Declining Rates of Oropharyngeal Candidiasis and Carriage of Candida albicans Associated with Trends Toward Reduced Rates of Carriage of Fluconazole‐Resistant C. albicans in Human Immunodeficiency Virus –Infected Patients

Martins, Marcelo D.; Lozano‐Chiu, Mario; Rex, John H.

doi:10.1086/515006

Cited by 103Antifungal resistance and susceptibilityHIV/AIDS oral health manifestationsOcular Infections and Treatments

Declining Rates of Oropharyngeal Candidiasis and Carriage of Candida albicans Associated with Trends Toward Reduced Rates of Carriage of Fluconazole‐Resistant C. albicans in Human Immunodeficiency Virus –Infected Patients

Martins, Marcelo D., Lozano‐Chiu, Mario, Rex, John H.·1998·Clinical Infectious Diseases

DOI 10.1086/515006

Open this paper in CoChat — free account

Abstract

In order to determine the current prevalence and incidence of fluconazole-resistant oropharyngeal candidiasis among human immunodeficiency virus (HIV)-infected patients, we conducted a prospective observational study of a consecutive series of HIV-infected patients. Of 128 enrolled patients, 70 patients completed four quarterly follow-up visits over a period of 1 year. Over this period, declining rates of carriage of Candida albicans (from 61% to 39%; P = .008) and of oropharyngeal candidiasis (from 30% to 4%; P < .001) were documented. Trends toward reduction in the frequency of fluconazole-resistant isolates (MIC, > or = 64 micrograms/mL) were also seen. During the survey period, the mean (median) number of antiretroviral agents used per patient rose from 0.5 (0) to 1.8 (2) (P < .001). Thus, rather than progression, we observed declining rates of oropharyngeal candidiasis, C. albicans carriage, and fluconazole-resistant C. albicans in a cohort of HIV-infected patients treated with increasingly effective antiretroviral therapy.

Integrity signals

Registry

Crossref · 10.1086/515006

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In North American oral candidiasis (HIV/AIDS-positive) patients, the prevalence of fluconazole-resistant C. albicans isolates was found to be between 12% and 22%.
“This has occurred with greatest frequency in the setting of patients suffering from HIV/AIDS during treatment for oropharyngeal candidiasis, where the prevalence of fluconazole-resistant C. albicans isolates in North American oral candidiasis (HIV/AIDS-positive) patients was found to be between 12% and 22%.38–42”
From Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungusCandida albicans (2020) · cites this paper as [38]

