, J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.030 · Cited by 295 · see citing works
Immunity and behavior: Antibodies alter emotion
Huerta, P. T., Kowal, C., DeGiorgio, L. A., Volpe, B. T., & Diamond, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510055103 · Cited by 293 · see citing works
Saavedra, J. M., Sánchez-Lemus, E., & Benický, J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.10.001 · Cited by 260 · see citing works
Elimination of microglia improves cognitive function following cranial irradiation
Acharya, M. M., Green, K. N., Allen, B. D., Najafi, A. R., Syage, A., Minasyan, H., Le, M. T., Kawashita, T., Giedzinski, E., Parihar, V. K., et al. (2016) · Scientific Reports · doi:10.1038/srep31545 · Cited by 259 · see citing works
Arinuma, Y., Yanagida, T., & Hirohata, S. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23399 · Cited by 252 · see citing works
Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression
Ohrui, T., Tomita, N., Satoh‐Nakagawa, T., Matsui, T., Maruyama, M., Niwa, K., Arai, H., & Sasaki, H. (2004) · Neurology · doi:10.1212/01.wnl.0000140705.23869.e9 · Cited by 246 · see citing works
Neuropsychiatric events in systemic lupus erythematosus: attribution and clinical significance.
Hanly, J. G., McCurdy, G., Fougere, L., Douglas, J.-A., & Thompson, K. J. (2004) · PubMed · Cited by 236 · see citing works
Microglial repopulation resolves inflammation and promotes brain recovery after injury: RICE et al.
Rice, R. A., Pham, J., Lee, R. J., Najafi, A. R., West, B. L., & Green, K. N. (2017) · Glia · doi:10.1002/glia.23135 · Cited by 228 · see citing works
Savaskan, E., Höck, C., Olivieri, G., Bruttel, S., Rosenberg, C., Hulette, C., & Müller-Spahn, F. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00259-1 · Cited by 217 · see citing works
Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS
Rodríguez‐Pallares, J., Rey, P., Parga, J. A., Muñoz, A., Guerra, M. J., & Labandeira-García, J. L. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.03.003 · Cited by 212 · see citing works
Antihypertensive drugs decrease risk of Alzheimer disease
Yaşar, S., Xia, J., Yao, W., Furberg, C. D., Xue, Q., Mercado, C. I., Fitzpatrick, A. L., Fried, L. P., Kawas, C. H., Sink, K. M., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a35228 · Cited by 212 · see citing works
Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms
Faust, T. W., Chang, E. H., Kowal, C., Berlin, R., Gazaryan, I. G., Bertini, E., Zhang, J., Sánchez‐Guerrero, J., Fragoso-Loyo, H. E., Volpe, B. T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006980107 · Cited by 205 · see citing works
HMGB1 Mediates Cognitive Impairment in Sepsis Survivors
Chavan, S. S., Huerta, P. T., Robbiati, S. F., Valdés‐Ferrer, S. I., Ochani, M., Dancho, M. E., Frankfurt, M., Volpe, B. T., Tracey, K. J., & Diamond, B. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00195 · Cited by 199 · see citing works
Kim, J., Lim, C., Yu, Y., & Lee, J.-K. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21555 · Cited by 199 · see citing works
Putterman, C., & Diamond, B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.1.29 · Cited by 191 · see citing works
C1q and HMGB1 reciprocally regulate human macrophage polarization
Son, M., Porat, A., He, M., Suurmond, J., Santiago‐Schwarz, F., Andersson, U., Coleman, T. R., Volpe, B. T., Tracey, K. J., Al‐Abed, Y., et al. (2016) · Blood · doi:10.1182/blood-2016-05-719757 · Cited by 177 · see citing works
Balosso, S., Liu, J., Bianchi, M. E., & Vezzani, A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5349 · Cited by 161 · see citing works
Dong, Y., Kataoka, K., Tokutomi, Y., Nako, H., Nakamura, T., Toyama, K., Sueta, D., Koibuchi, N., Yamamoto, E., Ogawa, H., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-182873 · Cited by 142 · see citing works
Noda, M., Kariura, Y., Pannasch, U., Nishikawa, K., Wang, L., Seike, T., Ifuku, M., Kosai, Y., Wang, B., Nolte, C., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04339.x · Cited by 130 · see citing works
Hippocampal Neurophysiology in the Behaving Animal
John, O. (2006) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195100273.003.0011 · Cited by 121 · see citing works
Feldman, P., Due, M. R., Ripsch, M. S., Khanna, R., & White, F. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-180 · Cited by 114 · see citing works
Chang, E. H., Volpe, B. T., Mackay, M. C., Aranow, C. B., Watson, P., Kowal, C., Storbeck, J., Mattis, P. J., Berlin, R., Chen, H., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.05.027 · Cited by 84 · see citing works
