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Electronic nose: a non-invasive technology for breath analysis of diabetes and lung cancer patients
Abstract
In human exhaled breath, more than 3000 volatile organic compounds (VOCs) are found, which are directly or indirectly related to internal biochemical processes in the body. Electronic noses (E-noses) could play a potential role in screening/analyzing various respiratory and systemic diseases by studying breath signatures. An E-nose integrates a sensor array and an artificial neural network that responds to specific patterns of VOCs, and thus can act as a non-invasive technology for disease monitoring. The gold standard blood glucose monitoring test for diabetes diagnostics is invasive and highly uncomfortable. This contributes to the massive need for technologies which are non-invasive and can be used as an alternative to blood measurements for glucose detection. While lung cancer is one of the deadliest cancers with the highest death rate and an extremely high yearly global burden, the conventional diagnosis means, such as sputum cytology, chest radiography, or computed tomography, do not support wide-range population screening. A few standard non-invasive techniques, such as mass spectrometry and gas chromatography, are expensive, non-portable, and require skilled personnel for operation and are again not suitable for large-scale screening. Breath contains markers for both diabetes and lung cancer along with markers for several diseases and thus, a non-invasive technique such as the E-nose would greatly improve analysis procedures over existing invasive methods. This review shows the state-of-the-art technologies for VOC detection and machine learning approaches for two clinical models: diabetes and lung cancer detection.
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“VOCs in breath can also be used as biomarkers for the detection and monitoring of diabetes (Behera et al. 2019).”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Behera et al. 2019
In the citing paper
“Changes in the levels of certain VOCs, such as acetone and isoprene, have been associated with diabetes and its complications.”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Behera et al. 2019
Citations
Cites
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621
Revisions in the International System for Staging Lung Cancer
Mountain, C. F. (1997) · CHEST Journal · doi:10.1378/chest.111.6.1710 · Cited by 4,565
Early Lung Cancer Action Project: overall design and findings from baseline screening
Henschke, C. I., McCauley, D. I., Yankelevitz, D. F., Naidich, D. P., McGuinness, G., Miettinen, O. S., Libby, D. M., Pasmantier, M. W., Koizumi, J. H., Altorki, N. K., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)06093-6 · Cited by 2,504
Nanoscale metal oxide-based heterojunctions for gas sensing: A review
Miller, D. R., Akbar, S. A., & Morris, P. A. (2014) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2014.07.074 · Cited by 1,854
Hodgkinson, J., & Tatam, R. P. (2012) · Measurement Science and Technology · doi:10.1088/0957-0233/24/1/012004 · Cited by 1,759
Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose
Persaud, K. C., & Dodd, G. H. (1982) · Nature · doi:10.1038/299352a0 · Cited by 1,601
Acidic extracellular microenvironment and cancer
Kato, Y., Ozawa, S., Miyamoto, C., Maehata, Y., Suzuki, A., Maeda, T., & Baba, Y. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-89 · Cited by 1,295
Diagnosing lung cancer in exhaled breath using gold nanoparticles
Peng, G., Tisch, U., Adams, O., Hakim, M., Shehada, N., Broza, Y. Y., Billan, S., Abdah‐Bortnyak, R., Kuten, A., & Haick, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.235 · Cited by 1,268
A brief history of electronic noses
Gardner, J. W., & Bartlett, P. N. (1994) · Sensors and Actuators B Chemical · doi:10.1016/0925-4005(94)87085-3 · Cited by 1,264
SnO2: A comprehensive review on structures and gas sensors
Das, S., & Jayaraman, V. (2014) · Progress in Materials Science · doi:10.1016/j.pmatsci.2014.06.003 · Cited by 1,230
Highly ordered nanowire arrays on plastic substrates for ultrasensitive flexible chemical sensors
McAlpine, M. C., Ahmad, H., Wang, D., & Heath, J. R. (2007) · Nature Materials · doi:10.1038/nmat1891 · Cited by 959
Volatile Organic Compounds of Lung Cancer and Possible Biochemical Pathways
Hakim, M., Broza, Y. Y., Barash, O., Peled, N., Phillips, M., Amann, A., & Haick, H. (2012) · Chemical Reviews · doi:10.1021/cr300174a · Cited by 953
Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
DeBerardinis, R. J., & Thompson, C. B. (2012) · Cell · doi:10.1016/j.cell.2012.02.032 · Cited by 858
Selected ion flow tube mass spectrometry (SIFT‐MS) for on‐line trace gas analysis
Smith, D. C., & Španěl, P. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20033 · Cited by 801
Role of reactive oxygen species in apoptosis: implications for cancer therapy
Matés, J. M., & Sánchez‐Jiménez, F. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00088-6 · Cited by 791
Peng, G., Hakim, M., Broza, Y. Y., Billan, S., Abdah‐Bortnyak, R., Kuten, A., Tisch, U., & Haick, H. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605810 · Cited by 776
Maturity-onset diabetes of the young (MODY): how many cases are we missing?