A Trial Comparing Nucleoside Monotherapy with Combination Therapy in HIV-Infected Adults with CD4 Cell Counts from 200 to 500 per Cubic Millimeter
Hammer, S. M., Katzenstein, D. A., Hughes, M. D., Gundacker, H. M., Schooley, R. T., Haubrich, R., Henry, W. K., Lederman, M. M., Phair, J., Niu, M. T., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610103351501 · Cited by 1,075 · see citing works
Resistance of Candida species to fluconazole
Rex, J. H., Rinaldi, M. G., & Pfaller, M. A. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.1.1 · Cited by 879 · see citing works
Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals
Sullivan, D. J., Haynes, K. A., Bennett, D. E., Coleman, D. C., & Westerneng, T. J. (1995) · Microbiology · doi:10.1099/13500872-141-7-1507 · Cited by 763 · see citing works
Antiretroviral Therapy for HIV Infection in 1997
Carpenter, C. C. J. (1997) · JAMA · doi:10.1001/jama.1997.03540480062040 · Cited by 730 · see citing works
HIV-1 protease inhibitors. A review for clinicians
Deeks, S. G. (1997) · JAMA · doi:10.1001/jama.277.2.145 · Cited by 686 · see citing works
Antiretroviral Therapy for HIV Infection
Moyle, G. J., Gazzard, B., Cooper, D. A., & Gatell, J. M. (1998) · Drugs · doi:10.2165/00003495-199855030-00005 · Cited by 538 · see citing works
Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals
Darbyshire, J. H. (1996) · The Lancet · doi:10.1016/s0140-6736(96)05387-1 · Cited by 514 · see citing works
Epidemiology of oral candidiasis in HIV-infected patients: colonization, infection, treatment, and emergence of fluconazole resistance
Sangeorzan, J. A., Bradley, S. F., He, X., Zarins, L. T., Ridenour, G. L., Tiballi, R. N., & Kauffman, C. A. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90300-x · Cited by 322 · see citing works
Antiretroviral therapy for HIV infection in 1997. Updated recommendations of the International AIDS Society-USA panel
Carpenter, C. C. J. (1997) · JAMA · doi:10.1001/jama.277.24.1962 · Cited by 278 · see citing works
Candidiasis
Coleman, D. C., Sullivan, D. J., Bennett, D. E., Moran, G. P., Barry, H., & Shanley, D. B. (1997) · AIDS · doi:10.1097/00002030-199705000-00002 · Cited by 224 · see citing works
Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype
Millon, L., Manteaux, A., Reboux, G., Drobacheff, C., Monod, M., Barale, T., & Michel-Briand, Y. (1994) · Journal of Clinical Microbiology · doi:10.1128/jcm.32.4.1115-1118.1994 · Cited by 205 · see citing works
Widespread geographic distribution of oral Candida dubliniensis strains in human immunodeficiency virus-infected individuals
Sullivan, D. J., Haynes, K., Billé, J., Boerlin, P., Rodero, L., Lloyd, S., Henman, M. C., & Coleman, D. C. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.4.960-964.1997 · Cited by 181 · see citing works
Safety and Efficacy of Lamivudine-Zidovudine Combination Therapy in Antiretroviral-Naive Patients
Katlama, C. (1996) · JAMA · doi:10.1001/jama.1996.03540020040027 · Cited by 179 · see citing works
Restoration of immunity to chronic hepatitis B infection in HIV-infected patient on protease inhibitor
Carr, A. D., & Cooper, D. A. (1997) · The Lancet · doi:10.1016/s0140-6736(05)62892-9 · Cited by 172 · see citing works
Infection Due to Fluconazole-Resistant Candida in Patients with AIDS: Prevalence and Microbiology
Maenza, J. R., Merz, W. G., Romagnoli, M., Keruly, J. C., Moore, R. D., & Gallant, J. E. (1997) · Clinical Infectious Diseases · doi:10.1093/clinids/24.1.28 · Cited by 141 · see citing works
2·5 year remission of AIDS-associated progressive multifocal leukoencephalopathy with combined antiretroviral therapy
Elliot, B., Aromin, I., Gold, R., Flanigan, T., & Mileno, M. D. (1997) · The Lancet · doi:10.1016/s0140-6736(05)61753-9 · Cited by 93 · see citing works
Reversible fluconazole resistance in Candida albicans: a potential in vitro model
Calvet, H. M., Yeaman, M. R., & Filler, S. G. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.3.535 · Cited by 68 · see citing works
Remission of Progressive Multifocal Leukoencephalopathy Following Splenectomy and Antiretroviral Therapy in a Patient with HIV Infection
Power, C., Nath, A., Aoki, F. Y., & Bigio, M. R. D. (1997) · New England Journal of Medicine · doi:10.1056/nejm199702273360914 · Cited by 54 · see citing works
Can we prevent azole resistance in fungi?
Denning, D. W. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91314-9 · Cited by 52 · see citing works
Resolution of Intractable Molluscum Contagiosum in a Human Immunodeficiency Virus--Infected Patient After Institution of Antiretroviral Therapy with Ritonavir
Hicks, C. B., Myers, S. A., & Giner, J. (1997) · Clinical Infectious Diseases · doi:10.1093/clinids/24.5.1023 · Cited by 48 · see citing works
Survival in HIV-Infected Patients Who Have Received Zidovudine: Comparison of Combination Therapy with Sequential Monotherapy and Continued Zidovudine Monotherapy
Graham, N. M. H., Hoover, D. R., Park, L. P., Stein, D. S., Phair, J. P., Mellors, J. W., Detels, R., & Saah, A. J. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-12-199606150-00002 · Cited by 42 · see citing works
Antiretroviral effect of zidovudine–didanosine combination on blood and lymph nodes
Lafeuillade, A., Tamalet, C., Poggi, C., Pellegrino, P., Tourrès, C., & Izopet, J. (1997) · AIDS · doi:10.1097/00002030-199701000-00010 · Cited by 42 · see citing works
What we know so far.
Gazzard, B. (1996) · PubMed · Cited by 39 · see citing works
AIDS and the Mouth: Diagnosis and Management of Oral Lesions
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-5-416_5 · Cited by 19 · see citing works

