An IL-7 Fusion Protein That Shows Increased Thymopoietic Ability

Sequence analysis of peptides bound to MHC class II molecules

Rudensky, A. Y., Preston‐Hurlburt, P., Hong, S., Barlow, A. K., & Janeway, C. A. (1991) · Nature · doi:10.1038/353622a0 · Cited by 1,073 · see citing works

IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor κB ligand and tumor necrosis factor α from T cells

Toraldo, G., Roggia, C., Qian, W.-P., Pacifici, R., & Weitzmann, M. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0136772100 · Cited by 276 · see citing works

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

Haynes, L., Eaton, S. M., Burns, E. M., Randall, T. D., & Swain, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2433717100 · Cited by 270 · see citing works

Immunogenicity and protective efficacy of influenza vaccination

HANNOUN, C., Megas, F., & Piercy, J. (2004) · Virus Research · doi:10.1016/j.virusres.2004.02.025 · Cited by 261 · see citing works

Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice.

Rich, B. E., Campos-Torres, J., Tepper, R. I., Moreadith, R. W., & Leder, P. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.2.305 · Cited by 243 · see citing works

Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase – increased expression with reduced muscle damage

McMahon, J. M., Signori, E., Wells, K., Fazio, V. M., & Wells, D. J. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301522 · Cited by 235 · see citing works

Pegylation: engineering improved pharmaceuticals for enhanced therapy

Molineux, G. (2002) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(02)80004-4 · Cited by 226 · see citing works

Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7

Bolotin, E., Smogorzewska, M., Smith, S. M., Widmer, M. B., & Weinberg, K. I. (1996) · Blood · doi:10.1182/blood.v88.5.1887.1887 · Cited by 225 · see citing works

Development of antibodies to unprotected glycosylation sites on recombinant human GM-CSF

Gribben, J. G., Devereux, S., Thomas, N. S. B., Keim, M., Jones, H. M., Goldstone, A. H., & Linch, D. C. (1990) · The Lancet · doi:10.1016/0140-6736(90)90665-r · Cited by 210 · see citing works

Cutting Edge: Identification of the Orphan Chemokine Receptor GPR-9-6 as CCR9, the Receptor for the Chemokine TECK

Zaballos, Á., Gutiérrez, J., Varona, R., Ardavı́n, C., & Márquez, G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.10.5671 · Cited by 203 · see citing works

Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine

Kang, I., Hong, M. S., Nolasco, H., Park, S. H., Dan, J. M., Choi, J.-Y., & Craft, J. E. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.673 · Cited by 197 · see citing works

Pharmacokinetic and Pharmacodynamic Studies of a Human Serum Albumin-Interferon-α Fusion Protein in Cynomolgus Monkeys

Osborn, B. L., Olsen, H. S., Nardelli, B., Murray, J. H., Zhou, J. X. H., Garcia, A., Moody, G. E., Zaritskaya, L., & Sung, C. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.037002 · Cited by 193 · see citing works

Age-associated thymic atrophy is linked to a decline in IL-7 production

Andrew, D. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00213-3 · Cited by 170 · see citing works

Interleukin-7 restores immunity in athymic T-cell–depleted hosts

Fry, T. J., Christensen, B. L., Komschlies, K. L., Gress, R. E., & Mackall, C. L. (2001) · Blood · doi:10.1182/blood.v97.6.1525 · Cited by 152 · see citing works

Pure Red-Cell Aplasia and Recombinant Erythropoietin

Gershon, S. K., Luksenburg, H., Coté, T. R., & Braun, M. M. (2002) · New England Journal of Medicine · doi:10.1056/nejm200205163462015 · Cited by 144 · see citing works

Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection

Po, J. L., Gardner, E. M., Anaraki, F., Katsikis, P. D., & Murasko, D. M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00010-6 · Cited by 143 · see citing works

IL-7 and Not Stem Cell Factor Reverses Both the Increase in Apoptosis and the Decline in Thymopoiesis Seen in Aged Mice

Andrew, D., & Aspinall, R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1524 · Cited by 138 · see citing works

Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction

Moore, N. C., Anderson, G., Smith, C. A., Owen, J. J. T., & Jenkinson, E. J. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230424 · Cited by 132 · see citing works

