The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations
Open accessAbstract
Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt . However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance. Here, we provide conclusive evidence that mutant haplotypes of the pfcrt gene product of Asian, African, or South American origin confer chloroquine resistance with characteristic verapamil reversibility and reduced chloroquine accumulation. pfcrt mutations increased susceptibility to artemisinin and quinine and minimally affected amodiaquine activity; hence, these antimalarials warrant further investigation as agents to control chloroquine-resistant falciparum malaria.
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Self-citationA Molecular Marker for Chloroquine-Resistant Falciparum Malaria
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Self-citationPgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
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The structure of malaria pigment β-haematin
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Medical need, scientific opportunity and the drive for antimalarial drugs
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Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
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Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil
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Cited by
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Ariey, F., Witkowski, B., Amaratunga, C., Beghain, J., Langlois, A.-C., Khim, N., Kim, S., Duru, V., Bouchier, C., Ma, L., et al. (2014) · Nature · doi:10.1038/nature12876 · Cited by 2,090
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Kublin, J. G., Cortese, J. F., Njunju, E. M., G. Mukadam, R. A., Wirima, J. J., Kazembe, P. N., Djimdé, A. A., Kouriba, B., Taylor, T. E., & Plowe, C. V. (2003) · The Journal of Infectious Diseases · doi:10.1086/375419 · Cited by 508
Artemisinin Action and Resistance in Plasmodium falciparum
Tilley, L., Straimer, J., Gnädig, N. F., Ralph, S. A., & Fidock, D. A. (2016) · Trends in Parasitology · doi:10.1016/j.pt.2016.05.010 · Cited by 359
Self-citationMolecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
Wicht, K. J., Mok, S., & Fidock, D. A. (2020) · Annual Review of Microbiology · doi:10.1146/annurev-micro-020518-115546 · Cited by 322
Self-citation
Metadata
- Authors
- Sidhu, A. B. S., Verdier-Pinard, D., & Fidock, D. A.
- Venue
- Science
- Published
- 2002-10-04
- Volume
- 298
- Issue
- 5591
- Pages
- 210-213
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037350416
- Cited by
- 720
- References
- 29
- FWCI
- 31.32
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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