The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
High-Throughput Analysis of Promoter Occupancy Reveals Direct Neural Targets of FOXP2, a Gene Mutated in Speech and Language Disorders
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327
Fitting a mixture model by expectation maximization to discover motifs in biopolymers.
Bailey, T. L., & Elkan, C. (1994) · PubMed · Cited by 4,982
The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,088
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
A forkhead-domain gene is mutated in a severe speech and language disorder
Lai, C. S. L., Fisher, S. E., Hurst, J. A., Vargha-Khadem, F., & Monaco, A. P. (2001) · Nature · doi:10.1038/35097076 · Cited by 2,054
Self-citationNormalization of cDNA microarray data
Smyth, G. K., & Speed, T. (2003) · Methods · doi:10.1016/s1046-2023(03)00155-5 · Cited by 1,871
Molecular evolution of FOXP2, a gene involved in speech and language
Enard, W., Przeworski, M., Fisher, S. E., Lai, C. S. L., Wiebe, V., Kitano, T., Monaco, A. P., & Pääbo, S. (2002) · Nature · doi:10.1038/nature01025 · Cited by 1,603
Self-citationCombining evidence using p-values: application to sequence homology searches.
Bailey, T. L., & Gribskov, M. (1998) · Bioinformatics · doi:10.1093/bioinformatics/14.1.48 · Cited by 1,253
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
Wu, Y., Borde, M., Heissmeyer, V., Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L., Guo, L., Han, A., Ziegler, S. F., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.042 · Cited by 1,189
A PCR primer bank for quantitative gene expression analysis
Wang, X. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng154 · Cited by 859
Forkhead Transcription Factors: Key Players in Development and Metabolism
Carlsson, P., & Mahlapuu, M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0780 · Cited by 840
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
Zheng, Y., Josefowicz, S. Z., Kas, A., Chu, T.-T., Gavin, M. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05563 · Cited by 835
Saura, C. A., Choi, S.-Y., Beglopoulos, V., Malkani, S., Zhang, D., Rao, B. S. S., Chattarji, S., Kelleher, R. J., Kandel, E. R., Duff, K., et al. (2004) · Neuron · doi:10.1016/s0896-6273(04)00182-5 · Cited by 757
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724
URBANEK, P. (1994) · Cell · doi:10.1016/0092-8674(94)90079-5 · Cited by 670
Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation
Schubert, L. A., Jeffery, E., Zhang, Y., Ramsdell, F., & Ziegler, S. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104521200 · Cited by 548
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
Li, Z., Van Calcar, S., Qu, C., Cavenee, W. K., Zhang, M. Q., & Ren, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332764100 · Cited by 524
Human FOX gene family (Review)
Katoh, M., & Katoh, M. (2004) · International Journal of Oncology · doi:10.3892/ijo.25.5.1495 · Cited by 504
Pittenger, C., Huang, Y. Y., Paletzki, R. F., Bourtchouladze, R., Scanlin, H., Vronskaya, S., & Kandel, E. R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00684-0 · Cited by 465
Zhang, B., Schmoyer, D., Kirov, S., & Snoddy, J. (2004) · BMC Bioinformatics · doi:10.1186/1471-2105-5-16 · Cited by 450
Identification of FOXP2 Truncation as a Novel Cause of Developmental Speech and Language Deficits