Flagged first, then by citations

Sorted by citations

Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America
Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ933 · Cited by 4,200 · see citing works
Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America
Pappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191 · see citing works
Self-citation
Guidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440 · see citing works
Practice Guidelines for the Treatment of Candidiasis
Rex, J. H., Walsh, T. J., Sobel, J. D., Filler, S. G., Pappas, P. G., Dismukes, W. E., & Edwards, J. E. (2000) · Clinical Infectious Diseases · doi:10.1086/313749 · Cited by 927 · see citing works
Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences
Sanglard, D., & Odds, F. C. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00181-0 · Cited by 784 · see citing works
Trends in Mortality Due to Invasive Mycotic Diseases in the United States, 1980–1997
McNeil, M. M., Nash, S. L., Hajjeh, R. A., Phelan, M. A., Conn, L. A., Plikaytis, B. D., & Warnock, D. W. (2001) · Clinical Infectious Diseases · doi:10.1086/322606 · Cited by 657 · see citing works
Antifungal drug resistance of pathogenic fungi
Kontoyiannis, D. P., & Lewis, R. E. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08162-x · Cited by 553 · see citing works
Twelve years of fluconazole in clinical practice: global trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida
Pfaller, M. A., & Diekema, D. J. (2004) · Clinical Microbiology and Infection · doi:10.1111/j.1470-9465.2004.t01-1-00844.x · Cited by 422 · see citing works
Antifungal drug resistance to azoles and polyenes
Canuto, M. M., & Rodero, F. G. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00371-7 · Cited by 310 · see citing works
Gain of Function Mutations in CgPDR1 of Candida glabrata Not Only Mediate Antifungal Resistance but Also Enhance Virulence
Ferrari, S., Ischer, F., Calabrese, D., Posteraro, B., Sanguinetti, M., Fadda, G., Rohde, B., Bauser, C., Bader, O., & Sanglard, D. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000268 · Cited by 295 · see citing works
Treatment of oral candidiasis with methylene blue-mediated photodynamic therapy in an immunodeficient murine model
Teichert, M. C., Jones, J., Усачева, М. Н., & Biel, M. A. (2002) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1067/moe.2002.120051 · Cited by 239 · see citing works
Comparison of the epidemiology, drug resistance mechanisms, and virulence of and
Sullivan, D. J., Moran, G. P., Pinjon, E., Mosaid, A. A., Stokes, C. R., Vaughan, C. W., & Coleman, D. C. (2003) · FEMS Yeast Research · doi:10.1016/s1567-1356(03)00240-x · Cited by 234 · see citing works
Immunopathogenesis of Oropharyngeal Candidiasis in Human Immunodeficiency Virus Infection
de Repentigny, L., Lewandowski, D., & Jolicoeur, P. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.729-759.2004 · Cited by 227 · see citing works
Mouse model of oropharyngeal candidiasis
Solis, N. V., & Filler, S. G. (2012) · Nature Protocols · doi:10.1038/nprot.2012.011 · Cited by 195 · see citing works
Global Trends in the Antifungal Susceptibility of Cryptococcus neoformans (1990 to 2004)
Pfaller, M. A., Messer, S. A., Boyken, L. B., Rice, C., Tendolkar, S., Hollis, R. J., Doern, G. V., & Diekema, D. J. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.5.2163-2167.2005 · Cited by 205 · see citing works
Fluconazole for the management of invasive candidiasis: where do we stand after 15 years?
Charlier, C., Hart, E. J., Lefort, A., Ribaud, P., Dromer, F., Denning, D. W., & Lortholary, O. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki473 · Cited by 187 · see citing works
Oropharyngeal candidiasis in the era of antiretroviral therapy
Thompson, G. R., Patel, P., Kirkpatrick, W. R., Westbrook, S. D., Berg, D., Erlandsen, J. E., Redding, S. W., & Patterson, T. F. (2010) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2009.11.026 · Cited by 164 · see citing works
The Changing Clinical Spectrum of Human Immunodeficiency Virus (HIV)-Related Oral Lesions in 1,000 Consecutive Patients
Ramírez‐Amador, V., Esquivel‐Pedraza, L., Sierra-Madero, J. G., Anaya‐Saavedra, G., González-Ramírez, I., & Ponce‐de‐León, S. (2003) · Medicine · doi:10.1097/00005792-200301000-00004 · Cited by 137 · see citing works
Oral Lesions of HIV Disease and HAART in Industrialized Countries
Hodgson, T. A., Greenspan, D., & Greenspan, J. S. (2006) · Advances in Dental Research · doi:10.1177/154407370601900112 · Cited by 136 · see citing works
Candida glabrata Biofilms: How Far Have We Come?
Rodrigues, C., Rodrigues, M., Silva, S., & Henriques, M. (2017) · Journal of Fungi · doi:10.3390/jof3010011 · Cited by 129 · see citing works
Oral candidiasis and angular cheilitis
Sharon, V. R., & Fazel, N. (2010) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2010.01320.x · Cited by 115 · see citing works
Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungusCandida albicans
Nishimoto, A. T., Sharma, C., & Rogers, P. D. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz400 · Cited by 102 · see citing works
Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies
Polvi, E. J., Li, X., O’Meara, T. R., Leach, M. D., & Cowen, L. E. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1860-z · Cited by 90 · see citing works
A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) ofCandida albicansas a mucosal anticandidal vaccine
Sandini, S., Valle, R. L., Deaglio, S., Malavasi, F., Cassone, A., & Bernardis, F. D. (2011) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2011.00802.x · Cited by 88 · see citing works
Impact of protease inhibitor therapy on HIV-related oropharyngeal candidiasis
Arribas, J. R., Hernández-Albujar, S., González‐García, J., Peña, J. M., Gonzalez, A., Cañedo, T., Madero, R., Vázquez, J. J., & Powderly, W. G. (2000) · AIDS · doi:10.1097/00002030-200005260-00009 · Cited by 88 · see citing works
Longitudinal Study of MucosalCandidaSpecies Colonization and Candidiasis among Human Immunodeficiency Virus (HIV)–Seropositive and At‐Risk HIV‐Seronegative Women
Ohmit, S. E., Sobel, J. D., Schuman, P. C., Duerr, A. C., Mayer, K. H., Rompalo, A. M., & Klein, R. S. (2003) · The Journal of Infectious Diseases · doi:10.1086/375746 · Cited by 84 · see citing works
A Randomized Study of the Use of Fluconazole in Continuous versus Episodic Therapy in Patients with Advanced HIV Infection and a History of Oropharyngeal Candidiasis: AIDS Clinical Trials Group Study 323/Mycoses Study Group Study 40
Goldman, M. D., Cloud, G. A., Wade, K. D., Reboli, A. C., Fichtenbaum, C. J., Hafner, R., Sobel, J. D., Powderly, W. G., Patterson, T. F., Wheat, L. J., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/497373 · Cited by 83 · see citing works
Clinical relevance of mechanisms of antifungal drug resistance in yeasts
Sanglard, D. (2002) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/s0213-005x(02)72842-5 · Cited by 79 · see citing works
Diagnosis and Treatment of Oropharyngeal Candidiasis in Patients Infected with HIV: A Critical Reassessment
Powderly, W. G., Mayer, K. H., & Perfect, J. R. (1999) · AIDS Research and Human Retroviruses · doi:10.1089/088922299309900 · Cited by 79 · see citing works
Prevalencia, microbiología y patrones de sensibilidad a los antifúngicos de los aislamientos orales de Candida que colonizaban o infectaban a pacientes mexicanos con infección por VIH o sida y a personas sanas
Sánchez-Vargas, L. O., Ortiz-López, N. G., Villar, M., Moragues, M. D., Aguirre, J. M., Cashat-Cruz, M., Lopez-Ribot, J. L., Gaitán-Cepeda, L. A., & Quindós, G. (2005) · Revista Iberoamericana de Micología · doi:10.1016/s1130-1406(05)70014-0 · Cited by 74 · see citing works
OralCandidaIsolates Colonizing or Infecting Human Immunodeficiency Virus-Infected and Healthy Persons in Mexico
Sánchez-Vargas, L. O., Ortiz-López, N. G., Villar, M., Moragues, M. D., Aguirre, J. M., Cashat-Cruz, M., Lopez-Ribot, J. L., Gaitán-Cepeda, L. A., & Quindós, G. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.8.4159-4162.2005 · Cited by 69 · see citing works
Is there a serious risk of resistance development to azoles among fungi due to the widespread use and long-term application of azole antifungals in medicine?
Hof, H. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.01.001 · Cited by 60 · see citing works
Antifungal Resistance Among Candida Species
Klepser, M. E. (2001) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.21.12.124s.34511 · Cited by 60 · see citing works
Antifungal drug susceptibility of Cryptococcus neoformans from clinical sources in Nairobi, Kenya
Bii, C. C., Makimura, K., Abe, S., Taguchi, H., Mugasia, O. M., Revathi, G., Wamae, N., & Kamiya, S. (2006) · Mycoses · doi:10.1111/j.1439-0507.2006.01293.x · Cited by 57 · see citing works
Point prevalence, microbiology and fluconazole susceptibility patterns of yeast isolates colonizing the oral cavities of HIV-infected patients in the era of highly active antiretroviral therapy
Barchiesi, F. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf233 · Cited by 55 · see citing works
Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis
Plantinga, T. S., Hamza, O. J. M., Willment, J. A., Ferwerda, B., van de Geer, N. M. D., Verweij, P. E., Matee, M. I. N., Banahan, K., O'Neill, L. A. J., Kullberg, B.-J., et al. (2010) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181e53c64 · Cited by 53 · see citing works
Current trends of HIV disease of the mouth
Frezzini, C., Leão, J. C., & Porter, S. R. (2005) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2005.00337.x · Cited by 51 · see citing works
Transcriptional landscape of trans‐kingdom communication between C andida albicans and S treptococcus gordonii
Dutton, L. C., Paszkiewicz, K. H., Silverman, R. J., Splatt, P., Shaw, S., Nobbs, A. H., Lamont, R. J., Jenkinson, H. F., & Ramsdale, M. (2015) · Molecular Oral Microbiology · doi:10.1111/omi.12111 · Cited by 47 · see citing works
Determinants for the development of oropharyngeal colonization or infection by fluconazole-resistant Candida strains in HIV-infected patients