Induction of TCR Gene Rearrangements in Uncommitted Stem Cells by a Subset of IL-7 Producing, MHC Class II–Expressing Thymic Stromal Cells

Oosterwegel, M. A., Haks, M. C., Jeffry, U. B., Murray, R., & Kruisbeek, A. M. (1997) · Immunity · doi:10.1016/s1074-7613(00)80337-4 · Cited by 113 · see citing works

A Critical Role for OX40 in T Cell–mediated Immunopathology during Lung Viral Infection

Humphreys, I. R., Walzl, G., Edwards, L., Rae, A. J., Hill, S., & Hussell, T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030351 · Cited by 105 · see citing works

IL-7 Gene Therapy in Aging Restores Early Thymopoiesis without Reversing Involution

Phillips, J. A., Brondstetter, T. I., English, C. A., Lee, H. E., Virts, E. L., & Thoman, M. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.8.4867 · Cited by 104 · see citing works

Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus

Bruno, R., Sabater, L., Sospedra, M., Ferrer-Francesch, X., Escudero, D., Martínez-Cáceres, E. M., & Pujol‐Borrell, R. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(2002010)32:10 · Cited by 102 · see citing works

Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

Haynes, L., Eaton, S. M., Burns, E. M., Randall, T. D., & Swain, S. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041933 · Cited by 102 · see citing works

TECK, an Efficacious Chemoattractant for Human Thymocytes, Uses GPR-9-6/CCR9 as a Specific Receptor

Youn, B., Kim, C. H., Smith, F. O., & Broxmeyer, H. E. (1999) · Blood · doi:10.1182/blood.v94.7.2533.419k37_2533_2536 · Cited by 86 · see citing works

A comparative study of the relative bioavailability of different interferon beta preparations

Deisenhammer, F., Mayringer, I., Harvey, J. L., Dilitz, E., Gasse, T., Stadlbauer, D., Reindl, M., & Berger, T. (2000) · Neurology · doi:10.1212/wnl.54.11.2055 · Cited by 84 · see citing works

Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys

Storek, J., Gillespy, T., Lu, H., Joseph, A., Dawson, M. A., Gough, M., Morris, J. C., Hackman, R. C., Horn, P. A., Sale, G. E., et al. (2003) · Blood · doi:10.1182/blood-2002-08-2671 · Cited by 84 · see citing works

In vivo gene electrotransfer into skeletal muscle: effects of plasmid DNA on the occurrence and extent of muscle damage

Durieux, A., Bonnefoy, R., Busso, T., & Freyssenet, D. G. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.534 · Cited by 82 · see citing works

Prevalence and significance of anticardiolipin, anti‐β2 glycoprotein I and anti‐prothrombin antibodies in chronic hepatitis C

Leroy, V., Arvieux, J., Jacob, M., Maynard, M., Baud, M., & Zarski, J. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00722.x · Cited by 81 · see citing works

High-efficiency plasmid gene transfer into dystrophic muscle

Gollins, H., McMahon, J. M., Wells, K. E., & Wells, D. J. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301927 · Cited by 81 · see citing works

A dose effect of IL-7 on thymocyte development

Kassar, N. E., Lucas, P. J., Klug, D. B., Zamisch, M., Merchant, M. S., Bare, C. V., Choudhury, B., Sharrow, S. O., Richie, E. R., Mackall, C. L., et al. (2004) · Blood · doi:10.1182/blood-2004-01-0201 · Cited by 75 · see citing works

T Cell Responses to Influenza Virus Infection: Effector and Memory Cells

Swain, S. L., Dutton, R. W., & Woodland, D. L. (2004) · Viral Immunology · doi:10.1089/0882824041310577 · Cited by 63 · see citing works

Five‐year follow‐up of growth hormone antibodies in growth hormone deficient children treated with recombinant human growth hormone

Massa, G., Vanderschueren‐Lodeweyckx, M., & Bouillon, R. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb00985.x · Cited by 51 · see citing works

Efficient DNA transfection of quiescent mammalian cells using poly-L-ornithine

Dong, Y., Skoultchi, A. I., & Pollard, J. W. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.3.771 · Cited by 48 · see citing works

Age-Associated Thymic Atrophy Is Not Associated with a Deficiency in the CD44+CD25−CD3−CD4−CD8− Thymocyte Population

