The RAGE axis: A fundamental mechanism signaling danger to the vulnerable vasculature

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RAGE Mediates a Novel Proinflammatory Axis

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Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE

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Circulating Endothelial Progenitor Cells Are Reduced in Peripheral Vascular Complications of Type 2 Diabetes Mellitus

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High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

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RAGE Blockade Stabilizes Established Atherosclerosis in Diabetic Apolipoprotein E–Null Mice

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A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane‐bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)

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Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response

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Release of High Mobility Group Box 1 by Dendritic Cells Controls T Cell Activation via the Receptor for Advanced Glycation End Products

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Morphologic Findings of Coronary Atherosclerotic Plaques in Diabetics

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Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

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Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials

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Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response

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The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage

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Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes

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Rage and arthritis: The G82S polymorphism amplifies the inflammatory response

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The Receptor RAGE as a Progression Factor Amplifying Arachidonate-Dependent Inflammatory and Proteolytic Response in Human Atherosclerotic Plaques

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Identification, classification, and expression of RAGE gene splice variants

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Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice

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Interaction of the RAGE Cytoplasmic Domain with Diaphanous-1 Is Required for Ligand-stimulated Cellular Migration through Activation of Rac1 and Cdc42

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Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

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The myeloperoxidase system of human phagocytes generates Nε-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation

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Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis

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Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products.

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S100A8 and S100A9 Mediate Endotoxin-Induced Cardiomyocyte Dysfunction via the Receptor for Advanced Glycation End Products

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Exogenous High-Mobility Group Box 1 Protein Induces Myocardial Regeneration After Infarction via Enhanced Cardiac C-Kit + Cell Proliferation and Differentiation

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Receptor for Advanced Glycation End Products Is Subjected to Protein Ectodomain Shedding by Metalloproteinases

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RAGE: therapeutic target and biomarker of the inflammatory response—the evidence mounts

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ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO

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Receptor for Advanced-Glycation End Products: Key Modulator of Myocardial Ischemic Injury

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Soluble Receptor for Advanced Glycation End Products: From Disease Marker to Potential Therapeutic Target

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Nonhistone Proteins HMG 1 and HMG 2 Change the DNA Helical Structure

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RAGE Control of Diabetic Nephropathy in a Mouse Model

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RAGE modulates vascular inflammation and atherosclerosis in a murine model of type 2 diabetes

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Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation.

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Advanced glycation end-product cross-link breakersA novel approach to cardiovascular pathologies related to the aging process

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Activation of Poly(ADP)-ribose Polymerase (PARP-1) Induces Release of the Pro-inflammatory Mediator HMGB1 from the Nucleus

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The receptor for advanced glycation end‐products (RAGE) directly binds to ERK by a D‐domain‐like docking site

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Advanced Oxidation Protein Products Activate Vascular Endothelial Cells via a RAGE-Mediated Signaling Pathway

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Soluble Forms of RAGE in Human Diseases: Clinical and Therapeutical Implications

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RAGE: a novel biological and genetic marker for vascular disease

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Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling

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Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection

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Soluble Receptor for Advanced Glycation End Products in Patients With Decreased Renal Function

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RAGE Ligation Affects T Cell Activation and Controls T Cell Differentiation

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Roles of the Receptor for Advanced Glycation Endproducts in Diabetes-Induced Vascular Injury

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The receptor for advanced glycation endproducts (RAGE) and cardiovascular disease

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High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice

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RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model

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The Functional −374 T/A RAGE Gene Polymorphism Is Associated With Proteinuria and Cardiovascular Disease in Type 1 Diabetic Patients

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The Relationship between Apoptosis and High-Mobility Group Protein 1 Release from Murine Macrophages Stimulated with Lipopolysaccharide or Polyinosinic-Polycytidylic Acid

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Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: cohort study

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RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium

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Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products

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Formins in cell signaling

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Oxygen Deprivation Triggers Upregulation of Early Growth Response-1 by the Receptor for Advanced Glycation End Products

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RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice

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Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains

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RAGE Ligand Upregulation of VEGF Secretion in ARPE-19 Cells

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The Receptor for Advanced Glycation End Products Impairs Host Defense in Pneumococcal Pneumonia

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Advanced glycation end products impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2

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Receptor for Advanced Glycation End Products Expression on T Cells Contributes to Antigen-Specific Cellular Expansion In Vivo

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Blockade of RAGE Suppresses Alloimmune Reactions In Vitro and Delays Allograft Rejection in Murine Heart Transplantation

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Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia

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Modulated Inflammation by Injection of High-Mobility Group Box 1 Recovers Post-Infarction Chronically Failing Heart

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The role of RAGE in amyloid-beta peptide-mediated pathology in Alzheimer's disease.

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S100B Expression Modulates Left Ventricular Remodeling After Myocardial Infarction in Mice

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Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model

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Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype

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The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer’s disease

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Resveratrol and Amyloid-Beta: Mechanistic Insights

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Pharmacologic approaches against Advanced Glycation End Products (AGEs) in diabetic cardiovascular disease

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Kidney, heart and brain: three organs targeted by ageing and glycation

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Genetic Pathways of Vascular Calcification

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Aldose reductase, ocular diabetic complications and the development of topical Kinostat®

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Linking RAGE and Nox in diabetic micro- and macrovascular complications

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Heparan Sulfate Is Essential for High Mobility Group Protein 1 (HMGB1) Signaling by the Receptor for Advanced Glycation End Products (RAGE)

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Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction

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Functional Role of Soluble Receptor for Advanced Glycation End Products in Stroke

