Clinical applications of magnetic nanoparticles for hyperthermia
Open accessAbstract
Magnetic fluids are increasingly used for clinical applications such as drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. The latter technique that has been developed as a cancer treatment for several decades comprises the injection of magnetic nanoparticles into tumors and their subsequent heating in an alternating magnetic field. Depending on the applied temperature and the duration of heating this treatment either results in direct tumor cell killing or makes the cells more susceptible to concomitant radio- or chemotherapy. Numerous groups are working in this field worldwide, but only one approach has been tested in clinical trials so far. Here, we summarize the clinical data gained in these studies on magnetic fluid induced hyperthermia.
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Cites
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Gupta, A. K., & Gupta, M. S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.012 · Cited by 6,795 · see citing works
Thermal dose determination in cancer therapy
Sapareto, S. A., & Dewey, W. C. (1984) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(84)90379-1 · Cited by 2,505 · see citing works
Li, Y., Yang, Y., Lu, M., & Shen, L. (2011) · Hepatogastroenterology · doi:10.5754/hge11753 · Cited by 2,435 · see citing works
Hyperthermia in combined treatment of cancer
Wust, P., Hildebrandt, B., Sreenivasa, G., Rau, B., Gellermann, J., Riess, H. B., FELIX, R., & Schlag, P. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00818-5 · Cited by 2,002 · see citing works
Selective Inductive Heating of Lymph Nodes
Gilchrist, R. K., Medal, R., Shorey, W. D., Hanselman, R. C., Jc, P., & TAYLOR, C. B. (1957) · Annals of Surgery · doi:10.1097/00000658-195710000-00007 · Cited by 1,096 · see citing works
Johannsen, M., Gneveckow, U., Eckelt, L., Feussner, A., Waldöfner, N., Scholz, R., Değer, S., Wust, P., Loening, S. A., & Jordan, A. (2005) · International Journal of Hyperthermia · doi:10.1080/02656730500158360 · Cited by 802 · see citing works
Self-citationMaier-Hauff, K., Rothe, R., Scholz, R., Gneveckow, U., Wust, P., Thiesen, B., Feussner, A., von Deimling, A., Waldöfner, N., Felix, R., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9195-0 · Cited by 772 · see citing works
Self-citationJordan, A., Wust, P., Fählin, H., John, W., Hinz, A., & FELIX, R. (1993) · International Journal of Hyperthermia · doi:10.3109/02656739309061478 · Cited by 694 · see citing works
Self-citationJohannsen, M., Gneveckow, U., Thiesen, B., Taymoorian, K., Cho, C. H., Waldöfner, N., Scholz, R., Jordan, A., Loening, S. A., & Wust, P. (2006) · European Urology · doi:10.1016/j.eururo.2006.11.023 · Cited by 531 · see citing works
Self-citationThe current and potential role of hyperthermia in radiotherapy
Overgaard, J. (1989) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(89)90470-7 · Cited by 507 · see citing works
The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma
Jordan, A., Scholz, R., Maier-Hauff, K., van Landeghem, F. K. H., Waldoefner, N., Teichgraeber, U., Pinkernelle, J., Bruhn, H., Neumann, F., Thiesen, B., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9059-z · Cited by 459 · see citing works
Self-citationJohannsen, M., Gneveckow, U., Taymoorian, K., Thiesen, B., Waldöfner, N., Scholz, R., Jung, K., Jordan, A., Wust, P., & Loening, S. A. (2007) · International Journal of Hyperthermia · doi:10.1080/02656730601175479 · Cited by 382 · see citing works
Self-citationSneed, P. K., Stauffer, P. R., McDermott, M., Diederich, C. J., Lamborn, K. R., Prados, M. D., Chang, S., Weaver, K. A., Spry, L., Malec, M. K., et al. (1998) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(97)00731-1 · Cited by 363 · see citing works
