Recombinant Interferon‐γ1b as Adjunctive Therapy for AIDS‐Related Acute Cryptococcal Meningitis
Open accessAbstract
We conducted a phase 2, double-blind, placebo-controlled study to evaluate the safety and antifungal activity of adjuvant recombinant interferon (rIFN)- gamma 1b in patients with acquired immunodeficiency syndrome and acute cryptococcal meningitis. Patients received 100 or 200 microg of rIFN- gamma 1b or placebo, thrice weekly for 10 weeks, plus standard therapy with intravenous amphotericin B, with or without flucytosine, followed by therapy with fluconazole. End points included conversion of cerebrospinal fluid fungal cultures from positive to negative at 2 weeks, resolution of symptoms, and survival. Among 75 patients, 2-week culture conversion occurred in 13% of placebo recipients, 36% of rIFN- gamma 1b (100 microg) recipients, and 32% of rIFN- gamma 1b (200 microg) recipients. There was a trend toward improved combined mycologic and clinical success in rIFN- gamma 1b recipients (26% vs. 8%; P=.078). Therapy with rIFN- gamma 1b was well tolerated, and there was no apparent influence on serial CD4 cell counts and human immunodeficiency virus load measurements. Adjunctive therapy with rIFN- gamma 1b holds promise for patients with acute cryptococcal meningitis and warrants further study.
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Addition of adjuvant IFNγ to the standard of care enhanced fungal clearance from the cerebrospinal fluid with no reported increase in adverse effects in two phase II clinical trials.
“Two phase II clinical trials investigated the safety and efficacy of administering exogenous, recombinant IFNγ as a cryptococcal therapy and found that addition of adjuvant IFNγ to the standard of care enhanced fungal clearance from the cerebrospinal fluid with no reported increase in adverse effects124,125.”
From Treatment strategies for cryptococcal infection: challenges, advances and future outlook (2021) · cites this paper as [125]
Cites
Practice Guidelines for the Management of Cryptococcal Disease
Saag, M. S., Graybill, R. J., Larsen, R. A., Pappas, P. G., Perfect, J. R., Powderly, W. G., Sobel, J. D., Dismukes, W. E., & Mycoses Study Group Cryptococcal Subproject (2000) · Clinical Infectious Diseases · doi:10.1086/313757 · Cited by 1,101 · see citing works
Self-citationBennett, J. E., Dismukes, W. E., Duma, R. J., Medoff, G., Sande, M. A., Gallis, H. A., Leonard, J. M., Fields, B. T., Bradshaw, M. W., Haywood, H. B., et al. (1979) · New England Journal of Medicine · doi:10.1056/nejm197907193010303 · Cited by 861 · see citing works
A Controlled Trial of Interferon Gamma to Prevent Infection in Chronic Granulomatous Disease
The International Chronic Granulomatous Disease Cooperative Study Group* (1991) · New England Journal of Medicine · doi:10.1056/nejm199102213240801 · Cited by 830 · see citing works
Treatment of Cryptococcal Meningitis Associated with the Acquired Immunodeficiency Syndrome
van der Horst, C. M., Saag, M. S., Cloud, G. A., Hamill, R. J., Graybill, J. R., Sobel, J. D., Johnson, P. C., Tuazon, C. U., Kerkering, T. M., Moskovitz, B. L., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707033370103 · Cited by 808 · see citing works
Self-citationInfections withCryptococcus neoformansin the Acquired Immunodeficiency Syndrome
Chuck, S. L., & Sande, M. A. (1989) · New England Journal of Medicine · doi:10.1056/nejm198909213211205 · Cited by 801 · see citing works
Kaplan, J. E., Hanson, D. L., Dworkin, M. S., Frederick, T., Bertolli, J., Lindegren, M. L., Holmberg, S. D., & Jones, J. L. (2000) · Clinical Infectious Diseases · doi:10.1086/313843 · Cited by 703 · see citing works
HIV-associated neurologic disease incidence changes:
Sacktor, N., Lyles, R. H., Skolasky, R. L., Kleeberger, C. A., Selnes, O. A., Miller, E. N., Becker, J. T., Cohen, B. A., & McArthur, J. C. (2001) · Neurology · doi:10.1212/wnl.56.2.257 · Cited by 589 · see citing works