MacDermot, K. D., Bonora, E., Sykes, N., Coupe, A.-M., Lai, C. S. L., Vernes, S. C., Vargha-Khadem, F., McKenzie, F., Smith, R. L., Monaco, A. P., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/430841 · Cited by 411
Self-citationLai, C. S. L. (2003) · Brain · doi:10.1093/brain/awg247 · Cited by 390
Foxg1 Suppresses Early Cortical Cell Fate
Hanashima, C., Li, S. C., Shen, L., Lai, E., & Fishell, G. (2004) · Science · doi:10.1126/science.1090674 · Cited by 380
Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia
Watkins, K. E., Dronkers, N. F., & Vargha-Khadem, F. (2002) · Brain · doi:10.1093/brain/awf058 · Cited by 352
Overdier, D. G., Porcella, A., & Costa, R. H. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2755 · Cited by 351
Fox's in development and disease
Lehmann, O. J., Sowden, J. C., Carlsson, P., Jordan, T., & Bhattacharya, S. S. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00111-2 · Cited by 350
The eloquent ape: genes, brains and the evolution of language
Fisher, S. E., & Marcus, G. F. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1747 · Cited by 349
Self-citationMRI analysis of an inherited speech and language disorder: structural brain abnormalities
Watkins, K. E., Vargha-Khadem, F., Ashburner, J., Passingham, R. E., Connelly, A., Friston, K. J., Frackowiak, R. S. J., Mishkin, M., & Gadian, D. G. (2002) · Brain · doi:10.1093/brain/awf057 · Cited by 344
Apoptosis, Axonal Growth Defects, and Degeneration of Peripheral Neurons in Mice Lacking CREB
Lonze, B. E., Riccio, A., Cohen, S., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00686-4 · Cited by 343
Li, S., Weidenfeld, J., & Morrisey, E. E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.809-822.2004 · Cited by 331
Language fMRI abnormalities associated with FOXP2 gene mutation
Liégeois, F., Baldeweg, T., Connelly, A., Gadian, D. G., Mishkin, M., & Vargha-Khadem, F. (2003) · Nature Neuroscience · doi:10.1038/nn1138 · Cited by 328
Rudolph, D., Tafuri, A., Gass, P., Hämmerling, G. J., Arnold, B., & Schütz, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4481 · Cited by 309
Spiteri, E., Konopka, G., Coppola, G., Bomar, J., Oldham, M., Ou, J., Vernes, S. C., Fisher, S. E., Ren, B., & Geschwind, D. H. (2007) · The American Journal of Human Genetics · doi:10.1086/522237 · Cited by 285
Self-citationAccelerated Protein Evolution and Origins of Human-Specific Features: FOXP2 as an Example
Zhang, J., Webb, D. M., & Podlaha, O. (2002) · Genetics · doi:10.1093/genetics/162.4.1825 · Cited by 252
Wang, B., Lin, D., Li, C., & Tucker, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207174200 · Cited by 231
Structure of the Forkhead Domain of FOXP2 Bound to DNA
Stroud, J. C., Wu, Y., Bates, D. L., Han, A., Nowick, K., Paabo, S., Tong, H., & Chen, L. (2006) · Structure · doi:10.1016/j.str.2005.10.005 · Cited by 205
Absence of a Paternally Inherited FOXP2 Gene in Developmental Verbal Dyspraxia
Feuk, L., Kalervo, A., Lipsanen-Nyman, M., Skaug, J., Nakabayashi, K., Finucane, B., Hartung, D., Innes, M., Kerem, B., Nowaczyk, M. J., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/508902 · Cited by 186
Organic anion transport is the primary function of the SLC17/type I phosphate transporter family
Reimer, R. J., & Edwards, R. H. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1087-y · Cited by 181
Human neuroblastoma cells in culture: a model for neuronal cell differentiation and function.
