Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA Titration Trial
Abstract
Objective Results of the NIMH Collaborative Multisite Multimodal Treatment Study of Children With Attention-Deficit/Hyperactivity Disorder (MTA) were analyzed to determine whether a double-blind, placebo-controlled methylphenidate (MPH) titration trial identified the best MPH dose for each child with attention-deficit/hyperactivity disorder (ADHD).Method Children with ADHD assigned to MTA medication treatment groups (n = 289) underwent a controlled 28-day titration protocol that administered different MPH doses (placebo, low, middle, and high) on successive days.Results A repeated-measures analysis of variance revealed main effects for MPH dose with greater effects on teacher ratings of impairment and deportment (F3 = 100.6, n = 223, p = .0001; effect sizes 0.8-1.3) than on parent ratings of similar endpoints (F3 = 55.61, n = 253, p = .00001; effect sizes 0.4-0.6). Dose did not interact with period, dose order, comorbid diagnosis, site, or treatment group.Conclusions The MTA titration protocol validated the efficacy of weekend MPH dosing and established a total daily dose limit of 35 mg of MPH for children weighing less than 25 kg. It replicated previously reported MPH response rates (77%), distribution of best doses (10-50 mg/day) across subjects, effect sizes on impairment and deportment, as well as dose-related adverse events.
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The present study focuses on 289 subjects in the medication-only and combined treatment groups, who were assigned to systematic, carefully titrated, monitored, and adjusted medication.
“The present study focuses on the 289 subjects in the medication-only and combined treatment groups, who were assigned to systematic, carefully titrated, 26 monitored, and adjusted medication.27”
From Medication Adherence in the MTA: Saliva Methylphenidate Samples Versus Parent Report and Mediating Effect of Concomitant Behavioral Treatment (2009) · cites this paper as [26]
In the early 1990s, Ritalin was prescribed for most cases when stimulant medication was used to treat children with ADHD.
“which then was prescribed for most cases when stimulant medication was used to treat children with ADHD”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Greenhill et al., 2001
The MTA implemented state-of-the-art treatment in the early 1990s.
“The MTA implemented state-of-the-art treatment in the early 1990s”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Greenhill et al., 2001
The MTA used an immediate-release formulation of methylphenidate (Ritalin).
“used an immediate-release formulation of methylphenidate (Ritalin”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Greenhill et al., 2001
Cites
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923 · see citing works
(1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.12.1073 · Cited by 3,372 · see citing works
Pharmacotherapy of Attention-Deficit Hyperactivity Disorder across the Life Cycle
SPENCER, T., BIEDERMAN, J., WILENS, T., HARDING, M., O'DONNELL, D., & GRIFFIN, S. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199604000-00008 · Cited by 830 · see citing works
Attention-deficit hyperactivity disorder and hyperkinetic disorder
Jm, S., Sergeant, J. A., Taylor, E. A., Sonuga-Barke, E. J. S., Jensen, P. S., & Dp, C. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11450-7 · Cited by 602 · see citing works
Self-citationAttention-deficit hyperactivity disorder and hyperkinetic disorder
Swanson, J. M., Sergeant, J. A., Taylor, E., Sonuga-Barke, E. J. S., Jensen, P. S., & Cantwell, D. P. (2001) · Routledge eBooks · doi:10.4324/9781315054315-2 · Cited by 573 · see citing works
Self-citationHyperactivity, inattention, and aggression in clinical practice
Milich, R. S., & Loney, J. (1982) · UKnowledge (University of Kentucky) · Cited by 520 · see citing works
Barkley, R. A., McMurray, M. B., EDELBROCK, C. S., & Robbins, K. (1990) · PubMed · Cited by 433 · see citing works
Increased Methylphenidate Usage for Attention Deficit Disorder in the 1990s
Safer, D. J., ZITO, J. M., & Fine, E. M. (1996) · PEDIATRICS · doi:10.1542/peds.98.6.1084 · Cited by 410 · see citing works