Masiá Canuto, M., Gutiérrez Rodero, F., Ortiz de la Tabla Ducasse, V., Hernández Aguado, I., Martín González, C., Sánchez Sevillano, A., & Martín Hidalgo, A. (2000) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s100960000323 · Cited by 46 · see citing works
Antifungal use in HIV infection
Mylonakis, E. E., & Marty, F. M. (2002) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.3.2.91 · Cited by 45 · see citing works
Evidence for Differential Expression ofCandida albicansVirulence Genes during Oral Infection in Intact and Human Immunodeficiency Virus Type 1–Transgenic Mice
Ripeau, J., Fiorillo, M., Aumont, F., Belhumeur, P., & de Repentigny, L. (2002) · The Journal of Infectious Diseases · doi:10.1086/340035 · Cited by 43 · see citing works
Therapy and prophylaxis of opportunistic infections in HIV-infected patients: a guideline by the German and Austrian AIDS societies (DAIG/ÖAG) (AWMF 055/066)
Thoden, J., Potthoff, A. V., Bogner, J. R., Brockmeyer, N. H., Esser, S., Grabmeier‐Pfistershammer, K., Haas, B. J., Hahn, K., Härter, G., Hartmann, M., et al. (2013) · Infection · doi:10.1007/s15010-013-0504-1 · Cited by 40 · see citing works
Mucosal and Systemic Fungal Infections in Patients with AIDS
Ruhnke, M. (2004) · Drugs · doi:10.2165/00003495-200464110-00002 · Cited by 38 · see citing works
Mucosal Candidiasis in Transgenic Mice Expressing Human Immunodeficiency Virus Type 1
de Repentigny, L., Aumont, F., Ripeau, J., Fiorillo, M., Kay, D. G., Hanna, Z., & Jolicoeur, P. (2002) · The Journal of Infectious Diseases · doi:10.1086/340036 · Cited by 35 · see citing works
CD8+T Cells but Not Polymorphonuclear Leukocytes Are Required To Limit Chronic Oral Carriage ofCandida albicansin Transgenic Mice Expressing Human Immunodeficiency Virus Type 1
Marquis, M., Lewandowski, D., Dugas, V., Aumont, F., Sénéchal, S., Jolicoeur, P., Hanna, Z., & de Repentigny, L. (2006) · Infection and Immunity · doi:10.1128/iai.74.4.2382-2391.2006 · Cited by 34 · see citing works
Molecular epidemiology of Candida albicans strains isolated from the oropharynx of HIV-positive patients at successive clinic visits
Lasker, B. A., Elie, C. M., Lott, T. J., Espinel-Ingroff, A. V., Gallagher, L., Kuykendall, R. J., Kellum, M. E., Pruitt, W. R., Warnock, D. W., Rimland, D., et al. (2001) · Medical Mycology · doi:10.1080/mmy.39.4.341.352 · Cited by 33 · see citing works
InCandida albicans, resistance to flucytosine and terbinafine is linked toMAT locus homozygosity and multilocus sequence typing clade 1
Odds, F. C. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00577.x · Cited by 32 · see citing works
Candidaspecies diversity and antifungal susceptibility patterns in oral samples of HIV/AIDS patients in Baja California, Mexico
Clark-Ordóñez, I., Callejas-Negrete, O. A., Aréchiga‐Carvajal, E. T., & Mouriño-Pérez, R. R. (2016) · Medical Mycology · doi:10.1093/mmy/myw069 · Cited by 29 · see citing works
Oropharyngeal Candidiasis in Patients with Human Immunodeficiency Virus: Correlation of Clinical Outcome with In Vitro Resistance, Serum Azole Levels, and Immunosuppression
Walmsley, S. L., King, S., McGeer, A., Ye, Y., & Richardson, S. E. (2001) · Clinical Infectious Diseases · doi:10.1086/320517 · Cited by 29 · see citing works
A Clinical Perspective for the Management of Invasive Fungal Infections: Focus on IDSA Guidelines
Kontoyiannis, D. P. (2001) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.21.12.175s.34506 · Cited by 29 · see citing works
Defective IL-17- and IL-22-dependent mucosal host response to Candida albicans determines susceptibility to oral candidiasis in mice expressing the HIV-1 transgene
Goupil, M., Cousineau-Côté, V., Aumont, F., Sénéchal, S., Gaboury, L., Hanna, Z., Jolicoeur, P., & de Repentigny, L. (2014) · BMC Immunology · doi:10.1186/s12865-014-0049-9 · Cited by 23 · see citing works
Oropharyngeal C andida colonization in human immunodeficiency virus infected patients
Li, X., Lei, L., Tan, D., Jiang, L., Zeng, X. Y., Dan, H., Liao, G., & Chen, Q. (2012) · Apmis · doi:10.1111/apm.12006 · Cited by 26 · see citing works
Fluconazole susceptibility testing of Candida species by flow cytometry
Joung, Y. H., Kim, H. R., Lee, M. K., & Park, A. J. (2007) · Journal of Infection · doi:10.1016/j.jinf.2006.09.016 · Cited by 22 · see citing works
The use of caspofungin in HIV-infected individuals
Waters, L. J., & Nelson, M. R. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.6.899 · Cited by 23 · see citing works
Will resistance in fungi emerge on a scale similar to that seen in bacteria?
Hof, H. (2008) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-007-0451-9 · Cited by 22 · see citing works
Azole Susceptibility Patterns and Genetic Relationship Among Oral Candida Strains Isolated in the Era of Highly Active Antiretroviral Therapy
Tacconelli, E., Bertagnolio, S., Posteraro, B., Tumbarello, M., Boccia, S., Fadda, G., & Cauda, R. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200209010-00005 · Cited by 20 · see citing works
