Stimulant Rebound: How Common Is It and What Does It Mean?
Abstract
OBJECTIVE: To examine rates and implications of stimulant-induced rebound - the behavioral deterioration that may occur as stimulant medications wear off. METHODS: This study compares nurse observations on evening shifts compared to day shifts in 149 psychiatrically hospitalized children treated with short-acting stimulants, usually methylphenidate, comparing nonmedication and stimulant-treated states. RESULTS: Behavioral deterioration (rebound), was observed in 30% of children on at least one dose of stimulants but was serious enough to discontinue treatment in only 8.7%. Children experiencing rebound did not differ clinically from those who did not. CONCLUSIONS: Rebound exists, occurs significantly in less than 10% of psychiatrically hospitalized children with attention deficit hyperactivity disorder, and does not appear to have specific diagnostic significance.
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Long-acting formulations may have insufficient duration of action, leading to symptom rebound at bedtime.
“Long-acting formulations may have insufficient duration of action, leading to symptom rebound at bedtime.”
From Associations of sleep disturbance with ADHD: implications for treatment (2015) · cites this paper as Carlson and Kelly 2003
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Rao, N. P. (2025) · Springer eBooks · doi:10.1007/978-3-031-85765-2_80
(2025) · Wiley eBooks · doi:10.1002/9781118941430.refs
Chopra, I., Horng, J., Krause, M., Sellinger, E. P., & Potenziano, J. (2025) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s575004
“18 Because age-specific estimates were scarce, these rates were applied across all age groups.”
- Authors
- Carlson, G. A., & Kelly, K. L.
- Affiliations
- State University of New York (US)
- Stony Brook University (US)
- Venue
- Journal of Child and Adolescent Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2003-06
- Volume
- 13
- Issue
- 2
- Pages
- 137-142
- ISSN
- 1044-5463 (ISSN-L)
- 1557-8992
- OpenAlex
- W1999039388
- Cited by
- 76
- References
- 17
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 1
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child and Adolescent Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- methylphenidate, attention deficit hyperactivity disorder, psychiatric hospitalization, children, treatment discontinuation
- MeSH terms
- Central Nervous System Stimulants, Analysis of Variance, Mental Disorders, Child, Female, Humans, Male, Psychiatric Status Rating Scales, Observation
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