Shields, B. M., Hicks, S., Shepherd, M. H., Colclough, K., Hattersley, A. T., & Ellard, S. (2010) · Diabetologia · doi:10.1007/s00125-010-1799-4 · Cited by 725
A European Respiratory Society technical standard: exhaled biomarkers in lung disease
Horváth, I., Barnes, P. J., Loukides, S., Sterk, P. J., Högman, M., Olin, A., Amann, A., Antus, B., Baraldi, E., Bikov, A., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.00965-2016 · Cited by 668
Natale, C. D., Macagnano, A., Martinelli, E., Paolesse, R., D’Arcangelo, G., Roscioni, C., Finazzi‐Agrò, A., & D’Amico, A. (2003) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(03)00086-1 · Cited by 664
The scent of disease: volatile organic compounds of the human body related to disease and disorder
Shirasu, M., & Touhara, K. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr090 · Cited by 633
Righettoni, M., Tricoli, A., & Pratsinis, S. E. (2010) · Analytical Chemistry · doi:10.1021/ac902695n · Cited by 631
Detection of Lung Cancer by Sensor Array Analyses of Exhaled Breath
Machado, R. F., Laskowski, D. M., Deffenderfer, O., Burch, T., Zheng, S., Mazzone, P. J., Mekhail, T. M., Jennings, C. A., Stoller, J. K., Pyle, J., et al. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200409-1184oc · Cited by 607
Deng, C., ZHANG, J., Xiang, Y., Zhang, W., & ZHANG, X. (2004) · Journal of Chromatography B · doi:10.1016/s1570-0232(04)00657-9 · Cited by 591
McNair, H. M., Miller, J. M., & Snow, N. H. (2019) · Wiley eBooks · doi:10.1002/9781119450795 · Cited by 589
Detection of Lung Cancer With Volatile Markers in the Breatha
Phillips, M., Cataneo, R. N., Cummin, A. R. C., Gagliardi, A. J., Gleeson, K., Greenberg, J. H., Maxfield, R. A., & Rom, W. N. (2003) · CHEST Journal · doi:10.1378/chest.123.6.2115 · Cited by 567
Nakhleh, M. K., Amal, H., Jeries, R., Broza, Y. Y., Aboud, M., Gharra, A., Ivgi, H., Khatib, S., Badarneh, S., Har‐Shai, L., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b04930 · Cited by 521
Harkema, J. R., Carey, S. A., & Wagner, J. G. (2006) · Toxicologic Pathology · doi:10.1080/01926230600713475 · Cited by 513
Diagnostic Accuracy of Canine Scent Detection in Early- and Late-Stage Lung and Breast Cancers
McCulloch, M., Jezierski, T. A., Broffman, M., Hubbard, A., Turner, K., & Janecki, T. (2006) · Integrative Cancer Therapies · doi:10.1177/1534735405285096 · Cited by 491
Review on ion mobility spectrometry. Part 1: current instrumentation
Cumeras, R., Figueras, E., Davis, C. E., Baumbach, J. I., & Gràcia, I. (2015) · The Analyst · doi:10.1039/c4an01100g · Cited by 459
Data analysis for electronic nose systems
Scott, S. M., James, D., & Ali, Z. (2006) · Microchimica Acta · doi:10.1007/s00604-006-0623-9 · Cited by 452
Classification, Pathophysiology, Diagnosis and Management of Diabetes Mellitus
Baynes, H. W. (2015) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000541 · Cited by 426
Poli, D., Carbognani, P., Corradi, M., Goldoni, M., Acampa, O., Balbi, B., Bianchi, L. N. C., Rusca, M., & Mutti, A. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-71 · Cited by 416
An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD
Dragonieri, S., Annema, J. T., Schot, R., van der Schee, M. P., Spanevello, A., Carratù, P., Resta, O., Rabe, K. F., & Sterk, P. J. (2008) · Lung Cancer · doi:10.1016/j.lungcan.2008.08.008 · Cited by 411
Bogardus, C., Lillioja, S., Howard, B. V., Reaven, G. M., & Mott, D. M. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111533 · Cited by 397
Choi, S., Jang, B.-H., Lee, S.-J., Min, B. K., Rothschild, A., & Kim, I. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am405088q · Cited by 394
TiO2 thin film gas sensor for monitoring ammonia
Karunagaran, B., Uthirakumar, P., Chung, S., Velumani, S., & Suh, E. ‐. (2007) · Materials Characterization · doi:10.1016/j.matchar.2006.11.007 · Cited by 394
Shin, J., Choi, S., Lee, I., Youn, D., Park, C. O., Lee, J., Tuller, H. L., & Kim, I. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201202729 · Cited by 392
Two-dimensional layered nanomaterials for gas-sensing applications
Yang, W. S., Gan, L., Li, H., & Zhai, T. (2016) · Inorganic Chemistry Frontiers · doi:10.1039/c5qi00251f · Cited by 374
Volatile organic compounds in exhaled air from patients with lung cancer.