Effects of Magnetic Fluid Hyperthermia (MFH) on C3H mammary carcinomain vivo
Jordan, A., Scholz, R., Wust, P., Fähling, H., Krause, J., Wlodarczyk, W., Sander, B., Vogl, T., & FELIX, R. (1997) · International Journal of Hyperthermia · doi:10.3109/02656739709023559 · Cited by 325 · see citing works
Self-citationGordon, R. T., Hines, J., & Gordon, D. (1979) · Medical Hypotheses · doi:10.1016/0306-9877(79)90063-x · Cited by 311 · see citing works
Sneed, P. K., Stauffer, P. R., Diederich, C. J., McDermott, M. W., Lamborn, K. R., Weaver, K. A., Prados, M. D., Chang, S. M., Malec, M. K., Spry, L., et al. (1996) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(97)85343-6 · Cited by 302 · see citing works
Wust, P., Gneveckow, U., Wust, P., Gneveckow, U., Johannsen, M., Böhmer, D., Henkel, T. O., Kahmann, F., Sehouli, J., FELIX, R., et al. (2006) · International Journal of Hyperthermia · doi:10.1080/02656730601106037 · Cited by 295 · see citing works
Self-citationGneveckow, U., Jordan, A., Scholz, R., Brüß, V., Waldöfner, N., Ricke, J., Feussner, A., Hildebrandt, B., Rau, B., & Wust, P. (2004) · Medical Physics · doi:10.1118/1.1748629 · Cited by 259 · see citing works
Self-citationThermal Ablation of Tumors Using Magnetic Nanoparticles
Hilger, I., Hiergeist, R., Hergt, R., Winnefeld, K., Schubert, H., & Kaiser, W. A. (2002) · Investigative Radiology · doi:10.1097/00004424-200210000-00008 · Cited by 224 · see citing works
Itô, A., Tanaka, K., Kondo, K., Shinkai, M., Honda, H., Matsumoto, K., Saida, T., & Kobayashi, T. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01438.x · Cited by 217 · see citing works
Intracellular hyperthermia for cancer using magnetite cationic liposomes
Shinkai, M., Yanase, M., Suzuki, M., Honda, H., Wakabayashi, T., Yoshida, J., & Kobayashi, T. (1999) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(98)00586-1 · Cited by 210 · see citing works
Johannsen, M., Thiesen, B., Jordan, A., Taymoorian, K., Gneveckow, U., Waldöfner, N., Scholz, R., Koch, M., Lein, M., Jung, K., et al. (2005) · The Prostate · doi:10.1002/pros.20213 · Cited by 198 · see citing works
Self-citationAntitumor Immunity Induction by Intracellular Hyperthermia Using Magnetite Cationic Liposomes
Yanase, M., Shinkai, M., Honda, H., et al. (1998) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1998.tb03283.x · Cited by 183 · see citing works
Vascularization of small liver metastases
Archer, S. G., & Gray, B. N. (1989) · British journal of surgery · doi:10.1002/bjs.1800760607 · Cited by 158 · see citing works
Herman, T. S., Teicher, B. A., Jochelson, M. S., Clark, J., Svensson, G. K., & Coleman, C. N. (1988) · International Journal of Hyperthermia · doi:10.3109/02656738809029305 · Cited by 147 · see citing works
Sreenivasa, G., Gellermann, J., Rau, B., et al. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)04144-5 · Cited by 134 · see citing works
Johannsen, M., Thiesen, B., Gneveckow, U., Taymoorian, K., Waldöfner, N., Scholz, R., Değer, S., Jung, K., Loening, S. A., & Jordan, A. (2005) · The Prostate · doi:10.1002/pros.20324 · Cited by 123 · see citing works
Self-citationTanaka, K., Itô, A., Kobayashi, T., Kawamura, T., Shimada, S., Matsumoto, K., Saida, T., & Honda, H. (2005) · International Journal of Cancer · doi:10.1002/ijc.21061 · Cited by 122 · see citing works
Targeting liver tumors with hyperthermia: Ferromagnetic embolization in a rabbit liver tumor model
Moroz, P., Jones, S. K., Winter, J., et al. (2001) · Journal of Surgical Oncology · doi:10.1002/jso.1118 · Cited by 118 · see citing works
Kawai, N., Itô, A., Nakahara, Y., Futakuchi, M., Shirai, T., Honda, H., Kobayashi, T., & Kohri, K. (2005) · The Prostate · doi:10.1002/pros.20253 · Cited by 116 · see citing works
Preparation of Tumor-Specific Magnetoliposomes and Their Application for Hyperthermia.