Aspinall, R., & Andrew, D. (2001) · Cellular Immunology · doi:10.1006/cimm.2001.1848 · Cited by 47 · see citing works

Differential Disposition of Soluble and Liposome-Formulated Human Recombinant Interleukin-7: Effects on Blood Lymphocyte Population in Guinea Pigs

Bui, T., Faltynek, C. R., & Ho, R. J. Y. (1994) · Pharmaceutical Research · doi:10.1023/a:1018955708443 · Cited by 25 · see citing works

Development of Anti‐hGH Antibodies during Therapy with Authentic Human Growth Hormone

Lundin, K. E. A., BERGER, L., Blomberg, F., & Wilton, P. (1991) · Acta Paediatrica · doi:10.1111/j.1651-2227.1991.tb17996.x · Cited by 23 · see citing works

Interleukin-7 and Immunorestoration in HIV: Beyond the Thymus

Fry, T. J., & Mackall, C. L. (2002) · Stem Cells and Development · doi:10.1089/152581602760404603 · Cited by 21 · see citing works

Augmentation of cell-mediated immunotherapy against herpes simplex virus by interleukins: comparison of in vivo effects of IL-2 and IL-7 on adoptively transferred T cells

Wiryana, P., Bui, T., Faltynek, C. R., & Ho, R. J. Y. (1997) · Vaccine · doi:10.1016/s0264-410x(96)00212-5 · Cited by 21 · see citing works

N-linked carbohydrates in tyrosinase are required for its recognition by human MHC class II-restricted CD4+ T cells

Housseau, F., Moorthy, A., Langer, D., Robbins, P. F., Gonzales, M. I., & Topalian, S. L. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200109)31:9 · Cited by 20 · see citing works

An IL-2/Ig Fusion Protein Influences CD4 + T Lymphocytes in Naive and Simian Immunodeficiency Virus-Infected Rhesus Monkeys

Craiu, A., Barouch, D. H., Zheng, X. X., Kuroda, M. J., Schmitz, J. E., Lifton, M. A., Steenbeke, T. D., Nickerson, C. E., Beaudry, K. R., Frost, J. D., et al. (2001) · AIDS Research and Human Retroviruses · doi:10.1089/088922201750290005 · Cited by 18 · see citing works

Interleukin-7-enhanced cytotoxic T lymphocyte activity after viral infection in marrow transplanted mice

Abdul-Hai, A., Ben-Yehuda, A., Weiss, L., Friedman, G., Zakay-Rones, Z., Slavin, S., & Or, R. (1997) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1700706 · Cited by 17 · see citing works

Autoantibodies to factor VIII

Lacroix‐Desmazes, S., Misra, N., Bayry, J., Mohanty, D., Kaveri, S. V., & Kazatchkine, M. D. (2002) · Autoimmunity Reviews · doi:10.1016/s1568-9972(01)00017-9 · Cited by 15 · see citing works

A recombinant single-chain antibody interleukin-2 fusion protein

Savage, P. M., So, A., Spooner, R. A., & Epenetos, A. A. (1993) · Cell Biophysics · doi:10.1007/bf03033867 · Cited by 10 · see citing works

Immunosenescence: a key player in cancer development

Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works

Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

Thomas, R., Wang, W., & Su, D.-M. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-0173-8 · Cited by 442 · see citing works

Interconnections between Inflammageing and Immunosenescence during Ageing

Teissier, T., Boulanger, É., & Cox, L. S. (2022) · Cells · doi:10.3390/cells11030359 · Cited by 310 · see citing works

Cytomegalovirus Infection: A Driving Force in Human T Cell Immunosenescence

KOCH, S., LARBI, A., ÖZCELIK, D., SOLANA, R., GOUTTEFANGEAS, C., ATTIG, S., WIKBY, A., STRINDHALL, J., FRANCESCHI, C., & PAWELEC, G. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.043 · Cited by 242 · see citing works

Targeting immune dysfunction in aging

Borgoni, S., Kudryashova, K. S., Burka, K., & de Magalhães, J. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101410 · Cited by 227 · see citing works

Innate and adaptive immunosenescence

Agarwal, S., & Busse, P. J. (2010) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2009.11.009 · Cited by 215 · see citing works