Gordon, S. M., Szidon, J. P., Krotoszynski, B. K., Gibbons, R. D., & O’Neill, H. J. (1985) · Clinical Chemistry · doi:10.1093/clinchem/31.8.1278 · Cited by 366
Insights into Direct Nose to Brain Delivery: Current Status and Future Perspective
Mittal, D., Ali, A., Md, S., Baboota, S., Sahni, J. K., & Ali, J. (2014) · Drug Delivery · doi:10.3109/10717544.2013.838713 · Cited by 359
Ferroelectric WO3 Nanoparticles for Acetone Selective Detection
Wang, L., Teleki, A., Pratsinis, S. E., & Gouma, P. (2008) · Chemistry of Materials · doi:10.1021/cm800761e · Cited by 358
Electronic Nose Feature Extraction Methods: A Review
Jia, Y., Guo, X., Duan, S., Jia, P., Wang, L., Peng, C. H., & Zhang, S. (2015) · Sensors · doi:10.3390/s151127804 · Cited by 340
Clinical Application of Volatile Organic Compound Analysis for Detecting Infectious Diseases
Sethi, S., Nanda, R. K., & Chakraborty, T. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-13 · Cited by 333
An investigation on electronic nose diagnosis of lung cancer
D’Amico, A., Pennazza, G., Santonico, M., Martinelli, E., Roscioni, C., Galluccio, G., Paolesse, R., & Natale, C. D. (2009) · Lung Cancer · doi:10.1016/j.lungcan.2009.11.003 · Cited by 330
Diagnosis of lung cancer by the analysis of exhaled breath with a colorimetric sensor array
Mazzone, P. J., Hammel, J., Dweik, R. A., Na, J., Czich, C., Laskowski, D., & Mekhail, T. M. (2007) · Thorax · doi:10.1136/thx.2006.072892 · Cited by 329
Is breath acetone a biomarker of diabetes? A historical review on breath acetone measurements
Wang, Z., & Wang, C. (2013) · Journal of Breath Research · doi:10.1088/1752-7155/7/3/037109 · Cited by 319
Breath acetone monitoring by portable Si:WO3 gas sensors
Righettoni, M., Tricoli, A., Gass, S., Schmid, A., Amann, A., & Pratsinis, S. E. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.06.002 · Cited by 317
Breath Analysis in Disease Diagnosis: Methodological Considerations and Applications
Lourenco, C. M., & Turner, C. (2014) · Metabolites · doi:10.3390/metabo4020465 · Cited by 314
Choi, S., Lee, I., Jang, B.-H., Youn, D., Ryu, W., Park, C. O., & Kim, I. (2012) · Analytical Chemistry · doi:10.1021/ac303148a · Cited by 312
A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis
Chen, X., Xu, F., Wang, Y., Pan, Y., Lu, D., Wang, P., Ying, K., Chen, E., & Zhang, W. (2007) · Cancer · doi:10.1002/cncr.22844 · Cited by 251
Kim, N. H., Choi, S., Yang, D., Bae, J., Park, J., & Kim, I. (2013) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2013.12.011 · Cited by 247
Mazzone, P. J., Wang, X. F., Xu, Y., Mekhail, T. M., Beukemann, M., Na, J., Kemling, J. W., Suslick, K. S., & Sasidhar, M. (2011) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e318233d80f · Cited by 246
Wang, C., Mbi, A., & Shepherd, M. D. (2009) · IEEE Sensors Journal · doi:10.1109/jsen.2009.2035730 · Cited by 236
Peng, G., Trock, E., & Haick, H. (2008) · Nano Letters · doi:10.1021/nl801577u · Cited by 232
A layered surface acoustic wave gas sensor based on a polyaniline/In 2 O 3 nanofibre composite
Sadek, A. Z., Włodarski, W., Shin, K., Kaner, R. B., & Kalantar‐Zadeh, K. (2006) · Nanotechnology · doi:10.1088/0957-4484/17/17/034 · Cited by 225
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals,,
Musa‐Veloso, K., Likhodii, S. S., & Cunnane, S. C. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.65 · Cited by 220
Analysis of Volatile Organic Compounds in the Exhaled Breath for the Diagnosis of Lung Cancer
Mazzone, P. J. (2008) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31817c7439 · Cited by 215
HEWITT, C. N., Hayward, S., & Tani, A. (2002) · Journal of Environmental Monitoring · doi:10.1039/b204712h · Cited by 211
O’Neill, H. J., Gordon, S. M., O'Neill, M. H., Gibbons, R. D., & Szidon, J. P. (1988) · Clinical Chemistry · doi:10.1093/clinchem/34.8.1613 · Cited by 207
Neonatal diabetes mellitus: a disease linked to multiple mechanisms
Polak, M., & Cavé, H. (2007) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-2-12 · Cited by 200
McNair, H. M., & Miller, J. M. (2008) · Wiley eBooks · doi:10.1002/9780470480106 · Cited by 199
Non-invasive Breath Analysis of Pulmonary Nodules
Peled, N., Hakim, M., Bunn, P. A., Miller, Y. E., Kennedy, T. C., Mattei, J., Mitchell, J. D., Hirsch, F. R., & Haick, H. (2012) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3182637d5f · Cited by 194
Electronic Nose Technology in Respiratory Diseases
Dragonieri, S., Pennazza, G., Carratù, P., & Resta, O. (2017) · Lung · doi:10.1007/s00408-017-9987-3 · Cited by 183
Sniffing the Unique “Odor Print” of Non‐Small‐Cell Lung Cancer with Gold Nanoparticles
Barash, O., Peled, N., Hirsch, F. R., & Haick, H. (2009) · Small · doi:10.1002/smll.200900937 · Cited by 182
Xiao, T., Wang, X.-Y., Zhao, Z., Liu, L., Zhang, L., Yao, H., Wang, J., & Li, Z. (2014) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2014.04.015 · Cited by 181
A Novel Breath Analysis System Based on Electronic Olfaction
Guo, D., Zhang, D. D., Li, N., Lei Zhang, A., & Yang, J. (2010) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2010.2055864 · Cited by 178