Dismukes, W. E., Cloud, G. A., Gallis, H. A., Kerkering, T. M., Medoff, G., Craven, P. C., Kaplowitz, L. G., Fisher, J. F., Gregg, C. R., Bowles, C. A., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708063170602 · Cited by 416 · see citing works
Cryptococcal Meningitis in Patients with AIDS
Dismukes, W. E. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/157.4.624 · Cited by 389 · see citing works
Nathan, C., Kaplan, G., Levis, W. R., Nusrat, A., Witmer, M. D., Sherwin, S. A., Job, C. K., Horowitz, C. R., Steinman, R. M., & Cohn, Z. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607033150102 · Cited by 323 · see citing works
Holland, S. M., Eisenstein, E. M., Kuhns, D. B., Turner, M. L. C., Fleisher, T. A., Strober, W., & Gallin, J. I. (1994) · New England Journal of Medicine · doi:10.1056/nejm199405123301904 · Cited by 302 · see citing works
Early Mycological Treatment Failure in AIDS‐Associated Cryptococcal Meningitis
Robinson, P. A., Bauer, M., Leal, M. A. E., Evans, S., Holtom, P. D., Diamond, D. M., Leedom, J. M., & Larsen, R. A. (1999) · Clinical Infectious Diseases · doi:10.1086/515074 · Cited by 159 · see citing works
Interferon-gamma and host antimicrobial defense: Current and future clinical applications
Murray, H. W. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90326-3 · Cited by 109 · see citing works
Kawakami, K., Tohyama, M., Teruya, K., Kudeken, N., Xie, Q., & Saitô, A. (1996) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1996.tb00225.x · Cited by 90 · see citing works
Enhancement of antifungal chemotherapy by interferon-gamma in experimental systemic cryptococcosis
Lutz, J. E. (2000) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/46.3.437 · Cited by 60 · see citing works
Joly, V., Saint-Julien, L., Carbon, C., & Yéni, P. (1994) · The Journal of Infectious Diseases · doi:10.1093/infdis/170.5.1331 · Cited by 58 · see citing works
Harms, G., Chehade, A. K., Douba, M., Roepke, M., Mouakeh, A., Rosenkaimer, F., & Bienzle, U. (1991) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(91)90026-u · Cited by 46 · see citing works
Herrmann, J., Dubois, N., Fourgeaud, M., Basset, D., & Lagrange, P. H. (1994) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/34.6.1051 · Cited by 37 · see citing works
Mulliez, P., Jaggi, F., Darras, A., Demory, J. L., & Smith, M. H. (2000) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hidden Killers: Human Fungal Infections
Brown, G. D., Denning, D. W., Gow, N. A. R., Levitz, S. M., Netea, M. G., & White, T. C. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004404 · Cited by 4,284 · see citing works
Perfect, J. R., Dismukes, W. E., Dromer, F., Goldman, D. L., Graybill, J. R., Hamill, R. J., Harrison, T. S., Larsen, R. A., Lortholary, O., Nguyen, M.-H., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/649858 · Cited by 2,660 · see citing works
Self-citationThe antifungal pipeline: a reality check
Perfect, J. R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.46 · Cited by 866 · see citing works
Maziarz, E. K., & Perfect, J. R. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.006 · Cited by 698 · see citing works
Resistance to Antifungal Agents: Mechanisms and Clinical Impact
Kanafani, Z. A., & Perfect, J. R. (2008) · Clinical Infectious Diseases · doi:10.1086/524071 · Cited by 619 · see citing works
LIMPER, A. H., Knox, K. S., Sarosi, G. A., Ampel, N. M., Bennett, J. E., Catanzaro, A., Davies, S. F., Dismukes, W. E., Hage, C. A., Marr, K. A., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2008-740st · Cited by 608 · see citing works
Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy
Williamson, P. R., Jarvis, J. N., Panackal, A. A., Fisher, M. C., Molloy, S. F., Loyse, A., & Harrison, T. S. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.167 · Cited by 479 · see citing works
Chayakulkeeree, M., & Perfect, J. R. (2006) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2006.07.001 · Cited by 396 · see citing works
Treatment strategies for cryptococcal infection: challenges, advances and future outlook
Iyer, K. R., Revie, N. M., Fu, C., Robbins, N., & Cowen, L. E. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00511-0 · Cited by 363 · see citing works
Bicanic, T. A., & Harrison, T. S. (2004) · British Medical Bulletin · doi:10.1093/bmb/ldh043 · Cited by 362 · see citing works
Chang, C. C., Harrison, T. S., Bicanic, T. A., Chayakulkeeree, M., Sorrell, T. C., Warris, A., Hagen, F., Spec, A., Oladele, R. O., Govender, N. P., et al. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(23)00731-4 · Cited by 339 · see citing works
Self-citationMiller, C. H. T., Maher, S. G., & Young, H. A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05069.x · Cited by 304 · see citing works
Jarvis, J. N., Meintjes, G., Rebe, K., Williams, G. N., Bicanic, T., Williams, A., Schutz, C., Bekker, L.-G., Wood, R., & Harrison, T. S. (2012) · AIDS · doi:10.1097/qad.0b013e3283536a93 · Cited by 290 · see citing works
Mousset, S., Buchheidt, D., Heinz, W., Ruhnke, M., Cornely, O. A., Egerer, G., Krüger, W., Link, H., Neumann, S., Ostermann, H., et al. (2013) · Annals of Hematology · doi:10.1007/s00277-013-1867-1 · Cited by 253 · see citing works
HIV-associated cryptococcal meningitis
Jarvis, J. N., & Harrison, T. S. (2007) · AIDS · doi:10.1097/qad.0b013e3282a4a64d · Cited by 252 · see citing works
Singh, N. R., Lortholary, O., Alexander, B. D., Gupta, K. L., John, G. T., Pursell, K. J., Munoz, P., Klintmalm, G. B. G., Stosor, V., Busto, R. D., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/430606 · Cited by 249 · see citing works
Bicanic, T., Muzoora, C., Brouwer, A. E., Meintjes, G., Longley, N., Taseera, K., Rebe, K., Loyse, A., Jarvis, J., Bekker, L., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/604716 · Cited by 227 · see citing works
Immune reconstitution syndrome associated with opportunistic mycoses
Singh, N., & Perfect, J. R. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70085-3 · Cited by 224 · see citing works
Long-term outcome of AIDS-associated cryptococcosis in the era of combination antiretroviral therapy
Lortholary, O., Poizat, G., Zeller, V., Neuville, S., Boibieux, A., Alvarez, M., Dellamonica, P., Botterel, F., Dromer, F., & Chêne, G. (2006) · AIDS · doi:10.1097/01.aids.0000252060.80704.68 · Cited by 197 · see citing works
Wormley, F. L., Perfect, J. R., Steele, C., & Cox, G. M. (2007) · Infection and Immunity · doi:10.1128/iai.00274-06 · Cited by 187 · see citing works
Chang, C. C., Crane, M., Zhou, J., Mina, M., Post, J. J., Cameron, B., Lloyd, A. R., Jaworowski, A., French, M. A., & Lewin, S. R. (2013) · Immunological Reviews · doi:10.1111/imr.12063 · Cited by 169 · see citing works
Paradoxical Immune Responses in Non-HIV Cryptococcal Meningitis
Panackal, A. A., Wuest, S. C., Lin, Y.-C., Wu, T., Zhang, N., Kosa, P., Komori, M., Blake, A., Browne, S. K., Rosen, L. B., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004884 · Cited by 162 · see citing works
Nami, S., Aghebati‐Maleki, A., Morovati, H., & Maleki, L. A. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.009 · Cited by 162 · see citing works
Geddes‐McAlister, J., & Shapiro, R. S. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13739 · Cited by 159 · see citing works
IFN-γ at the Site of Infection Determines Rate of Clearance of Infection in Cryptococcal Meningitis
Siddiqui, A. A., Brouwer, A. E., Wuthiekanun, V., Jaffar, S. S., Shattock, R. J., Irving, D., Sheldon, J., Chierakul, W., Peacock, S. J., Day, N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1746 · Cited by 146 · see citing works