Challenges for vaccination in the elderly

Aspinall, R., Giudice, G. D., Effros, R. B., Grubeck‐Loebenstein, B., & Sambhara, S. R. (2007) · Immunity & Ageing · doi:10.1186/1742-4933-4-9 · Cited by 205 · see citing works

Age-associated remodeling of T cell immunity and metabolism

Han, S., Georgiev, P., Ringel, A. E., Sharpe, A. H., & Haigis, M. C. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.005 · Cited by 193 · see citing works

Immunosenescence: signaling pathways, diseases and therapeutic targets

Fu, Y., Wang, B., Alu, A., Hong, W., Hong, L., He, X., Shi, H., Cheng, P., & Yang, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02371-z · Cited by 157 · see citing works

. Persistent viral infections and immune aging.

Brunner, S., Herndler-Brandstetter, D., Weinberger, B., & Grubeck-Loebenstein, B. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.003 · Cited by 143 · see citing works

Factors that may impact on immunosenescence: an appraisal

Ongrádi, J., & Kövesdi, V. (2010) · Immunity & Ageing · doi:10.1186/1742-4933-7-7 · Cited by 128 · see citing works

Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population.

Reber, A. J., Chirkova, T., Kim, J. H., Cao, W., Biber, R., Shay, D. K., & Sambhara, S. R. (2012) · Europe PMC (PubMed Central) · Cited by 128 · see citing works

Influenza control in the 21st century: Optimizing protection of older adults

Monto, A. S., Ansaldi, F., Aspinall, R., McElhaney, J. E., Montaño, L. F., Nichol, K. L., Puig‐Barberà, J., Schmitt, J., & Stephenson, I. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.06.032 · Cited by 125 · see citing works

Declining expression of a single epithelial cell‐autonomous gene accelerates age‐related thymic involution

Sun, L., Guo, J., Brown, R., Amagai, T., Zhao, Y., & Su, D. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00559.x · Cited by 83 · see citing works

Effects of IL-7 on memory CD8+ T cell homeostasis are influenced by the timing of therapy in mice

Nanjappa, S. G., Walent, J. H., Morre, M., & Suresh, M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32020 · Cited by 77 · see citing works

Reversing T cell immunosenescence: why, who, and how

Lang, P. O., Govind, S., & Aspinall, R. (2012) · AGE · doi:10.1007/s11357-012-9393-y · Cited by 76 · see citing works

Uremia-Associated Ageing of the Thymus and Adaptive Immune Responses

Betjes, M. G. H. (2020) · Toxins · doi:10.3390/toxins12040224 · Cited by 57 · see citing works

Immunity in the Elderly: The Role of the Thymus

Aspinall, R., Pitts, D. G., Lapenna, A., & Mitchell, W. (2009) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2009.10.022 · Cited by 55 · see citing works

Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions

Duggal, N. A. (2018) · Biogerontology · doi:10.1007/s10522-018-9771-7 · Cited by 53 · see citing works

Thymic Aging May Be Associated with COVID-19 Pathophysiology in the Elderly

Wang, W., Thomas, R. G., Oh, J., & Su, D. (2021) · Cells · doi:10.3390/cells10030628 · Cited by 52 · see citing works

Plasticity of neuroendocrine–thymus interactions during ontogeny and ageing: Role of zinc and arginine

Mocchegiani, E., Santarelli, L., Costarelli, L., Cipriano, C., Muti, E., Giacconi, R., & Malavolta, M. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.06.001 · Cited by 45 · see citing works

Thymic output, ageing and zinc

Mitchell, W. A., Meng, I., Nicholson, S. A., & Aspinall, R. (2006) · Biogerontology · doi:10.1007/s10522-006-9061-7 · Cited by 47 · see citing works

Bone Marrow Precursor Cells from Aged Mice Generate CD4 T Cells That Function Well in Primary and Memory Responses

Eaton, S. M., Maue, A. C., Swain, S. L., & Haynes, L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4825 · Cited by 45 · see citing works

Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19

Ma, Y., Huang, Y., Zhao, S., Yao, Y., Zhang, Y., Qu, J., Wu, N., & Su, J. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab125 · Cited by 43 · see citing works