Metal oxide nanowires for chemiresistive gas sensors: Issues, challenges and prospects
Ramgir, N. S., Datta, N., Kaur, M., Kailasaganapathi, S., Debnath, A. K., Aswal, D. K., & Gupta, S. K. (2013) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2013.02.029 · Cited by 177
Drug-induced Hypoglycemia: A Review Based on 473 Cases
Seltzer, H. S. (1972) · Diabetes · doi:10.2337/diab.21.9.955 · Cited by 176
Surface acoustic wave-based gas sensors
Jakubik, W. P. (2011) · Thin Solid Films · doi:10.1016/j.tsf.2011.04.174 · Cited by 176
Wilson, A. D. (2018) · Sensors · doi:10.3390/s18082613 · Cited by 174
Persaud, K. C. (2005) · Materials Today · doi:10.1016/s1369-7021(05)00793-5 · Cited by 168
Dakhale, G., Chaudhari, H. V., & Shrivastava, M. (2011) · Advances in Pharmacological Sciences · doi:10.1155/2011/195271 · Cited by 163
Wang, Y., Hu, Y., Wang, D., Yu, K., Wang, L., Zou, Y., Zhao, C., Zhang, X., Wang, P., & Ying, K. (2012) · Cancer Biomarkers · doi:10.3233/cbm-2012-00270 · Cited by 162
Chatterjee, S., Castro, M., & Feller, J. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20819b · Cited by 162
Taking your breath away: metabolomics breathes life in to personalized medicine
Rattray, N. J. W., Rattray, Z., Trivedi, D. K., Goodacre, R., & Fowler, S. J. (2014) · Trends in biotechnology · doi:10.1016/j.tibtech.2014.08.003 · Cited by 159
Targeting the Metabolic Microenvironment of Tumors
Bailey, K. M., Wojtkowiak, J. W., Hashim, A. I., & Gillies, R. J. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-397927-8.00004-x · Cited by 157
Volatile signature for the early diagnosis of lung cancer
Gasparri, R., Santonico, M., Valentini, C., Sedda, G., Borri, A., Petrella, F., Maisonneuve, P., Pennazza, G., D’Amico, A., Natale, C. D., et al. (2016) · Journal of Breath Research · doi:10.1088/1752-7155/10/1/016007 · Cited by 156
A novel method for diabetes diagnosis based on electronic nose
Wang, P., Yi, T., Haibao, X., & Farong, S. (1997) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(97)00059-6 · Cited by 146
Analysis of diabetic patient's breath with conducting polymer sensor array
Yu, J.-B., Byun, H., So, M.-S., & Huh, J.-S. (2005) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2005.01.040 · Cited by 146
Exhaled Breath Analysis for Lung Cancer Detection Using Ion Mobility Spectrometry
Handa, H., Usuba, A. T., Maddula, S., Baumbach, J., Mineshita, M., & Miyazawa, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114555 · Cited by 142
Multivariate optimization techniques in food analysis – A review
Ferreira, S. L. C., Silva, M. M., Felix, C. S. A., da Silva, D. L. F., Santos, A. S., Neto, J. H. S., de Souza, C. T., Cruz, R. A., & Souza, A. S. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.11.114 · Cited by 142
Kim, N. H., Choi, S., Kim, S., Cho, H., Jang, J., Koo, W., Kim, M., & Kim, I. (2015) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2015.10.021 · Cited by 139
Design of a Breath Analysis System for Diabetes Screening and Blood Glucose Level Prediction
Yan, K., Zhang, D. D., Wu, D., Wei, H., & Lu, G. (2014) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2014.2329753 · Cited by 137
Rapid acetone detection using indium loaded WO3/SnO2 nanohybrid sensor
Tomer, V. K., Singh, K., Kaur, H., Shorie, M., & Sabherwal, P. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.06.179 · Cited by 137
Exhaled Breath Analysis for Monitoring Response to Treatment in Advanced Lung Cancer
Agmon, I. N., Abud-Hawa, M., Liran, O., Gai-Mor, N., Ilouze, M., Onn, A., Bar, J., Shlomi, D., Haick, H., & Peled, N. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.02.017 · Cited by 136
Castro, M., Kumar, B., Feller, J., Haddi, Z., Amari, A., & Bouchikhi, B. (2011) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2011.06.073 · Cited by 134
Samnakay, R., Jiang, C., Rumyantsev, S., Shur, M. S., & Balandin, A. A. (2015) · Applied Physics Letters · doi:10.1063/1.4905694 · Cited by 131
A carbon nanotube sensor array for sensitive gas discrimination using principal component analysis
Lu, Y., Partridge, C., Meyyappan, M., & Li, J. (2006) · Journal of Electroanalytical Chemistry · doi:10.1016/j.jelechem.2006.03.056 · Cited by 131
Detecting cancer by breath volatile organic compound analysis: a review of array-based sensors
Queraltó, N., Berliner, A., Goldsmith, B. R., Martino, R. A., Rhodes, P., & Lim, S. H. (2014) · Journal of Breath Research · doi:10.1088/1752-7155/8/2/027112 · Cited by 131
A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines
Filipiak, W., Mochalski, P., Filipiak, A., Ager, C., Cumeras, R., Davis, C. E., Agapiou, A., Unterkofler, K., & Troppmair, J. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666160510122913 · Cited by 131
Dhatariya, K. (2016) · The Review of Diabetic Studies · doi:10.1900/rds.2016.13.217 · Cited by 130
An innovative gas sensor incorporating ZnO–CuO nanoflakes in planar MEMS technology
Behera, B., & Chandra, S. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.01.079 · Cited by 123