Barkley, R. A., McMurray, M. B., EDELBROCK, C. S., & Robbins, K. (1990) · PEDIATRICS · doi:10.1542/peds.86.2.184 · Cited by 372 · see citing works
Medication treatment strategies in the MTA Study: relevance to clinicians and researchers
GREENHILL, L. L., ABIKOFF, H. B., ARNOLD, L. E., CANTWELL, D. P., CONNERS, C. K., ELLIOTT, G., HECHTMAN, L., HINSHAW, S. P., HOZA, B., JENSEN, P. S., et al. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199610000-00017 · Cited by 297 · see citing works
Self-citationEffect of Anxiety on Cognition, Behavior, and Stimulant Response in ADHD
PLISZKA, S. R. (1989) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198911000-00012 · Cited by 293 · see citing works
GREENHILL, L. L., HALPERIN, J. M., & ABIKOFF, H. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199905000-00011 · Cited by 268 · see citing works
Self-citationPelham, W. E., Carlson, C. L., Sams, S. E., Vallano, G., Dixon, M. J., & Hoza, B. (1993) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.61.3.506 · Cited by 266 · see citing works
Self-citationArnold, L. E. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830210113015 · Cited by 240 · see citing works
Analog Classroom Assessment of Adderall® in Children With ADHD
SWANSON, J. M., WIGAL, S., GREENHILL, L. L., BROWNE, R., WASLIK, B., LERNER, M., WILLIAMS, L., FLYNN, D., AGLER, D., CROWLEY, K., et al. (1998) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199805000-00014 · Cited by 218 · see citing works
Self-citationSwanson, J., Gupta, S., Guinta, D., Flynn, D., Agler, D., Lerner, M., Williams, L., Shoulson, I., & Wigal, S. (1999) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(99)70038-x · Cited by 216 · see citing works
Self-citationPharmacotherapy for Children with Attention-Deficit Hyperactivity Disorder
Pelham, W. E. (1993) · School Psychology Review · doi:10.1080/02796015.1993.12085647 · Cited by 207 · see citing works
Behavioral, situational, and temporal effects of treatment of ADHD with methylphenidate.
Schachar, R., Tannock, R., Cunningham, C. H., & Corkum, P. (1997) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-199706000-00011 · Cited by 202 · see citing works
Ritalin: Theory and Patient Management
Greenhill, L. L. (1991) · Cited by 164 · see citing works
Self-citationHinshaw, S. P., March, J. S., Abikoff, H., Arnold, L. E., Cantwell, D. P., Conners, C. K., Elliott, G. R., Halperin, J. M., Greenhill, L. L., Hechtman, L. T., et al. (1997) · Journal of Attention Disorders · doi:10.1177/108705479700100403 · Cited by 164 · see citing works
Self-citationVITIELLO, B., SEVERE, J. B., GREENHILL, L. L., ARNOLD, L. E., ABIKOFF, H. B., BUKSTEIN, O. G., ELLIOTT, G. R., HECHTMAN, L., JENSEN, P. S., HINSHAW, S. P., et al. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200102000-00013 · Cited by 163 · see citing works
Self-citationResponse to Methylphenidate in Children With ADHD and Comorbid Anxiety
DIAMOND, I. R., TANNOCK, R., & SCHACHAR, R. J. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199904000-00012 · Cited by 132 · see citing works
(1998) · PubMed · Cited by 130 · see citing works
Pliszka, S. R., GREENHILL, L. L., Crismon, M. L., Sedillo, A., Carlson, C. L., Conners, C. K., McCracken, J. T., Swanson, J. M., Hughes, C. W., LLANA, M. E., et al. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200007000-00022 · Cited by 104 · see citing works
Self-citationRapport, M. D., DUPAUL, G., & Kl, K. (1989) · PubMed · Cited by 74 · see citing works
Swanson, J. M., Wigal, S. B., Greenhill, L. L., Browne, R., WASLICK, B. D., Lerner, M., Williams, L., Flynn, D., AGLER, D., Crowley, K., et al. (1998) · PubMed · Cited by 72 · see citing works
Self-citationWallace, A. E., & Kofoed, L. (1994) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.1994.4.141 · Cited by 12 · see citing works
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Sorted by citations
Merikangas, K. R., He, J.-P., Burstein, M., Swendsen, J., Avenevoli, S., Case, B., Georgiades, K., Heaton, L., Swanson, S., & Olfson, M. (2011) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.10.006 · Cited by 1,579 · see citing works
