Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Open accessAbstract
Bacteria go the distance in cancer: The bacterial species Fusobacterium nucleatum is associated with a subset of human colorectal cancers, but its role in tumorigenesis is unclear. Studying patient samples, Bullman et al. found that F. nucleatum and certain co-occurring bacteria were present not only in primary tumors but also in distant metastases. Preliminary evidence suggests that the bacterium is localized primarily within the metastatic cancer cells rather than in the stroma. Antibiotic treatment of mice carrying xenografts of F. nucleatum –positive human colorectal cancer slowed tumor growth, consistent with a causal role for the bacterium in tumorigenesis. Science , this issue p. 1443
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The intratumor microbiome has emerged as a novel and rapidly evolving research frontier, with discovery of microorganisms in various cancer types, including organs traditionally considered sterile, primarily gastrointestinal cancers.
“The intratumor microbiome has emerged as a novel and rapidly evolving research frontier, with the discovery of microorganisms in various cancer types, including in some organs traditionally considered to be sterile, primarily in gastrointestinal cancers [155–157].”
From Single-cell sequencing to multi-omics: technologies and applications (2024) · cites this paper as [156]
The Abstract reports microorganisms in colorectal cancers and their liver metastases, supporting the gastrointestinal-cancer example. It does not establish discovery across various cancer types or characterize any organs as traditionally sterile. No page number is available in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredMicrobes can translocate into solid tumors via various routes.
“Microbes can translocate into solid tumors via various routes.”
From Melanoma and microbiota: Current understanding and future directions (2024) · cites this paper as [110]
Microbiota in the gut and in tumours can influence cancer patient survival and treatment response.
“as the gut and tumour microbiota can affect the survival of patients with cancer and their responses to therapy8,14,40–42,50”
From Identification of bacteria-derived HLA-bound peptides in melanoma (2021) · cites this paper as [8]
Fusobacterium spp. is important in development and progression of gastrointestinal tumors.
“Fusobacterium spp. is important in the development and progression of gastrointestinal tumors1,19,34,35”
From RETRACTED ARTICLE: Microbiome analyses of blood and tissues suggest cancer diagnostic approach (2020) · cites this paper as [1]
Fusobacterium appears to be an important component of the tumor microenvironment.
“So, Fusobacterium appears to be an important component of the tumor microenvironment.34”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [34]
Evidence suggests that intratumoral bacteria exist and are functionally active, with overlapping immunohistochemistry, immunofluorescence, electron microscopy, and sequencing data across about 10 cancer types.
“Emerging evidence also suggests the existence and functional activity of intratumoral bacteria, with overlapping immunohistochemistry, immunofluorescence, electron microscopy, and sequencing data on them in ~10 cancer types.”
From The microbiome and human cancer (2021) · cites this paper as [19]
Research in lung, colon, and pancreatic cancer indicates that removing intratumoral microbiota can halt tumor-promoting inflammation, lower cellular proliferation, or shift a tolerogenic tumor microenvironment toward an immunogenic one.
“Several studies in lung, colon, and pancreatic cancer suggest that eliminating intratumoral microbiota can check tumor-promoting inflammatory processes, reduce cellular proliferation, or convert a tolerogenic TME to an immunogenic one (18, 19, 23, 46).”
From The microbiome and human cancer (2021) · cites this paper as [19]
Intratumoral microbes influence many aspects of cancer biology, including tumor initiation and growth, invasion, and metastasis.
“Intratumoral microbes have been shown to affect nearly all aspects of cancer biology including tumor initiation/growth, invasion and metastasis”
From Hallmarks of response, resistance, and toxicity to immune checkpoint blockade (2021) · cites this paper as Bullman et al., 2017
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- Authors
- Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., Chipashvili, O., Hagan, T., Walker, M., Ramachandran, A., Diosdado, B., Serna, G., Mulet, N., Landolfi, S., Ramon y Cajal, S., Fasani, R., Aguirre, A. J., Ng, K., Élez, E., Ogino, S., Tabernero, J., Fuchs, C. S., Hahn, W. C., Nuciforo, P., & Meyerson, M.
- Affiliations
- Broad Institute (US)
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Universitat Autònoma de Barcelona (ES)
- Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, CIBERONC, Universitat Autònoma de Barcelona, Spain.
- Yale Cancer Center (US)
- Corresponding author
- Meyerson, Matthew
- ORCID
- Bullman, Susan
- Pedamallu, Chandra S.
- Clancy, Thomas E.
- Zhang, Xiaoyang
- Cai, Diana
- Neuberg, Donna
- Huang, Katherine
- Nelson, Timothy
- Chipashvili, Otari
- Hagan, Timothy
- Walker, Mark
- Diosdado, Begoña
- Serna, Garazi
- Landolfi, Stefania
- Fasani, Roberta
- Aguirre, Andrew J.
- Ng, Kimmie
- Élez, Elena
- Ogino, Shuji
- Tabernero, Josep
- Fuchs, Charles S.
- Hahn, William C.
- Nuciforo, Paolo
- Meyerson, Matthew
- Venue
- Science
- Published
- 2017-12-15
- Volume
- 358
- Issue
- 6369
- Pages
- 1443-1448
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5823247
- OpenAlex
- W2768799378
- Cited by
- 1,574
- References
- 44
- Citations by year
- 2026: 181 · 2025: 229 · 2024: 199 · 2023: 197 · 2022: 218 · 2021: 188 · 2020: 166 · 2019: 115 · 2018: 76 · 2017: 3
- FWCI
- 40.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (CA197568, CA197735)
- Prevent Cancer Foundation (Figdor Family Fellowship)
- National Institute of Health (CA148894, CA205406, CA118553, CA169141)
- DF/HCC GI SPORE P50 (CA127003)
- American Cancer Society Research Professorship
- Cellex Private Foundation
- Banco Bilbao Vizcaya Argentaria Foundation
- Hale Family Center for Pancreatic Cancer
- Project P Fund for Colorectal Cancer Research
- Stand-up-to-Cancer
- Chambers Family Fund for Colorectal Cancer Research
- Team Perry Fund
- Clark Family Fund for GI Cancer Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Keywords
- Fusobacterium nucleatum, colorectal cancer, metastasis, antibiotic treatment response, tumor microenvironment, gut microbiota, carcinogenesis, xenografts
- MeSH terms
- Adenocarcinoma, Animals, Anti-Bacterial Agents, Bacteroides, Fusobacterium, Humans, Liver Neoplasms, Metronidazole, Colorectal Neoplasms, Prevotella, HT29 Cells, Xenograft Model Antitumor Assays, Mice, Carcinogenesis, Microbiota
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