Self-citationMeasuring airway exchange of endogenous acetone using a single-exhalation breathing maneuver
Anderson, J. C., Lamm, W. J., & Hlastala, M. P. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00868.2005 · Cited by 118
Gas Sensors Based on Semiconducting Nanowire Field-Effect Transistors
Feng, P., Shao, F., Shi, Y., & Wan, Q. C. (2014) · Sensors · doi:10.3390/s140917406 · Cited by 113
Schallschmidt, K., Becker, R., Jung, C., Bremser, W., Walles, T., Neudecker, J., Leschber, G., Frese, S., & Nehls, I. (2016) · Journal of Breath Research · doi:10.1088/1752-7155/10/4/046007 · Cited by 113
Acetone, ammonia and hydrogen cyanide in exhaled breath of several volunteers aged 4–83 years
Španěl, P., Dryahina, K., & Smith, D. C. (2007) · Journal of Breath Research · doi:10.1088/1752-7155/1/1/011001 · Cited by 112
Buljubasic, F., & Buchbauer, G. (2014) · Flavour and Fragrance Journal · doi:10.1002/ffj.3219 · Cited by 110
McWilliams, A. M., Beigi, P., Srinidhi, A., Lam, S. C., & MacAulay, C. E. (2015) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2015.2409092 · Cited by 109
Synthesis of WO3 nanorods by thermal oxidation technique for NO2 gas sensing application
Behera, B., & Chandra, S. (2018) · Materials Science in Semiconductor Processing · doi:10.1016/j.mssp.2018.06.022 · Cited by 108
Self-citationChemical sensing with ZnO nanowire field-effect transistor
Fan, Z., & Lu, J. G. (2006) · IEEE Transactions On Nanotechnology · doi:10.1109/tnano.2006.877428 · Cited by 106
Real‐time endoscopic Raman spectroscopy forin vivoearly lung cancer detection
McGregor, H. C., Short, M. A., McWilliams, A. M., Shaipanich, T., Ionescu, D. N., Zhao, J., Wang, W., Chen, G., Lam, S. C., & Zeng, H. (2016) · Journal of Biophotonics · doi:10.1002/jbio.201500204 · Cited by 106
Nanosensor Device for Breath Acetone Detection
Wang, L., Kalyanasundaram, K., Stanaćević, M., & Gouma, P. (2010) · Sensor Letters · doi:10.1166/sl.2010.1334 · Cited by 106
Non-invasive blood glucose monitoring for diabetics by means of breath signal analysis
Guo, D., Zhang, D. D., Lei Zhang, A., & Lu, G. (2012) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2012.06.025 · Cited by 105
Shen, J.-Y., Zhang, L., Ren, J., Wang, J., Yao, H., & Li, Z. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.08.069 · Cited by 104
Preparation and characterization of NiO thin films for gas sensor applications
Hotový, I., Huran, J., Spieß, L., CAPKOVIC, R., & Haščík, Š. (2000) · Vacuum · doi:10.1016/s0042-207x(00)00182-2 · Cited by 102
Smith, D. C., Španěl, P., Enderby, B., Lenney, W., Turner, C., & Davies, S. (2009) · Journal of Breath Research · doi:10.1088/1752-7155/4/1/017101 · Cited by 101
Rydosz, A. M. (2015) · Journal of Diabetes Science and Technology · doi:10.1177/1932296815572366 · Cited by 100
Digital PCR quantification of miRNAs in sputum for diagnosis of lung cancer
Li, N., Ma, J., Guarnera, M. A., Fang, H., Cai, L., & Jiang, F. (2013) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-013-1555-5 · Cited by 99
Lung Cancer Screening Based on Type-different Sensor Arrays
Li, W., Liu, H., Xie, D., He, Z., & Pi, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-02154-9 · Cited by 96
Analysis of exhaled breath for diagnosing head and neck squamous cell carcinoma: a feasibility study
Gruber, M., Tisch, U., Jeries, R., Amal, H., Hakim, M., Ronen, O., Marshak, T., Zimmerman, D., Israel, O., Amiga, E., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.361 · Cited by 95
Narjinary, M. B., Rana, P., Sen, A., & Pal, M. (2016) · Materials & Design · doi:10.1016/j.matdes.2016.11.042 · Cited by 94
Buffered end-tidal (BET) sampling—a novel method for real-time breath-gas analysis
Herbig, J., Titzmann, T., Beauchamp, J. D., Kohl, I., & Hansel, A. (2008) · Journal of Breath Research · doi:10.1088/1752-7155/2/3/037008 · Cited by 93
Comparison of classification methods in breath analysis by electronic nose
Leopold, J. H., Bos, L. D. J., Sterk, P. J., Schultz, M. J., Fens, N., Horváth, I., Bikov, A., Montuschi, P., Natale, C. D., Yates, D. H., et al. (2015) · Journal of Breath Research · doi:10.1088/1752-7155/9/4/046002 · Cited by 91
Detection of lung cancer with electronic nose and logistic regression analysis
Tirzīte, M., Bukovskis, M., Strazda, G., Jurka, N., & Taivāns, I. (2018) · Journal of Breath Research · doi:10.1088/1752-7163/aae1b8 · Cited by 91
Tirzīte, M., Bukovskis, M., Strazda, G., Jurka, N., & Taivāns, I. (2017) · Journal of Breath Research · doi:10.1088/1752-7163/aa7799 · Cited by 89
Synthesis and excellent acetone sensing properties of porous WO 3 nanofibers
Wei, S., Zhao, G., Du, W., & Tian, Q. (2015) · Vacuum · doi:10.1016/j.vacuum.2015.11.010 · Cited by 87
Bikov, A., Paschalaki, K. E., Logan-Sinclair, R., Horváth, I., Kharitonov, S. A., Barnes, P. J., Usmani, O. S., & Paredi, P. (2013) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-13-43 · Cited by 83
Predicting Type 2 diabetes using an electronic nose-based artificial neural network analysis.
