Fluoxetine is a potent inhibitor of coxsackievirus replication
Open accessAbstract
No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life threatening. Molecular screening of small molecule libraries identified fluoxetine, a selective serotonin reuptake inhibitor, as a potent inhibitor of coxsackievirus replication. Fluoxetine did not interfere with either viral entry or translation of the viral genome. Instead, fluoxetine and its metabolite norfluoxetine markedly reduced the synthesis of viral RNA and protein. In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections.
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Fluoxetine inhibits viral RNA and proteins of Coxsackievirus.
“Indeed, this drug was able to inhibit the viral RNA and proteins of Coxsackievirus [66].”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [66]
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- Authors
- Zuo, J., Quinn, K. K., Kye, S., Cooper, P., Damoiseaux, R., & Krogstad, P.
- Affiliations
- University of California, Los Angeles (US)
- California NanoSystems Institute (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2012-09
- Volume
- 56
- Issue
- 9
- Pages
- 4838-4844
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC3421851
- OpenAlex
- W2131952231
- Cited by
- 104
- References
- 49
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 17 · 2021: 14 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 1 · 2016: 8 · 2015: 8 · 2014: 5 · 2013: 2
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Food and Drug Administration
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Keywords
- fluoxetine, Coxsackie virus, enterovirus infection, antiviral agents, viral RNA synthesis, norfluoxetine, selective serotonin reuptake inhibitors, small molecule screening, viral replication inhibition
- MeSH terms
- Antidepressive Agents, Antiviral Agents, Enterovirus, Fluoxetine, HeLa Cells, Humans, RNA, Viral, Transfection, Virus Replication, Genes, Reporter, Inhibitory Concentration 50, Green Fluorescent Proteins, Small Molecule Libraries, High-Throughput Screening Assays
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