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Cited by 373

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Treatment of Potentially Life-Threatening Enterovirus Infections with Pleconaril

Rotbart, H. A., Webster, A. D., for the Pleconaril Treatment Registry Group·2001·Clinical Infectious Diseases
DOI 10.1086/318452
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Abstract

Enteroviruses usually cause self-limited disease that, although associated with high morbidity, is rarely fatal. In certain patient populations, however, the enteroviruses may cause potentially life-threatening infections. Pleconaril is a novel compound that integrates into the capsid of picornaviruses, including enteroviruses and rhinoviruses, preventing the virus from attaching to cellular receptors and uncoating to release RNA into the cell. Pleconaril was used on a compassionate-release basis to treat patients with potentially life-threatening enterovirus infections, and for 38 of these patients sufficient follow-up data were available for determining responses to therapy. Response was evaluated in 4 categories: clinical, virological, laboratory, and radiological. Most patients (28 [78%] of 36), including 12 of 16 with chronic enterovirus meningoencephalitis, were judged to have a clinical response temporally associated with pleconaril therapy. Similarly, nearly all patients whose virological responses (12 [92%] of 13), laboratory responses (14 [88%] of 16), and radiological responses (3 [60%] of 5) could be evaluated were judged to have responded favorably to a course of pleconaril treatment. Adverse effects were minimal and the drug was generally well-tolerated.

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Metadata

Authors
Rotbart, H. A., Webster, A. D., & for the Pleconaril Treatment Registry Group
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2001-01-15
Volume
32
Issue
2
Pages
228-235
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/318452
OpenAlex
W2082290107
Cited by
373
References
0
FWCI
19.05
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.