Major Role for Amphotericin B–Flucytosine Combination in Severe Cryptococcosis
Dromer, F., Bernède‐Bauduin, C., Guillemot, D., Lortholary, O., & for the French Cryptococcosis Study Group (2008) · PLoS ONE · doi:10.1371/journal.pone.0002870 · Cited by 143 · see citing works
Immunocompromised Hosts: Immunopharmacology of Modern Antifungals
Ben‐Ami, R., Lewis, R. E., & Kontoyiannis, D. P. (2008) · Clinical Infectious Diseases · doi:10.1086/589290 · Cited by 140 · see citing works
Immunotherapeutic approaches to treatment of fungal diseases
Armstrong-James, D., Brown, G. D., Netea, M. G., Zelante, T., Gresnigt, M. S., van de Veerdonk, F. L., & Levitz, S. M. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30442-5 · Cited by 135 · see citing works
Cytokines and fungal infections
Antachopoulos, C., & Roilides, E. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05498.x · Cited by 131 · see citing works
Tugume, L., Ssebambulidde, K., Kasibante, J., Ellis, J. P., Wake, R. M., Gakuru, J., Lawrence, D. S., Abassi, M., Rajasingham, R., Meya, D. B., et al. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00472-z · Cited by 125 · see citing works
The Significance of Interferon-γ in HIV-1 Pathogenesis, Therapy, and Prophylaxis
Roff, S. R., Noon-Song, E. N., & Yamamoto, J. K. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00498 · Cited by 124 · see citing works
Böhme, A., Ruhnke, M., Buchheidt, D., Cornely, O. A., Einsele, H., Enzensberger, R., Hebart, H. F., Heinz, W., Junghanß, C., Karthaus, M., et al. (2008) · Annals of Hematology · doi:10.1007/s00277-008-0622-5 · Cited by 122 · see citing works
Antifungal Combination Therapy
Baddley, J. W., & Pappas, P. G. (2005) · Drugs · doi:10.2165/00003495-200565110-00002 · Cited by 119 · see citing works
Self-citationChapter 5 Virulence in Cryptococcus Species
Ma, H., & May, R. C. (2009) · Advances in applied microbiology · doi:10.1016/s0065-2164(08)01005-8 · Cited by 112 · see citing works
Immunomodulators as adjuvants for vaccines and antimicrobial therapy
Nicholls, E. F., Madera, L., & Hancock, R. E. W. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05787.x · Cited by 111 · see citing works
Immunotherapy for Fungal Infections
Segal, B. H., Kwon‐Chung, J., Walsh, T. J., Klein, B. S., Battiwalla, M., Almyroudis, N. G., Holland, S. M., & Romani, L. R. (2006) · Clinical Infectious Diseases · doi:10.1086/499811 · Cited by 110 · see citing works
Immunology of Cryptococcal Infections: Developing a Rational Approach to Patient Therapy
Elsegeiny, W. A. W., Marr, K. A., & Williamson, P. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00651 · Cited by 106 · see citing works
The Impact of the Host on Fungal Infections
Perfect, J. R. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.10.010 · Cited by 100 · see citing works
Netea, M. G., Brouwer, A. E., Hoogendoorn, E., van der Meer, J. W. M., Koolen, M. I., Verweij, P. E., & Kullberg, B. J. (2004) · Clinical Infectious Diseases · doi:10.1086/425121 · Cited by 100 · see citing works
Wozniak, K. L., Ravi, S., Macias, S., Young, M. L., Olszewski, M. A., Steele, C., & Wormley, F. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006854 · Cited by 99 · see citing works
Exogenous Interferon-γ Immunotherapy for Invasive Fungal Infections in Kidney Transplant Patients
Armstrong-James, D. P. H., Teo, I. A., Shrivastava, S., Petrou, M. A., Taube, D. H., Dorling, A., & Shaunak, S. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03094.x · Cited by 97 · see citing works
Cryptococcal therapies and drug targets: the old, the new and the promising
Coelho, C., & Casadevall, A. (2016) · Cellular Microbiology · doi:10.1111/cmi.12590 · Cited by 94 · see citing works
Chen, Y., Shi, Z. W., Strickland, A. B., & Shi, M. (2022) · Journal of Fungi · doi:10.3390/jof8101069 · Cited by 94 · see citing works
