The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes
Open accessAbstract
Infection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended with metronidazole (MNA). Acetic acid (HAc) was introduced to improve the miscibility of PCL and gelatin to fabricate homogeneous hybrid nanofiber membranes. The effects of the addition of HAc and the MNA content (0, 1, 5, 10, 20, 30, and 40 wt.% of polymer) on the properties of the membranes were investigated. The membranes showed good mechanical properties, appropriate biodegradation rate and barrier function. The controlled and sustained release of MNA from the membranes significantly prevented the colonization of anaerobic bacteria. Cells could adhere to and proliferate on the membranes without cytotoxicity until the MNA content reached 30%. Subcutaneous implantation in rabbits for 8 months demonstrated that MNA-loaded membranes evoked a less severe inflammatory response depending on the dose of MNA than bare membranes. The biodegradation time of the membranes was appropriate for tissue regeneration. These results indicated the potential for using MNA-loaded PCL/gelatin electrospun membranes as anti-infective GTR/GBR membranes to optimize clinical application of GTR/GBR strategies.
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Cited by
Degradation mechanisms of polycaprolactone in the context of chemistry, geometry and environment
Bartnikowski, M., Dargaville, T. R., Ivanovski, S., & Hutmacher, D. W. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.05.004 · Cited by 769
Ren, K., Wang, Y., Sun, T., Yue, W., & Zhang, H. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.04.084 · Cited by 373
Biodegradable Polymer Membranes Applied in Guided Bone/Tissue Regeneration: A Review
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Fabrication of Electrospun Polymer Nanofibers with Diverse Morphologies
Wang, C., Wang, J., Zeng, L., Qiao, Z., Liu, X., Liu, H., Zhang, J., & Ding, J. (2019) · Molecules · doi:10.3390/molecules24050834 · Cited by 331
Self-citationNanofibers for Biomedical and Healthcare Applications
Rasouli, R., Barhoum, A., Bechelany, M., & Dufresne, A. (2019) · Macromolecular Bioscience · doi:10.1002/mabi.201800256 · Cited by 319
Metadata
- Authors
- Xue, J., He, M., Liu, H., Niu, Y., Crawford, A., Coates, P. D., Chen, D., Shi, R., & Zhang, L.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 35
- Issue
- 34
- Pages
- 9395-9405
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1966053823
- Cited by
- 358
- References
- 33
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Xue, J., He, M., Liu, H., Niu, Y., Crawford, A., Coates, P. D., Chen, D., Shi, R., & Zhang, L. (2014). Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes. Biomaterials. https://doi.org/10.1016/j.biomaterials.2014.07.060
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