The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Degradability of superparamagnetic nanoparticles in a model of intracellular environment: follow-up of magnetic, structural and chemical properties
Open accessAbstract
The unique magnetic properties of iron oxide nanoparticles have paved the way for various biomedical applications, such as magnetic resonance cellular imaging or magnetically induced therapeutic hyperthermia. Living cells interact with nanoparticles by internalizing them within intracellular acidic compartments. Although no acute toxicity of iron oxide nanoparticles has been reported up to now, the mechanisms of nanoparticle degradation by the cellular environment are still unknown. In the organism, the long term integrity and physical state of iron-based nanoparticles are challenged by iron homeostasis. In this study, we monitored the degradation of 7 nm sized maghemite nanoparticles in a medium mimicking the intracellular environment. Magnetic nanoparticles with three distinct surface coatings, currently evaluated as MRI contrast agents, were shown to exhibit different kinetics of dissolution at an acidic pH in the presence of a citrate chelating agent. Our assessment of the physical state of the nanoparticles during degradation revealed that the magnetic properties, size distribution and structure of the remaining nanocrystals were identical to those of the initial suspension. This result suggests a model for nanoparticle degradation with rapidly dissolved nanocrystals and a reservoir of intact nanoparticles.
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Clinical applications of magnetic nanoparticles for hyperthermia
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Intracellular iron transport and storage: from molecular mechanisms to health implications
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In vivo MRI cell tracking: clinical studies
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Lysosomes in iron metabolism, ageing and apoptosis
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Biological applications of magnetic nanoparticles
Colombo, M., Carregal-Romero, S., Casula, M. F., Gutiérrez, L., Morales, M. P., Böhm, I. B., Heverhagen, J. T., Prosperi, D., & Parak, W. J. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15337h · Cited by 1,315
Soenen, S. J., Rivera-Gil, P., Montenegro, J.-M., Parak, W. J., De Smedt, S. C., & Braeckmans, K. (2011) · Nano Today · doi:10.1016/j.nantod.2011.08.001 · Cited by 699
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
In vivo MRI cell tracking: clinical studies
Bulte, J. W. M. (2009) · American Journal of Roentgenology · doi:10.2214/ajr.09.3107 · Cited by 430
In vivo degeneration and the fate of inorganic nanoparticles
Feliu, N., Docter, D., Heine, M., del Pino, P., Ashraf, S., Kolosnjaj-Tabi, J., Macchiarini, P., Nielsen, P., Alloyeau, D., Gazeau, F., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00699f · Cited by 423
Self-citation
Metadata
- Authors
- Lévy, M., Lagarde, F., Maraloiu, V.-A., Blanchin, M.-G., Gendron, F., Wilhelm, C., & Gazeau, F.
- Venue
- Nanotechnology
- Publisher
- IOP Publishing
- Published
- 2010-09-06
- Volume
- 21
- Issue
- 39
- Pages
- 395103
- ISSN
- 0957-4484 (ISSN-L)
- 1361-6528
- OpenAlex
- W1967042074
- Cited by
- 193
- References
- 8
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Lévy, M., Lagarde, F., Maraloiu, V.-A., Blanchin, M.-G., Gendron, F., Wilhelm, C., & Gazeau, F. (2010). Degradability of superparamagnetic nanoparticles in a model of intracellular environment: follow-up of magnetic, structural and chemical properties. Nanotechnology. https://doi.org/10.1088/0957-4484/21/39/395103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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