Siderophores: More than Stealing Iron
Behnsen, J., & Raffatellu, M. (2016) · mBio · doi:10.1128/mbio.01906-16 · Cited by 79 · see citing works
Chen, S. C., Sorrell, T. C., Chang, C. C., Paige, E. K., Bryant, P. A., & Slavin, M. A. (2014) · Internal Medicine Journal · doi:10.1111/imj.12597 · Cited by 78 · see citing works
The war on cryptococcosis: A Review of the antifungal arsenal
Mourad, A., & Perfect, J. R. (2018) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760170391 · Cited by 77 · see citing works
Adaptive Immunity to Cryptococcus neoformans Infections
Mukaremera, L., & Nielsen, K. (2017) · Journal of Fungi · doi:10.3390/jof3040064 · Cited by 75 · see citing works
New Approaches for Cryptococcosis Treatment
Spadari, C. D. C., Wirth, F., Lopes, L. B., & Ishida, K. (2020) · Microorganisms · doi:10.3390/microorganisms8040613 · Cited by 73 · see citing works
Dignani, M. C., Rex, J. H., Chan, K., Dow, G., Magalhaes-Silverman, M. D., Maddox, A., Walsh, T. J., & Anaissie, E. J. (2005) · Cancer · doi:10.1002/cncr.21142 · Cited by 69 · see citing works
Immunomodulation as Therapy for Fungal Infection: Are We Closer?
Sam, Q. H., Yew, W. S., Seneviratne, C. J., Chang, M. W., & Chai, L. Y. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01612 · Cited by 68 · see citing works
Treatment for HIV-associated cryptococcal meningitis
Tenforde, M. W., Shapiro, A. E., Rouse, B., Jarvis, J. N., Li, T., Eshun‐Wilson, I., & Ford, N. P. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005647.pub3 · Cited by 64 · see citing works
Present and Future Therapy of Cryptococcus Infections
Mourad, A., & Perfect, J. R. (2018) · Journal of Fungi · doi:10.3390/jof4030079 · Cited by 61 · see citing works
Cryptococcal Infections: Changing Epidemiology and Implications for Therapy
Hoz, R. M. L., & Pappas, P. G. (2013) · Drugs · doi:10.1007/s40265-013-0037-z · Cited by 59 · see citing works
Self-citationCombination antifungal therapy: a critical review of the evidence
Ostrosky‐Zeichner, L. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2008.01983.x · Cited by 59 · see citing works
Diagnosis and Management of Cryptococcal Relapse
Musubire, A. K. (2013) · Journal of AIDS & Clinical Research · doi:10.4172/2155-6113.s3-003 · Cited by 59 · see citing works
Keshwania, P., Kaur, N., Chauhan, J., Sharma, G., Afzal, O., Altamimi, A. S. A., & Almalki, W. H. (2023) · ACS Omega · doi:10.1021/acsomega.3c01988 · Cited by 57 · see citing works
Managing cryptococcosis in the immunocompromised host
Jarvis, J. N., Dromer, F., Harrison, T. S., & Lortholary, O. (2008) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e3283177f6c · Cited by 57 · see citing works
Immunotherapy of Cryptococcus infections
Antachopoulos, C., & Walsh, T. J. (2011) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03741.x · Cited by 55 · see citing works
Treatment of cryptococcal meningitis in resource limited settings
Sloan, D. J., Dedicoat, M. J., & Lalloo, D. G. (2009) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32832fa214 · Cited by 55 · see citing works
Cryptococcal meningoencephalitis: time for action
Stott, K. E., Loyse, A., Jarvis, J. N., Alufandika, M., Harrison, T. S., Mwandumba, H. C., Day, J., Lalloo, D. G., Bicanic, T. A., Perfect, J. R., et al. (2021) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30771-4 · Cited by 56 · see citing works
Chang, C. C., Lim, A. Y. F., Omarjee, S., Levitz, S. M., Gosnell, B. I., Spelman, T. D., Elliott, J., Carr, W. H., Moosa, M.-Y. S., Ndung’u, T., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit271 · Cited by 53 · see citing works
Thymosin Alpha 1 and HIV-1: Recent Advances and Future Perspectives
Matteucci, C., Grelli, S., Balestrieri, E., Minutolo, A., Argaw-Denboba, A., Macchi, B., Vallebona, P. S., Perno, C. F., Mastino, A., & Garaci, E. (2017) · Future Microbiology · doi:10.2217/fmb-2016-0125 · Cited by 51 · see citing works