Ó’Caoimh, R., Healy, L. O., Gao, Y., Svendrovski, A., Kerins, D. M., Eustace, J. A., Kehoe, P. G., Guyatt, G. H., & Molloy, D. W. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131694 · Cited by 80 · see citing works
Soto, M. E., van Kan, G. A., Nourhashémi, F., Guyonnet, S., Cesari, M., Cantet, C., Rolland, Y., & Vellas, B. J. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12415 · Cited by 80 · see citing works
Zhuang, S., Wang, H., Wang, X., Li, J., & Xing, C.-M. (2016) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2016.02.036 · Cited by 75 · see citing works
Sun, H. B., Wu, H., Yu, X., Zhang, G., Zhang, R., Zhan, S., Wang, H., Bu, N., Ma, X., & Li, Y. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.02.014 · Cited by 65 · see citing works
Torika, N., Asraf, K., Roasso, E., Danon, A., & Fleisher‐Berkovich, S. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9703-8 · Cited by 63 · see citing works
Recent advances in the understanding of microglial development and homeostasis
Low, D., & Ginhoux, F. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.004 · Cited by 54 · see citing works
Hajjar, I. M., Keown, M., Lewis, P., & Almor, A. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507309803 · Cited by 52 · see citing works
Pedrazzi, M., Averna, M., Sparatore, B., Patrone, M., Salamino, F., Marcoli, M., Maura, G., Cervetto, C., Frattaroli, D., Pontremoli, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044518 · Cited by 51 · see citing works
de Oliveira, F. F., Chen, E., Smith, M. D. A. C., & Bertolucci, P. H. F. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666171016101816 · Cited by 51 · see citing works
Parsa, A., Peden, E. A., Lum, R. F., Seligman, V. A., Olson, J. L., Li, H., Seldin, M. F., & Criswell, L. A. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363907 · Cited by 50 · see citing works
Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies
Asraf, K., Torika, N., Apte, R. N., & Fleisher‐Berkovich, S. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00116 · Cited by 46 · see citing works
Female mouse fetal loss mediated by maternal autoantibody
Wang, L., Zhou, D., Lee, J., Niu, H., Faust, T. W., Frattini, S., Kowal, C., Huerta, P. T., Volpe, B. T., & Diamond, B. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20111986 · Cited by 44 · see citing works
de Oliveira, F. F., Bertolucci, P. H. F., Chen, E., & Smith, M. D. A. C. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132189 · Cited by 43 · see citing works
T Cell Studies in a Peptide-Induced Model of Systemic Lupus Erythematosus
Khalil, M., Inaba, K., Steinman, R. M., Ravetch, J. V., & Diamond, B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1667 · Cited by 40 · see citing works
Abbas, D., Ezzat, Y., Hamdy, E., & Gamil, M. (2011) · Lupus · doi:10.1177/0961203311418268 · Cited by 36 · see citing works
Seliga, A., Lee, M. H., Fernandes, N. C., Zuluaga‐Ramirez, V., Didukh, M., Persidsky, Y., Potula, R., Gallucci, S., & Sriram, U. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00156 · Cited by 36 · see citing works
Involvement of the Bradykinin B1 Receptor in Microglial Activation: In Vitro and In Vivo Studies
Asraf, K., Torika, N., Danon, A., & Fleisher‐Berkovich, S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00082 · Cited by 33 · see citing works
Lee, Y. H., Choi, S. J., Ji, J. D., & Song, G. G. (2012) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320312459979 · Cited by 13 · see citing works
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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
Immunoneuropsychiatry — novel perspectives on brain disorders
Pape, K., Tamouza, R., Leboyer, M., & Zipp, F. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0174-4 · Cited by 455 · see citing works
Neuropsychiatric lupus: new mechanistic insights and future treatment directions
Schwartz, N., Stock, A. D., & Putterman, C. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0156-8 · Cited by 441 · see citing works
New insights into the role of antinuclear antibodies in systemic lupus erythematosus
Pisetsky, D. S., & Lipsky, P. E. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0480-7 · Cited by 311 · see citing works
Nikolopoulos, D., Manolakou, T., Polissidis, A., Filia, A., Bertsias, G. K., Koutmani, Y., & Boumpas, D. T. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-223506 · Cited by 121 · see citing works
The management of neuropsychiatric lupus in the 21st century: still so many unmet needs?
