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Cited by 451Antifungal resistance and susceptibilityAcute Kidney Injury ResearchFungal Infections and Studies

Mortality and Costs of Acute Renal Failure Associated with Amphotericin B Therapy

Bates, D. W., Su, L., Yu, D. T., Chertow, G. M., Seger, D. L., Gomes, D. R. J., Dasbach, E. J., Platt, R.·2001·Clinical Infectious Diseases
DOI 10.1086/319211
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Abstract

To assess the mortality and resource utilization that results from acute renal failure associated with amphotericin B therapy, 707 adult admissions in which parenteral amphotericin B therapy was given were studied at a tertiary-care hospital. Main outcome measures were mortality, length of stay, and costs; we controlled for potential confounders, including age, sex, insurance status, baseline creatinine level, length of stay before beginning amphotericin B therapy, and severity of illness. Among 707 admissions, there were 212 episodes (30%) of acute renal failure. When renal failure developed, the mortality rate was much higher: 54% versus 16% (adjusted odds of death, 6.6). When acute renal failure occurred, the mean adjusted increase in length of stay was 8.2 days, and the adjusted total cost was $29,823. Although residual confounding exists despite adjustment, the increases in resource utilization that we found are large and the associated mortality is high when acute renal failure occurs following amphotericin B therapy.

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Crossref · 10.1086/319211

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  • Data show that amphotericin B-induced nephrotoxicity may be associated with an up to 6.6-fold increase in mortality.

    “However, data showing that amphotericin B-induced nephrotoxicity may be associated with an up to 6.6-fold increase in mortality [80] makes consideration of initial use of lipid-associated amphotericin B appropriate for individuals who are at high risk of being intolerant of amphotericin B deoxycholate”

    From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [80]

  • Consideration of initial use of lipid-associated amphotericin B is appropriate for individuals at high risk of being intolerant of amphotericin B deoxycholate.

    “However, data showing that amphotericin B-induced nephrotoxicity may be associated with an up to 6.6-fold increase in mortality [80] makes consideration of initial use of lipid-associated amphotericin B appropriate for individuals who are at high risk of being intolerant of amphotericin B deoxycholate”

    From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [80]

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Authors
Bates, D. W., Su, L., Yu, D. T., Chertow, G. M., Seger, D. L., Gomes, D. R. J., Dasbach, E. J., & Platt, R.
Affiliations
  • Brigham and Women's Hospital (US)
  • Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
  • University of California, San Francisco (US)
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2001-03-01
Volume
32
Issue
5
Pages
686-693
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/319211
OpenAlex
W2085440534
Cited by
451
References
40
Citations by year
2026: 7 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 12 · 2021: 12 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 22 · 2016: 17 · 2015: 26 · 2014: 14 · 2013: 17 · 2012: 26
FWCI
14.56
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
acute kidney injury, amphotericin B, mortality, health care costs, length of hospital stay, resource utilization (health care), adverse drug reactions, antifungal therapy, hospitalized adults
MeSH terms
Adult, Amphotericin B, Antifungal Agents, Female, Hospitalization, Hospitals, Urban, Humans, Length of Stay, Male, Middle Aged, Retrospective Studies, Cohort Studies, Hospital Costs, Acute Kidney Injury

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