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Restoration of Nrf2 Signaling Normalizes the Regenerative Niche

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Drosophila Models of Cardiac Disease

Piazza, N., & Wessells, R. J. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-384878-9.00005-4 · Cited by 79 · see citing works

Redox-inflammatory synergy in the metabolic syndrome

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Methylglyoxal-Derived Advanced Glycation Endproducts in Multiple Sclerosis

Wetzels, S., Wouters, K., Schalkwijk, C. G., Vanmierlo, T., & Hendriks, J. J. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020421 · Cited by 80 · see citing works

The importance of Ca2 Zn2 signaling S100 proteins and RAGE in translational medicine

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Enzymatically Modified Low-Density Lipoprotein Promotes Foam Cell Formation in Smooth Muscle Cells via Macropinocytosis and Enhances Receptor-Mediated Uptake of Oxidized Low-Density Lipoprotein

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Endothelial Control of Cerebral Blood Flow

Ashby, J. W., & Mack, J. J. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.02.023 · Cited by 76 · see citing works

Loss of RAGE Defense: A Cause of Charcot Neuroarthropathy?

Witzke, K. A., Vinik, A. I., Grant, L. M., Grant, W. P., Parson, H. K., Pittenger, G. L., & Burcus, N. I. (2011) · Diabetes Care · doi:10.2337/dc10-2315 · Cited by 76 · see citing works

Skin autofluorescence as a measure of advanced glycation endproduct deposition: a novel risk marker in chronic kidney disease

Smit, A. J., & Gerrits, E. G. (2010) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e32833e9259 · Cited by 76 · see citing works

Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm

Wang, Y., Ge, M., Wang, J., Xu, Y., Wang, N., & Xu, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08114-w · Cited by 75 · see citing works

Glycine Suppresses AGE/RAGE Signaling Pathway and Subsequent Oxidative Stress by Restoring Glo1 Function in the Aorta of Diabetic Rats and in HUVECs

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A Novel Cellular Defect in Diabetes

Howard, A. C., McNeil, A. K., Xiong, F., Xiong, W., & McNeil, P. L. (2011) · Diabetes · doi:10.2337/db11-0851 · Cited by 73 · see citing works

Closing the anion gap: Contribution of d-lactate to diabetic ketoacidosis

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Uric acid: from a biological advantage to a potential danger. A focus on cardiovascular effects

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RANKL–OPG and RAGE modulation in vascular calcification and diabetes: novel targets for therapy

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Advanced glycation end products: Key mediator and therapeutic target of cardiovascular complications in diabetes

Bansal, S., Burman, A., & Tripathi, A. K. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i8.1146 · Cited by 66 · see citing works

Transthyretin Cardiac Amyloidosis: Pathogenesis, Treatments, and Emerging Role in Heart Failure with Preserved Ejection Fraction

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Efficacy of alogliptin, a dipeptidyl peptidase‐4 inhibitor, on glucose parameters, the activity of the advanced glycation end product (AGE) – receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes

Sakata, K., Hayakawa, M., Yano, Y., Tamaki, N., Yokota, N., Eto, T., Watanabe, R., Hirayama, N., Matsuo, T., Kuroki, K., et al. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2437 · Cited by 65 · see citing works

LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells

Figarola, J. L., Singhal, J., Rahbar, S., Awasthi, S., & Singhal, S. S. (2014) · APOPTOSIS · doi:10.1007/s10495-014-0974-3 · Cited by 65 · see citing works

Vascular Remodeling and Arterial Calcification Are Directly Mediated by S100A12 (EN-RAGE) in Chronic Kidney Disease

Gawdzik, J. C., Mathew, L., Kim, G. H., Puri, T. S., & Bowman, M. A. H. (2011) · American Journal of Nephrology · doi:10.1159/000324693 · Cited by 64 · see citing works

Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells

Maulucci, G., Daniel, B., Cohen, O., Avrahami, Y., & Sasson, S. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.03.001 · Cited by 63 · see citing works

RAGE mediates vascular injury and inflammation after global cerebral ischemia

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Heparin inhibits the inflammatory response induced by LPS and HMGB1 by blocking the binding of HMGB1 to the surface of macrophages

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Beneficial effects of quinoline-3-carboxamide (ABR-215757) on atherosclerotic plaque morphology in S100A12 transgenic ApoE null mice

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Lentinan, β-glucan from Shiitake (Lentinula edodes): A review on structure, conformational transition, and gastro-intestinal interaction contributing towards its anti-diabetic potential

Chakraborty, S., Beura, M., Sharma, S. K., Singh, A., Dahuja, A., & Krishnan, V. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104224 · Cited by 59 · see citing works

Pkcδ Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products (Ages)

Yang, Y., Tsai, C.-Y., Chen, C.-L., Kuo, C., Hou, C., Cheng, S.-Y., Aneja, R., Huang, C., & Kuo, W. (2018) · Aging and Disease · doi:10.14336/ad.2017.0924 · Cited by 59 · see citing works

The RAGE Axis and Endothelial Dysfunction: Maladaptive Roles in the Diabetic Vasculature and Beyond

Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.08.003 · Cited by 91 · see citing works

Receptor for AGE (RAGE) and its ligands—cast into leading roles in diabetes and the inflammatory response

Yan, S. F., Ramasamy, R., & Schmidt, A. M. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0439-2 · Cited by 236 · see citing works

Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes

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Glycation, Inflammation, and RAGE: A Scaffold for the Macrovascular Complications of Diabetes and Beyond

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The RAGE Connection To Diabetes And Atherosclerosis: An Intertwined Web Of Advanced Glycation And Inflammation

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