Govoni, M., & Hanly, J. G. (2020) · Rheumatology · doi:10.1093/rheumatology/keaa404 · Cited by 112 · see citing works
Endres, D., Leypoldt, F., Bechter, K., Hasan, A., Steiner, J. H., Domschke, K., Wandinger, K., Falkai, P., Arolt, V., Stich, O., et al. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01113-2 · Cited by 109 · see citing works
Complement-Mediated Events in Alzheimer’s Disease: Mechanisms and Potential Therapeutic Targets
Tenner, A. J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901068 · Cited by 99 · see citing works
Microglia responses to interleukin‐6 and type I interferons in neuroinflammatory disease
West, P. K., Viengkhou, B., Campbell, I. L., & Hofer, M. J. (2019) · Glia · doi:10.1002/glia.23634 · Cited by 97 · see citing works
Bohlson, S. S., & Tenner, A. J. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-035639 · Cited by 101 · see citing works
Han, X., Xu, T., Ding, C., Wang, D., Yao, G., Chen, H., Fang, Q., Hu, G., & Sun, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00867-y · Cited by 89 · see citing works
Kamintsky, L., Beyea, S., Fisk, J., Hashmi, J., Omisade, A., Calkin, C., Bardouille, T., Bowen, C., Quraan, M., Mitnitski, A., et al. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2020-218004 · Cited by 69 · see citing works
The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease
Bonham, L. W., Sirkis, D. W., & Yokoyama, J. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01170 · Cited by 83 · see citing works
From Systemic Inflammation to Neuroinflammation: The Case of Neurolupus
Bendorius, M., Po, C., Muller, S., & Jeltsch‐David, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113588 · Cited by 96 · see citing works
Seet, D., Allameen, N. A., Tay, S. H., Cho, J., & Mak, A. (2021) · Rheumatology and Therapy · doi:10.1007/s40744-021-00312-0 · Cited by 80 · see citing works
Dong, X., Fan, J., Lin, D., Wang, X., Kuang, H., Gong, L., Chen, C., Jiang, J., Xia, N., He, D., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02587-8 · Cited by 79 · see citing works
Moore, E., Huang, M. W., & Putterman, C. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000682 · Cited by 78 · see citing works
Reconstruction of Cell-type-Specific Interactomes at Single-Cell Resolution
Mohammadi, S., Davila-Velderrain, J., & Kellis, M. (2019) · Cell Systems · doi:10.1016/j.cels.2019.10.007 · Cited by 73 · see citing works
Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy
Rajchgot, T., Thomas, S. C., Wang, J.-C., Ahmadi, M., Balood, M., Crosson, T., Dias, J. P., Couture, R., Claing, A., & Talbot, S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00025 · Cited by 72 · see citing works
Cognitive dysfunction in autoimmune rheumatic diseases
Oláh, C., Schwartz, N., Denton, C. P., Kardos, Z., Putterman, C., & Szekanecz, Z. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02180-5 · Cited by 72 · see citing works
Pathogenesis and treatment of neuropsychiatric systemic lupus erythematosus: A review
Liu, Y., Tu, Z., Zhang, X., Du, K., Xie, Z., & Lin, Z. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.998328 · Cited by 71 · see citing works
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Kello, N., Anderson, E., & Diamond, B. (2019) · Arthritis & Rheumatology · doi:10.1002/art.40933 · Cited by 71 · see citing works
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Lu, L., Wang, H., Liu, X., Tan, L., Qiao, X., Ni, J., Sun, Y., Liang, J., Hou, Y., & Dou, H. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02279-9 · Cited by 63 · see citing works
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Chan, K., Nestor, J., Huerta, T. S., Certain, N., Moody, G. R., Kowal, C., Huerta, P. T., Volpe, B. T., Diamond, B., & Wollmuth, L. P. (2020) · Nature Communications · doi:10.1038/s41467-020-15224-w · Cited by 57 · see citing works
Exploring the Impact of ACE Inhibition in Immunity and Disease
Oosthuizen, D., & Sturrock, E. D. (2022) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1155/2022/9028969 · Cited by 51 · see citing works
