Cited by 105Viral Infections and Immunology Researchinterferon and immune responsesMosquito-borne diseases and control

Fluoxetine is a potent inhibitor of coxsackievirus replication

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Zuo, Jun, Quinn, Kevin K., Kye, Steve, Cooper, Paige, Damoiseaux, Robert, Krogstad, Paul·2012·Antimicrobial Agents and Chemotherapy

Abstract

No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life threatening. Molecular screening of small molecule libraries identified fluoxetine, a selective serotonin reuptake inhibitor, as a potent inhibitor of coxsackievirus replication. Fluoxetine did not interfere with either viral entry or translation of the viral genome. Instead, fluoxetine and its metabolite norfluoxetine markedly reduced the synthesis of viral RNA and protein. In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections.

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  1. [14]14. Fry EE, Stuart DI. 2010. Virion structure, p 59–72 In Ehrenfeld DE, Roos RP. (ed), The picornaviruses. ASM Press, Washington, DC [Google Scholar]
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Authors
Zuo, J., Quinn, K. K., Kye, S., Cooper, P., Damoiseaux, R., & Krogstad, P.
Affiliations
  • University of California, Los Angeles (US)
  • California NanoSystems Institute (US)
Venue
Antimicrobial Agents and Chemotherapy
Published
2012-09
Volume
56
Issue
9
Pages
4838-4844
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
OpenAlex
W2131952231
Cited by
104
References
49
Citations by year
2026: 8 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 17 · 2021: 14 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 1 · 2016: 8 · 2015: 8 · 2014: 5 · 2013: 2
FWCI
3.09
Type
journal article
Language
en
Open access
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Food and Drug Administration
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
Keywords
fluoxetine, Coxsackie virus, enterovirus infection, antiviral agents, viral RNA synthesis, norfluoxetine, selective serotonin reuptake inhibitors, small molecule screening, viral replication inhibition
MeSH terms
Antidepressive Agents, Antiviral Agents, Enterovirus, Fluoxetine, HeLa Cells, Humans, RNA, Viral, Transfection, Virus Replication, Genes, Reporter, Inhibitory Concentration 50, Green Fluorescent Proteins, Small Molecule Libraries, High-Throughput Screening Assays

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