Cited by 72Malaria Research and ControlPreterm Birth and ChorioamnionitisPregnancy and preeclampsia studies

MALARIA-ASSOCIATED CYTOKINE CHANGES IN THE PLACENTA OF WOMEN WITH PRE-TERM DELIVERIES IN YAOUNDE, CAMEROON

SUGUITAN, AMORSOLO L., CADIGAN, TIMOTHY J., NGUYEN, THU A., ZHOU, AINONG, LEKE, ROBERT J. I., METENOU, SIMON, THUITA, LUCY, MEGNEKOU, ROSETTE +3 more·2003·The American Journal of Tropical Medicine and Hygiene

Abstract

The prevalence of pre-term deliveries (PTDs) is increased in women who become infected with Plasmodium falciparum during pregnancy. Because prematurity is a risk factor for newborns, it is important to identify conditions that contribute to malaria-associated PTDs. Plasmodium falciparum-infected erythrocytes sequester in the placenta and attract activated mononuclear cells that secrete pro-inflammatory cytokines. Increased inflammatory cytokine levels in other microbial infections are associated with PTDs. To determine if such is the case in women with placental malaria, concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and IL-10 were measured in placental plasma of 391 malaria-infected and -uninfected Cameroonian women with premature and full-term deliveries. Risk factors for malaria-associated PTDs included peripheral and placental parasitemias greater than 1%, maternal anemia, elevated IL-10 levels, and low TNF-alpha:IL-10 ratios due to over-expression of IL-10. Alterations in cytokine levels may contribute to PTDs through the induction of anemia and/or altering cellular immune responses required for eliminating placental parasites.

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Crossref · 10.4269/ajtmh.2003.69.574

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  • Fever, anaemia, and high levels of TNF alpha or interleukin 10 have been identified as important risk factors for malaria-related preterm delivery.

    “It is unclear what the mechanism at the basis of malaria-related preterm delivery is, though fever, anaemia, and high levels of TNF alpha or interleukin 10 have been identified as important risk factors.18,83–84”

    From Malaria in pregnancy. (2013) · cites this paper as [84]

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Authors
SUGUITAN, A. L., CADIGAN, T. J., NGUYEN, T. A., ZHOU, A., LEKE, R. J. I., METENOU, S., THUITA, L., MEGNEKOU, R., FOGAKO, J., LEKE, R. G. F., & TAYLOR, D. W.
Affiliations
University of Scranton (US)
Venue
The American Journal of Tropical Medicine and Hygiene
Published
2003-12
Volume
69
Issue
6
Pages
574-581
ISSN
0002-9637 (ISSN-L)
OpenAlex
W2128610917
Cited by
72
References
42
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 1
FWCI
3.73
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Tropical Medicine and Hygiene (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (UO1A153)
  • National Institute of Allergy and Infectious Diseases (UO1AI43888, U01AI043888)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
placental malaria, Plasmodium falciparum, preterm birth, cytokines, interferon-gamma, TNF-α, IL-4, IL-10, TNF-α/IL-10 ratio, anemia in pregnancy, inflammation
MeSH terms
Adult, Animals, Cameroon, Enzyme-Linked Immunosorbent Assay, Female, Humans, Obstetric Labor, Premature, Placenta, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Case-Control Studies, Cytokines, Malaria, Falciparum

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