Biao, L., Shinkai, M., Kitade, T., Honda, H., Yoshida, J., Wakabayashi, T., & Kobayashi, T. (2001) · JOURNAL OF CHEMICAL ENGINEERING OF JAPAN · doi:10.1252/jcej.34.66 · Cited by 101 · see citing works
Minamimura, T., Sato, H., Kasaoka, S., et al. (2000) · International Journal of Oncology · doi:10.3892/ijo.16.6.1153 · Cited by 90 · see citing works
Development of intra-arterial hyperthermia using a dextran-magnetite complex
Mitsumori, M., Hiraoka, M., Shibata, T., et al. (1994) · International Journal of Hyperthermia · doi:10.3109/02656739409012371 · Cited by 90 · see citing works
Anscher, M. S., Samulski, T. V., Dodge, R. K., et al. (1997) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(97)00109-0 · Cited by 90 · see citing works
Detecting and Treating Cancer with Nanotechnology
Hartman, K. B., Wilson, L. J., & Rosenblum, M. G. (2008) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256264 · Cited by 85 · see citing works
Targeted hyperthermia using dextran magnetite complex: a new treatment modality for liver tumors.
Mitsumori, M., Hiraoka, M., Shibata, T., et al. (1997) · PubMed · Cited by 76 · see citing works
van Vulpen, M., de Leeuw, A. A. C., Raaymakers, B. W., et al. (2003) · British Journal of Urology · doi:10.1111/j.1464-410x.2004.04551.x · Cited by 65 · see citing works
Treatment of experimental rabbit liver tumours by selectively targeted hyperthermia
Jones, S. K., Winter, J., & Gray, B. N. (2002) · International Journal of Hyperthermia · doi:10.1080/02656730110103519 · Cited by 58 · see citing works
Ohno, T., Wakabayashi, T., Takemura, A., Yoshida, J., Itô, A., Shinkai, M., Honda, H., & Kobayashi, T. (2002) · Journal of Neuro-Oncology · doi:10.1023/a:1015080808031 · Cited by 50 · see citing works
Archer, S. G., & Gray, B. N. (1990) · The American Journal of Surgery · doi:10.1016/s0002-9610(05)81228-0 · Cited by 44 · see citing works
The effect of tumour size on ferromagnetic embolization hyperthermia in a rabbit liver tumour model
Moroz, P., Jones, S. K., & Gray, B. N. (2002) · International Journal of Hyperthermia · doi:10.1080/02656730110095609 · Cited by 42 · see citing works
Hyperthermia in cancer therapy: current status
Anderson, R. L., & Kapp, D. S. (1990) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1990.tb120955.x · Cited by 37 · see citing works
Thermomagnetic surgery for cancer
Rand, R. W., Snow, H. D., & Brown, W. J. (1982) · Journal of Surgical Research · doi:10.1016/0022-4804(82)90026-9 · Cited by 34 · see citing works
Hurwitz, M., Kaplan, I., Hansen, J. L., et al. (2002) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)02809-2 · Cited by 19 · see citing works
Hepatic clearance of arterially infused ferromagnetic particles
Moroz, P., Jones, S. K., Metcalf, C., et al. (2003) · International Journal of Hyperthermia · doi:10.1080/02656730210147303 · Cited by 14 · see citing works
[Modern technologies of diagnosis and combined surgical treatment in liver tumors].
