ADHD Symptom Rebound and Emotional Lability With Lisdexamfetamine Dimesylate in Children Aged 6 to 12 Years
Abstract
Objective: To describe symptom rebound in children with ADHD treated with lisdexamfetamine dimesylate (LDX) or placebo. Method: During a 4-week, randomized, double-blind, placebo-controlled trial of LDX, parents/caregivers completed the Conners’ Parent Rating Scale–Revised: Short Form symptom rating scale throughout the day. Response, rebound, and emotional lability (EL) were assessed post hoc based on predefined criteria. Results: Most participants given LDX ( n = 207) were responders throughout the day (50.7%-55.6%) versus placebo ( n = 72; 11.1%-22.2%). A total of seven (3.4%) LDX participants showed rebound in the afternoon and/or evening versus seven (9.7%) with placebo. In both groups, most incidences of rebound occurred in the evening. EL (mean) was higher in LDX rebounders and nonresponders (range = 4.2-9.0) versus LDX responders (range = 1.3-1.6) and versus placebo rebounders (range = 0.7-1.9). Conclusion: ADHD symptom rebound occurred in few participants (3.3%) given LDX (accompanied by clinically significant EL). Overall, more participants given LDX versus placebo responded throughout the day.
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Several studies indicate a positive impact of stimulant and non-stimulant treatment on emotional symptoms in children and adolescents.
“while the majority of these studies target adult ADHD populations, several studies also indicate a positive impact of stimulant and non-stimulant treatment on emotional symptoms in children and adolescents (Kutlu et al., 2017; López et al., 2017; Shih et al., 2019).”
From A Post-Hoc Analysis of Emotional Lability With Delayed-Release/Extended-Release Methylphenidate in Children Aged 6 to 12 Years of Age Participating in Two Phase 3 Clinical Trials (2024) · cites this paper as López et al., 2017
Some studies have reported improvements in EL with stimulant treatment, including MPH.
“some studies have reported improvements in EL with stimulant treatment, including MPH (Baweja et al., 2021; A. C. Childress et al., 2014; López et al., 2017).”
From A Post-Hoc Analysis of Emotional Lability With Delayed-Release/Extended-Release Methylphenidate in Children Aged 6 to 12 Years of Age Participating in Two Phase 3 Clinical Trials (2024) · cites this paper as López et al., 2017
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BackgroundSelf-citation
- Authors
- López, F. A., Childress, A., Adeyi, B., Dirks, B., Babcock, T., Scheckner, B., Lasser, R. A., Shepski, J., & Arnold, V.
- Affiliations
- Children’s Developmental Center, Winter Park, FL, USA
- Center for Psychiatry and Behavioral Medicine (US)
- Shire Development LLC, Wayne, PA, USA
- Pharmanet/i3, an inVentiv Health clinical, Princeton, NJ, USA
- University of Tennessee Health Science Center (US)
- Corresponding author
- López, Frank A.
- Venue
- Journal of Attention Disorders
- Publisher
- SAGE Publications
- Published
- 2016-07-28
- Volume
- 21
- Issue
- 1
- Pages
- 52-61
- ISSN
- 1087-0547 (ISSN-L)
- 1557-1246
- OpenAlex
- W2038262125
- Semantic Scholar
- 1a326650ef0b087cdfd7cb890cde09412859ef12
- Cited by
- 11
- References
- 31
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2014: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Attention Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attention deficit hyperactivity disorder, lisdexamfetamine dimesylate, emotional lability, children, stimulant medication, treatment response, diurnal variation
- MeSH terms
- Lisdexamfetamine Dimesylate, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Dextroamphetamine, Double-Blind Method, Drug Administration Schedule, Emotions, Female, Humans, Male, Parents, Treatment Outcome, Mood Disorders
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