Diversity of neuropsychiatric manifestations in systemic lupus erythematosus
Fujieda, Y. (2020) · Immunological Medicine · doi:10.1080/25785826.2020.1770947 · Cited by 52 · see citing works
What's New in the Treatment of Systemic Lupus Erythematosus
Liossis, S. C., & Staveri, C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.655100 · Cited by 47 · see citing works
Makinde, H. M., Winter, D. R., Procissi, D., Mike, E. V., Stock, A. D., Kando, M. J., Gadhvi, G. T., Droho, S., Bloomfield, C. L., Dominguez, S. T., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00230 · Cited by 45 · see citing works
Alarmins in autoimmune diseases
Danieli, M. G., Antonelli, E., Piga, M. A., Claudi, I., Palmeri, D., Tonacci, A., Allegra, A., & Gangemi, S. (2022) · Autoimmunity Reviews · doi:10.1016/j.autrev.2022.103142 · Cited by 45 · see citing works
Understanding the contextual functions of C1q and LAIR-1 and their applications
Son, M. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00774-4 · Cited by 42 · see citing works
Cognitive dysfunction in SLE: An understudied clinical manifestation
Mizrachi, M., Anderson, E., Carroll, K. R., Tehrani, N., Volpe, B. T., & Diamond, B. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102911 · Cited by 38 · see citing works
Carroll, K. R., Mizrachi, M., Simmons, S., Toz, B., Kowal, C., Wingard, J., Tehrani, N., Zarfeshani, A., Kello, N., Khoury, L. E., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01772-6 · Cited by 36 · see citing works
The diverse and complex modes of action of anti-NMDA receptor autoantibodies
Wollmuth, L. P., Chan, K., & Groc, L. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108624 · Cited by 37 · see citing works
Chan, C. K. W., Szeto, C., Lee, L. K. C., Xiao, Y., Yin, B., Ding, X., Lee, T. W. Y., Lau, J. Y. W., & Choi, C. H. J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2305662120 · Cited by 35 · see citing works
Progress in the Pathogenesis and Treatment of Neuropsychiatric Systemic Lupus Erythematosus
Wang, Q., Wang, Z., Zhang, S., Wu, Y., Zhang, L., Zhao, J., Wang, Q., Tian, X., Li, M., & Zeng, X. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11174955 · Cited by 34 · see citing works
Hippocampal microglia CD40 mediates NPSLE cognitive dysfunction in mice
Qiao, X., Wang, H., Li, L., Chen, J., Cheng, Q., Guo, M., Hou, Y., & Dou, H. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577620 · Cited by 32 · see citing works
Galectins in the brain: advances in neuroinflammation, neuroprotection and therapeutic opportunities
Barake, F., Soza, A., & González, A. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000812 · Cited by 32 · see citing works
Nocito, C., Lubinsky, C., Hand, M., Khan, S., Patel, T., Seliga, A., Winfield, M., Zuluaga‐Ramirez, V., Fernandes, N. C., Shi, X., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573677 · Cited by 32 · see citing works
Update on the pathogenesis of central nervous system lupus
Nikolopoulos, D., Fanouriakis, A., & Boumpas, D. T. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000655 · Cited by 33 · see citing works
Gao, L., Slack, M. A., McDavid, A., Anolik, J. H., & Looney, R. J. (2019) · Current Rheumatology Reports · doi:10.1007/s11926-019-0800-6 · Cited by 29 · see citing works
Nikolopoulos, D., Fanouriakis, A., & Bertsias, G. K. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1899810 · Cited by 29 · see citing works
Ruggieri, E., Domenico, E. D., Locatelli, A. G., Isopo, F., Damanti, S., LORENZO, R. D., Milan, E., Musco, G., Rovere, P. Q., Cenci, S., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102550 · Cited by 27 · see citing works
Wahane, S., & Sofroniew, M. V. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03487-8 · Cited by 25 · see citing works
Lü, L., Liu, X., Fu, J., Liang, J., Hou, Y., & Dou, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-10973-8 · Cited by 26 · see citing works
