Cited by 1,486Neutrophil, Myeloperoxidase and Oxidative MechanismsCOVID-19 Clinical Research StudiesInflammation biomarkers and pathways

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Targeting potential drivers of COVID-19: Neutrophil extracellular traps

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Barnes, Betsy J., Adrover, Jose M., Baxter-Stoltzfus, Amelia, Borczuk, Alain, Cools-Lartigue, Jonathan, Crawford, James M., Daßler-Plenker, Juliane, Guerci, Philippe, Huynh, Caroline, Knight, Jason S., Loda, Massimo, Looney, Mark R., McAllister, Florencia, Rayes, Roni, Renaud, Stephane, Rousseau, Simon, Salvatore, Steven, Schwartz, Robert E., Spicer, Jonathan D., Yost, Christian C., Weber, Andrew, Zuo, Yu, Egeblad, Mikala·2020·Journal of Experimental Medicine

DOI 10.1084/jem.20200652PMC PMC7161085

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Abstract

Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10–15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils—the ability to form neutrophil extracellular traps (NETs)—may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.

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Schön, M. P., Berking, C., Biedermann, T., Buhl, T., Erpenbeck, L., Eyerich, K., Eyerich, S., Ghoreschi, K., Goebeler, M., Ludwig, R. J., et al. (2020) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.14169_g · Cited by 28
Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution
Ong, E. Z., Kalimuddin, S., Chia, W. C., Ooi, S. H., Koh, C. W., Tan, H. C., Zhang, S. L.-X., Low, J. G. H., Ooi, E. E., & Chan, K. R. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103262 · Cited by 25
Cancer and Covid-19: Collectively catastrophic
du Plessis, M., Fourie, C., Riedemann, J., de Villiers, W. J. S., & Engelbrecht, A. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.10.005 · Cited by 31
Colchicine Is Safe Though Ineffective in the Treatment of Severe COVID-19: a Randomized Clinical Trial (COLCHIVID)
Absalón‐Aguilar, A., Rull‐Gabayet, M., Pérez‐Fragoso, A., Mejía‐Domínguez, N. R., Núñez‐Álvarez, C. A., Kershenobich, D., Sifuentes‐Osornio, J., Ponce‐de‐León, A., González‐Lara, F., Martín‐Nares, E., et al. (2021) · Journal of General Internal Medicine · doi:10.1007/s11606-021-07203-8 · Cited by 28
Emerging Role of Platelet-Endothelium Interactions in the Pathogenesis of Severe SARS-CoV-2 Infection-Associated Myocardial Injury
Rossouw, T. M., Anderson, R., Manga, P., & Feldman, C. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.776861 · Cited by 27
Coagulopathy and Fibrinolytic Pathophysiology in COVID-19 and SARS-CoV-2 Vaccination
Yamada, S., & Asakura, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063338 · Cited by 33
New-onset dermatomyositis following COVID-19: A case report
Shimizu, H., Matsumoto, H., Sasajima, T., Suzuki, T., Okubo, Y., Fujita, Y., Temmoku, J., Yoshida, S., Asano, T., Ohira, H., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1002329 · Cited by 27
A Web of Challenges: The Therapeutic Struggle to Target NETs in Disease
Espiritu, A., & O’Sullivan, K. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104773 · Cited by 30
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Seheult, J. N., Seshadri, A. J., & Neal, M. D. (2020) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2020.05.021 · Cited by 26
Host/genetic factors associated with COVID-19 call for precision medicine
Thierry, A. R. (2020) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbaa026 · Cited by 26
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Farooqi, F. I., Morgan, R. C., Dhawan, N., Dinh, J., Yatzkan, G. D., & Michel, G. (2020) · American Journal of Case Reports · doi:10.12659/ajcr.926596 · Cited by 26
No Small Matter: A Perspective on Nanotechnology-Enabled Solutions to Fight COVID-19
Jones, G. W., Monopoli, M. P., Campagnolo, L., Pietroiusti, A., Tran, L., & Fadeel, B. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0286 · Cited by 28
Clinical characteristics of moderate and severe cases with COVID-19 in Wuhan, China: a retrospective study
Sheng, L., Wang, X., Tang, N., Meng, F., Huang, L., & Li, D. (2020) · Clinical and Experimental Medicine · doi:10.1007/s10238-020-00662-z · Cited by 26
Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor
Agarwal, S., Pethani, J. P., Shah, H. A., Vyas, V., Sasane, S., Bhavsar, H., Bandyopadhyay, D., Giri, P., Viswanathan, K., Jain, M. R., et al. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127571 · Cited by 26
The SARS-CoV-2 induced targeted amino acid profiling in patients at hospitalized and convalescent stage
Wu, J., Zhao, M., Li, C., Zhang, Y., & Wang, D. W. (2021) · Bioscience Reports · doi:10.1042/bsr20204201 · Cited by 25
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19
Ding, J., Hostallero, D. E., Khili, M. R. E., Fonseca, G. J., Milette, S., Noorah, N. B., Guay-Belzile, M., Spicer, J. D., Daneshtalab, N., Sirois, M. G., et al. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008810 · Cited by 26
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Mazzitelli, I. G., Bleichmar, L., Ludueña, G., Pisarevsky, A. A., Labato, M. I., Chiaradia, V., Finocchietto, P. V., Paulín, F., Hormanstorfer, M., Baretto, M. C., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab174 · Cited by 26
Mood Disorders and Outcomes of COVID-19 Hospitalizations
Castro, V. M., Gunning, F. M., McCoy, T. H., & Perlis, R. H. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20060842 · Cited by 31
Neutrophil subsets and their differential roles in viral respiratory diseases
Zhang, Y., Wang, Q., Mackay, C. R., Ng, L. G., & Kwok, I. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.1mr1221-345r · Cited by 26
Hamsters Expressing Human Angiotensin-Converting Enzyme 2 Develop Severe Disease following Exposure to SARS-CoV-2
Golden, J. W., Li, R., Cline, C. R., Zeng, X., Mucker, E. M., Fuentes-Lao, A. J., Spik, K. W., Williams, J. A., Twenhafel, N. A., Davis, N., et al. (2022) · mBio · doi:10.1128/mbio.02906-21 · Cited by 27
Impact of Toll-Like Receptor 2 and 9 Gene Polymorphisms on COVID-19: Susceptibility, Severity, and Thrombosis
Alhabibi, A. M., Hassan, A. S., Elbaky, N. M. A., Eid, H. A., Khalifa, M. A. A. A., Wahab, M. A. A., Althoqapy, A. A., Abdou, A. E.-S., Zakaria, D. M., Nassef, E. M., et al. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s394927 · Cited by 26
Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives
Soltani‐Zangbar, M. S., Parhizkar, F., Abdollahi, M., Shomali, N., Maleki, L. A., Farid, S. S., Roshangar, L., Mahmoodpoor, A., & Yousefi, M. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00948-7 · Cited by 25
DNase I targeted degradation of neutrophil extracellular traps to reduce the damage on IgAV rat
Chen, X.-Q., Tu, L., Tang, Q., Zou, J.-S., Yun, X., & Qin, Y.-H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291592 · Cited by 25
naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation
Bork, F., Greve, C. L., Youn, C., Chen, S., Leal, V. N. C., Wang, Y., Fischer, B., Nasri, M., Focken, J., Scheurer, J., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00150-5 · Cited by 25
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Diamond, B. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201000 · Cited by 25
Blood myeloperoxidase‐DNA, a biomarker of early response to SARS‐CoV‐2 infection?
Guéant, J., Fromonot, J., Guéant‐Rodriguez, R., Lacolley, P. J., Guieu, R., & Regnault, V. (2020) · Allergy · doi:10.1111/all.14533 · Cited by 25
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Horowitz, N. A., & Brenner, B. (2020) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0040-1714275 · Cited by 25
Understanding Viral Infection Mechanisms and Patient Symptoms for the Development of COVID-19 Therapeutics
Choi, H. M., Moon, S. Y., Yang, H.-I., & Kim, K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041737 · Cited by 28

