T Cell Responses to Influenza Virus Infection: Effector and Memory Cells

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

Förster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner‐Müller, I., Wolf, E., & Lipp, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80059-8 · Cited by 2,348 · see citing works

Lineage relationship and protective immunity of memory CD8 T cell subsets

Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864 · see citing works

Noncytolytic Control of Viral Infections by the Innate and Adaptive ImmuneResponse

Guidotti, L. G., & Chisari, F. V. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.65 · Cited by 1,003 · see citing works

Virus-Specific CD8+ T Cells in Primary and Secondary Influenza Pneumonia

Flynn, K. J., Belz, G. T., Altman, J. D., Ahmed, R., Woodland, D. L., & Doherty, P. C. (1998) · Immunity · doi:10.1016/s1074-7613(00)80573-7 · Cited by 674 · see citing works

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

Homann, D., Teyton, L., & Oldstone, M. B. A. (2001) · Nature Medicine · doi:10.1038/90950 · Cited by 587 · see citing works

CD8+ T cells clear influenza virus by perforin or Fas-dependent processes

Topham, D. J., Tripp, R. A., & Doherty, P. C. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.11.5197 · Cited by 486 · see citing works

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

Lukacher, A. E., Braciale, V. L., & Braciale, T. J. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.160.3.814 · Cited by 436 · see citing works

Effector CD4+ and CD8+ T‐cell mechanisms in the control of respiratory virus infections

Doherty, P. C., Topham, D. J., Tripp, R. A., Cardin, R. D., Brooks, J. W., & Stevenson, P. G. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01010.x · Cited by 429 · see citing works

Class II-Independent Generation of CD4 Memory T Cells from Effectors

Swain, S. L., Hu, H., & Huston, G. E. (1999) · Science · doi:10.1126/science.286.5443.1381 · Cited by 413 · see citing works

Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity.

Liang, S., Mozdzanowska, K., Palladino, G., & Gerhard, W. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1653 · Cited by 400 · see citing works

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

Bender, B. S., Croghan, T. W., Zhang, L., & Small, P. A. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.4.1143 · Cited by 383 · see citing works

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

Eichelberger, M. C., Allan, W., Zijlstra, M., Jaenisch, R., & Doherty, P. C. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.4.875 · Cited by 367 · see citing works

CD4 Effector T Cell Subsets in the Response to Influenza

Román, E., Miller, E., Harmsen, A. G., Wiley, J., von Andrian, U. H., Huston, G. E., & Swain, S. L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021052 · Cited by 327 · see citing works

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells

Li, J., Huston, G. E., & Swain, S. L. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030725 · Cited by 309 · see citing works

Compromised Influenza Virus-Specific CD8 + -T-Cell Memory in CD4 + -T-Cell-Deficient Mice

Belz, G. T., Wodarz, D., Diaz, G. M., Nowak, M. A., & Doherty, P. C. (2002) · Journal of Virology · doi:10.1128/jvi.76.23.12388-12393.2002 · Cited by 290 · see citing works

Protection from Respiratory Virus Infections Can Be Mediated by Antigen-Specific Cd4+ T Cells That Persist in the Lungs

Hogan, R. J., Zhong, W., Usherwood, E. J., Cookenham, T. S., Roberts, A. D., & Woodland, D. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.8.981 · Cited by 288 · see citing works

Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection.

Graham, M. B., Braciale, V. L., & Braciale, T. J. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.4.1273 · Cited by 283 · see citing works

Accessing Complexity: The Dynamics of Virus-Specific T Cell Responses

Doherty, P. C., & Christensen, J. P. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.561 · Cited by 279 · see citing works

Resistance to and Recovery from Lethal Influenza Virus Infection in B Lymphocyte–deficient Mice

Graham, M. B., & Braciale, T. J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.12.2063 · Cited by 241 · see citing works

The Role of the Antibody Response in Influenza Virus Infection

Gerhard, W. (2001) · Current topics in microbiology and immunology · doi:10.1007/978-3-662-05783-4_9 · Cited by 211 · see citing works