Molina, B. S. G., Hinshaw, S. P., Swanson, J. M., Arnold, L. E., Vitiello, B., Jensen, P. S., Epstein, J. N., Hoza, B., Hechtman, L., Abikoff, H. B., et al. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31819c23d0 · Cited by 1,182 · see citing works
Self-citationMichelson, D., Faries, D., Wernicke, J., Kelsey, D., Kendrick, K., Sallee, F. R., Spencer, T., & the Atomoxetine ADHD Study Group (2001) · Pediatrics · doi:10.1542/peds.108.5.e83 · Cited by 666 · see citing works
Michelson, D., Allen, A. J., Busner, J., Casat, C., Dunn, D., Kratochvil, C., Newcorn, J., Sallee, F. R., Sangal, R. B., Saylor, K., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1896 · Cited by 599 · see citing works
Self-citation(2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1266 · Cited by 521 · see citing works
Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis
Faraone, S. V., & Buitelaar, J. (2010) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0054-3 · Cited by 485 · see citing works
Variables That Affect the Clinical Use and Abuse of Methylphenidate in the Treatment of ADHD
Volkow, N. D., & Swanson, J. M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.11.1909 · Cited by 475 · see citing works
Self-citationEfficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD
GREENHILL, L., KOLLINS, S., ABIKOFF, H., MCCRACKEN, J., RIDDLE, M., SWANSON, J., MCGOUGH, J., WIGAL, S., WIGAL, T., VITIELLO, B., et al. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000235077.32661.61 · Cited by 467 · see citing works
Self-citationKelsey, D. K., Sumner, C. R., Casat, C. D., Coury, D. L., Quintana, H., Saylor, K. E., Sutton, V. K., Gonzales, J., Malcolm, S. K., Schuh, K. J., et al. (2004) · Pediatrics · doi:10.1542/peds.114.1.e1 · Cited by 464 · see citing works
Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
Storebø, O. J., Ramstad, E., Krogh, H. B., Nilausen, T. D., Skoog, M., Holmskov, M., Rosendal, S., Groth, C., Magnusson, F. L., Moreira-Maia, C. R., et al. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009885.pub2 · Cited by 347 · see citing works
CONNOR, D. F., GLATT, S. J., LOPEZ, I. D., JACKSON, D., & MELLONI, R. H. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200203000-00004 · Cited by 333 · see citing works
Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up
SWANSON, J. M., ELLIOTT, G. R., GREENHILL, L. L., WIGAL, T., ARNOLD, L. E., VITIELLO, B., HECHTMAN, L., EPSTEIN, J. N., PELHAM, W. E., ABIKOFF, H. B., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180686d7e · Cited by 323 · see citing works
Self-citationVetter, V. L., Elia, J., Erickson, C., Berger, S., Blum, N., Uzark, K., & Webb, C. L. (2008) · Circulation · doi:10.1161/circulationaha.107.189473 · Cited by 296 · see citing works
KRATOCHVIL, C. J., HEILIGENSTEIN, J. H., DITTMANN, R., SPENCER, T. J., BIEDERMAN, J., WERNICKE, J., NEWCORN, J. H., CASAT, C., MILTON, D., & MICHELSON, D. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200207000-00008 · Cited by 292 · see citing works
Self-citationEmotional Dysregulation in Adult ADHD and Response to Atomoxetine
Reimherr, F. W., Marchant, B. K., Strong, R. E., Hedges, D. W., Adler, L., Spencer, T. J., West, S. A., & Soni, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.040 · Cited by 258 · see citing works
MOLINA, B. S. G., FLORY, K., HINSHAW, S. P., GREINER, A. R., ARNOLD, L. E., SWANSON, J. M., HECHTMAN, L., JENSEN, P. S., VITIELLO, B., HOZA, B., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180686d96 · Cited by 255 · see citing works
Self-citationAttention-deficit/hyperactivity disorder with obstructive sleep apnea: A treatment outcome study
Huang, Y.-S., Guilleminault, C., Li, H.-Y., Yang, C.-M., Wu, Y.-Y., & Chen, N.-H. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.05.016 · Cited by 202 · see citing works
Attention-deficit/hyperactivity disorder in the context of autism spectrum disorders
Murray, M. J. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0145-3 · Cited by 185 · see citing works
Sibley, M. H., Kuriyan, A. B., Evans, S. W., Waxmonsky, J. G., & Smith, B. H. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.02.001 · Cited by 190 · see citing works
Remission versus response as the goal of therapy in ADHD: A new standard for the field?