Mohamed, E. I., Linder, R., Perriello, G., Daniele, N. D., Pöppl, S. J., & LORENZO, A. D. (2002) · PubMed · Cited by 80
Human breath analysis: methods for sample collection and reduction of localized background effects
Martin, A. N., Farquar, G. R., Jones, A. D., & Frank, M. A. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-3217-7 · Cited by 79
Breath Analysis of Lung Cancer Patients Using an Electronic Nose Detection System
Tran, V. H., Chan, H. P., Thurston, M. C., Jackson, P., Lewis, C. R., Yates, D. H., Bell, G., & Thomas, P. S. (2010) · IEEE Sensors Journal · doi:10.1109/jsen.2009.2038356 · Cited by 78
Bikov, A., Hernadi, M., Kőrösi, B., Kunos, L., Zsamboki, G., Süttő, Z., Tárnoki, Á. D., Tárnoki, D. L., Losonczy, G., & Horváth, I. (2014) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-14-202 · Cited by 77
Choi, S., Ryu, W., Kim, S., Cho, H., & Kim, I. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb00767k · Cited by 76
Integration of ZnO nanostructures with MEMS for ethanol sensor
Pandya, H. J., Chandra, S., & Vyas, A. L. (2011) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2011.11.063 · Cited by 74
Self-citationExhaled breath analysis by electronic nose in respiratory diseases
Scarlata, S., Pennazza, G., Santonico, M., Pedone, C., & Incalzi, R. A. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2015.1043895 · Cited by 64
Breath Ketone Testing: A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis
Qiao, Y., Gao, Z., Liu, Y., Cheng, Y., Yu, M., 赵玲玲, Duan, Y., & Liu, Y. (2014) · BioMed Research International · doi:10.1155/2014/869186 · Cited by 62
CO sensing characteristics of In-doped ZnO semiconductor nanoparticles
Dhahri, R., Hjiri, M., Mir, L. E., Alamri, H. R., Bonavita, A., Iannazzo, D., Leonardi, S. G., & Neri, G. (2017) · Journal of Science Advanced Materials and Devices · doi:10.1016/j.jsamd.2017.01.003 · Cited by 62
Aksenov, A. A., Gojová, A., Zhao, W., Morgan, J. T., Sankaran, S., Sandrock, C. E., & Davis, C. E. (2012) · ChemBioChem · doi:10.1002/cbic.201200011 · Cited by 59
Saraoğlu, H. M., Selvı, A. O., Ebeoğlu, M. A., & Taşaltın, C. (2013) · IEEE Sensors Journal · doi:10.1109/jsen.2013.2265233 · Cited by 57
Diagnostic bronchoscopy: state of the art
Dooms, C., Seijo, L. M., Gasparini, S., Trisolini, R., Ninane, V., & Tournoy, K. G. (2010) · European Respiratory Review · doi:10.1183/09059180.00005710 · Cited by 57
Rydosz, A. M., Szkudlarek, A., Ziąbka, M., Domanski, K., Maziarz, W., & Pisarkiewicz, T. (2015) · IEEE Sensors Journal · doi:10.1109/jsen.2015.2496212 · Cited by 57
Liu, F., Xiao, P., Fang, H. L., Dai, H. F., Qiao, L., & Zhang, Y. (2011) · Physica E Low-dimensional Systems and Nanostructures · doi:10.1016/j.physe.2011.08.033 · Cited by 56
Dunayevskiy, Y. M., Lai, J., Quinn, C. L., Talley, F., & Vouros, P. (1997) · Rapid Communications in Mass Spectrometry · doi:10.1002/(sici)1097-0231(199707)11:11 · Cited by 54
de Meij, T. G. J., de Boer, N. K. H., Benninga, M. A., Lentferink, Y. E., de Groot, E. F. J., van de Velde, M. E., Bodegraven, A. A. V., & van der Schee, M. P. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.09.004 · Cited by 49
Molina, D. K., Nichols, J. J., & DiMaio, V. J. M. (2007) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000236055.33085.77 · Cited by 48
Elective haemodialysis increases exhaled isoprene
Lirk, P. B., Bodrogi, F., Raifer, H., Greiner, K., Ulmer, H., & Rieder, J. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg049 · Cited by 45
Lung Cancer Identification by an Electronic Nose based on an Array of MOS Sensors
Blatt, R., Bonarini, A., Calabrò, E., Torre, M. D., Matteucci, M., & Pastorino, U. (2007) · IEEE International Conference on Neural Networks/IEEE ... International Conference on Neural Networks · doi:10.1109/ijcnn.2007.4371167 · Cited by 45
Cui, S., Wang, J., & Wang, X. (2015) · RSC Advances · doi:10.1039/c5ra06388d · Cited by 44
Chen, B., Liu, C., Ge, L., & Hayashi, K. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.03.117 · Cited by 44
Sputum cytology in suspected cases of carcinoma of lung (Sputum cytology a poor man′s bronchoscopy!)
