Cited by 437Genetics, Aging, and Longevity in Model OrganismsNF-κB Signaling PathwaysExercise and Physiological Responses

The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.

The Molecular Inflammatory Process in Aging

Chung, Hae Young, Sung, Bokyung, Jung, Kyung Jin, Zou, Yani, Yu, Byung Pal·2006·Antioxidants & Redox Signaling

DOI 10.1089/ars.2006.8.572

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Abstract

Emerging pathological evidence indicates that major chronic aging-related diseases such as atherosclerosis, arthritis, dementia, osteoporosis, and cardiovascular diseases, are inflammation-related. In this review, inflammation is examined as a possible underlying basis for the molecular alterations that link aging and age-related pathological processes. A proposal for the molecular inflammation hypothesis of the aging views the redox derangement that occurs during aging as the major factor for increased risk for age-related inflammation. Accumulated data strongly indicate the activation of redox-sensitive transcription factors and dysregulated gene expression under the age-related oxidative stress seems to be the major culprits. Key players involved in the inflammatory process are the age-related upregulation of NF-kappaB, IL-1beta, IL-6, TNFalpha, cyclooxygenase-2, adhesion molecules, and inducible NO synthase. Furthermore, data are presented on the molecular events involved in age-related NF-kappaB activation and phosphorylation by IkappaB kinase/NIK and MAPKs. Experimental data on anti-aging calorie restriction (CR) for its antiinflammatory efficacy by suppressing the upregulated proinflammatory mediators will be reviewed. Also, the involvement of another super family of transcription factors, PPARs (PPARalpha, gamma) as regulators of proinflammatory responses and NF-kappaB signaling pathway is described as well as a discussion on the physiological significance of a well-maintained balance between NF-kappaB and PPARs.

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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
NF-κB: Ten Years After
Baeuerle, P. A., & Baltimore, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81318-5 · Cited by 3,002
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899
The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation
Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., & Karin, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80406-7 · Cited by 1,814
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588
Gene expression profile of aging and its retardation by caloric restriction
Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473
Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)
Schreck, R., Albermann, K., & Baeuerle, P. A. (1992) · Free Radical Research Communications · doi:10.3109/10715769209079515 · Cited by 1,388
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239

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Research works printed but not linked: 6

Bazan NG, 1989, Prog Clin Biol Res, 312, 15
Bodamyali T, 2000, Birkhaüser Verlag, 11
10.1379/1466-1268(2004)009<0099:HSTPAA>2.0.CO;2 · DOI
Kwon HJ, 2001, J Am Aging Assoc, 24, 161
Maeda H, 1998, Biochemistry (Mosc), 63, 854
Wahli W, 2002, Swiss Med Wkly, 132, 83

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Ke, K. (2008) · Deep Blue (University of Michigan)
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Authors: Chung, H. Y., Sung, B., Jung, K. J., Zou, Y., & Yu, B. P.
Affiliations: Pusan National University (KR)
The University of Texas at San Antonio Health Science Center (US)
ORCID: Chung, Hae Young
Sung, Bokyung
Jung, Kyung Jin
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2006-03
Volume: 8
Issue: 3-4
Pages: 572-581
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2006.8.572
OpenAlex: W2045601200
Cited by: 437
References: 120
Citations by year: 2026: 6 · 2025: 18 · 2024: 10 · 2023: 19 · 2022: 17 · 2021: 25 · 2020: 26 · 2019: 13 · 2018: 21 · 2017: 17 · 2016: 21 · 2015: 21 · 2014: 27 · 2013: 22 · 2012: 20
FWCI: 3.30
Type: journal article
Language: en
Open access: closed
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: aging, inflammation, oxidative stress, redox imbalance, NF-κB signaling, IκB kinase, mitogen-activated protein kinase, peroxisome proliferator-activated receptors, caloric restriction, anti-aging, inflammatory cytokines, cyclooxygenase-2, inducible nitric oxide synthase, adhesion molecules, age-related diseases
MeSH terms: Aging, Animals, Humans, Inflammation, Models, Biological, Oxidation-Reduction, Up-Regulation, NF-kappa B, Caloric Restriction, Peroxisome Proliferator-Activated Receptors

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