Clinical Applications of the Relaxation Response and Mind-Body Interventions
Abstract
Several hundred peer-reviewed studies in the past 20 years have shown that the relaxation response and mind-body interventions are clinically effective in the treatment of many health problems that are caused or made worse by stress. Recent studies show that mind-body interventions may improve prognosis in coronary heart disease and can enhance immune functioning. It is hypothesized that mind-body interventions reduce sympathetic nervous system activation and increase parasympathetic nervous system activity, and thereby restore homeostasis. Researchers have also concluded that cognitive therapy is as effective, and possibly more effective than antidepressant medication in the treatment of major depression. This report provides an overview of some studies that have shown a beneficial role of the relaxation response and cognitive restructuring in the treatment of headaches, insomnia, and cardiovascular disorders. Studies to date suggest that mind-body interventions are effective and can also provide cost savings in patient treatment. It is also clear, however, that mind-body therapies are not panaceas, and should be used in conjunction with standard medical care.
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Both novice and long-term practitioners of the relaxation response experience significant gene expression changes, with long-term practitioners showing greater effects.
“Research indicates that both novice and long-term practitioners of RR experience significant gene expression changes, with long-term practitioners showing greater effects.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [61]
The relaxation response enhances genes associated with energy metabolism, mitochondrial function, insulin secretion, and telomere maintenance, while reducing those linked to inflammation and stress.
“RR enhances genes associated with energy metabolism, mitochondrial function, insulin secretion, and telomere maintenance, while reducing those linked to inflammation and stress [40,60,61].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [61]
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- Authors
- Jacobs, G. D.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Jacobs, Gregg D.
- Venue
- The Journal of Alternative and Complementary Medicine
- Publisher
- SAGE Publications
- Published
- 2001-12-02
- Volume
- 7
- Issue
- supplement 1
- Pages
- 93-101
- ISSN
- 1075-5535 (ISSN-L)
- 1557-7708
- OpenAlex
- W2055246641
- Cited by
- 120
- References
- 31
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 17 · 2016: 2 · 2015: 7 · 2014: 9 · 2013: 8 · 2012: 5
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Alternative and Complementary Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Health Professions › General Health Professions › Health, psychology, and well-being
- Keywords
- relaxation response, mind-body interventions, stress, coronary artery disease, immune function, sympathetic nervous system, parasympathetic nervous system, homeostasis, cognitive therapy, major depressive disorder, cognitive restructuring, headache, insomnia, cardiovascular disease, cost reduction
- MeSH terms
- Cardiovascular Diseases, Humans, Internal-External Control, Parasympathetic Nervous System, Relaxation, Relaxation Therapy, Stress, Psychological, Sympathetic Nervous System, Mind-Body Relations, Metaphysical
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