Differential T Cell Function and Fate in Lymph Node and Nonlymphoid Tissues

Harris, N. L., Watt, V., Ronchese, F., & Gros, G. S. L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011558 · Cited by 204 · see citing works

Migration Kinetics and Final Destination of Type 1 and Type 2 CD8 Effector Cells Predict Protection against Pulmonary Virus Infection

Cerwenka, A., Morgan, T., Harmsen, A. G., & Dutton, R. W. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.423 · Cited by 196 · see citing works

CD4+ T cell effectors can become memory cells with high efficiency and without further division

Hu, H., Huston, G. E., Duso, D. K., Lepak, N. M., Román, E., & Swain, S. L. (2001) · Nature Immunology · doi:10.1038/90643 · Cited by 184 · see citing works

Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin.

Bradley, L. M., Watson, S. R., & Swain, S. L. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2401 · Cited by 178 · see citing works

CD4 T cell responses to influenza infection

Brown, D. M., Román, E., & Swain, S. L. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.02.004 · Cited by 175 · see citing works

Clearance of an Influenza A Virus by CD4+T Cells Is Inefficient in the Absence of B Cells

Topham, D. J., & Doherty, P. C. (1998) · Journal of Virology · doi:10.1128/jvi.72.1.882-885.1998 · Cited by 173 · see citing works

Naive, Effector, and Memory CD8 T Cells in Protection Against Pulmonary Influenza Virus Infection: Homing Properties Rather Than Initial Frequencies Are Crucial

Cerwenka, A., Morgan, T., & Dutton, R. W. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5535 · Cited by 170 · see citing works

Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig

Topham, D. J., Tripp, R. A., Hamilton-Easton, A. M., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.7.2947 · Cited by 157 · see citing works

Antigen-Specific CD8+ T Cells Persist in the Upper Respiratory Tract Following Influenza Virus Infection

Wiley, J. A., Hogan, R. J., Woodland, D. L., & Harmsen, A. G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3293 · Cited by 146 · see citing works

Functional Subsets of Memory T Cells Identified by CCR7 Expression

Sallusto, F., Langenkamp, A., Geginat, J., & Lanzavecchia, A. (2000) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-57276-0_21 · Cited by 145 · see citing works

Nonspecific Recruitment of Memory CD8+ T Cells to the Lung Airways During Respiratory Virus Infections

Ely, K. H., Cauley, L. S., Roberts, A. D., Brennan, J. W., Cookenham, T. S., & Woodland, D. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1423 · Cited by 141 · see citing works

CD4 + T cell-mediated control of a γ-herpesvirus in B cell-deficient mice is mediated by IFN-γ

Christensen, J. P., Cardin, R. D., Branum, K. C., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5135 · Cited by 126 · see citing works

Antibody-forming cells in the nasal-associated lymphoid tissue during primary influenza virus infection.

Tamura, S., Suzuki, Y., Iwasaki, T., et al. (1998) · Journal of General Virology · doi:10.1099/0022-1317-79-2-291 · Cited by 111 · see citing works

Long-Term Maintenance of Virus-Specific Effector Memory CD8+ T Cells in the Lung Airways Depends on Proliferation

Hogan, R. J., Cauley, L. S., Ely, K. H., Cookenham, T. S., Roberts, A. D., Brennan, J. W., Monard, S. P., & Woodland, D. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4976 · Cited by 108 · see citing works

Cellular immunity and memory to respiratory virus infections

Woodland, D. L., Hogan, R. J., & Zhong, W. (2001) · Immunologic Research · doi:10.1385/ir:24:1:53 · Cited by 97 · see citing works

Th Cell-Deficient Mice Control Influenza Virus Infection More Effectively Than Th- and B Cell-Deficient Mice: Evidence for a Th-Independent Contribution by B Cells to Virus Clearance

Mozdzanowska, K., Maiese, K., & Gerhard, W. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2635 · Cited by 96 · see citing works