Abe, N., Tarumi, M., Fujieda, Y., Takahashi, N., Karino, K., Uchida, M., Kono, M., Tanaka, Y., Hasebe, R., Kato, M., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-222566 · Cited by 26 · see citing works
Sim, T. M., Mak, A., & Tay, S. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.957303 · Cited by 24 · see citing works
Microglia orchestrate synaptic and neuronal stripping: Implication in neuropsychiatric lupus
Zhou, Y., Chen, L., Zheng, X., Fang, Q., Qian, Y., Xu, T., Liang, J., Zhang, H., Han, X., & Sun, L. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18190 · Cited by 23 · see citing works
Soto, M., Delatorre, N., Hurst, C., & Rodgers, K. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01572 · Cited by 22 · see citing works
Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse
Gaboriaud, C., Lorvellec, M., Rossi, V., Dumestre‐Pérard, C., & Thielens, N. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.869720 · Cited by 23 · see citing works
Shiwaku, H., Katayama, S., Gao, M., Kondo, K., Nakano, Y., Motokawa, Y., Toyoda, S., Yoshida, F., Hori, H., Kubota, T., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.03.028 · Cited by 20 · see citing works
Polis, B., Cuda, C. M., & Putterman, C. (2024) · Autoimmunity · doi:10.1080/08916934.2024.2330387 · Cited by 19 · see citing works
Mader, S., Brimberg, L., Vo, A., Strohl, J. J., Crawford, J. M., Bonnin, A., Carrión, J., Campbell, D., Huerta, T. S., Bella, A. L., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abe9726 · Cited by 19 · see citing works
Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-α
West, P. K., Viengkhou, B., Campbell, I. L., & Hofer, M. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1036799 · Cited by 19 · see citing works
Silvagni, E., Inglese, F., Bortoluzzi, A., Borrelli, M., Goeman, J. J., Revenaz, A., Groppo, E., Steup‐Beekman, G. M., Huizinga, T. W. J., Ronen, I., et al. (2020) · Lara D. Veeken · doi:10.1093/rheumatology/keaa677 · Cited by 18 · see citing works
Cognitive Impairment in SLE: Mechanisms and Therapeutic Approaches
Zarfeshani, A., Carroll, K. R., Volpe, B. T., & Diamond, B. (2021) · Current Rheumatology Reports · doi:10.1007/s11926-021-00992-1 · Cited by 17 · see citing works
Bagnall-Moreau, C., Huerta, P. T., Comoletti, D., Bella, A. L., Berlin, R., Zhao, C., Volpe, B. T., Diamond, B., & Brimberg, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-71201-9 · Cited by 18 · see citing works
Karino, K., Kono, M., Takeyama, S., Kudo, Y., Kanda, M., Abe, N., Aso, K., Fujieda, Y., Kato, M., Oku, K., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42352 · Cited by 17 · see citing works
Type I interferons in health and disease: molecular aspects and clinical implications
Mavragani, C. P., & Crow, M. K. (2025) · Physiological Reviews · doi:10.1152/physrev.00047.2024 · Cited by 15 · see citing works
Neuropsychiatric lupus erythematosus: Focusing on autoantibodies
Wang, J., Xu, J., & Yang, P. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102892 · Cited by 16 · see citing works
Ding, X., Yang, W., Ren, Q., Hu, J., Shen, Y., Han, W., Wang, J., Wang, X., & Wang, H. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01839-9 · Cited by 14 · see citing works
Role of F-18 FDG PET-CT in neuropsychiatric systemic lupus erythematosus
Berndorfler, B. D., Warwick, J., & Doruyter, A. (2024) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2024.152480 · Cited by 13 · see citing works
Persistent inflammatory states and their implications in brain disease
Valdés‐Ferrer, S. I., Benkendorff, A., & Sankowski, R. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000809 · Cited by 13 · see citing works
Hanly, J. G., & İnanç, M. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.117419 · Cited by 13 · see citing works
Neuropsychiatric disorders: An immunological perspective
Aw, E., Zhang, Y., Yalçın, E., Herrmann, U., & Carroll, M. C. (2021) · Advances in immunology · doi:10.1016/bs.ai.2021.09.002 · Cited by 13 · see citing works
Cognitive dysfunction in systemic lupus erythematosus: how do we advance our understanding?