Age and immunity

Vasto, S., Malavolta, M., & Pawelec, G. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-2 · Cited by 45 · see citing works

Reversal of age-associated thymic atrophy: Treatments, delivery, and side effects

Aspinall, R., & Mitchell, W. A. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.014 · Cited by 44 · see citing works

Interventions to restore appropriate immune function in the elderly

Aspinall, R., & Lang, P. O. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0111-6 · Cited by 38 · see citing works

Probiotic Consumption Boosts Thymus in Obesity and Senescence Mouse Models

Balcells, M. F., Monteros, M. J. M., Gómez, A. L., Cazorla, S. I., Perdigón, G., & Maldonado-Galdeano, C. (2022) · Nutrients · doi:10.3390/nu14030616 · Cited by 20 · see citing works

Non-human primate models of T-cell reconstitution

Nikolich‐Žugich, J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.003 · Cited by 20 · see citing works

Age-related thymic involution: Mechanistic insights and rejuvenating approaches to restore immune function

Santamaria, J. C., & Irla, M. (2026) · Science Advances · doi:10.1126/sciadv.aeb2970 · Cited by 19 · see citing works

Uremia-Associated Immunological Aging and Severity of COVID-19 Infection

Betjes, M. G. H. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.675573 · Cited by 14 · see citing works

Improvement of glucocorticoid-impaired thymus function by dihydromyricetin via up-regulation of PPARγ-associated fatty acid metabolism

Li, T., Yan, F., Meng, X., Wang, J., Kam, R. K. T., Zeng, X., Liu, Z., Zhou, H., Yang, F., Ren, R., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.09.011 · Cited by 14 · see citing works

The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment

Shi, H., Xiao, M., Li, Y., Liu, X., Na, J., Liang, C., Hua, J., Meng, Q., Wei, M., Wang, W., et al. (2025) · Theranostics · doi:10.7150/thno.112633 · Cited by 12 · see citing works

Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification

Lázničková, P., Bendíčková, K., Kepák, T., & Frič, J. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.708788 · Cited by 9 · see citing works

Central Immune Senescence, Reversal Potentials

Kvell, K., & Judit, E. (2012) · InTech eBooks · doi:10.5772/32905 · Cited by 8 · see citing works

Recombinant FOXN1 fusion protein increases T cell generation in old mice

Zhao, J. X., Hu, R., Lai, K. C., Zhang, Z., & Lai, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1423488 · Cited by 7 · see citing works

Dose response kinetics of CD8 lymphocytes from young animals transfused into old animals and challenged with influenza

Aspinall, R., Govind, S., Lapenna, A., & Lang, P. O. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-34 · Cited by 7 · see citing works

Immunosenescence and vaccination of the elderly II. New strategies to restore age-related immune impairment

Ongrádi, J., Stercz, B., Kövesdi, V., & Vértes, L. (2009) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/amicr.56.2009.4.1 · Cited by 8 · see citing works

Exploring the Complexity and Promise of Tumor Immunotherapy in Drug Development

Feng, Y., He, C., Liu, C., Shao, B., Wang, D., & Wu, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126444 · Cited by 6 · see citing works

Immunosenescence, Thymic Involution and Autoimmunity

Mitchell, W. A., & Aspinall, R. (2008) · Springer eBooks · doi:10.1007/978-0-387-76842-7_7 · Cited by 5 · see citing works

Pulmonary Delivery of Interleukin-7 Provides Efficient and Safe Delivery to the Aging Immune System

Mitchell, W. A., Castells, A. A., Lang, P. O., Matas, E., Lapenna, A., & Aspinall, R. (2012) · Rejuvenation Research · doi:10.1089/rej.2011.1258 · Cited by 4 · see citing works

Adding Insult to Injury: Improving the Regenerative Capacity of the Aged Thymus Following Clinically Induced Damage

Dudakov, J. A., Hun, M. L., Wong, K., Holländer, G. A., & Chidgey, A. P. (2019) · Springer eBooks · doi:10.1007/978-3-030-12040-5_13 · Cited by 4 · see citing works

Ergebnisse aus der biomedizinischen Alternsforschung

Pfister, G., Herndler‐Brandstetter, D., & Grubeck-Loebenstein, B. (2006) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-006-1278-8 · Cited by 4 · see citing works

