Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
Open accessAbstract
Cholangiocarcinoma (CCA) results from the malignant transformation of cholangiocytes. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are chronic diseases in which cholangiocytes are primarily damaged. Although PSC is an inflammatory condition predisposing to CCA, CCA is almost never found in the autoimmune context of PBC. Here, we hypothesized that PBC might favor CCA immunosurveillance. In preclinical murine models of cholangitis challenged with syngeneic CCA, PBC (but not PSC) reduced the frequency of CCA development and delayed tumor growth kinetics. This PBC-related effect appeared specific to CCA as it was not observed against other cancers, including hepatocellular carcinoma. The protective effect of PBC was relying on type 1 and type 2 T cell responses and, to a lesser extent, on B cells. Single-cell TCR/RNA sequencing revealed the existence of TCR clonotypes shared between the liver and CCA tumor of a PBC host. Altogether, these results evidence a mechanistic overlapping between autoimmunity and cancer immunosurveillance in the biliary tract.
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Patients with PSC, fluke infections, and MASLD have an increased risk of cholangiocarcinoma, whereas patients with PBC have a relatively lower risk.
“Patients with PSC, fluke infections, and MASLD have an increased risk of cholangiocarcinoma, whereas patients with PBC have a relatively lower risk [208, 209].”
From Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells (2025) · cites this paper as [208]
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Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
Alraies, Z., Rivera, C. A., Delgado, M.-G., Sanséau, D., Maurin, M., Amadio, R., Maria Piperno, G., Dunsmore, G., Yatim, A., Lacerda Mariano, L., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01856-3 · Cited by 106 · see citing works
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- Authors
- Paillet, J., Plantureux, C., Lévesque, S., Le Naour, J., Stoll, G., Sauvat, A., Caudana, P., Tosello Boari, J., Bloy, N., Lachkar, S., Martins, I., Opolon, P., Checcoli, A., Delaune, A., Robil, N., de la Grange, P., Hamroune, J., Letourneur, F., Autret, G., Leung, P. S. C., Gershwin, M. E., Zhu, J. S., Kurth, M. J., Lekbaby, B., Augustin, J., Kim, Y., Gujar, S., Coulouarn, C., Fouassier, L., Zitvogel, L., Piaggio, E., Housset, C., Soussan, P., Maiuri, M. C., Kroemer, G., & Pol, J. G.
- Affiliations
- Inserm (FR)
- Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France 1
- Institut Curie, Paris Sciences et Lettres Research University, Institut National de la Santé et de la Recherche Médicale U932, Paris, France 4
- Institut Gustave Roussy (FR)
- GenoSplice Technology, Paris, France 8
- Université de Paris, Paris Cardiovascular Research Centre, Institut National de la Santé et de la Recherche Médicale U970, Paris, France 10
- University of California, Davis (US)
- Dalhousie University (CA)
- Institut Curie (FR)
- Karolinska University Hospital (SE)
- Corresponding author
- Kroemer, Guido
- ORCID
- Paillet, Juliette
- Plantureux, Céleste
- Lévesque, Sarah
- Le Naour, Julie
- Stoll, Gautier
- Sauvat, Allan
- Caudana, Pamela
- Tosello Boari, Jimena
- Bloy, Norma
- Lachkar, Sylvie
- Martins, Isabelle
- Opolon, Paule
- Checcoli, Andrea
- Delaune, Agathe
- Robil, Noémie
- de la Grange, Pierre
- Hamroune, Juliette
- Letourneur, Franck
- Autret, Gwennhael
- Leung, Patrick S.C.
- Gershwin, M. Eric
- Zhu, Jie S.
- Kurth, Mark J.
- Lekbaby, Bouchra
- Augustin, Jérémy
- Kim, Youra
- Gujar, Shashi
- Coulouarn, Cédric
- Fouassier, Laura
- Zitvogel, Laurence
- Piaggio, Eliane
- Housset, Chantal
- Soussan, Patrick
- Maiuri, Maria Chiara
- Kroemer, Guido
- Pol, Jonathan G.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2021-09-08
- Volume
- 218
- Issue
- 10
- Pages
- 1-33
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC8429038
- OpenAlex
- W3197804636
- Cited by
- 41
- References
- 118
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 9 · 2023: 9 · 2022: 5 · 2021: 2
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-sa)
- Funders
- Association pour la lutte contre les maladies inflammatoires du foie et des voies biliaires
- Dalhousie Medical Research Foundation
- Canadian Cancer Society
- Canadian Institutes of Health Research
- Association Française d'Hépatologie
- Site de Recherche intégrée sur le Cancer Cancer Research and Personalized Medicine
- Seerave Foundation
- Institut National du Cancer
- Ligue contre le Cancer
- Agence National de la Recherche
- ERA-Net for Research on Rare Diseases
- Association pour la recherche sur le cancer
- Cancéropôle Ile-de-France
- Chancellerie des universités de Paris
- Fondation pour la Recherche Médicale
- Elior
- European Research Area Network on Cardiovascular Diseases
- Gustave Roussy Odyssea
- European Union Horizon 2020
- Project Oncobiome
- Fondation Carrefour
- High-end Foreign Expert Program in China (GDW20171100085, GDW20181100051)
- Inserm
- Institut Universitaire de France
- LeDucq Foundation
- LabEx
- Recherche Hospitalo-Universitaire Torino Lumière
- Site de Recherche intégrée sur le Cancer Stratified Oncology Cell DNA Repair and Tumor Immune Elimination
- Cancer Research and Personalized Medicine
- Multi-Organism Institute (ITMO) Aviesan Cancer
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Keywords
- cholangiocarcinoma, primary biliary cirrhosis, primary sclerosing cholangitis, autoimmunity, tumor surveillance, T cell response, TCR clonotypes, B cells, hepatocellular carcinoma, cholangiocytes, tumor growth kinetics
- MeSH terms
- Animals, Bile Duct Neoplasms, Cholangitis, Female, Liver, Mice, Inbred C57BL, Neoplasms, Experimental, Monitoring, Immunologic, CD4-Positive T-Lymphocytes, Autoimmunity, Cytokines, Cholangiocarcinoma, CD8-Positive T-Lymphocytes, Cell Line, Tumor, Mice, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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