Raghunath, S., Glikmann‐Johnston, Y., Hanly, J. G., Morand, E. F., Stout, J. C., & Hoi, A. Y.-B. (2022) · The Lancet Rheumatology · doi:10.1016/s2665-9913(21)00331-3 · Cited by 13 · see citing works
DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity
Ramesh, R., Sundaresh, A., Rajkumar, R. P., Negi, V. S., Vijayalakshmi, M. A., Krishnamoorthy, R., Tamouza, R., Leboyer, M., & Kamalanathan, A. S. (2021) · Schizophrenia · doi:10.1038/s41537-021-00143-6 · Cited by 13 · see citing works
Hurst, C., Soto, M., Vina, E. R., & Rodgers, K. E. (2022) · The American Journal of Medicine · doi:10.1016/j.amjmed.2022.11.016 · Cited by 12 · see citing works
Espinoza, S., Arredondo, S. B., Barake, F., Carvajal, F. J., Guerrero, F. G., Segovia‐Miranda, F., Valenzuela, D. M., Wyneken, Ú., Rojas‐Fernández, A., Cerpa, W. F., et al. (2020) · BMC Biology · doi:10.1186/s12915-020-00877-2 · Cited by 12 · see citing works
Promise and complexity of lupus mouse models
Moore, E., Reynolds, J. A., Davidson, A., Gallucci, S., Morel, L. M., Rao, D. A., Young, H. A., & Putterman, C. (2021) · Nature Immunology · doi:10.1038/s41590-021-00914-4 · Cited by 12 · see citing works
Kammeyer, R., Ogbu, E. A., Cooper, J. C., Stolz, E. R., Piquet, A. L., Fuhlbrigge, R. C., Bennett, J. L., & Hutaff-Lee, C. F. (2023) · Child Neuropsychology · doi:10.1080/09297049.2023.2273573 · Cited by 11 · see citing works
Castellazzi, M., Candeloro, R., Pugliatti, M., Govoni, M., Silvagni, E., & Bortoluzzi, A. (2024) · Diagnostics · doi:10.3390/diagnostics14030242 · Cited by 13 · see citing works
Nikolopoulos, D., Sentis, G., Kitsios, I., Garantziotis, P., Kapsala, N., Pieta, A., Flouda, S., Manolakou, T., Nikoloudaki, M., Banos, A., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.04.006 · Cited by 10 · see citing works
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Ünal, D., Çam, V., Emreol, H. E., & Özen, S. (2024) · Pediatric Drugs · doi:10.1007/s40272-024-00632-y · Cited by 9 · see citing works
Weissman-Tsukamoto, R., Carroll, K. R., & Diamond, B. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.101981 · Cited by 9 · see citing works
Xu, J., Yang, C., Zeng, S., Wang, X., Yang, P., & Qin, L. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02832-8 · Cited by 9 · see citing works
Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
Ramos, A., Ishizuka, K., Hayashida, A., Namkung, H., Hayes, L. N., Srivastava, R., Zhang, M., Kariya, T., Elkins, N., Palen, T., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02553-1 · Cited by 9 · see citing works
Vitale, F., Ortolan, J., Volpe, B. T., Marambaud, P., Giliberto, L., & d’Abramo, C. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01003-7 · Cited by 8 · see citing works
Back to the Future: The Role of Infections in Psychopathology. Focus on OCD.
Vecchia, A. D., & Marazziti, D. (2022) · PubMed Central · doi:10.36131/cnfioritieditore20220407 · Cited by 10 · see citing works
Lindblom, J., Barturen, G., Beretta, L., Dominguez, D. T., Carnero‐Montoro, E., Borghi, M. O., Castillo, J., Iacobaeus, E., Enman, Y., Pers, J., et al. (2025) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2025.100296 · Cited by 8 · see citing works
Neuroimmune mechanisms of neuropsychiatric systemic lupus erythematosus
Lin, S. L., & Carroll, M. C. (2025) · Current Opinion in Immunology · doi:10.1016/j.coi.2025.102608 · Cited by 8 · see citing works
Wang, X., Feng, D., Ke, Y., Gu, L., Lv, C., Zhang, M., Wang, Q., & Wang, Y. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s359698 · Cited by 8 · see citing works
Arinuma, Y., & Yamaoka, K. (2020) · Immunological Medicine · doi:10.1080/25785826.2020.1791401 · Cited by 8 · see citing works
Bhoj, P. S., Nocito, C., Togre, N. S., Winfield, M., Lubinsky, C., Khan, S., Mogadala, N., Seliga, A., Unterwald, E. M., Persidsky, Y., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810080 · Cited by 7 · see citing works
Dobrowolski, C., Barraclough, M. L., Su, J., Tanic, M., Bingham, K. S., Ruttan, L., Beaton, D., Wither, J., Tartaglia, M. C., Sano, M. C., et al. (2023) · Lupus Science & Medicine · doi:10.1136/lupus-2023-000923 · Cited by 7 · see citing works
