In vivo MRI cell tracking: clinical studies
Open accessAbstract
OBJECTIVE: The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed. CONCLUSION: Clinical MRI cell tracking is likely to become an important tool at the bedside once (stem) cell therapy becomes mainstream. The most prominent role of this technique probably will be verification of accurate cell delivery with MRI-guided injection, in which interventional radiologists will play a role in the near future. All clinical studies described as of this writing have been performed outside the United States.
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Different parameters like core size of SPION, shape, hydrodynamic diameter, size distribution, nanoparticle coating and aggregation influence the longitudinal and transverse relaxivities of iron oxide nanoparticles.
“Different parameters like core size of SPION, shape, hydrodynamic diameter, size distribution, nanoparticles coating and aggregation influence the longitudinal and transverse relaxivities of iron oxide nanoparticles.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [112]
r2 typically shows a linear increase with increasing particle core size from 4-5 to 18 nm, while r1 remains rather invariant for particles larger than approximately 8 nm.
“While r2 typically shows a linear increase with increasing the particle core size from 4-5 to 18 nm, r1 remains rather invariant for particles larger than approximately 8 nm.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [112]
For large clusters, if the size exceeds 90 nm, r2 decreases with increasing size due to a reduction in proton exchange rate arising from reduced surface accessibility.
“In the case of large clusters, if the size exceeds 90 nm, r2 decreases with increasing size due to a reduction in the proton exchange rate arising from the reduction in surface accessibility.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [112]
For small clusters, r2 gradually increases with hydrodynamic diameter up until approximately 80 nm.
“Regarding the effect of hydrodynamic diameter and aggregation on relaxivities, r2 gradually increases with the hydrodynamic diameter (up until approximately 80 nm) for small clusters, because SPION are consistently dispersed in water and protons diffuse between the magnetic cores.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [112]
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- Authors
- Bulte, J. W. M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Bulte, Jeff W. M.
- ORCID
- Bulte, Jeff W. M.
- Venue
- American Journal of Roentgenology
- Publisher
- American Roentgen Ray Society
- Published
- 2009-08
- Volume
- 193
- Issue
- 2
- Pages
- 314-325
- ISSN
- 0002-9580 (ISSN-L)
- 0361-803X
- 1546-3141
- PMC
- PMC2857985
- OpenAlex
- W2052324533
- Cited by
- 430
- References
- 72
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 15 · 2023: 13 · 2022: 14 · 2021: 19 · 2020: 16 · 2019: 23 · 2018: 25 · 2017: 25 · 2016: 33 · 2015: 32 · 2014: 35 · 2013: 34 · 2012: 60
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Roentgenology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ns045062-10)
- National Institute on Drug Abuse (R01 DA02699, R01DA026299)
- National Institute of Neurological Disorders and Stroke (R01-NS045062)
- National Institute of Biomedical Imaging and Bioengineering (R01EB007825, R21EB005252)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Keywords
- MRI cell tracking, superparamagnetic iron oxide nanoparticles, stem cell therapy, interventional radiology, clinical trials
- MeSH terms
- Adult, Aged, Animals, Cell Movement, Contrast Media, Dendritic Cells, Female, Ferric Compounds, Humans, Immunotherapy, Lymphatic Metastasis, Magnetic Resonance Imaging, Male, Melanoma, Skin Neoplasms, Staining and Labeling, Stem Cells, Swine, Cell Transplantation, Cancer Vaccines, Stem Cell Transplantation, Mice
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