Maintenance and Restoration of Immune System Function

Aspinall, R., & Mitchell, W. A. (2010) · Springer eBooks · doi:10.1007/978-90-481-3999-6_15 · Cited by 3 · see citing works

Age-Related Thymic Atrophy: Mechanisms and Outcomes

Thomas, R. G., & Su, D. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.86412 · Cited by 3 · see citing works

¿Somos tan viejos como nuestros linfocitos? Inmunosenescencia

Ledesma-Heyer, J. P., Valdes-Escarcega, M., & Ramos-Ostos, M. H. (2011) · Médica Sur · Cited by 2 · see citing works

Novel Strategies for Improved Vaccines for the Elderly: The Example of Influenza

Giudice, G. D., & Rappuoli, R. (2011) · Springer eBooks · doi:10.1007/978-3-0346-0219-8_10 · Cited by 2 · see citing works

IL-7 Immunotherapies: Current Applications and Engineering Opportunities

Ariail, E. C., Biggs, B. A., O’Flanagan, R., & Schneck, J. P. (2025) · Immunological Investigations · doi:10.1080/08820139.2025.2464055 · Cited by 1 · see citing works

Strategies for Thymic Regeneration: Recent Advances Towards Clinical Therapy

Barsanti, M., Hun, M. L., Boyd, R. L., & Chidgey, A. P. (2016) · Springer eBooks · doi:10.1007/978-4-431-56027-2_3 · Cited by 2 · see citing works

Interleukin-7 and Immunorejuvenation

Aspinall, R., Mitchell, W. A., & Lang, P. O. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_72 · Cited by 1 · see citing works

Ergebnisse aus der biomedizinischen Alternsforschung: Trends und aktuelle Beispiele aus der Immunologie

Pfister, G., Herndler‐Brandstetter, D., & Grubeck-Loebenstein, B. (2006) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · Cited by 1 · see citing works

Energy metabolism in developing chicken lymphocytes during the embryonic to posthatch transition

Rudrappa, S. G. (2007) · University Libraries (University of Maryland)

Immunosenescence and the 3Rs: Restoration, Replacement and Reprogramming

Mitchell, W. A., Pink, R. C., Lapenna, A., & Aspinall, R. (2011) · Springer eBooks · doi:10.1007/978-3-0346-0219-8_9

Interleukin -7 and Immunorejuvenation

Mitchell, W. A., & Aspinall, R. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_72

Interleukin-7 and Immunorejuvenation

Aspinall, R., Mitchell, W. A., & Lang, P. O. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_72-1

A GMCSF and IL7 fusion cytokine leads to functional thymic‐dependent T‐cell regeneration in age‐associated immune deficiency

Hsieh, J., Ng, S., Bosinger, S. E., Wu, J. H., Tharp, G. K., García, A., Hossain, M. S., Yuan, S., Waller, E. K., & Galipeau, J. (2015) · Clinical & Translational Immunology · doi:10.1038/cti.2015.8 · Cited by 7 · see citing works

In vivo administration of a novel synthetic GMCSF and IL7 fusion cytokine (GIFT7) leads to transient thymic hyperplasia by driving double-negative (DN), single-positive CD8 (SPCD8) and gamma-delta (γδ) thymocyte proliferation (165.7)

Hsieh, J., & Galipeau, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.188.supp.165.7

A Novel Synthetic GMCSF and IL7 Fusion Cytokine (GIFT7) Leads to T Cell Neogenesis by Reversing Age-Related Thymic Atrophy and Overcoming PD-1-Assocaited CD8 Exhaustion

Hsieh, J., McGary, C. S., Wu, J., Paiardini, M., Micci, L., García, A., Silvestri, G., Hossain, M. S., Waller, E. K., & Galipeau, J. (2012) · Blood · doi:10.1182/blood.v120.21.3289.3289

Checkpoint modulation of T cell immunity by novel fusion cytokines

Hsieh, H. C. (2014) · doi:10.82308/12121

Reviewing the potential utility of interleukin-7 as a promoter of thymopoiesis and immune recovery.

Or, R., Abdul-Hai, A., & Ben-Yehuda, A. (1998) · PubMed · Cited by 16 · see citing works