Modulating host immune responses to fight invasive fungal infections
Scriven, J. E., Tenforde, M. W., Levitz, S. M., & Jarvis, J. N. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.10.018 · Cited by 51 · see citing works
Mora, D. J., Fortunato, L. R., Andrade-Silva, L. E., Paim, K. F., Rocha, I. H., Vasconcelos, R. R., Silva-Teixeira, D. N., Nascentes, G. A. N., & Silva-Vergara, M. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120297 · Cited by 50 · see citing works
Immunomodulators as an antimicrobial tool
Pirofski, L., & Casadevall, A. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.08.004 · Cited by 50 · see citing works
Panackal, A. A., Komori, M., Kosa, P. F., Khan, O. I., Hammoud, D. A., Rosen, L. B., Browne, S., Lin, Y.-C., Romm, E., Ramaprasad, C., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw739 · Cited by 49 · see citing works
Clinical implications of interferon‐γ genetic and epigenetic variants
Smith, N. L. D., & Denning, D. W. (2014) · Immunology · doi:10.1111/imm.12362 · Cited by 48 · see citing works
The Third Age of Antimicrobial Therapy
Casadevall, A. (2006) · Clinical Infectious Diseases · doi:10.1086/503431 · Cited by 48 · see citing works
Metcalf, S. C., & Dockrell, D. H. (2007) · Journal of Infection · doi:10.1016/j.jinf.2007.06.012 · Cited by 46 · see citing works
Adriaensen, W. J., Dorlo, T. P. C., Vanham, G., Kestens, L., Kaye, P. M., & van Griensven, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01943 · Cited by 46 · see citing works
Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections
Panackal, A. A., Williamson, K. C., van de Beek, D., Boulware, D. R., & Williamson, P. R. (2016) · mBio · doi:10.1128/mbio.01906-15 · Cited by 44 · see citing works
Phospholipase B Is Critical for Cryptococcus neoformans Survival in the Central Nervous System
Hamed, M. F., Araújo, G. R. D. S., Munzen, M. E., Reguera-Gómez, M., Epstein, C., Lee, H. H., Frasés, S., & Martinez, L. R. (2023) · mBio · doi:10.1128/mbio.02640-22 · Cited by 43 · see citing works
Chang, C. C., Hall, V. G., Cooper, C. M., Grigoriadis, G., Beardsley, J., Sorrell, T. C., & Heath, C. H. (2021) · Internal Medicine Journal · doi:10.1111/imj.15590 · Cited by 43 · see citing works
Update on therapeutic approaches for invasive fungal infections in adults
Boutin, C.-A., & Luong, M. (2024) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361231224980 · Cited by 43 · see citing works
Thoden, J., Potthoff, A. V., Bogner, J. R., Brockmeyer, N. H., Esser, S., Grabmeier‐Pfistershammer, K., Haas, B. J., Hahn, K., Härter, G., Hartmann, M., et al. (2013) · Infection · doi:10.1007/s15010-013-0504-1 · Cited by 40 · see citing works
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Stevens, D. A., Brummer, E., & Clemons, K. V. (2006) · The Journal of Infectious Diseases · doi:10.1086/505357 · Cited by 38 · see citing works
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Adjunctive immunotherapy with recombinant cytokines for the treatment of disseminated candidiasis
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Immunotherapy of Fungal Infections
Datta, K., & Hamad, M. A. (2015) · Immunological Investigations · doi:10.3109/08820139.2015.1093913 · Cited by 33 · see citing works
Williamson, P. R. (2016) · Macrophage · doi:10.14800/macrophage.1078 · Cited by 31 · see citing works
Louis, I. V.-S., Chang, C. C., Shahid, S. M. A., French, M. A., & Bohjanen, P. R. (2018) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy157 · Cited by 31 · see citing works
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Armstrong-James, D. P. H., & Harrison, T. S. (2012) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.06.001 · Cited by 31 · see citing works
How I Treat Cryptococcosis in Organ Transplant Recipients