Granov, A. M., La, T., Pg, T., et al. (2003) · PubMed · Cited by 4 · see citing works
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Cited by
Sorted by citations
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date
Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1958-5 · Cited by 2,586 · see citing works
Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles
Laurent, S., Dutz, S., Häfeli, U. O., & Mahmoudi, M. (2011) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2011.04.003 · Cited by 1,326 · see citing works
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
The big picture on nanomedicine: the state of investigational and approved nanomedicine products
Etheridge, M. L., Campbell, S. A., Erdman, A. G., Haynes, C. L., Wolf, S. M., & McCullough, J. (2013) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2012.05.013 · Cited by 1,088 · see citing works
Guardia, P., Di Corato, R., Lartigue, L., Wilhelm, C., Espinosa, A., Garcia-Hernandez, M., Gazeau, F., Manna, L., & Pellegrino, T. (2012) · ACS Nano · doi:10.1021/nn2048137 · Cited by 752 · see citing works
Nanotoxicology: An Interdisciplinary Challenge
Krug, H. F., & Wick, P. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201001037 · Cited by 556 · see citing works
Tay, Z. W., Chandrasekharan, P., Chiu-Lam, A., Hensley, D. W., Dhavalikar, R., Zhou, X. Y., Yu, E. Y., Goodwill, P. W., Zheng, B., Rinaldi, C., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b00893 · Cited by 459 · see citing works
Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia
Blanco-Andujar, C., Walter, A., Cotin, G., Bordeianu, C., Mertz, D., Felder-Flesch, D., & Begin-Colin, S. (2016) · Nanomedicine · doi:10.2217/nnm-2016-5001 · Cited by 276 · see citing works
Palanisamy, S., & Wang, Y.-M. (2019) · Dalton Transactions · doi:10.1039/c9dt00459a · Cited by 230 · see citing works
Drug releasing nanoplatforms activated by alternating magnetic fields
Mertz, D., Sandre, O., & Bégin-Colin, S. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.02.025 · Cited by 119 · see citing works
Synthesis and characterization of magnetite nanoparticles coated with lauric acid
Mamani, J. B., Costa-Filho, A. J., Cornejo, D. R., Vieira, E. D., & Gamarra, L. F. (2013) · Materials Characterization · doi:10.1016/j.matchar.2013.04.001 · Cited by 116 · see citing works
Kratz, H., Taupitz, M., Ariza de Schellenberger, A., Kosch, O., Eberbeck, D., Wagner, S., Trahms, L., Hamm, B., & Schnorr, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190214 · Cited by 92 · see citing works
- Authors
- Thiesen, B., & Jordan, A.
- Affiliations
- MagForce Nanotechnologies AG, Berlin, Germany
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Thiesen, Burghard
- Venue
- International Journal of Hyperthermia
- Publisher
- Informa UK Limited
- Published
- 2008-01-01
- Volume
- 24
- Issue
- 6
- Pages
- 467-474
- ISSN
- 0265-6736 (ISSN-L)
- 1464-5157
- OpenAlex
- W2004685020
- Cited by
- 829
- References
- 46
- Citations by year
- 2026: 31 · 2025: 35 · 2024: 40 · 2023: 49 · 2022: 53 · 2021: 82 · 2020: 57 · 2019: 62 · 2018: 58 · 2017: 49 · 2016: 60 · 2015: 37 · 2014: 54 · 2013: 44 · 2012: 40
- FWCI
- 17.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Hyperthermia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- magnetic nanoparticles, magnetic hyperthermia, cancer therapy, clinical trials, alternating magnetic field, tumor cell killing, radiosensitization, chemosensitization, drug delivery, magnetic resonance imaging
- MeSH terms
- Animals, Clinical Trials as Topic, Heating, Humans, Hyperthermia, Induced, Magnetics, Neoplasms, Nanomedicine, Nanoparticles
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