Påhlman, S., Mamaeva, S. E., Meyerson, G., Mattsson, M. E. K., Bjelfman, C., Örtoft, E., & Hammerling, U. (1990) · PubMed · Cited by 173
DECIPHERING THE GENETIC BASIS OF SPEECH AND LANGUAGE DISORDERS
Fisher, S. E., Lai, C. S. L., & Monaco, A. P. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131144 · Cited by 171
Self-citationGenome-Wide Analysis of Protein-DNA Interactions
Kim, T. H., & Ren, B. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115634 · Cited by 171
Functional genetic analysis of mutations implicated in a human speech and language disorder
Vernes, S. C., Nicod, J., Elahi, F. M., Coventry, J. A., Kenny, N., Coupe, A.-M., Bird, L. E., Davies, K. E., & Fisher, S. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl392 · Cited by 167 · cited 8×
“SH-SY5Y cells have been exploited commonly for many years as a standard model for investigating human neuronal function(36) and were used effectively in a previous investigation to explore properties of etiological FOXP2 mutations implicated in speech-language disorder.(18) For the present study, we employed stable tr…”
MethodResultInfluentialBeima, K. M., Miazgowicz, M. M., Lewis, M. D., Yan, P. S., Huang, T. H. ‐., & Weinmann, A. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513613200 · Cited by 139
Shriberg, L. D., Ballard, K. J., Tomblin, J. B., Duffy, J. R., Odell, K. H., & Williams, C. A. (2006) · Journal of Speech Language and Hearing Research · doi:10.1044/1092-4388(2006/038 · Cited by 130
Zhou, C. J., Borello, U., Rubenstein, J. L. R., & Pleasure, S. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.007 · Cited by 122
Speech and language impairment and oromotor dyspraxia due to deletion of 7q31 that involves FOXP2
Zeesman, S., Nowaczyk, M. J. M., Teshima, I. E., Roberts, W., Cardy, J. O., Brian, J. A., Senman, L., Feuk, L., Osborne, L. R., & Scherer, S. W. (2006) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31110 · Cited by 120
Yoon, J., Li, G., & Roeder, R. G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1776 · Cited by 104
An evolutionary perspective on FoxP2: strictly for the birds?
Scharff, C., & Haesler, S. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.10.004 · Cited by 100
Washburn, B. K., & Esposito, R. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2057-2069.2001 · Cited by 91
The search for autism disease genes
Wassink, T. H., Brzustowicz, L. M., Bartlett, C. W., & Szatmari, P. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20041 · Cited by 89
Breslin, M. B., Zhu, M., & Lan, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306795200 · Cited by 89
Abu‐Khalil, A., Fu, L., Grove, E. A., Zečević, N., & Geschwind, D. H. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20112 · Cited by 87
Self-citationWhite, S. A., Fisher, S. E., Geschwind, D. H., Scharff, C., & Holy, T. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3379-06.2006 · Cited by 87
Self-citationBird, A. J., Blankman, E., Stillman, D. J., Eide, D. J., & Winge, D. R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600122 · Cited by 79
Fkh5 -deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body
Wehr, R., Mansouri, A., de Maeyer, T., & Gruß, P. (1997) · Development · doi:10.1242/dev.124.22.4447 · Cited by 69
Oberley, M. J., & Farnham, P. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)71043-x · Cited by 60
Cited by
A functional genetic link between distinct developmental language disorders
Vernes, S. C., Newbury, D. F., Abrahams, B. S., Winchester, L., Nicod, J., Groszer, M., Alarcón, M., Oliver, P. L., Davies, K. E., Geschwind, D. H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802828 · Cited by 676
Self-citationForkhead box proteins: tuning forks for transcriptional harmony.
Lam, E. W.-F., Brosens, J. J., Gomes, A. R., & Koo, C.-Y. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3539 · Cited by 684
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S. M., Blass, T., Somel, M., Brückner, M. K., Schreiweis, C., Winter, C., Sohr, R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.041 · Cited by 605
Self-citationGenome-wide association studies in ADHD
Franke, B., Neale, B. M., & Faraone, S. V. (2009) · Human Genetics · doi:10.1007/s00439-009-0663-4 · Cited by 422
Human-specific transcriptional regulation of CNS development genes by FOXP2
Konopka, G., Bomar, J. M., Winden, K., Coppola, G., Jonsson, Z. O., Gao, F., Peng, S., Preuss, T. M., Wohlschlegel, J. A., & Geschwind, D. H. (2009) · Nature · doi:10.1038/nature08549 · Cited by 390
Metadata
- Authors
- Vernes, S. C., Spiteri, E., Nicod, J., Groszer, M., Taylor, J. M., Davies, K. E., Geschwind, D. H., & Fisher, S. E.
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 81
- Issue
- 6
- Pages
- 1232-1250
- ISSN
- 0002-9297 (ISSN-L)
- OpenAlex
- W1965639825
- Cited by
- 268
- References
- 60
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.