The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
The Molecular Inflammatory Process in Aging
Abstract
Emerging pathological evidence indicates that major chronic aging-related diseases such as atherosclerosis, arthritis, dementia, osteoporosis, and cardiovascular diseases, are inflammation-related. In this review, inflammation is examined as a possible underlying basis for the molecular alterations that link aging and age-related pathological processes. A proposal for the molecular inflammation hypothesis of the aging views the redox derangement that occurs during aging as the major factor for increased risk for age-related inflammation. Accumulated data strongly indicate the activation of redox-sensitive transcription factors and dysregulated gene expression under the age-related oxidative stress seems to be the major culprits. Key players involved in the inflammatory process are the age-related upregulation of NF-kappaB, IL-1beta, IL-6, TNFalpha, cyclooxygenase-2, adhesion molecules, and inducible NO synthase. Furthermore, data are presented on the molecular events involved in age-related NF-kappaB activation and phosphorylation by IkappaB kinase/NIK and MAPKs. Experimental data on anti-aging calorie restriction (CR) for its antiinflammatory efficacy by suppressing the upregulated proinflammatory mediators will be reviewed. Also, the involvement of another super family of transcription factors, PPARs (PPARalpha, gamma) as regulators of proinflammatory responses and NF-kappaB signaling pathway is described as well as a discussion on the physiological significance of a well-maintained balance between NF-kappaB and PPARs.
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“Nuclear factor κ B (NF-κB) is a major transcriptional factors responsible for pro-inflammatory cytokine production, such as tumor necrosis factor α (TNFα), interleukins (ILs), inducible nitric oxide synthase and cyclooxygenase-2, under inflammatory conditions [9, 10].”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [10]
Citations
Cites
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1 of the 120 references couldn’t be matched to a known paper.
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Molecular inflammation: Underpinnings of aging and age-related diseases
Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203
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The Role of Inflammation in Age-Related Sarcopenia
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Gene expression changes in the course of normal brain aging are sexually dimorphic
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Metadata
- Authors
- Chung, H. Y., Sung, B., Jung, K. J., Zou, Y., & Yu, B. P.
- Affiliations
- Pusan National University (KR)
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2006-03
- Volume
- 8
- Issue
- 3-4
- Pages
- 572-581
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2045601200
- Cited by
- 437
- References
- 120
- Citations by year
- 2026: 6 · 2025: 18 · 2024: 10 · 2023: 19 · 2022: 17 · 2021: 25 · 2020: 26 · 2019: 13 · 2018: 21 · 2017: 17 · 2016: 21 · 2015: 21 · 2014: 27 · 2013: 22 · 2012: 20
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- aging, inflammation, oxidative stress, redox imbalance, NF-κB signaling, IκB kinase, mitogen-activated protein kinase, peroxisome proliferator-activated receptors, caloric restriction, anti-aging, inflammatory cytokines, cyclooxygenase-2, inducible nitric oxide synthase, adhesion molecules, age-related diseases
- MeSH terms
- Aging, Animals, Humans, Inflammation, Models, Biological, Oxidation-Reduction, Up-Regulation, NF-kappa B, Caloric Restriction, Peroxisome Proliferator-Activated Receptors
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