Antifungal Susceptibility of Cryptococcus neoformans Isolates in HIV-Infected Patients to Fluconazole, Itraconazole and Voriconazole in Spain: 1994–1996 and 1997–2005
Aller, A. I., Claro, R. M., Castro, C., Serrano, C., Colom, M. F., & Martín‐Mazuelos, E. (2007) · Chemotherapy · doi:10.1159/000102585 · Cited by 20 · see citing works
Evaluation of the VITEK 2 system to test the susceptibility of Candida spp., Trichosporon asahii and Cryptococcus neoformans to amphotericin B, flucytosine, fluconazole and voriconazole: a comparison with the M27-A3 reference method
Cejudo, M. T. G., Gallego, A. G., Lacasa, E. C., Aller, A. I., Romero, A., Pemán, J., Quindós, G., & Martín‐Mazuelos, E. (2010) · Medical Mycology · doi:10.3109/13693780903473343 · Cited by 18 · see citing works
Candida
Dignani, M. C., Solomkin, J. S., & Anaissie, E. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-5680-5.00008-6 · Cited by 18 · see citing works
Differences in risk factors among clinical types of oral candidiasis in the Women's Interagency HIV Study
MacPhail, L. A., Komaroff, E., Alves, M. E. A. F., Navazesh, M., Phelan, J. A., & Redford, M. (2002) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1067/moe.2002.120050 · Cited by 18 · see citing works
Tratamiento de las infecciones oportunistas en pacientes adultos y adolescentes infectados por el virus de la inmunodeficiencia humana en la era del tratamiento antirretrovírico de gran actividad
Podzamczer, D., Arribas, J. R., Mallolas, J., Peña, J. M., Pulido, F., Aguirrebengoa, K., Barros, C., Blázquez, R., Costa, J. R., Dronda, F., et al. (2001) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/s0213-005x(01)72670-5 · Cited by 17 · see citing works
Fungal Infections in the Immunocompromised Host
Wheat, L. J., Goldman, M., & Sarosi, G. A. (2002) · Springer eBooks · doi:10.1007/0-306-47527-8_6 · Cited by 16 · see citing works
Guías de práctica clínica para el manejo de la candidiasis: actualización del 2009, de la Infectious Diseases Society of America
Pappas, P. G., Kauffman, C. A., Andes, D. R., Benjamin, D. K., Calandra, T., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B. J., Ostrosky-Zeichner, L. L., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/598961 · Cited by 15 · see citing works
Altered CD4+ T Cell Phenotype and Function Determine the Susceptibility to Mucosal Candidiasis in Transgenic Mice Expressing HIV-1
Lewandowski, D., Marquis, M., Aumont, F., Lussier-Morin, A.-C., Raymond, M., Sénéchal, S., Hanna, Z., Jolicoeur, P., & de Repentigny, L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.479 · Cited by 15 · see citing works
Persistence of Oropharyngeal Candida albicans Strains with Reduced Susceptibilities to Fluconazole among Human Immunodeficiency Virus-Seropositive Children and Adults in a Long-Term Care Facility
Makarova, N. U., Pokrowsky, V. V., Kravchenko, A. V., Serebrovskaya, L. V., James, M. J., McNeil, M. M., Lasker, B. A., Warnock, D. W., & Reiss, E. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.5.1833-1837.2003 · Cited by 15 · see citing works
Antifungal Susceptibility Data and Epidemiological Distribution of Candida spp.: An In Vitro Five-Year Evaluation at University Hospital Policlinico of Catania and a Comprehensive Literature Review
Calvo, M., Scalia, G., & Trovato, L. (2024) · Antibiotics · doi:10.3390/antibiotics13100914 · Cited by 12 · see citing works
Macrophage-Mediated Responses toCandida albicansin Mice Expressing the Human Immunodeficiency Virus Type 1 Transgene
Goupil, M., Bélanger-Trudelle, É., Dugas, V., Racicot-Bergeron, C., Aumont, F., Sénéchal, S., Hanna, Z., Jolicoeur, P., & de Repentigny, L. (2009) · Infection and Immunity · doi:10.1128/iai.00453-09 · Cited by 10 · see citing works
Fungal Infections of the Gastrointestinal Tract
Chao, A. W., & Vázquez, J. A. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.02.009 · Cited by 9 · see citing works
Azole Resistance in Candida Spp.
Kakeya, H., Miyazaki, T., Miyazaki, Y., & Kohno, S. (2003) · Nippon Ishinkin Gakkai Zasshi · doi:10.3314/jjmm.44.87 · Cited by 9 · see citing works
Diagnosis and management of Candida and other fungal infections of the head and neck
Miller, D. J. (2002) · Current Infectious Disease Reports · doi:10.1007/s11908-002-0078-z · Cited by 9 · see citing works
Two-year surveillance on fluconazole susceptibility of Candida spp isolates in a general and university hospital in Rome
Testore, G. P., Falco, F., Sarrecchia, C., Sordillo, P., Bontempo, G., & Andreoni, M. (2001) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(01)00280-2 · Cited by 9 · see citing works
Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis
Bernardis, F. D., Arancia, S., Tringali, G., Greco, M. C., Ragazzoni∘, E., Calugi, C., Trabocchi, A., Sandini, S., Graziani, S., Cauda, R., et al. (2014) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12240 · Cited by 8 · see citing works
Oral candidal carriage correlates with CD4+ cell count but not with HIV and highly active antiretroviral therapy status