Cutting Edge: Virus-Specific CD4+ Memory T Cells in Nonlymphoid Tissues Express a Highly Activated Phenotype

Cauley, L. S., Cookenham, T. S., Miller, T. B., Adams, P. S., Vignali, K. M., Vignali, D. A. A., & Woodland, D. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.6655 · Cited by 91 · see citing works

Influenza virus-specific antibody-secreting cells in the murine lung during primary influenza virus infection

Jones, P. D., & Ada, G. (1986) · Journal of Virology · doi:10.1128/jvi.60.2.614-619.1986 · Cited by 87 · see citing works

Cutting Edge: Effector Memory CD8+ T Cells in the Lung Airways Retain the Potential to Mediate Recall Responses

Ely, K. H., Roberts, A. D., & Woodland, D. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3338 · Cited by 80 · see citing works

Functionally Heterogeneous CD8+T-Cell Memory Is Induced by Sendai Virus Infection of Mice

Usherwood, E. J., Hogan, R. J., Crowther, G., Surman, S. L., Hogg, T. L., Altman, J. D., & Woodland, D. L. (1999) · Journal of Virology · doi:10.1128/jvi.73.9.7278-7286.1999 · Cited by 77 · see citing works

High Antigen Density and IL-2 Are Required for Generation of CD4 Effectors Secreting Th1 Rather Than Th0 Cytokines

Rogers, P., Huston, G. E., & Swain, S. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.8.3844 · Cited by 71 · see citing works

Cell-mediated immunity to respiratory virus infections

Woodland, D. L. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(03)00067-0 · Cited by 64 · see citing works

IgG isotype distribution of local and systemic immune responses induced by influenza virus infection

Fazekas, G., Rosenwirth, B., Dukor, P., Gergely, J., & Rajnavölgyi, É. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241222 · Cited by 50 · see citing works

CD4+ T Cell Priming Accelerates the Clearance of Sendai Virus in Mice, but Has a Negative Effect on CD8+ T Cell Memory

Zhong, W., Marshall, D. R., Coleclough, C., & Woodland, D. L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3274 · Cited by 44 · see citing works

Antibody-Independent Antiviral Function of Memory CD4+ T Cells In Vivo Requires Regulatory Signals from CD8+ Effector T Cells

Zhong, W., Roberts, A. D., & Woodland, D. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1379 · Cited by 43 · see citing works

The airway epithelium: soldier in the fight against respiratory viruses

Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works

Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection

Sun, K., & Metzger, D. W. (2008) · Nature Medicine · doi:10.1038/nm1765 · Cited by 587 · see citing works

An IL-7 Fusion Protein That Shows Increased Thymopoietic Ability

Henson, S. M., Snelgrove, R., Hussell, T., Wells, D. J., & Aspinall, R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.4112 · Cited by 55 · see citing works

Aging, cytomegalovirus (CMV) and influenza vaccine responses

Frasca, D., & Blomberg, B. B. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1105413 · Cited by 46 · see citing works

Humans and Ferrets with Prior H1N1 Influenza Virus Infections Do Not Exhibit Evidence of Original Antigenic Sin after Infection or Vaccination with the 2009 Pandemic H1N1 Influenza Virus

O'Donnell, C. D., Wright, A. R., Vogel, L., et al. (2014) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00790-13 · Cited by 20 · see citing works

Minor Changes in the Hemagglutinin of Influenza A(H1N1)2009 Virus Alter Its Antigenic Properties

Strengell, M., Ikonen, N., Ziegler, T. T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025848 · Cited by 69 · see citing works

[Importance of cross-reacting antibodies in creating resistance to influenza].

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Most influenza A virus-specific memory cytotoxic T lymphocytes react with antigenic epitopes associated with internal virus determinants.

Kees, U. R., & Krammer, P. H. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.159.2.365 · Cited by 112 · see citing works

Virus-specific T cells as correlate of (cross-)protective immunity against influenza

Altenburg, A. F., Rimmelzwaan, G. F., & de Vries, R. D. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.11.054 · Cited by 140 · see citing works