Steele, M., Jensen, P. S., & Quinn, D. M. P. (2006) · Clinical Therapeutics · doi:10.1016/j.clinthera.2006.11.006 · Cited by 174 · see citing works
Self-citationRubia, K., Noorloos, J., Smith, A., Gunning, B., & Sergeant, J. (2003) · Journal of Abnormal Child Psychology · doi:10.1023/a:1023233630774 · Cited by 170 · see citing works
VITIELLO, B., SEVERE, J. B., GREENHILL, L. L., ARNOLD, L. E., ABIKOFF, H. B., BUKSTEIN, O. G., ELLIOTT, G. R., HECHTMAN, L., JENSEN, P. S., HINSHAW, S. P., et al. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200102000-00013 · Cited by 163 · see citing works
Self-citationSwanson, J. (2003) · CNS Drugs · doi:10.2165/00023210-200317020-00004 · Cited by 162 · see citing works
Self-citationEffects of ethnicity on treatment attendance, stimulant response/dose, and 14-month outcome in ADHD
Arnold, L. E., Elliott, M., Sachs, L., Bird, H., Kraemer, H. C., Wells, K. C., Abikoff, H. B., Comarda, A., Conners, C. K., Elliott, G. R., et al. (2003) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.71.4.713 · Cited by 159 · see citing works
WILENS, T., PELHAM, W., STEIN, M., CONNERS, C. K., ABIKOFF, H., ATKINS, M., AUGUST, G., GREENHILL, L., MCBURNETT, K., PALUMBO, D., et al. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046814.95464.7d · Cited by 148 · see citing works
Self-citationAProspective Open Trial of Guanfacine in Children with Pervasive Developmental Disorders
Scahill, L., Aman, M. G., McDougle, C. J., McCracken, J. T., Tierney, E., Dziura, J., Arnold, L. E., Posey, D., Young, C., Shah, B., et al. (2006) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2006.16.589 · Cited by 117 · see citing works
Self-citationCubillo, A., Smith, A. B., Barrett, N., Giampietro, V., Brammer, M. J., Simmons, A., & Rubia, K. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs296 · Cited by 116 · see citing works
Simonoff, E., Taylor, E., Baird, G., Bernard, S., Chadwick, O., Liang, H., Whitwell, S., Riemer, K., Sharma, K., Sharma, S. P., et al. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02569.x · Cited by 115 · see citing works
Pappadopulos, E., Jensen, P. S., Chait, A. R., Arnold, L. E., Swanson, J. M., Greenhill, L. L., Hechtman, L., Chuang, S., Wells, K. C., Pelham, W., et al. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31819c23ed · Cited by 112 · see citing works
Self-citationWIGAL, S., SWANSON, J. M., FEIFEL, D., SANGAL, R. B., ELIA, J., CASAT, C. D., ZELDIS, J. B., & CONNERS, C. K. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000138351.98604.92 · Cited by 101 · see citing works
Self-citationRiggs, P. D., Hall, S. K., Mikulich-Gilbertson, S. K., Lohman, M., & Kayser, A. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200404000-00008 · Cited by 89 · see citing works
Wang, Y., Zheng, Y., Du, Y., Song, D. H., Shin, Y.-J., Cho, S. C., Kim, B. N., Ahn, D. H., Marquez-Caraveo, M. E., Gao, H., et al. (2007) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670601057767 · Cited by 84 · see citing works
Epstein, J. N., Brinkman, W. B., Froehlich, T., Langberg, J. M., Narad, M. E., Antonini, T. N., Shiels, K., Simon, J. O., & Altaye, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.243 · Cited by 78 · see citing works
Stimulant Rebound: How Common Is It and What Does It Mean?