Li, R.-X., Han, R., Wu, G., Han, F., & Gao, J. (2020) · Marine Drugs · doi:10.3390/md18060306 · Cited by 7 · see citing works
New Insights Into Systemic Lupus Erythematosus Therapies
Wang, D. H., & Wallace, D. J. (2020) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000001603 · Cited by 7 · see citing works
Sobel, R. A., Eaton, M. J., Jaju, P. D., Lowry, E. A., & Hinojoza, J. R. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlz058 · Cited by 7 · see citing works
Pain in systemic lupus erythematosus: emerging insights and paradigms
Pisetsky, D. S., Eudy, A. M., Rogers, J. L., Ji, R., Martucci, K. T., Svensson, C. I., & Lipsky, P. E. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01290-1 · Cited by 7 · see citing works
The Correlation between Two Angiotensin-Converting Enzyme Inhibitor’s Concentrations and Cognition
Nagy, A. C., Majer, R. L., Csikai, E., Dobos, A., Süvegh, G., & Csiba, L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192114375 · Cited by 6 · see citing works
Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL/6 background
Li, Y., Zhang, S., Tang, C., Yang, B., Atrooz, F., Ren, Z., Mohan, C., Salim, S., & Wu, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1370254 · Cited by 5 · see citing works
Han, X., Wang, D., Chen, L., Song, H., Zheng, X., Zhang, X., Zhao, S., Liang, J., Xu, T., Hu, Z., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.181885 · Cited by 5 · see citing works
ACE inhibitors preserve cognitive function
McHugh, J. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0102-9 · Cited by 5 · see citing works
Barake, F., Bravo‐Zehnder, M., & González, A. (2022) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001054 · Cited by 5 · see citing works
Díaz-Valdivia, N., Labarca, M., Retamal, C., Espinoza, S., Venegas, J., Catenaccio, A., de la Peña, A., Ricca, M., Jara, C., Cortés-Díaz, D., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01339-7 · Cited by 4 · see citing works
Butler, H. M., Zehntner, M. E., & Beusecum, J. P. V. (2026) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-026-10753-z · Cited by 4 · see citing works
Using the Mouse to Model Human Diseases: Cognitive Impairment in Systemic Lupus Erythematosus
Khoury, L. E., Zarfeshani, A., & Diamond, B. (2020) · The Journal of Rheumatology · doi:10.3899/jrheum.200410 · Cited by 4 · see citing works
Formal neurocognitive function and anti-N-methyl-D-aspartate receptor antibodies in paediatric lupus
Nowling, T. K., Kral, M. C., Wolf, B. J., Gilkeson, G. S., & Ruth, N. M. (2021) · Lupus Science & Medicine · doi:10.1136/lupus-2020-000462 · Cited by 4 · see citing works
- Authors
- Nestor, J., Arinuma, Y., Huerta, T. S., Kowal, C., Nasiri, E., Kello, N., Fujieda, Y., Bialas, A., Hammond, T., Sriram, U., Stevens, B., Huerta, P. T., Volpe, B. T., & Diamond, B.
- Affiliations
- Feinstein Institute for Medical Research (US)
- Kitasato University (JP)
- Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 1
- Hokkaido University (JP)
- Boston Children's Hospital (US)
- Temple University (US)
- Corresponding author
- Diamond, Betty
- ORCID
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2018-09-05
- Volume
- 215
- Issue
- 10
- Pages
- 2554-2566
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC6170183
- OpenAlex
- W2889875251
- Cited by
- 146
- References
- 61
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 20 · 2023: 12 · 2022: 28 · 2021: 20 · 2020: 30 · 2019: 12 · 2018: 3
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NIH P01AI073693, NIH R03-AR065157)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Keywords
- systemic lupus erythematosus, anti-DNA antibodies, NMDA receptor, excitotoxicity, microglial activation, C1q, spatial memory impairment, cognitive impairment, ACE inhibitors, neuronal injury, autoantibodies
- MeSH terms
- Angiotensin-Converting Enzyme Inhibitors, Animals, Antibodies, Antinuclear, Autoantibodies, Brain, Female, Lupus Erythematosus, Systemic, Memory Disorders, Mice, Inbred BALB C, Neurons, Receptors, N-Methyl-D-Aspartate, Microglia, Mice
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