Ammanagi, A., Dombale, V. D., Miskin, A., Dandagi, G., & Sangolli, S. S. (2012) · Lung India · doi:10.4103/0970-2113.92356 · Cited by 40
Yoo, H. Y., & Bruckenstein, S. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.04.052 · Cited by 40
Photoluminescence based H2 and O2 gas sensing by ZnO nanowires
Yadav, K., Gahlaut, S. K., Mehta, B. R., & Singh, J. P. (2016) · Applied Physics Letters · doi:10.1063/1.4942092 · Cited by 40
The biochemical basis of disease
Barr, A. (2018) · Essays in Biochemistry · doi:10.1042/ebc20170054 · Cited by 40
Advances in NO2 sensing with individual single-walled carbon nanotube transistors
Chikkadi, K., Muoth, M., Roman, C. I., Haluska, M., & Hierold, C. (2014) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.5.227 · Cited by 39
Optimal feature selection for classifying a large set of chemicals using metal oxide sensors
Nowotny, T., Berna, A. Z., Binions, R., & Trowell, S. (2013) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2013.01.088 · Cited by 38
Early Detection of Lung Cancer Using Nano-Nose - A Review
Fernandes, M. P., Venkatesh, S., & Sudarshan, B. (2015) · The Open Biomedical Engineering Journal · doi:10.2174/1874120701509010228 · Cited by 37
Magnetic resonance imaging for lung cancer screen.
Wáng, Y. X. J., Lo, G. G., Yuan, J., Larson, P. E. Z., & Zhang, X. (2014) · PubMed Central · doi:10.3978/j.issn.2072-1439.2014.08.43 · Cited by 35
Chakraborty, S., Mandal, I., Ray, I., Majumdar, S., Sen, A., & Maiti, H. S. (2007) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2007.05.005 · Cited by 34
Huo, D., Xu, Y., Hou, C., Yang, M. J., & Fa, H. (2014) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2014.03.114 · Cited by 33
Influence of respiratory variables on the on-line detection of exhaled trace gases by PTR-MS
Boshier, P. R., Priest, O. H., Hanna, G. B., & Marczin, N. (2011) · Thorax · doi:10.1136/thx.2011.161208 · Cited by 33
Chen, X., Cao, M., Yan, H., Li, Y., Wang, P., Ying, K., & Pan, H. (2005) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2005.1615826 · Cited by 30
Two techniques to sample non-volatiles in breath—exemplified by methadone
Ljungkvist, G., Ullah, S., Tinglev, Å., Stein, K., Bake, B., Larsson, P., Almstrand, A., Viklund, E., Hammar, O., Sandqvist, S., et al. (2017) · Journal of Breath Research · doi:10.1088/1752-7163/aa8b25 · Cited by 28
Diabetes diagnosis by direct measurement from urine odor using electronic nose
Siyang, S., Wongchoosuk, C., & Kerdcharoen, T. (2012) · Biomedical Engineering International Conference · doi:10.1109/bmeicon.2012.6465441 · Cited by 27
Wang, D., Yu, K., Wang, Y., Hu, Y., Zhao, C., Wang, L., Ying, K., & Wang, P. (2011) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545811500064 · Cited by 25
7.1.3 Breath acetone monitoring by portable Si:WO3 gas sensors
Righettoni, M., Tricoli, A., Gass, S., Pratsinis, S. E., Schmid, A., & Amann, A. (2012) · Proceedings IMCS 2012 · doi:10.5162/imcs2012/7.1.3 · Cited by 24
Real-time metabolic monitoring with proton transfer reaction mass spectrometry
Winkler, K., Herbig, J., & Kohl, I. (2013) · Journal of Breath Research · doi:10.1088/1752-7155/7/3/036006 · Cited by 23
A MEMS based acetone sensor incorporating ZnO nanowires synthesized by wet oxidation of Zn film
Behera, B., & Chandra, S. (2014) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/25/1/015007 · Cited by 20
Self-citationWu, C.-H., Wang, W.-H., Hong, C.-C., & Hwang, K. C. (2016) · Lab on a Chip · doi:10.1039/c6lc01157h · Cited by 20
A novel breath analysis system for diabetes diagnosis
Yan, K., & Zhang, D. D. (2012) · doi:10.1109/icch.2012.6724490 · Cited by 19
Ammonia Sensing and a Cross Sensitivity Evaluation with Atmosphere Gases using Optical Fiber Sensor
Manap, H., Muda, R., O’Keeffe, S., & Lewis, E. (2009) · Procedia Chemistry · doi:10.1016/j.proche.2009.07.239 · Cited by 17
Behera, B., & Chandra, S. (2015) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2015.09.009 · Cited by 16
Self-citationKuch'yanov, A. S., Chubakov, P. A., & Plekhanov, A. I. (2015) · Optics Communications · doi:10.1016/j.optcom.2015.04.045 · Cited by 13