Singh, N. (2011) · Transplantation · doi:10.1097/tp.0b013e318236cd1a · Cited by 30 · see citing works
Chamilos, G., & Kontoyiannis, D. P. (2006) · Current Opinion in Infectious Diseases · doi:10.1097/01.qco.0000235166.16421.e5 · Cited by 30 · see citing works
Gamaletsou, M. N., Sipsas, N. V., Kontoyiannis, D. P., Tsiakalos, A., Kontos, A. N., Stefanou, I., & Kordossis, T. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.08.009 · Cited by 29 · see citing works
Cryptococcal meningitis in AIDS
Spec, A., & Powderly, W. G. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63849-6.00011-6 · Cited by 29 · see citing works
Clemons, K. V., & Stevens, D. A. (2006) · Current Opinion in Infectious Diseases · doi:10.1097/01.qco.0000235163.70678.59 · Cited by 29 · see citing works
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Beardsley, J., Dao, A., Keighley, C., Garnham, K., Halliday, C. L., Chen, S. C.-A., & Sorrell, T. C. (2022) · Journal of Fungi · doi:10.3390/jof9010041 · Cited by 26 · see citing works
Liu, T., Subbian, S., Pan, W., Eugenín, E. A., Xie, J., & Xue, C. (2014) · Cell Communication and Signaling · doi:10.1186/s12964-014-0051-0 · Cited by 26 · see citing works
Kullberg, B. J., van de Veerdonk, F. L., & Netea, M. G. (2014) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000105 · Cited by 26 · see citing works
Summers, S., Dorling, A., Boyle, J., & Shaunak, S. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.00947.x · Cited by 24 · see citing works
Immune Modulators as Adjuncts for the Prevention and Treatment of Invasive Fungal Infections
Pikman, R., & Ben‐Ami, R. (2012) · Immunotherapy · doi:10.2217/imt.12.127 · Cited by 24 · see citing works
Wormley, F. L., Cox, G. M., & Perfect, J. R. (2005) · Microbial Pathogenesis · doi:10.1016/j.micpath.2004.12.007 · Cited by 23 · see citing works
Treatment of cryptococcal meningitis in Peruvian AIDS Patients using amphotericin B and fluconazole
Dammert, P., Bustamante, B., Ticona, E., Llanos‐Cuentas, A., Huaroto, L., Chávez, V., & Campos, P. E. (2008) · Journal of Infection · doi:10.1016/j.jinf.2008.06.020 · Cited by 22 · see citing works
Self-citationFungal Molecular Pathogenesis: What Can It Do and Why Do We Need It?
Perfect, J. R., & Casadevall, A. (2014) · ASM Press eBooks · doi:10.1128/9781555815776.ch1 · Cited by 23 · see citing works
- Authors
- Pappas, P. G., Bustamante, B., Ticona, E., Hamill, R. J., Johnson, P. C., Reboli, A., Aberg, J., Hasbun, R., & Hsu, H. H.
- Affiliations
- University of Alabama at Birmingham (US)
- Universidad Peruana Cayetano Heredia (PE)
- Hospital Nacional Dos de Mayo (PE)
- Baylor University (US)
- Cooper University Hospital (US)
- Washington University in St. Louis (US)
- Tulane University (US)
- Corresponding author
- Pappas, Peter G.
- ORCID
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-06-15
- Volume
- 189
- Issue
- 12
- Pages
- 2185-2191
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2084004341
- Cited by
- 202
- References
- 19
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 7 · 2018: 13 · 2017: 11 · 2016: 11 · 2015: 8 · 2014: 19 · 2013: 7 · 2012: 7
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Universidad Peruana Cayetano Heredia Institutional Repository (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- cryptococcal meningitis, AIDS, adjunctive antifungal therapy, amphotericin B, 5-fluorocytosine, fluconazole, CD4 count, HIV viral load, drug safety
- MeSH terms
- Acute Disease, Adult, Aged, Aged, 80 and over, Antifungal Agents, Antiviral Agents, Cerebrospinal Fluid, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Injections, Subcutaneous, Interferon-gamma, Male, Middle Aged, Recombinant Proteins, HIV-1, HIV Infections, Treatment Outcome, Meningitis, Cryptococcal, AIDS-Related Opportunistic Infections
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