Sah, P., Patel, P., Chandrashekar, C., Devadas, S. M., Ballal, M., Hegde, M., Guddattu, V., Murdoch, C., Sharma, M., & Radhakrishnan, R. A. (2019) · Journal of Investigative and Clinical Dentistry · doi:10.1111/jicd.12438 · Cited by 8 · see citing works
Mecanismos de resistencia a la terapéutica antifúngica
Pontón, J., & Quindós, G. (2006) · Medicina Clínica · doi:10.1157/13097528 · Cited by 8 · see citing works
Clinical Guidelines for the Treatment and Prevention of Opportunistic Infections in HIV-infected Koreans
The Korean Society for AIDS (2012) · Infection and Chemotherapy · doi:10.3947/ic.2012.44.3.93 · Cited by 8 · see citing works
Clinical Syndromes: Candida and Candidosis
Ruhnke, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-92300-0_4 · Cited by 7 · see citing works
Fungal Opportunistic Infections in HIV Disease
Duffalo, M. L. (2006) · Journal of Pharmacy Practice · doi:10.1177/0897190005284095 · Cited by 6 · see citing works
The Role of Resistance in Candida Infections: Epidemiology and Treatment
Sobel, J. D., & Akins, R. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-47266-9_18 · Cited by 6 · see citing works
Mechanisms and clinical significance of antifungal resistance
Billé, J. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(00)00260-0 · Cited by 5 · see citing works
Pathology and Management of Periodontal Problems in Patients with HIV Infection
Rees, T. D. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0416-7.00019-6 · Cited by 5 · see citing works
Resistance to Antifungal Drugs
Sanglard, D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6640-7_9 · Cited by 3 · see citing works
The nucleoside reverse transcriptase inhibitors didanosine, lamivudine, stavudine and zidovudine show little effect on the virulence of Candida albicans in vitro
Ahidjo, B. A., Veale, R. B., Duse, A. G., Becker, P., & Marais, E. (2008) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2008.03.008 · Cited by 3 · see citing works
Antibiotic Resistance and Implications for the Appropriate Use of Antimicrobial Agents
Deutscher, M., & Friedman, C. R. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-239-1_1 · Cited by 3 · see citing works
Oral Mucosal Cell Response to Candida albicans in Transgenic Mice Expressing HIV-1
de Repentigny, L., Lewandowski, D., Aumont, F., Hanna, Z., & Jolicoeur, P. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-204-5_25 · Cited by 3 · see citing works
Antifungal Agents: Resistance and Rational Use
Odds, F. C. (2005) · Springer eBooks · doi:10.1007/0-387-22852-7_17 · Cited by 3 · see citing works
South African medicinal orchids : a pharmacological and phytochemical evaluation.
Chinsamy, M. (2012) · ResearchSpace (University of KwaZulu-Natal) · Cited by 3 · see citing works
The Role of Resistance in Candida Infections: Epidemiology and Treatment
Sobel, J. D., & Akins, R. A. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-595-8_18 · Cited by 2 · see citing works
The Impact of Antifungal Drug Resistance in the Clinic
Lewis, R. E., & Kontoyiannis, D. P. (2014) · ASM Press eBooks · doi:10.1128/9781555817176.ch23 · Cited by 2 · see citing works
Common Infectious Diseases in HIV Infected Persons
Choi, J. Y. (2013) · Korean Journal of Medicine · doi:10.3904/kjm.2013.84.2.179 · Cited by 1 · see citing works
[Mycoses in HIV-infected patients in the era of highly active antiretroviral therapy]
Jáuregui, J. M. S., & Zubero, Z. (2002) · PubMed · Cited by 1 · see citing works
Infecciones fúngicas en un hospital público de referencia para la atención de personas con VIH/SIDA, Medellín 2013-2017
Rosado, L. L. M., & Cardona‐Arias, J. A. (2020) · Revista Médicas UIS · doi:10.18273/revmed.v33n2-2020002 · Cited by 1 · see citing works
Introduction to medical mycology
Warnock, D. W. (2017) · doi:10.1093/med/9780198755388.003.0001 · Cited by 1 · see citing works
Oropharyngeal candidiasis in HIV infection in Tanzania
Hamza, O. J. (2005) · Radboud Repository (Radboud University) · Cited by 1 · see citing works
Management of Resistant Candida Infections
Clements, S., & Kibbler, C. C. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-738-3_16 · Cited by 1 · see citing works
Antibiotic Resistance and Implications for the Appropriate Use of Antimicrobial Agents
Benin, A. L., & Dowell, S. F. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-036-0_1 · Cited by 1 · see citing works
Animal Models of Mucosal Candida Infections
Bernardis, F. D., Arancia, S., & Sandini, S. (2010) · Methods in microbiology · doi:10.1016/s0580-9517(10)37014-0
Reconstitution of the immunological defence and Candida albicans infection in oral mucosa of HIV+ patients under HAART
Santo, M. D. (2016) · JORDI - Journal of Oral Diagnosis · doi:10.5935/2525-5711.20160005
Mechanisms of Multidrug Resistance in Fungal Pathogens
Ferrari, S., & Sanglard, D. (2009) · Springer eBooks · doi:10.1007/978-3-642-03150-2_15
S2.1 Los retos de la Micología Oral
Pontón, J. (2001) · Gaceta Médica de Bilbao · doi:10.1016/s0304-4858(01)74368-5
Multidrug Resistance Transcriptional Regulatory Networks in Candida
Rogers, P. D., & Barker, K. S. (2014) · ASM Press eBooks · doi:10.1128/9781555817176.ch25