Catalyst-Free Synthesis of ZnO Nanowires on Oxidized Silicon Substrate for Gas Sensing Applications
Behera, B., & Chandra, S. (2014) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2015.9783 · Cited by 11
Self-citationA Study on Electronic Nose for Clinical Breath Diagnosis of Lung Cancer
Wang, D., Wang, L., Jin, Y., Wang, P., Hu, Y., Ying, K., Pardo, M., & Sberveglieri, G. (2009) · AIP conference proceedings · doi:10.1063/1.3156535 · Cited by 8
Righettoni, M., Tricoli, A., & Pratsinis, S. E. (2010) · Proceedings of IEEE Sensors/Proceedings of IEEE Sensors ... · doi:10.1109/icsens.2010.5690350 · Cited by 7
Behera, B., & Chandra, S. (2016) · Advanced Materials Letters · doi:10.5185/amlett.2016.6101 · Cited by 7
Self-citationAn Investigation about the origin of the lung cancer signalling VOCs in breath
Capuano, R., Martinelli, E., Ghezzi, S., Paolesse, R., Natale, C. D., D’Amico, A., Santonico, M., & Pennazza, G. (2014) · Proceedings of IEEE Sensors/Proceedings of IEEE Sensors ... · doi:10.1109/icsens.2014.6985267 · Cited by 6
Tumor Diagnosis 2Ed: Practical approach and pattern analysis
Al-Nafussi, A. (2005) · Medical Entomology and Zoology · Cited by 6
Leopold, J. H., Bos, L. D. J., Colombo, C., Sterk, P. J., Schultz, M. J., & Abu–Hanna, A. (2017) · Journal of Breath Research · doi:10.1088/1752-7163/aa6488 · Cited by 6
Progress of Different Sensing Materials Modified QCM Gas Sensors
Wang, Z., Mingqing, Y., He, J., & Qiaowen, Y. (2015) · Huaxue jinzhan · doi:10.7536/pc140914 · Cited by 6
Fabrication and Characterization of Low Temperature Acetone Sensor Using CuO Nanowires
Pandya, H. J., Chandra, S., & Vyas, A. L. (2011) · Nanoscience and Nanotechnology Letters · doi:10.1166/nnl.2011.1269 · Cited by 5
Self-citation
Research works printed but not linked: 3
- Covington, 2011, Detection and identification of inflammatory bowel disease electronic nose, vol. 1362, 285
- Bai, 2007, Gas Sensors Based on Conducting Polymers Sensors, 7, 267
- Jungwoo, 2012, Thin‐wall assembled SnO2 fibers functionalized by catalytic Pt nanoparticles and their superior exhaled‐breath‐sensing properties for the diagnosis of diabetes, Adv. Funct. Mater., 23, 2357, 10.1002/adfm.201202729 · DOI
Cited by
Sorted by citations
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Wang, C., He, T., Zhou, H., Zhang, Z., & Lee, C. (2023) · Bioelectronic Medicine · doi:10.1186/s42234-023-00118-1 · Cited by 295
Chaki, J., Ganesh, S. T., Cidham, S. K., & Theertan, S. A. (2020) · Journal of King Saud University - Computer and Information Sciences · doi:10.1016/j.jksuci.2020.06.013 · Cited by 301
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Metadata
- Authors
- Behera, B., Joshi, R., Anil Vishnu, G. K., Bhalerao, S., & Pandya, H. J.
- Affiliations
- Indian Institute of Science Bangalore (IN)
- Corresponding author
- Pandya, Hardik J
- Venue
- Journal of Breath Research
- Publisher
- IOP Publishing
- Published
- 2019-03-06
- Volume
- 13
- Issue
- 2
- Pages
- 024001
- ISSN
- 1752-7155 (ISSN-L)
- 1752-7163
- OpenAlex
- W2910501941
- Cited by
- 179
- References
- 170
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 28 · 2023: 25 · 2022: 35 · 2021: 24 · 2020: 25 · 2019: 9
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Breath Research (publishedVersion)
- PubMed (publishedVersion)
- NOT FOUND REPOSITORY (Indian Institute of Science Bangalore) (acceptedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
- Physical Sciences › Chemistry › Spectroscopy › Spectroscopy and Laser Applications
- Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
- Keywords
- electronic nose, breath analysis, volatile organic compounds, diabetes diagnosis, lung cancer detection, non-invasive diagnosis, blood glucose monitoring, VOC detection, machine learning classification, disease screening
- MeSH terms
- Machine Learning, Breath Tests, Diabetes Mellitus, Humans, Lung Neoplasms, Nanoparticles, Electronic Nose
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