The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Transforming growth factor–β in tissue fibrosis
Open accessAbstract
TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-β, some fibrogenic actions may reflect activation of other cell types, including macrophages, epithelial cells, and vascular cells. TGF-β–driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks. This review discusses the role of TGF-β in fibrosis, highlighting mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic translation.
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Cites
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
Macrophages in Tissue Repair, Regeneration, and Fibrosis
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SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
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Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
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Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites
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“Although investigations in both animal models and human patients have identified “fibrocytes” as mesenchymal cells derived from circulating monocyte precursors (Abe et al., 2001; Reilkoff et al., 2011), their contribution to the fibrotic process remains poorly documented.”
BackgroundPerivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.004 · Cited by 922 · cited 1×
“Studies in both animal models of fibrosis and human patients suggested that activated myofibroblasts in fibrotic lesions may be derived, at least in part, from activated perivascular cells (Sava et al., 2017; Kramann et al., 2015; Dulauroy et al., 2012).”
Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis
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Cited by
Frangogiannis, N. G. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa324 · Cited by 1,229
Self-citationSARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
Wendisch, D., Dietrich, O., Mari, T., von Stillfried, S., Ibarra, I. L., Mittermaier, M., Mache, C., Chua, R. L., Knoll, R., Timm, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.033 · Cited by 528
Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer
Buechler, M. B., Fu, W., & Turley, S. J. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.021 · Cited by 494
TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities
Budi, E. H., Schaub, J. R., Decaris, M., Turner, S., & Derynck, R. (2021) · The Journal of Pathology · doi:10.1002/path.5680 · Cited by 292
Savin, I. A., Zenkova, M. A., & Sen’kova, A. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314959 · Cited by 279
Metadata
- Authors
- Frangogiannis, N. G.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2020-02-20
- Volume
- 217
- Issue
- 3
- Pages
- e20190103-e20190103
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W3007757041
- Cited by
- 1,278
- References
- 22
- FWCI
- 19.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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