Carlson, G. A., & Kelly, K. L. (2003) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/104454603322163853 · Cited by 76 · see citing works
Sonuga-Barke, E. J. S., Coghill, D., Wigal, T., DeBacker, M., & Swanson, J. (2009) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2009.0024 · Cited by 71 · see citing works
Self-citationKambeitz, J., Romanos, M., & Ettinger, U. (2014) · The Pharmacogenomics Journal · doi:10.1038/tpj.2013.9 · Cited by 64 · see citing works
Stimulant Medication Treatment of Target Behaviors in Children with Autism: A Population-Based Study
Nickels, K. C., Katusic, S. K., Colligan, R. C., Weaver, A. L., Voigt, R. G., & Barbaresi, W. J. (2008) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e31815f24f7 · Cited by 51 · see citing works
Psychopharmacological treatment of ADHD symptoms in children with autism spectrum disorder
Handen, B. L., Taylor, J., & Tumuluru, R. (2011) · ijamh · doi:10.1515/ijamh.2011.039 · Cited by 26 · see citing works
Wigal, S. B., Kollins, S. H., Childress, A. C., & Adeyi, B. (2010) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-4-32 · Cited by 23 · see citing works
Ghuman, J. K., & Ghuman, H. S. (2013) · Pediatric Drugs · doi:10.1007/s40272-012-0001-5 · Cited by 21 · see citing works
Lilja, M. M., Sandblom, E., Lichtenstein, P., Serlachius, E., Hellner, C., Bhagia, J., & Halldner, L. (2022) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-022-09424-2 · Cited by 14 · see citing works
- Authors
- GREENHILL, L. L., SWANSON, J. M., VITIELLO, B., DAVIES, M., CLEVENGER, W., WU, M., ARNOLD, L. E., ABIKOFF, H. B., BUKSTEIN, O. G., CONNERS, C. K., ELLIOTT, G. R., HECHTMAN, L., HINSHAW, S. P., HOZA, B., JENSEN, P. S., KRAEMER, H. C., MARCH, J. S., NEWCORN, J. H., SEVERE, J. B., WELLS, K., & WIGAL, T.
- Affiliations
- Columbia University (US)
- University of California, Irvine (US)
- Corresponding author
- GREENHILL, LAURENCE L.
- ORCID
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 40
- Issue
- 2
- Pages
- 180-187
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2047162520
- Cited by
- 287
- References
- 27
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 9 · 2017: 12 · 2016: 10 · 2015: 14 · 2014: 10 · 2013: 13 · 2012: 10
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- National Institute of Mental Health (UO1 MH50453, UO1 MH50461, UO1 MH-50454, UO1 MH50440, U01MH050467, U01MH050447, U01MH050440, UO1MH50467, U01MH050453, 5-UO1-MH5045402, UO1 MH50447, U01MH050461, U01MH050454)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- methylphenidate, attention deficit hyperactivity disorder, dose titration, drug dosing, children, teacher ratings, parent ratings, impairment, deportment
- MeSH terms
- Central Nervous System Stimulants, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Child, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Methylphenidate, Regression Analysis, Cross-Over Studies
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