The DOI matches its Crossref record; 228 of the 230 references it cites were found in a registry or an index.
Learning to see again: biological constraints on cortical plasticity and the implications for sight restoration technologies
Open accessPublished version of a preprint
Abstract
The ‘bionic eye’—so long a dream of the future—is finally becoming a reality with retinal prostheses available to patients in both the US and Europe. However, clinical experience with these implants has made it apparent that the visual information provided by these devices differs substantially from normal sight. Consequently, the ability of patients to learn to make use of this abnormal retinal input plays a critical role in whether or not some functional vision is successfully regained. The goal of the present review is to summarize the vast basic science literature on developmental and adult cortical plasticity with an emphasis on how this literature might relate to the field of prosthetic vision. We begin with describing the distortion and information loss likely to be experienced by visual prosthesis users. We then define cortical plasticity and perceptual learning, and describe what is known, and what is unknown, about visual plasticity across the hierarchy of brain regions involved in visual processing, and across different stages of life. We close by discussing what is known about brain plasticity in sight restoration patients and discuss biological mechanisms that might eventually be harnessed to improve visual learning in these patients.
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“However, this number might underestimate the real needs of implanted patients due to the perceptual and behavioural learning required to adapt to artificial vision [121,122].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [121]
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Cites
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2 of the 230 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Fine, 2003b, Long-term deprivation affects visual perception and cortex, Nat. Neurosci., 6, 915, 10.1038/nn1102 · DOI
- Kohler, 1951, Warum sehen wir aufrecht—obwohl die Bilder im Inneren des Auges verkehrt stehen?, Die Pyramide, 28
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Gamification Enhances User Engagement and Task Performance in Prosthetic Vision Testing
Turkstra, L. M., Johnson, B. A., Kartha, A., Dagnelie, G., & Beyeler, M. (2026) · Translational Vision Science & Technology · doi:10.1167/tvst.15.5.16
Self-citationLi, X., Khalil, I., Rahman, F., & Khan, M. N. (2026) · Biomimetics · doi:10.3390/biomimetics11090649 · Cited by 6
Metadata
- Authors
- Beyeler, M., Rokem, A., Boynton, G. M., & Fine, I.
- Affiliations
- University of Washington (US)
- Corresponding author
- Beyeler, Michael
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2017-08-22
- Volume
- 14
- Issue
- 5
- Pages
- 051003
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- PMC
- PMC5953572
- OpenAlex
- W2950139901
- Cited by
- 102
- References
- 230
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 8 · 2023: 2 · 2022: 16 · 2021: 13 · 2020: 15 · 2019: 12 · 2018: 9 · 2017: 7
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Neural Engineering (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Gordon and Betty Moore Foundation
- Washington Research Foundation (Funds for Innovation in Neuroengineering and Data-Intensive Discovery (MB))
- Alfred P Sloan Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- retinal prosthesis, cortical plasticity, visual plasticity, perceptual learning, vision restoration, hierarchical visual processing, developmental plasticity, adult plasticity, visual learning
- MeSH terms
- Humans, Learning, Neuronal Plasticity, Visual Cortex, Visual Perception, Visual Prosthesis, Optogenetics
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