The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Metronidazole Is Still the Drug of Choice for Treatment of Anaerobic Infections
Abstract
Metronidazole has been used for the treatment of infections for >45 years and is still successfully used for the treatment of trichomoniasis, amoebiasis, and giardiasis. Anaerobic bacterial infections caused by Bacteroides species, fusobacteria, and clostridia respond favorably to metronidazole therapy. Good clinical results in the treatment of vaginosis due to Gardnerella vaginalis have also been reported. Rates of resistance to metronidazole are still generally low; however, several studies have reported decreased susceptibility among Bacteroides species, as well as different mechanisms of resistance. Metronidazole-resistant Helicobacter pylori strains have been described, but combination therapy (eg, metronidazole, amoxicillin, or clarithromycin plus omeprazole) is still recommended for eradication of this pathogen in patients with gastroduodenal ulcers. Metronidazole is considered to be a cost-effective drug because of its low cost, good activity against pathogenic anaerobic bacteria, favorable pharmacokinetic and pharmacodynamic properties, and minor adverse effects. Metronidazole is still the criterion standard for therapy of anaerobic infections, as was described by Tally and colleagues 35 years ago.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wadsworth anaerobic bacteriology manual
Sutter, V. L., Citron, D. M., & Finegold, S. M. (1980) · Medical Entomology and Zoology · Cited by 1,388
Zar, F. A., Bakkanagari, S. R., Moorthi, K. M. L. S. T., & Davis, M. B. (2007) · Clinical Infectious Diseases · doi:10.1086/519265 · Cited by 1,252
Human intestinal bacteria as reservoirs for antibiotic resistance genes
SALYERS, A., GUPTA, A., & WANG, Y. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.07.004 · Cited by 846
Effect of antimicrobial agents on the ecological balance of human microflora
Sullivan, Å., Edlund, C., & Nord, C. E. (2001) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(01)00066-4 · Cited by 818
Self-citationShoemaker, N. B., Vlamakis, H., Hayes, K., & Salyers, A. A. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.2.561-568.2001 · Cited by 529
Metronidazole: A Therapeutic Review and Update
Freeman, C. D., Klutman, N. E., & Lamp, K. C. (1997) · Drugs · doi:10.2165/00003495-199754050-00003 · Cited by 473
Treatment of Clostridium difficile Infection
Gerding, D. N., Muto, C. A., & Owens, Jr. (2008) · Clinical Infectious Diseases · doi:10.1086/521860 · Cited by 287
Aldridge, K. E., Ashcraft, D., Cambre, K., Pierson, C. L., Jenkins, S. G., & Rosenblatt, J. E. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.4.1238-1243.2001 · Cited by 230
Nguyen, M. H., Yu, V. L., Morris, A. J., McDermott, L., Wagener, M. W., Harrell, L., & Snydman, D. R. (2000) · Clinical Infectious Diseases · doi:10.1086/313805 · Cited by 215
Review article: the treatment of refractory Helicobacter pylori infection
Mégraud, F., & Lamouliatte, H. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01592.x · Cited by 211
Cited by
Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., et al. (2017) · Science · doi:10.1126/science.aal5240 · Cited by 1,574
Xue, J., He, M., Liu, H., Niu, Y., Crawford, A., Coates, P. D., Chen, D., Shi, R., & Zhang, L. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.07.060 · Cited by 358
Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota
Peterson, C. T., Sharma, V, Elmén, L., & Peterson, S. N. (2015) · Clinical and Experimental Immunology · doi:10.1111/cei.12474 · Cited by 318
Metal centers in the anaerobic microbial metabolism of CO and CO2
Bender, G., Pierce, E., Hill, J. A., Darty, J. E., & Ragsdale, S. W. (2011) · Metallomics · doi:10.1039/c1mt00042j · Cited by 68
Bacterial vaginosis: A state of microbial dysbiosis
Mondal, A. S., Sharma, R., & Trivedi, N. (2023) · Medicine in Microecology · doi:10.1016/j.medmic.2023.100082 · Cited by 44
Metadata
- Authors
- Löfmark, S., Edlund, C., & Nord, C. E.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-01
- Volume
- 50
- Issue
- s1
- Pages
- S16-S23
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2112972569
- Cited by
- 656
- References
- 30
- FWCI
- 30.33
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Metronidazole Is Still the Drug of Choice for Treatment of Anaerobic Infections. https://app.cochat.ai/papers/10.1086/647939
- The paper
- Löfmark, S., Edlund, C., & Nord, C. E. (2010). Metronidazole Is Still the Drug of Choice for Treatment of Anaerobic Infections. Clinical Infectious Diseases. https://doi.org/10.1086/647939
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