Authors: Barnes, B. J., Adrover, J. M., Baxter-Stoltzfus, A., Borczuk, A., Cools-Lartigue, J., Crawford, J. M., Daßler-Plenker, J., Guerci, P., Huynh, C., Knight, J. S., Loda, M., Looney, M. R., McAllister, F., Rayes, R., Renaud, S., Rousseau, S., Salvatore, S., Schwartz, R. E., Spicer, J. D., Yost, C. C., Weber, A., Zuo, Y., & Egeblad, M.
Affiliations: Feinstein Institute for Medical Research (US)
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 2
Weill Cornell Medicine (US)
Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada 4
Hofstra University (US)
Centre Hospitalier Régional et Universitaire de Nancy (FR)
McGill University (CA)
University of Michigan (US)
University of California, San Francisco (US)
The University of Texas MD Anderson Cancer Center (US)
Centre Hospitalier Universitaire de Nancy, Nancy, France 6
Research Institute of the McGill University Health Centre (CA)
University of Utah (US)
Northwell Health (US)
Cold Spring Harbor Laboratory (US)
Corresponding author: Barnes, Betsy J.
Egeblad, Mikala
ORCID: Barnes, Betsy J.
Baxter-Stoltzfus, Amelia
Borczuk, Alain
Crawford, James M.
Guerci, Philippe
Huynh, Caroline
Knight, Jason S.
Loda, Massimo
Looney, Mark R.
McAllister, Florencia
Rayes, Roni
Rousseau, Simon
Salvatore, Steven
Schwartz, Robert E.
Spicer, Jonathan D.
Yost, Christian C.
Weber, Andrew
Zuo, Yu
Egeblad, Mikala
Venue: Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 2020-04-16
Volume: 217
Issue: 6
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.20200652
PMC: PMC7161085
OpenAlex: W3016393661
Cited by: 1,486
References: 84
Citations by year: 2026: 34 · 2025: 70 · 2024: 124 · 2023: 150 · 2022: 288 · 2021: 438 · 2020: 378
FWCI: 110.17
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
www.rupress.org/terms/ (vor)
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 227 d)
Locations: The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
eScholarship@McGill (McGill) (submittedVersion)
Funders: National Institutes of Health (5p30ca045508-35)
National Heart, Lung, and Blood Institute (R01HL130324, R01HL134846)
National Cancer Institute (P30-CA045508)
National Institute of Allergy and Infectious Diseases (R01AI125445)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK121072)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR076242)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD093826)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: COVID-19 pandemic, neutrophil extracellular traps, neutrophils, acute respiratory distress syndrome, cytokine storm, lung infiltration, organ damage, thrombosis, airway mucus secretion, targeted drug delivery, autopsy findings
MeSH terms: Betacoronavirus, COVID-19, SARS-CoV-2, Humans, Lung Diseases, Neutrophils, Pneumonia, Viral, Cytokines, Coronavirus Infections, Pandemics, Extracellular Traps

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Targeting potential drivers of COVID-19: Neutrophil extracellular traps

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