Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

Le Bert, Nina; Clapham, Hannah E.; Tan, Anthony T.; Chia, Wan Ni; Tham, Christine Y.L.; Lim, Jane M.; Kunasegaran, Kamini; Tan, Linda Wei Lin; Dutertre, Charles-Antoine; Shankar, Nivedita; Lim, Joey M.E.; Sun, Louisa Jin; Zahari, Marina; Tun, Zaw Myo; Kumar, Vishakha; Lim, Beng Lee; Lim, Siew Hoon; Chia, Adeline; Tan, Yee-Joo; Tambyah, Paul Anantharajah; Kalimuddin, Shirin; Lye, David; Low, Jenny G.H.; Wang, Lin-Fa; Wan, Wei Yee; Hsu, Li Yang; Bertoletti, Antonio; Tam, Clarence C.

doi:10.1084/jem.20202617

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between antiviral and inflammatory features. SARS-CoV-2–specific T cells in individuals who clear SARS-CoV-2 without symptoms could reveal nonpathological yet protective characteristics. We longitudinally studied…