Point Prevalence of Oropharyngeal Carriage of Fluconazole‐ResistantCandidain Human Immunodeficiency Virus–Infected Patients
Martins, M. D., Lozano‐Chiu, M., & Rex, J. H. (1997) · Clinical Infectious Diseases · doi:10.1086/515554 · Cited by 54 · see citing works
Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection
Ruhnke, M., Eigler, A., Tennagen, I., Geiseler, B., Engelmann, E., & Trautmann, M. (1994) · Journal of Clinical Microbiology · doi:10.1128/jcm.32.9.2092-2098.1994 · Cited by 250 · see citing works
Detection and Significance of Fluconazole Resistance in Oropharyngeal Candidiasis in Human Immunodeficiency Virus-Infected Patients
Revankar, S. G., Kirkpatrick, W. R., Mcatee, R. K., Dib, O. P., Fothergill, A. W., Redding, S. W., Rinaldi, M. G., & Patterson, T. F. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/174.4.821 · Cited by 108 · see citing works
CLINICAL ARTICLES Patterns of Fluconazole Susceptibility in Isolates from Human Immunodeficiency Virus—Infected Patients with Oropharyngeal Candidiasis Due to Candida
Laguna, O., Rodriguez-tudela, J. L., Martinez-suarez, J. V., Polo, R., Valencia, E., Dı́az-Guerra, T. M., Dronda, O., & Pulido, F. (2016)
Clinical Evaluation and Microbiology of Oropharyngeal Infection Due to Fluconazole‐ResistantCandidain Human Immunodeficiency Virus–Infected Patients
Revankar, S. G., Dib, O. P., Kirkpatrick, W. R., McAtee, R. K., Fothergill, A. W., Rinaldi, M. G., Redding, S. W., & Patterson, T. F. (1998) · Clinical Infectious Diseases · doi:10.1086/513950 · Cited by 66 · see citing works

Authors: Martins, M. D., Lozano‐Chiu, M., & Rex, J. H.
Corresponding author: Rex, John H.
ORCID: Rex, John H.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 1998-11
Volume: 27
Issue: 5
Pages: 1291-1294
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1086/515006
OpenAlex: W2156624117
Cited by: 103
References: 24
Citations by year: 2026: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 5
FWCI: 3.51
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords: oropharyngeal candidiasis, Candida albicans, fluconazole resistance, HIV infection, antiretroviral therapy, antifungal susceptibility, incidence trends
MeSH terms: Antifungal Agents, Candida albicans, Candidiasis, Oral, Carrier State, Drug Resistance, Microbial, Drug Therapy, Combination, Humans, Microbial Sensitivity Tests, Mouth, Prospective Studies, Fluconazole, Prevalence, AIDS-Related Opportunistic Infections, CD4 Lymphocyte Count, Anti-HIV Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Declining Rates of Oropharyngeal Candidiasis and Carriage of Candida albicans Associated with Trends Toward Reduced Rates of Carriage of Fluconazole‐Resistant C. albicans in Human Immunodeficiency Virus –Infected Patients

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks