The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Advanced Oxidation Protein Products Activate Vascular Endothelial Cells via a RAGE-Mediated Signaling Pathway
Open accessAbstract
The accumulation of advanced oxidation protein products (AOPPs) has been linked to vascular lesions in diabetes, chronic renal insufficiency, and atherosclerosis. However, the signaling pathway involved in AOPPs-induced endothelial cells (ECs) perturbation is unknown and was investigated. AOPPs modified human serum albumin (AOPPs-HSA) bound to the receptor for advanced glycation end products (RAGE) in a dose-dependent and saturable manner. AOPPs-HSA competitively inhibited the binding of soluble RAGE (sRAGE) with its preferential ligands advanced glycation end products (AGEs). Incubation of AOPPs, either prepared in vitro or isolated from uremic serum, with human umbilical vein ECs induced superoxide generation, activation of NAD(P)H oxidase, ERK 1/2 and p38, and nuclear translocation of NF-kappaB. Activation of signaling pathway by AOPPs-ECs interaction resulted in overexpression of VCAM-1 and ICAM-1 at both gene and protein levels. This AOPPs-triggered biochemical cascade in ECs was prevented by blocking RAGE with either anti-RAGE IgG or excess sRAGE, but was not affected by the neutralizing anti-AGEs IgG. These data suggested that AOPPs might be new ligands of endothelial RAGE. AOPPs-HSA activates vascular ECs via RAGE-mediated signals.
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“Interaction of AGEs with RAGE triggers an intracellular signaling pathway involving NADPH oxidase, MAPK, and NF-(cid:2) B activation, leading to vascular perturbation and inflammation (19, 34, 35, 42).”
Lander, H. M., Tauras, J. M., Ogiste, J. S., Hori, O., Moss, R. A., & Schmidt, A. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17810 · Cited by 813
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Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H Oxidase
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NOX2 and NOX4 Mediate Proliferative Response in Endothelial Cells
Petry, A., Djordjevic, T., Weitnauer, M., Kietzmann, T., Hess, J., & Görlach, A. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1473 · Cited by 243
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Cellular and molecular mechanisms of renal fibrosis
Liu, Y. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.149 · Cited by 1,446
Endothelial–mesenchymal transition in atherosclerosis
Souilhol, C., Harmsen, M. C., Evans, P. C., & Krenning, G. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvx253 · Cited by 401
The RAGE axis: A fundamental mechanism signaling danger to the vulnerable vasculature
Yan, S. F., Ramasamy, R., & Schmidt, A. M. (2010) · Circulation Research · doi:10.1161/circresaha.109.212217 · Cited by 381
RAGE: therapeutic target and biomarker of the inflammatory response—the evidence mounts
Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0409230 · Cited by 283
Role of RAGE in the Pathogenesis of Neurological Disorders
Juranek, J., Mukherjee, K., Kordas, B., Załęcki, M., Korytko, A., Zglejc-Waszak, K., Szuszkiewicz, J., & Banach, M. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00878-x · Cited by 45
Metadata
- Authors
- Guo, Z. J., Niu, H. X., Hou, F. F., Zhang, L., Fu, N., Nagai, R., Lu, X., Chen, B. H., Shan, Y. X., Tian, J. W., Nagaraj, R. H., Xie, D., & Zhang, X.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2008-10
- Volume
- 10
- Issue
- 10
- Pages
- 1699-1712
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2029777277
- Cited by
- 193
- References
- 5
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Guo, Z. J., Niu, H. X., Hou, F. F., Zhang, L., Fu, N., Nagai, R., Lu, X., Chen, B. H., Shan, Y. X., Tian, J. W., Nagaraj, R. H., Xie, D., & Zhang, X. (2008). Advanced Oxidation Protein Products Activate Vascular Endothelial Cells via a RAGE-Mediated Signaling Pathway. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2007.1999
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